Potassium in mecholyl-stimulated gastric secretion in the dog

Previous work indicated that K concentration ([K]) of gastric juice rises abruptly after histamine injection, concomitantly with acid efflux. Using Heidenhain and vagal pouch dogs, these experiments (26 in all) were repeated with mecholyl and histamine. The concentration-time curves for K were similar for both stimuli with early rise in [K], its late fall below preinjection level, and eventual recovery. The initial rise tended to be smaller and occurred less often with mecholyl. Its occurrence after histamine was also inconsistent. [K] was poorly correlated with both acidity and volume-rate. Time curves for K output likewise were similar with both stimuli, but correlation with acid output was high. Exogenous histamine is not essential to this K efflux, which may represent a basic process associated with glandular, neural, or muscular stimulation in general.

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Cephalic Phase of Gastric Secretion in the Rat

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1957.192.1.23 ◽

1957 ◽

Vol 192 (1) ◽

pp. 23-26 ◽

Cited By ~ 24

Author(s):

T. M. Lin ◽

R. S. Alphin

Keyword(s):

Gastric Secretion ◽

Gastric Juice ◽

Free Acid ◽

Acid Output ◽

Esophageal Fistula ◽

Depressing Effect ◽

Gastric Glands ◽

Sham Feeding ◽

Cephalic Phase ◽

Bilateral Vagotomy

Nineteen sham-feeding tests were performed on eleven rats with a chronic gastric and esophageal fistula. As compared with man and the dog, a slight increase in acid output occurred in 17 tests, the increase being quite definite in 13 tests. Sham feeding had no effect on gastric secretion in 16 tests on rats when performed from 1 to 14 days after bilateral vagotomy. The vagotomy had a profound depressing effect on the interdigestive secretion, no free acid being found in the fasting secretion in any of the rats during the period of these tests. The vagi exert a marked secretory tone on the gastric glands, but the conditioned secretion of gastric juice is probably not of much physiological significance in the rats studied in these tests.

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Evidence for the independence of K- and HCl-efflux into gastric secretion

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1960.198.4.729 ◽

1960 ◽

Vol 198 (4) ◽

pp. 729-736 ◽

Cited By ~ 12

Author(s):

Franklin Hollander ◽

Henry Colcher

Keyword(s):

Gastric Secretion ◽

Total Acidity ◽

Independent Manner ◽

Subcutaneous Injections ◽

Volume Rate ◽

Concentration Time

Further evidence is presented that the concentration of K in gastric secretion varies extensively (0.3–12.3 mEq/L.) with time following histamine injection—in refutation of the previously reported constancy. Interrelations among the concentrations of major electrolytes and volume rate following single subcutaneous injections were analyzed for individual experiments (7 dogs) and also statistically. Concentrations of neutral Cl, Na, and Na plus K varied inversely with total acidity, according to the usual rectilinear relation. K was wholly uncorrelated with acidity ( r = –0.13) and volume rate ( r = 0.08). The only regularity in K behavior was in relation to time following histamine administration. The characteristics of these concentration-time curves suggest that histamine triggers the efflux of K into gastric secretion by some mechanism which is independent of HCl efflux and, therefore, of the formation of parietal secretion. The two processes may be initiated simultaneously, but proceed thereafter in wholly independent manner. Several different explanations suggest themselves, but the data are still inadequate for preferential acceptance of any one of them.

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Effects of large intravenous electrolyte infusions on rat gastric secretion

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1965.209.5.961 ◽

1965 ◽

Vol 209 (5) ◽

pp. 961-965 ◽

Cited By ~ 4

Author(s):

Peter E. Baume ◽

H. C. Meng ◽

David H. Law

Keyword(s):

Sodium Chloride ◽

Gastric Secretion ◽

Gastric Juice ◽

Acid Output ◽

Chloride Ion ◽

Electrolyte Solutions ◽

Intravenous Injections ◽

Isotonic Sodium Chloride ◽

Per Se ◽

Related Increase

Gastric secretion was studied in pylorus-ligated rats following single large intravenous injections of electrolyte solutions of varying composition, volume, and tonicity. Single large injections of isotonic sodium chloride led to a volume-related increase in the volume and acid output of gastric secretion without any alteration in the acidity of the gastric juice. The tonicity of the injected fluid was a critical controlling factor and in one experiment marked alterations in tonicity exerted more effect on the subsequent secretory response than did simultaneous large alterations in the volume of fluid injected. The solute load per se was not as critical a factor as was the tonicity of the fluid containing it. It was shown that neither the sodium nor the chloride ion was specifically required in the injected fluid for production of this response and that injections of extremely anisotonic solutions caused profound gastric secretory depression. In view of these findings, it is suggested that care be taken to select appropriate control solutions for intravenous injection in experiments involving the pylorus-ligated rat.

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Effects of KCl and insulin on benzimidazole-inhibited canine gastric secretion

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1983.245.6.g739 ◽

1983 ◽

Vol 245 (6) ◽

pp. G739-G744

Author(s):

B. I. Hirschowitz ◽

J. Fong

Keyword(s):

Gastric Secretion ◽

Parietal Cell ◽

Acid Output ◽

Gastric Fistula ◽

Large Decrease ◽

Pepsin Secretion ◽

K Secretion ◽

Inhibited Acid ◽

K Concentration ◽

Bethanechol Chloride

The final step in acid secretion is believed to result from the H+-K+-ATPase-mediated exchange of H+ in the parietal cell, with K+ in the lumen. To study the K+ secretion we used Picoprazole and insulin separately and together to inhibit gastric secretion stimulated in gastric fistula dogs with histamine (100 micrograms X kg-1 X h-1). Picoprazole, a substituted benzimidazole (750 mg/kg), reduced gastric H+ concentration and volume with a rise in K+ concentration [( K+]) to 20–25 meq/l. Insulin alone inhibited acid output to the same extent as Picoprazole but with a marked fall in [K+]. Insulin (0.6 U/kg) given with Picoprazole did not alter inhibition of H+ but prevented the large decrease in gastric juice [K+]. An injection of KCl (1 meq/kg) 1 h after Picoprazole did not alter the effects of the inhibitor. Pepsin secretion after insulin was delayed by Picoprazole, whereas during bethanechol chloride infusion (80 micrograms X kg-1 X h-1) pepsin output was reduced for a shorter period and to a lesser extent than acid. We concluded that insulin affects gastric H+ and K+ secretion by a mechanism not related to H+-K+-ATPase and that Picoprazole affects pepsin secretion probably indirectly via its effect on the parietal cell, where its action is quite consistent with an effect limited to inhibition of the H+-K+-ATPase of the parietal cell.

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On the pathology of gastric secretion of the peasant population

Kazan medical journal ◽

10.17816/kazmj58933 ◽

1930 ◽

Vol 26 (12) ◽

pp. 1190-1194

Author(s):

V. E. Rodionov

Keyword(s):

Gastric Secretion ◽

Gastric Juice ◽

Motor Function ◽

Laboratory Data ◽

The State ◽

Objective Data ◽

Gastric Diseases ◽

Gastric Glands ◽

Chemical Studies ◽

Physiological Structure

As you know, the majority of gastric suffering is based on the pathology of the secretory and motor function of the stomach, depending or without it on the organic changes in its anatomical and physiological structure. In the presence of a complex of anamnestic and objective data, the state of secretion in each given case is laid on the basis for the diagnosis of gastric diseases, why the laboratory data in connection with the clinic serve as the starting material in our article. We took the result of chemical studies of gastric juice carried out in the Ardatov laboratory for 10 years from 1919 to 1928 inclusive in the amount of 2277 cases. We believe that this material is sufficient to reveal some aspects of the pathology of the function of the gastric glands depending on the conditions of nutrition and life of the peasant population, especially since in relation to nutrition during this period of time the population was in very different conditions.

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The Output of HCl in Gastric Juice and Free Histamine in Urine during Stimulation of Gastric Secretion

Digestion ◽

10.1159/000201836 ◽

1958 ◽

Vol 89 (5-6) ◽

pp. 290-291

Author(s):

W.T. Irvine

Keyword(s):

Gastric Secretion ◽

Gastric Juice ◽

Stimulation Of

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Inhibition of gastric secretion by thyroid preparations

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1959.196.6.1262 ◽

1959 ◽

Vol 196 (6) ◽

pp. 1262-1265 ◽

Cited By ~ 14

Author(s):

E. S. Nasset ◽

V. W. Logan ◽

M. L. Kelley ◽

Mary Thomas

Keyword(s):

Gastric Secretion ◽

Gastric Juice ◽

Gradual Decline ◽

Heidenhain Pouch ◽

Significant Fall ◽

Lean Beef ◽

Inhibition Of Gastric Secretion

Four dogs with Thomas gastric pouches and one dog with a Heidenhain pouch were stimulated to secrete gastric juice by feeding 100 gm of lean beef. Feeding whole desiccated thyroid ordinarily caused a significant fall in volume of gastric juice and in the total quantity of HCl secreted. Crystalline thyroxine yielded erratic results and one trial with triiodothyronine produced a significant increase in gastric secretion. Thyroidectomy in one dog resulted in a gradual decline in secretion, but hypothyroidism produced by administration of mercaptoimidazole in another animal lead to a significant increase in secretion.

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Secretin effect on gastrin, gastric secretion in dogs with chronic antral stimulation

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1975.228.6.1775 ◽

1975 ◽

Vol 228 (6) ◽

pp. 1775-1781 ◽

Cited By ~ 4

Author(s):

S Nasca ◽

M Mignon ◽

L Gramatica ◽

J-P Accary ◽

S Bonfils

Keyword(s):

Gastric Secretion ◽

Acid Output ◽

Physiological Activity ◽

Fold Increase ◽

Acid Inhibition ◽

Plasma Gastrin ◽

Heidenhain Pouch ◽

Fasting Plasma

Antrocolic transposition in four dogs with Heidenhain pouch and gastrojejunostomyresulted in a marked increase in fasting plasma gastrin concentration and sustained highacid secretion, closely related to gastrin levels. A marked production of pepsin output could not be correlated with plasma gastrin. Reduction in plasma gastrin concentration was more than twofold less pronounced than the reduction in acid output for 1 and 2 U/kg-h, while the 0.5 U/kg-h no effect was noted. For both acid output and gastrin concentrations, close correlations were noted between presecretion level and remaining level upon secretin infusion. Despite the reduction in the secretory volume of the pouch, 0.5 and 1 U/kg-h of secretin induced a 1.5- and 2-fold increase in pepsin output, respectively. Two untis per kilagram-hour decreased the secretory volume as well as the pepsin output. If the physiological release of secretin in dogs does not exceed the equivalent of the lowest dose studied, our results would indicate that acid inhibition is a physiological activity of secretin, while the effect on circulating gastrin concentration seems to be phamacological.

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Effects of the amount and type of food eaten on secretion from fundic abomasal pouches of sheep

British Journal Of Nutrition ◽

10.1079/bjn19740089 ◽

1974 ◽

Vol 32 (2) ◽

pp. 375-387 ◽

Cited By ~ 16

Author(s):

L. M. McLeay ◽

D. A. Titchen

Keyword(s):

Gastric Secretion ◽

Acid Concentration ◽

Dry Matter ◽

Acid Output ◽

Pyloric Antrum

1. The effects on gastric secretion of altering the amount and type of food eaten were examined in sheep with fundic abomasal pouches and in sheep which also had the antral region of the abomasum isolated into a pouch or removed (antrectomy). Secretion, which was continuous in all preparations, was collected over 24 h periods, and daily determinations of its acid and pepsin concentrations were made for periods of up to 10 weeks.2. Experimental diets consisting of chaffed lucerne, meadow and wheaten hays were fed on ad lib. or restricted regimens.3. Raising and lowering the dry matter (DM) intakes of lucerne chaff increased and decreased respectively the volume, acidity and acid and pepsin outputs (volume x concentration of acid or pepsin) of fundic pouch secretion.4. Increases of 27–64% in the amount of lucerne chaff eaten, after changing from restricted to ad lib. feeding, were followed by increases in the volume (19–66%), acid concentration (4–10 mequiv. H+/l, 3–9%) and acid output (18–76%) of pouch secretion.5. With DM intakes of mixed lucerne and wheaten chaffs between 88 and 107% of those of lucerne, the secretion from the pouches was reduced to 45–88% of the volume and 39–77% of the acid output observed with the lucerne diet. Acid concentration was least affected, being unchanged in one series of observations and decreased by, at the most, 13 mequiv. H+/l (12%) in another. Reverting to a diet of lucerne chaff reversed these effects: the volume was increased by 30–49%, acid concentration by 2–15 mequiv. H+/l (2–14%), acid output by 38–68% and pepsin output by 30–43% although the intake of DM was the same or 6% less than that on the wheaten chaff mixture.6. Secretion was greater when animals ate lucerne chaff than when they ate meadow chaff.7. The changes in secretion according to diet were obtained in animals with antral pouches and antrectomy as well as in those with only fundic pouches.8. It is argued in discussion that the markedly different abomasal secretions on different diets arise from abomasal stimulation due to the nature rather than the amount of digesta entering it and that although the pyloric antrum contributes to these changes it is not essential for their occurrence.

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