Steady-state response of quadriplegic subjects to inspiratory resistive load

1986 ◽  
Vol 60 (5) ◽  
pp. 1482-1492 ◽  
Author(s):  
V. Im Hof ◽  
H. Dubo ◽  
V. Daniels ◽  
M. Younes
Keyword(s):  
Steady State ◽  
Chest Wall ◽  
Muscle Spindles ◽  
Normal Subjects ◽  
Afferent Feedback ◽  
Resistive Load ◽  
State Response ◽  
The Face ◽  
Inspiratory Resistance

Normal subjects preserve tidal volume (VT) in the face of added inspiratory resistance by increasing maximal amplitude and duration of the rising phase of respiratory driving pressure (DP) and by changing the shape of this phase to one that is more concave to the time axis. To explore the possible role of chest wall afferents in mediating these responses, we determined averaged DP in eight quadriplegic subjects during steady-state unloaded breathing and while breathing through an inspiratory resistance (8.5 cmH2O X 1(-1) X s). As with normal subjects, quadriplegics preserved VT (loaded VT = 106% control) by utilizing all three mechanisms. However, prolongation of the inspiratory duration derived from the DP waveform (+22% vs. +42%) and shape response were significantly less in the quadriplegic subjects. Shape response was completely absent in subjects with C4 lesions. The results provide strong evidence that respiratory muscle spindles are responsible for shape response and that changes in afferent feedback from the chest wall play an important role in mediating inspiratory prolongation.

Steady-state response of normal subjects to inspiratory resistive load

1986 ◽  
Vol 60 (5) ◽  
pp. 1471-1481 ◽  
Author(s):  
V. Im Hof ◽  
P. West ◽  
M. Younes
Keyword(s):  
Steady State ◽  
Normal Subjects ◽  
Driving Pressure ◽  
Resistive Load ◽  
Steady State Response ◽  
Occlusion Pressure ◽  
State Response ◽  
Inspiratory Resistance ◽  
Residual Capacity ◽  
Loaded Breathing

Tidal volume (VT) is usually preserved when conscious humans are made to breathe against an inspiratory resistance. To identify the neural changes responsible for VT compensation we calculated the respiratory driving pressure waveform during steady-state unloaded and loaded breathing (delta R = 8.5 cmH2O X 1(-1) X s) in eight conscious normal subjects. Driving pressure (DP) was calculated according to the method of Younes et al. (J. Appl. Physiol. 51: 963–989, 1981), which provides the equivalent of occlusion pressure at functional residual capacity throughout the breath. VT during resistance breathing was 108% of unloaded VT, as opposed to a predicted value of 82% of control in the absence of neural compensation. Compensation was accomplished through three changes in the DP waveform: 1) peak amplitude increased (+/- 23%), 2) the duration of the rising phase increased (+42%); and 3) the rising phase became more concave to the time axis. There were no changes in the relative decay rate of inspiratory pressure during expiration, in the shape of the declining phase of DP, or in end-expiratory lung volume.

Effect of chest wall vibration on breathlessness in normal subjects

1991 ◽  
Vol 71 (1) ◽  
pp. 175-181 ◽  
Author(s):  
H. L. Manning ◽  
R. Basner ◽  
J. Ringler ◽  
C. Rand ◽  
V. Fencl ◽  
...  
Keyword(s):  
Steady State ◽  
Chest Wall ◽  
Minute Ventilation ◽  
Normal Subjects ◽  
Potential Contribution ◽  
Resistive Load ◽  
Residual Capacity ◽  
End Tidal ◽  
End Tidal Co2 ◽  
Hypercapnic Response

This study evaluated the effect of chest wall vibration (115 Hz) on breathlessness. Breathlessness was induced in normal subjects by a combination of hypercapnia and an inspiratory resistive load; both minute ventilation and end-tidal CO2 were kept constant. Cross-modality matching was used to rate breathlessness. Ratings during intercostal vibration were expressed as a percentage of ratings during the control condition (either deltoid vibration or no vibration). To evaluate their potential contribution to any changes in breathlessness, we assessed several aspects of ventilation, including chest wall configuration, functional residual capacity (FRC), and the ventilatory response to steady-state hypercapnia. Intercostal vibration reduced breathlessness ratings by 6.5 +/- 5.7% compared with deltoid vibration (P less than 0.05) and by 7.0 +/- 8.3% compared with no vibration (P less than 0.05). The reduction in breathlessness was accompanied by either no change or negligible change in minute ventilation, tidal volume, frequency, duty cycle, compartmental ventilation, FRC, and the steady-state hypercapnic response. We conclude that chest wall vibration reduces breathlessness and speculate that it may do so through stimulation of receptors in the chest wall.

New Insight Into Energy Harvesting via Axially-Loaded Beams

2009 ◽  
Author(s):  
Mohammed F. Daqaq
Keyword(s):  
Steady State ◽  
Energy Harvesting ◽  
Axial Load ◽  
Excitation Frequency ◽  
Axial Loading ◽  
Response Amplitude ◽  
Resistive Load ◽  
Steady State Response ◽  
State Response ◽  
Axially Loaded

Driven by the study of Leland and Wright [1], this manuscript delves into the qualitative understanding of energy harvesting using axially-loaded beams. Using a simple nonlinear electromechanical model and the method of multiple scales, we study the general nonlinear physics of energy harvesting from a piezoelectric beam subjected to static axial loading and traversal dynamic excitation. We obtain analytical expressions for the steady-state response amplitude, the voltage drop across a resistive load, and the output power. We utilize these expression to study the effect of the axial loading on the overall nonlinear behavior of the harvester. It is demonstrated that, in addition to the ability of tuning the harvester to the excitation frequency via axial load variations, the axial load aids in i) increasing the electric damping in the system thereby enhancing the energy transfer from the beam to the electric load, ii) amplifying the effect of the external excitation on the structure, and hence, increases the steady-state response amplitude and output voltage, and iii) increasing the bandwidth of the harvester by enhancing the effective nonlinearity of the system.

Mechanism of detection of resistive loads in conscious humans

1992 ◽  
Vol 72 (6) ◽  
pp. 2267-2270 ◽  
Author(s):  
A. Puddy ◽  
G. Giesbrecht ◽  
R. Sanii ◽  
M. Younes
Keyword(s):  
Chest Wall ◽  
Respiratory System ◽  
Primary Source ◽  
Intrathoracic Pressure ◽  
Normal Subjects ◽  
Resistive Load ◽  
Load Detection ◽  
Elastic Load ◽  
Resistive Loads ◽  
Source Of Information

Conscious humans easily detect loads applied to the respiratory system. Resistive loads as small as 0.5 cmH2O.l-1.s can be detected. Previous work suggested that afferent information from the chest wall served as the primary source of information for load detection, but the evidence for this was not convincing, and we recently reported that the chest wall was a relatively poor detector for applied elastic loads. Using the same setup of a loading device and body cast, we sought resistive load detection thresholds under three conditions: 1) loading of the total respiratory system, 2) loading such that the chest wall was protected from the load but airway and intrathoracic pressures experienced negative pressure in proportion to inspiratory flow, and 3) loading of the chest wall alone with no alteration of airway or intrathoracic pressure. The threshold for detection for the three types of load application in seven normal subjects was 1.17 +/- 0.33, 1.68 +/- 0.45, and 6.3 +/- 1.38 (SE) cmH2O.l-1.s for total respiratory system, chest wall protected, and chest wall alone, respectively. We conclude that the active chest wall is a less potent source of information for detection of applied resistive loads than structures affected by negative airway and intrathoracic pressure, a finding similar to that previously reported for elastic load detection.

scholarly journals Role of muscle spindle feedback in regulating muscle activity strength during walking at different speed in mice

2018 ◽  
Vol 120 (5) ◽  
pp. 2484-2497 ◽  
Author(s):  
William P. Mayer ◽  
Andrew J. Murray ◽  
Susan Brenner-Morton ◽  
Thomas M. Jessell ◽  
Warren G. Tourtellotte ◽  
...  
Keyword(s):  
Muscle Spindle ◽  
Amplitude Modulation ◽  
Muscle Activity ◽  
Sensory Feedback ◽  
Walking Speed ◽  
Muscle Spindles ◽  
Afferent Feedback ◽  
Triceps Surae ◽  
Extensor Muscles

Terrestrial animals increase their walking speed by increasing the activity of the extensor muscles. However, the mechanism underlying how this speed-dependent amplitude modulation is achieved remains obscure. Previous studies have shown that group Ib afferent feedback from Golgi tendon organs that signal force is one of the major regulators of the strength of muscle activity during walking in cats and humans. In contrast, the contribution of group Ia/II afferent feedback from muscle spindle stretch receptors that signal angular displacement of leg joints is unclear. Some studies indicate that group II afferent feedback may be important for amplitude regulation in humans, but the role of muscle spindle feedback in regulation of muscle activity strength in quadrupedal animals is very poorly understood. To examine the role of feedback from muscle spindles, we combined in vivo electrophysiology and motion analysis with mouse genetics and gene delivery with adeno-associated virus. We provide evidence that proprioceptive sensory feedback from muscle spindles is important for the regulation of the muscle activity strength and speed-dependent amplitude modulation. Furthermore, our data suggest that feedback from the muscle spindles of the ankle extensor muscles, the triceps surae, is the main source for this mechanism. In contrast, muscle spindle feedback from the knee extensor muscles, the quadriceps femoris, has no influence on speed-dependent amplitude modulation. We provide evidence that proprioceptive feedback from ankle extensor muscles is critical for regulating muscle activity strength as gait speed increases. NEW & NOTEWORTHY Animals upregulate the activity of extensor muscles to increase their walking speed, but the mechanism behind this is not known. We show that this speed-dependent amplitude modulation requires proprioceptive sensory feedback from muscle spindles of ankle extensor muscle. In the absence of muscle spindle feedback, animals cannot walk at higher speeds as they can when muscle spindle feedback is present.

Cold-induced bronchoconstriction: role of cutaneous reflexes vs. direct airway effects

1987 ◽  
Vol 63 (2) ◽  
pp. 659-664 ◽  
Author(s):  
J. L. Berk ◽  
K. A. Lenner ◽  
E. R. McFadden
Keyword(s):  
Random Sequence ◽  
Normal Subjects ◽  
Specific Conductance ◽  
Similar Degree ◽  
Cold Environment ◽  
Cutaneous Reflexes ◽  
Receptor Stimulation ◽  
The Face ◽  
Stimulation Of

To determine the relative contributions of direct airway vs. reflex cutaneous thermal receptor stimulation in cold-induced bronchoconstriction, we isolated these two aspects of cold exposure in 10 asthmatics and 13 normal subjects. Ice packs were applied to the skin of the face, chest, thigh, and upper arm in random sequence while serially measuring specific conductance. In this fashion a limited mapping of skin-mediated bronchoconstriction was established. Warm packs were applied to the same areas of control for any potential nonspecific stimulatory effects. Cooling the skin induced bronchoconstriction to a similar degree in both groups; this effect was very small, did not induce symptoms, and was only seen with stimulation of the face. At another time, the subjects performed isocapnic hyperventilation of frigid air to ascertain their response to direct airway cooling. A moderate but significant correlation existed between skin and airway sensitivity; however, the magnitude of the two responses differed markedly. Breathing cold air at rest had no effect on lung function; however, elevating ventilation promptly produced bronchial narrowing. Hence, in a cold environment, the most potent stimulus for the development of airway obstruction in asthmatics derives from a direct airway effect.

Effects of bronchoconstriction and external resistive loading on the sensation of dyspnea

1991 ◽  
Vol 71 (6) ◽  
pp. 2183-2190 ◽  
Author(s):  
O. Taguchi ◽  
Y. Kikuchi ◽  
W. Hida ◽  
N. Iwase ◽  
M. Satoh ◽  
...  
Keyword(s):  
Normal Subjects ◽  
Vagal Afferents ◽  
Vagal Activity ◽  
Resistive Load ◽  
Occlusion Pressure ◽  
Analog Scale ◽  
External Resistance ◽  
Resistive Loading ◽  
Afferent Vagal

To determine whether the intensity of dyspnea at a given level of respiratory motor output differs between bronchoconstriction and the presence of an external resistance, we compared the sensation of difficulty in breathing during isocapnic voluntary hyperventilation in six normal subjects. An external resistance of 1.9 cmH2O.1–1.s was applied during both inspiration and expiration. To induce bronchoconstriction, histamine aerosol (5 mg/ml) was inhaled until airway resistance (Raw) increased to a level approximately equal to the subject's control Raw plus the added external resistance. To clarify the role of vagal afferents on the genesis of dyspnea during both forms of obstruction to airflow, the effect of airway anesthesia by lidocaine aerosol inhalation was also examined after histamine and during external resistive loading. The sensation of difficulty in breathing was rated at 30-s intervals on a visual analog scale during isocapnic voluntary hyperpnea, in which the subjects were asked to copy an oscilloscope volume trace obtained previously during progressive hypercapnia. Histamine inhalation significantly increased the intensity of the dyspneic sensation over the equivalent external resistive load at the same levels of ventilation and occlusion pressure during voluntary hyperpnea. Inhaled lidocaine decreased the sensation of dyspnea during bronchoconstriction with no change in Raw, but it did not significantly change the sensation during external resistive loading. These results suggest that afferent vagal activity plays a role in the genesis of dyspnea during bronchoconstriction.

scholarly journals The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Christoph Metzner ◽  
Bartosz Zurowski ◽  
Volker Steuber
Keyword(s):  
Steady State ◽  
Therapeutic Interventions ◽  
Steady State Response ◽  
State Response ◽  
Basket Cells ◽  
Gamma Range ◽  
Auditory Steady State Response ◽  
Synaptic Dynamics ◽  
Chandelier Cells

AbstractDespite an increasing body of evidence demonstrating subcellular alterations in parvalbumin-positive (PV+) interneurons in schizophrenia, their functional consequences remain elusive. Since PV+ interneurons are involved in the generation of fast cortical rhythms, these changes have been hypothesized to contribute to well-established alterations of beta and gamma range oscillations in patients suffering from schizophrenia. However, the precise role of these alterations and the role of different subtypes of PV+ interneurons is still unclear. Here we used a computational model of auditory steady-state response (ASSR) deficits in schizophrenia. We investigated the differential effects of decelerated synaptic dynamics, caused by subcellular alterations at two subtypes of PV+ interneurons: basket cells and chandelier cells. Our simulations suggest that subcellular alterations at basket cell synapses rather than chandelier cell synapses are the main contributor to these deficits. Particularly, basket cells might serve as target for innovative therapeutic interventions aiming at reversing the oscillatory deficits.

Response of normal subjects to inspiratory resistive unloading

1989 ◽  
Vol 66 (3) ◽  
pp. 1113-1119 ◽  
Author(s):  
C. G. Gallagher ◽  
R. Sanii ◽  
M. Younes
Keyword(s):  
Average Rate ◽  
Minute Ventilation ◽  
Co2 Concentration ◽  
Normal Subjects ◽  
Resistive Load ◽  
Mouth Pressure ◽  
Inspiratory Resistance ◽  
Residual Capacity ◽  
Resistive Loads ◽  
End Tidal

The purpose of this study was to examine the role of the normal inspiratory resistive load in the regulation of respiratory motor output in resting conscious humans. We used a recently described device (J. Appl. Physiol. 62: 2491–2499, 1987) to make mouth pressure during inspiration positive and proportional to inspiratory flow, thus causing inspiratory resistive unloading (IRUL); the magnitude of IRUL (delta R = -3.0 cmH2O.1(-1).s) was set so as to unload most (approximately 86% of the normal inspiratory resistance. Six conscious normal humans were studied. Driving pressure (DP) was calculated according to the method of Younes et al. (J. Appl. Physiol. 51: 963–1001, 1981), which provides the equivalent of occlusion pressure at functional residual capacity throughout the breath. IRUL resulted in small but significant changes in minute ventilation (0.6 1/min) and in end-tidal CO2 concentration (-0.11%) with no significant change in tidal volume or respiratory frequency. There was a significant shortening of the duration (neural inspiratory time) of the rising phase of the DP waveform and the shape of the rising phase became more convex to the time axis. There was no change in the average rate of rise of DP or in the duration or shape of the declining phase. We conclude that 1) the normal inspiratory resistance is an important determinant of the duration and shape of the rising phase of DP and 2) the neural responses elicited by the normal inspiratory resistance are similar to those observed with added inspiratory resistive loads.

scholarly journals The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia

2019 ◽  
Author(s):  
Christoph Metzner ◽  
Bartosz Zurowski ◽  
Volker Steuber
Keyword(s):  
Steady State ◽  
Therapeutic Interventions ◽  
Steady State Response ◽  
State Response ◽  
Basket Cells ◽  
Gamma Range ◽  
Auditory Steady State Response ◽  
Synaptic Dynamics ◽  
Chandelier Cells

AbstractDespite an increasing body of evidence demonstrating subcellular alterations in parvalbumin-positive (PV+) interneurons in schizophrenia, their functional consequences remain elusive. Since PV+ interneurons are involved in the generation of fast cortical rhythms, these changes have been hypothesized to contribute to well-established alterations of beta and gamma range oscillations in patients suffering from schizophrenia. However, the precise role of these alterations and the role of different subtypes of PV+ interneurons is still unclear. Here we used a computational model of auditory steady-state response (ASSR) deficits in schizophrenia. We investigated the differential effects of decelerated synaptic dynamics, caused by subcellular alterations at two subtypes of PV+ interneurons: basket cells and chandelier cells. Our simulations suggest that subcellular alterations at basket cell synapses rather than chandelier cell synapses are the main contributor to these deficits Particularly, basket cells might serve as target for innovative therapeutic interventions aiming at reversing the oscillatory deficits.

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