Skeletal muscle adaptations following blood flow-restricted training during 30 days of muscular unloading

2010 ◽  
Vol 109 (2) ◽  
pp. 341-349 ◽  
Author(s):  
Summer B. Cook ◽  
Kimberly A. Brown ◽  
Keith DeRuisseau ◽  
Jill A. Kanaley ◽  
Lori L. Ploutz-Snyder
Keyword(s):  
Blood Flow ◽  
Muscle Strength ◽  
Knee Extensor ◽  
Exercise Group ◽  
Cross Sectional Area ◽  
Knee Extensors ◽  
Muscular Endurance ◽  
Sectional Area ◽  
Cross Sectional ◽  
Flow Restriction

This study evaluated the effectiveness of low-load resistance training with a blood flow restriction (LLBFR) to attenuate muscle loss and weakness after 30 days of unilateral lower limb suspension (ULLS). Sixteen subjects (ages 18–50 yr) underwent 30 days of ULLS. Measurements of muscle strength, cross-sectional area, and endurance on the knee extensors and plantar flexors were collected before and after ULLS. Plasma concentrations of IGF-1 and IGFBP-3 were also assessed. During ULLS, eight subjects (5 males, 3 females) participated in LLBFR three times per week (ULLS + Exercise) while eight subjects (4 males, 4 females) did not exercise (ULLS). The blood flow-restricted exercise consisted of dynamic knee extension at 20% of the subject's isometric maximum voluntary contraction coupled with a suprasystolic blood flow restriction. After 30 days of limb suspension, the ULLS + Exercise group experienced minimal and insignificant losses in knee extensor cross-sectional area and strength (1.2% and 2.0%, respectively; P ≤ 0.05), while the ULLS group demonstrated significant reductions in cross-sectional area and strength (7.4% and 21%, respectively). Decrements in plantar flexor strength (23.7%) and cross-sectional area (7.4%) were observed after ULLS ( P < 0.05) and were of similar magnitude between the experimental groups ( P > 0.05). Muscular endurance in the knee extensors improved 31% in the ULLS + Exercise group, while it decreased 24% in the ULLS group ( P = 0.01). No changes were seen in hormone concentrations throughout the study. In conclusion, LLBFR of the knee extensors is effective in maintaining muscle strength and size during 30 days of ULLS and results in improved knee extensor muscular endurance.

Sex-based differences in skeletal muscle function and morphology with short-term limb immobilization

2005 ◽  
Vol 99 (3) ◽  
pp. 1085-1092 ◽  
Author(s):  
Nobuo Yasuda ◽  
Elisa I. Glover ◽  
Stuart M. Phillips ◽  
Robert J. Isfort ◽  
Mark A. Tarnopolsky
Keyword(s):  
Muscle Strength ◽  
Lean Mass ◽  
Muscle Function ◽  
Knee Extensor ◽  
Quadriceps Femoris ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Short Term ◽  
Cross Sectional ◽  
Time Points

The purpose of this study was to determine the effects of short-term (14-day) unilateral leg immobilization using a simple knee brace (60° flexion)- or crutch-mediated model on muscle function and morphology in men (M, n = 13) and women (W, n = 14). Isometric and isokinetic (concentric-slow, 0.52 rad/s and fast, 5.24 rad/s) knee extensor peak torque was determined at three time points (Pre, Day-2, and Day-14). At the same time points, magnetic resonance imaging was used to measure the cross-sectional area of the quadriceps femoris and dual-energy X-ray absorptiometry scanning was used to calculate leg lean mass. Muscle biopsies were taken from vastus lateralis at Pre and Day-14 for myosin ATPase and myosin heavy chain analysis. Women showed greater decreases (Pre vs. Day-14) compared with men in specific strength (N/cm2) for isometric [M = 3.1 ± 13.3, W = 17.1 ± 15.9%; P = 0.055 (mean ± SD)] and concentric-slow (M = 4.7 ± 11.3, W = 16.6 ± 18.4%; P < 0.05) contractions. There were no immobilization-induced sex-specific differences in the decrease in quadriceps femoris cross-sectional area (M = 5.7 ± 5.0, W = 5.9 ± 5.2%) or leg lean mass (M = 3.7 ± 4.2, W = 2.7 ± 2.8%). There were no fiber-type transformations, and the decreases in type I (M = 4.8 ± 5.0, W = 5.9 ± 3.4%), IIa (M = 7.9 ± 9.9, W = 8.8 ± 8.0%), and IIx (M = 10.7 ± 10.8, W = 10.8 ± 12.1%) fiber areas were similar between sexes. These findings indicate that immobilization-induced loss of knee extensor muscle strength is greater in women compared with men despite a similar extent of atrophy at the myofiber and whole muscle levels after 14 days of unilateral leg immobilization. Furthermore, we have described an effective and safe knee immobilization method that results in reductions in quadriceps muscle strength and size.

scholarly journals Does Blood Flow Restriction Training Improve Quadriceps Measures After Arthroscopic Knee Surgery? A Critically Appraised Topic

2020 ◽  
Vol 25 (5) ◽  
pp. 221-226
Author(s):  
Erik H. Arve ◽  
Emily Madrak ◽  
Aric J. Warren
Keyword(s):  
Blood Flow ◽  
Cross Sectional Area ◽  
Knee Surgery ◽  
Blood Flow Restriction ◽  
Sectional Area ◽  
Bottom Line ◽  
Cross Sectional ◽  
Arthroscopic Knee Surgery ◽  
Flow Restriction ◽  
Arthroscopic Knee

Focused Clinical Question: Is there evidence to suggest that blood flow restriction (BFR) training improves strength, cross-sectional area, and thigh girth of the quadriceps musculature in patients after arthroscopic surgical procedures of the knee? Clinical Bottom Line: There is moderate consistent, but low-level, evidence supporting the use of BFR training to improve knee extensor muscular outcomes (strength, cross-sectional area, and/or thigh girth) immediately after arthroscopic knee surgery.

Effects of Blood Flow Restriction Combined With Resistance Training or Neuromuscular Electrostimulation on Muscle Cross-Sectional Area

2021 ◽  
pp. 1-6
Author(s):  
João Guilherme Almeida Bergamasco ◽  
Ieda Fernanda Alvarez ◽  
Thais Marina Pires de Campos Biazon ◽  
Carlos Ugrinowitsch ◽  
Cleiton Augusto Libardi
Keyword(s):  
Blood Flow ◽  
Resistance Training ◽  
Muscle Hypertrophy ◽  
Vastus Lateralis ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Flow Restriction ◽  
Neuromuscular Electrostimulation ◽  
Muscle Cross Sectional Area

Context: Low-load resistance training (LL) and neuromuscular electrostimulation (NES), both combined with blood flow restriction (BFR), emerge as effective strategies to maintain or increase muscle mass. It is well established that LL-BFR promotes similar increases in muscle cross-sectional area (CSA) and lower rating of perceived exertion (RPE) and pain compared with traditional resistance training protocols. On the other hand, only 2 studies with conflicting results have investigated the effects of NES-BFR on CSA, RPE, and pain. In addition, no study directly compared LL-BFR and NES-BFR. Objective: The aim of the study was to compare the effects of LL-BFR and NES-BFR on vastus lateralis CSA, RPE, and pain. Individual response for muscle hypertrophy was also compared between protocols. Design: Intrasubject longitudinal study. Setting: University research laboratory. Intervention: Fifteen healthy young males (age = 23 [5] y; weight = 77.6 [11.3] kg; height = 1.76 [0.08] m). Main Outcome Measures: Vastus lateralis CSA was measured through ultrasound at baseline (pre) and after 20 training sessions (post). The RPE and pain responses were obtained through modified 10-point scales, handled during all training sessions. Results: Both protocols demonstrated significant increases in muscle CSA (P < .0001). However, the LL-BFR demonstrated significantly greater CSA changes compared with NES-BFR (LL-BFR = 11.2%, NES-BFR = 4.6%; P < .0001). Comparing individual increases in CSA, 12 subjects (85.7% of the sample) presented greater muscle hypertrophy for LL-BFR than for the NES-BFR protocol. In addition, LL-BFR produced significantly lower RPE and pain responses (P < .0001). Conclusions: The LL-BFR produced significantly greater increases in CSA with significant less RPE and pain than NES-BFR. In addition, LL-BFR resulted in greater individual muscle hypertrophy responses for most subjects compared with NES-BFR.

Effect of Early Low-Intensity Exercise on Rat Hind-Limb Muscles Following Acute Ischemic Stroke

2006 ◽  
Vol 7 (3) ◽  
pp. 163-174 ◽  
Author(s):  
Myoung-Ae Choe ◽  
Gyeong Ju An ◽  
Yoon-Kyong Lee ◽  
Ji Hye Im ◽  
Smi Choi-Kwon ◽  
...  
Keyword(s):  
Hind Limb ◽  
Gastrocnemius Muscle ◽  
Exercise Group ◽  
Cross Sectional Area ◽  
Type I ◽  
Sectional Area ◽  
Muscle Type ◽  
Cross Sectional ◽  
Low Intensity ◽  
Low Intensity Exercise

This study examined the effects of daily low-intensity exercise following acute stroke on mass, Type I and II fiber cross-sectional area, and myofibrillar protein content of hind-limb muscles in a rat model. Adult male Sprague-Dawley rats were randomly assigned to 1 of 4 groups (n = 7-9 per group): stroke (occlusion of the right middle cerebral artery [RMCA]), control (sham RMCA procedure), exercise, and stroke-exercise. Beginning 48 hours post-stroke induction/sham operation, rats in the exercise group had 6 sessions of exercise in which they ran on a treadmill at grade 10 for 20 min/day at 10 m/min. At 8 days poststroke, all rats were anesthetized and soleus, plantaris, and gastrocnemius muscles were dissected from both the affected and unaffected sides. After 6 sessions of exercise following acute ischemic stroke, the stroke-exercise group showed the following significant (p < .05) increases compared to the stroke-only group: body weight and dietary intake, muscle weight of affected soleus and both affected and unaffected gastrocnemius muscle, Type I fiber cross-sectional area of affected soleus and both affected and unaffected gastrocnemius muscle, Type II fiber cross-sectional area of the unaffected soleus, both affected and unaffected plantaris and gastrocnemius muscle, Type II fiber distribution of affected gastrocnemius muscle, and myofibrillar protein content of both affected and unaffected soleus muscle. Daily low-intensity exercise following acute stroke attenuates hind-limb muscle atrophy in both affected and unaffected sides. The effects of exercise are more pronounced in the soleus and gastrocnemius as compared to the plantaris muscle.

Optimal parameters of blood flow restriction and resistance training on quadriceps strength and cross-sectional area and pain in knee osteoarthritis

2021 ◽  
pp. 1-10
Author(s):  
Waleed S. Mahmoud ◽  
Ahmed Osailan ◽  
Ahmed S. Ahmed ◽  
Ragab K. Elnaggar ◽  
Nadia L. Radwan
Keyword(s):  
Blood Flow ◽  
Resistance Training ◽  
Knee Osteoarthritis ◽  
Quadriceps Strength ◽  
Sectional Area ◽  
Occlusion Pressure ◽  
Total Occlusion ◽  
Cross Sectional ◽  
Flow Restriction ◽  
Low Intensity

BACKGROUND: Knee osteoarthritis (KOA) is one of the most common chronic diseases impacting millions of elderly people. OBJECTIVES: The study compared the effects of two intensities of partial blood flow restriction (BFR) with low-intensity resistance training on quadriceps strength and cross-sectional area (CSA), and pain in people with knee osteoarthritis (PwKOA). METHODS: Thirty-five PwKOA, aged 50–65, participated. Quadriceps CSA was measured by ultrasonography, quadriceps strength – by isokinetic dynamometry and pain by VAS. These outcome variables were obtained at the beginning of the study and re-evaluated eight weeks after the intervention. RESULTS: An interaction effect was present for quadriceps CSA (P= 0.042) and quadriceps strength (P= 0.006), showing that using 70% of total occlusion pressure with 30% 1RM had a more significant effect. Knee pain improved significantly through the main effect of BFR (P< 0.001), and low-intensity resistance training (P= 0.011). Pain improved more at 70% of total occlusion pressure, with 30% of 1RM (2.5 ± 1.06) than 50% total occlusion pressure with 10% of 1RM (5.77 ± 1.46). CONCLUSION: A combination of 70% of total occlusion pressure with 30% 1RM could be beneficial in PwKOA in improving pain, and increasing the quadriceps strength. The changes in the quadriceps strength could be a predictor for knee pain.

scholarly journals Sequential alterations in the diameters of capillaries in rabbit skeletal muscle following deep transverse friction - a morphometric study

2005 ◽  
Vol 61 (2) ◽  
Author(s):  
M. A. Gregory ◽  
M. N. Deane ◽  
M. Marsh
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Blood Flow ◽  
Biceps Femoris ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Biceps Femoris Muscle ◽  
Beneficial Effects ◽  
The Cross

Objective: The precise mechanisms by which massage promotes repair in injured soft tissue are unknown. Various authorshave attributed the beneficial effects of massage to vasodilation and increased skin and muscle blood flow. The aim of this study was to determine whether deep transverse friction massage (DTF) causes capillary vasodilation in untraumatised skeletal muscle. Setting: Academic institution.Interventions: Twelve New Zealand white rabbits were anaesthetised and the left biceps femoris muscle received 10 minutes of DTF. Following treatment, wedge biopsies were taken from the musclewithin 10 minutes of treatment (R1 - 4), 24 hours (R5 - 8) and 6 days(R9 - 12) after treatment. To serve as controls, similar biopsies weretaken from the right biceps femoris of animals. The samples were fixed, dehydrated and embedded in epoxy resin.Transverse sections (1µm) of muscle were cut, stained with 1% aqueous alkaline toluidine blue and examined with a light microscope using a 40X objective. Images containing capillaries were captured using an image analyser with SIS software and the cross sectional diameters of at least 60 capillaries were measured from each specimen. Main Outcome Measures: Changes in capillary diameter. Results: The mean capillary diameters in control muscle averaged 4.76 µm. DTF caused a significant immediate increase of 17.3% in cross sectional area (p<0.001), which was not significantly increased by 10.0% after 24 hours (p>0.05). Six days after treatment the cross-sectional area of the treated muscle was 7.6% smaller than the controls. Conclusions: This confirms the contention that DTF stimulates muscle blood flow immediately after treatment and this may account for its beneficial effects in certain conditions. 

scholarly journals Changes in lower extremity blood flow during advancing phases of pregnancy and the effects of special footwear

2017 ◽  
Vol 16 (3) ◽  
pp. 214-219 ◽  
Author(s):  
Marta Gimunová ◽  
Martin Zvonař ◽  
Kateřina Kolářová ◽  
Zdeněk Janík ◽  
Ondřej Mikeska ◽  
...  
Keyword(s):  
Blood Flow ◽  
Venous Blood ◽  
Cross Sectional Area ◽  
Popliteal Vein ◽  
Control Group ◽  
Venous Disease ◽  
Venous Blood Flow ◽  
Sectional Area ◽  
Cross Sectional ◽  
Experimental Group

Abstract Background During pregnancy, a number of changes affecting venous blood flow occur in the circulatory system, such as reduced vein wall tension or increased exposure to collagen fibers. These factors may cause blood stagnation, swelling of the legs, or endothelial damage and consequently lead to development of venous disease. Objectives The aim of this study is to evaluate the effect of special footwear designed to improve blood circulation in the feet on venous blood flow changes observed during advancing phases of pregnancy. Methods Thirty healthy pregnant women participated in this study at 25, 30, and 35 weeks of gestation. Participants were allocated at random to an experimental group (n = 15) which was provided with the special footwear, or a control group (n = 15). At each data collection session, Doppler measurements of peak systolic blood flow velocity and cross-sectional area of the right popliteal vein were performed using a MySonoU6 ultrasound machine with a linear transducer (Samsung Medison). The differences were compared using Cohen’s d test to calculate effect size. Results With advancing phases of pregnancy, peak systolic velocity in the popliteal vein decreased significantly in the control group, whereas it increased significantly in the experimental group. No significant change in cross-sectional area was observed in any of the groups. Conclusions Findings in the experimental group demonstrated that wearing the footwear tested may prevent venous blood velocity from reducing during advanced phases of pregnancy. Nevertheless, there is a need for further investigation of the beneficial effect on venous flow of the footwear tested and its application.

scholarly journals Comparison of Muscle Cross-sectional Area and Lumbar Muscle Strength According to Degenerative Spinal Diseases

2020 ◽  
Vol 22 (2) ◽  
pp. 1-10
Author(s):  
Ji-Hoon Cho ◽  
Ki-Hyuk Lee ◽  
Seung-Taek Lim ◽  
Buong-O Chun
Keyword(s):  
Muscle Strength ◽  
Cross Sectional Area ◽  
Spinal Diseases ◽  
Sectional Area ◽  
Multifidus Muscle ◽  
Cross Sectional ◽  
Total Group ◽  
Male Group ◽  
The Difference ◽  
Lumbar Extension

OBJECTIVES The purpose of this study was to investigate the difference in the cross - sectional area (CSA) of multifidus and Iliopsoas muscles and the lumbar extension muscle strength according to degenerative spinal diseases (LHI; lumbar herniation of intervertebral disc group, SS; spinal stenosis group, S; spondylolisthesis group).METHODS The CSA of multifidus and Iliopsoas muscles size were measured by PACS(Picture Achiving and Communication System) using MRI at the L4/5 level and lumbar extension muscle strength (72˚, 60˚, 48˚, 36˚, 24˚, 12˚, 0˚) was measured using lumbar extension machine(MedX) in 97 patients of degenerative spinal diseases(male: 57, female: 40). The collected data were analyzed by one-way ANOVA using the SPSS program.RESULTS The results of this study showed that the CSA of total and right multifidus muscle in the LHI was significantly higher than that of the S (p <.05; p <.05) in the male group. The difference between the left and right CSA of multifidus in the LHI group was significantly higher than that of the SS (p <.05) in the male group (p <.05) and total group (p <.05). The CSA of iliopsoas muscle in the S was significantly higher than that of the LHI in the male and total group (p <.05; p <.05). In case of lumbar extension muscle strength, the S showed significantly higher muscle strength at 36 and 48 degrees than that of the SS in the male group. In the total group, LHI showed significantly higher muscle strength at 60 degrees of lumbar extension muscle strength than that of the S.CONCLUSION Multifidus muscle appears to be a key factor in prevention and treatment intervention in low back pain patients. In particular, in the case of S group, exercise therapy for strengthening the multifidus muscle is need for the rehabilitation.

Sign in / Sign up

Export Citation Format

Share Document