Oxidation of indolic bases by cytochrome P450 and ferrous picolinate

K. Jankowski; M. Delaforge; M. Jaouen; H. Virelizier

doi:10.1155/1997/364081

Oxidation of indolic bases by cytochrome P450 and ferrous picolinate

Spectroscopy An International Journal ◽

10.1155/1997/364081 ◽

1997 ◽

Vol 13 (2) ◽

pp. 163-174

Author(s):

K. Jankowski ◽

M. Delaforge ◽

M. Jaouen ◽

H. Virelizier

Keyword(s):

Cytochrome P450 ◽

Reaction Products ◽

Major Reaction ◽

Hepatic Cytochrome

Oxidations performed on four indolic bases,β-carboline1, ibogaine2, reserpine3and ajmaline4, by hepatic cytochrome P450 (Cyt. P450) and ferrous picolinate (Fe(PA)2), lead to alicyclic hydroxylation as major reaction products.

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Effects of Andrographis paniculata crude extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities

Planta Medica ◽

10.1055/s-0028-1084228 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

D Pekthong ◽

N Blanchard ◽

C Abadie ◽

A Bonet ◽

B Heyd ◽

...

Keyword(s):

Cytochrome P450 ◽

Mrna Expression ◽

Crude Extract ◽

Andrographis Paniculata ◽

Hepatic Cytochrome

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P.615 Effect of cocaine self-administration on hepatic cytochrome P450 activity in the rat model of drug addiction

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2020.09.453 ◽

2020 ◽

Vol 40 ◽

pp. S350-S351

Author(s):

J. Jastrzębska ◽

R. Pukło ◽

M. Frankowska ◽

M. Filip ◽

W.A. Daniel

Keyword(s):

Cytochrome P450 ◽

Drug Addiction ◽

Rat Model ◽

Self Administration ◽

Cytochrome P450 Activity ◽

P450 Activity ◽

Hepatic Cytochrome

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Study of the Synchrotron Photoionization Oxidation of Alpha-Angelica Lactone (AAL) Initiated by O(3P) at 298, 550, and 700 K

Molecules ◽

10.3390/molecules26134070 ◽

2021 ◽

Vol 26 (13) ◽

pp. 4070

Author(s):

Golbon Rezaei ◽

Giovanni Meloni

Keyword(s):

Atomic Oxygen ◽

Fossil Fuels ◽

Reaction Products ◽

Photoionization Mass Spectrometry ◽

Natural Substances ◽

Primary Products ◽

Major Reaction ◽

Angelica Lactone ◽

Significant Attention

In recent years, biofuels have been receiving significant attention because of their potential for decreasing carbon emissions and providing a long-term renewable solution to unsustainable fossil fuels. Currently, lactones are some of the alternatives being produced. Many lactones occur in a range of natural substances and have many advantages over bioethanol. In this study, the oxidation of alpha-angelica lactone initiated by ground-state atomic oxygen, O(3P), was studied at 298, 550, and 700 K using synchrotron radiation coupled with multiplexed photoionization mass spectrometry at the Lawrence Berkeley National Lab (LBNL). Photoionization spectra and kinetic time traces were measured to identify the primary products. Ketene, acetaldehyde, methyl vinyl ketone, methylglyoxal, dimethyl glyoxal, and 5-methyl-2,4-furandione were characterized as major reaction products, with ketene being the most abundant at all three temperatures. Possible reaction pathways for the formation of the observed primary products were computed using the CBS–QB3 composite method.

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