scholarly journals A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study

2010 ◽  
Vol 2010 ◽  
pp. 1-6
Author(s):  
V. P. Diego ◽  
L. Almasy ◽  
D. L. Rainwater ◽  
M. C. Mahaney ◽  
A. G. Comuzzie ◽  
...  
Keyword(s):  
Quantitative Trait ◽  
Mexican Americans ◽  
San Antonio ◽  
Lod Score ◽  
Family Heart Study ◽  
Heart Study ◽  
A Genome ◽  
Increased Risk ◽  
Chromosome 5P ◽  
D Dimer

Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD).Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM.Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.

The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study

Human Biology ◽  
2003 ◽  
Vol 75 (5) ◽  
pp. 635-646 ◽  
Author(s):  
Anthony G. Comuzzie ◽  
Bratxton D. Mitchell ◽  
Shelley Cole ◽  
Lisa J. Martin ◽  
Wen-Chi Hsueh ◽  
...  
Keyword(s):  
Mexican Americans ◽  
San Antonio ◽  
Genome Scanning ◽  
Family Heart Study ◽  
Heart Study ◽  
Genetics Of Obesity

scholarly journals Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism: The San Antonio Family Heart Study

Diabetes ◽  
2004 ◽  
Vol 53 (5) ◽  
pp. 1369-1374 ◽  
Author(s):  
G. Cai ◽  
S. A. Cole ◽  
J. H. Freeland-Graves ◽  
J. W. MacCluer ◽  
J. Blangero ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Glucose Metabolism ◽  
Quantitative Trait ◽  
Insulin Action ◽  
San Antonio ◽  
Family Heart Study ◽  
Genome Wide ◽  
Heart Study ◽  
Trait Loci

scholarly journals Evidence of a Genetic Susceptibility Locus Influencing Interindividual Variation in Triglycerides: The NHLBI Family Heart Study

Circulation ◽  
2001 ◽  
Vol 103 (suppl_1) ◽  
pp. 1352-1352
Author(s):  
Donna K Arnett ◽  
Larry Atwood ◽  
Michael A Province ◽  
Hilary Coon ◽  
James Pankow
Keyword(s):  
Quantitative Trait ◽  
Early Onset ◽  
Mexican Americans ◽  
Interindividual Variation ◽  
Chromosome 15 ◽  
Chromosome 4 ◽  
Family Heart Study ◽  
Heart Study ◽  
The Mean ◽  
Putative Locus

P06 Genomic regions have been linked to hypertriglyceridemia associated with familial syndromes, such as familial combined hyperlipidemia. However, there is little information regarding chromosomal regions harboring susceptibility genes for more common forms of hypertriglyceridemia. Significant linkage of triglycerides (TGs) was recently identified on chromosome 15 in Mexican Americans (LOD=3.88). As part of the NHLBI-sponsored Family Heart Study (FHS), a genome-wide linkage analysis was done to replicate this finding or to identify other quantitative trait loci for TGs. Multi-generational families were recruited (a) at excess risk of early onset myocardial infarction and (b) randomly selected from Framingham, Atherosclerosis Risk in Communities, and Utah Family Tree Studies. The largest families were selected for genomic analysis (105 families, family size=8.6). Microsatellite markers (n=369), approximately equally spaced throughout the genome (CHLC-10), were typed by the NHLBI Mammalian Genotyping Service. TGs were measured in participants fasting for at least 12 hours. TGs were adjusted for sex, age and age 2 , and log-transformed to normalize the distribution. The search for quantitative trait loci for TGs was carried out using a multipoint model-free variance components method implemented in GENEHUNTER. The mean age was 60 years and 52% were female. The mean triglyceride value in the family members was 146 (±85) mg/dl in men and 155 (±102) mg/dl in women. Evidence for linkage was identified on chromosome 4 (LOD=3.23 (p<.0003) at position 35cM from the pter). Further evidence for linkage was found on chromosome 15 (LOD=1.90 (p<.007) at position 36cM from the pter), which overlaps the genomic region identified in Mexican Americans. In conclusion, we found significant evidence for linkage of TGs to a region on chromosome 4 in families either randomly recruited or at high risk of early onset coronary heart disease. This putative locus appears to have a major influence on the interindividual variation in triglycerides. Finally, these data add support for the existence of a putative locus for TGs on chromosome 15.

scholarly journals Genome-wide scans for microalbuminuria in Mexican Americans: The San Antonio Family Heart Study

2007 ◽  
Vol 9 (2) ◽  
pp. 80-87 ◽  
Author(s):  
Nedal Arar ◽  
Subrata Nath ◽  
Farook Thameem ◽  
Richard Bauer ◽  
Saroja Voruganti ◽  
...  
Keyword(s):  
Mexican Americans ◽  
San Antonio ◽  
Family Heart Study ◽  
Genome Wide ◽  
Heart Study

Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans: The San Antonio Family Heart Study

Human Biology ◽  
2004 ◽  
Vol 76 (5) ◽  
pp. 651-665 ◽  
Author(s):  
Guowen Cai ◽  
Shelley A. Cole ◽  
Jeanne H. Freeland-Graves ◽  
Jean W. MacCluer ◽  
John Blangero ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Mexican Americans ◽  
San Antonio ◽  
Principal Component ◽  
Family Heart Study ◽  
Heart Study ◽  
Risk Maps

Heritability of Commonly Measured Blood Cell Phenotypes in the San Antonio Family Heart Study.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3687-3687
Author(s):  
Kevin R. Viel ◽  
Tom Howard ◽  
Joanne E. Curran ◽  
Laura Almasy ◽  
Eric K. Moses ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
San Antonio ◽  
Genetic Influence ◽  
Blood Cell Count ◽  
Distribution Width ◽  
Family Heart Study ◽  
Heart Study ◽  
The Mean ◽  
Cell Phenotypes

Abstract Heritability (h2) indicates the extent to which genes contribute to the observed inter-individual variation in a phenotype. Traits that have a high h2 may be fruitful targets of a subsequent genome screen to identify quantitative trait loci (QTL) and the genetic variants underlying them. We have estimated the heritabilities of measurements that commonly comprise a complete blood cell count (CBC) for members of the San Antonio Family Heart Study (table). The number of white blood cells per μL of blood (WBC) was not under genetic influence (h2 = 0.160, p = 0.253), however, the individual components of the differential (lymphocyte, monocyte, and granulocyte percentage) did appear to be. Red blood cell count (RBC) had the highest heritability (h2 = 0.638, p &lt; 0.001) with both the mean corpuscular volume (MCV) and the red cell distribution width (RDW) demonstrating moderate heritability. The platelet count (Plt) and the mean platelet volume (MPV) had a mild genetic influence that was nominally significant. Currently, the fourth longitudinal examination of this cohort is in progress and to date we have measurements for 154 Mexican American subjects in 16 nuclear families. If prior recruitment rate is maintained, bivariate analyses assessing pleiotropy between traits may be available for presentation. Some of these traits have been investigated previously, but for many these are the first reported h2 estimates to our knowledge. This investigation is a necessary first step to understanding the contributions of genes to these important clinical measurements and to the elucidation of the biological pathways involved in their regulation, which may lead to improved diagnostics and therapies to treat blood cell-related disorders. Heritabilities of commonly measured blood cell phenotypes Phenotype h2 (p-value) 1 Inverse normal transformed value WBC 0.163 (0.253) LY (%) 0.599 (&lt;0.001) MO (%) 0.603 (0.011) GR (%) 0.500 (0.004) RBC 0.638 (&lt;0.001) Hgb 0.283 (0.094) Hct 0.432 (0.023) MCV 0.476 (0.005) MCH 0.429 (0.011) MCHC1 0.249 (0.139) RDW1 0.422 (0.014) Plt 0.290 (0.013) MPV 0.298 (0.006)

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