Digital Ischemia in Scleroderma Spectrum of Diseases
2010 ◽
Vol 2010
◽
pp. 1-8
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Keyword(s):
Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis and autoimmune processes. Digital ischemia (digital ulcers (DUs)) is the hallmark of SSc-related vasculopathy and is characterized by endothelial dysfunction leading to intimal proliferation and thrombosis. It happens frequently (30% of the patients each year) and it is associated with significant morbidity. This paper summarizes the current information regarding pathogenesis, definitions, management, and exploratory therapies in DUs associated with SSc.
Keyword(s):
2020 ◽
Vol 3
(3)
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pp. 1666-1680
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2011 ◽
Vol 30
(1)
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pp. 37-46
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Keyword(s):
Keyword(s):
2012 ◽
pp. n/a-n/a
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2021 ◽
Vol 19
(4)
◽
pp. 501-507
2011 ◽
Vol 301
(6)
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pp. G945-G949
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