scholarly journals Induction of Human Squamous Cell-Type Carcinomas by Arsenic

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Victor D. Martinez ◽  
Daiana D. Becker-Santos ◽  
Emily A. Vucic ◽  
Stephen Lam ◽  
Wan L. Lam
Keyword(s):  
Lung Cancer ◽  
Drinking Water ◽  
Health Effects ◽  
Squamous Cell ◽  
Chronic Exposure ◽  
Squamous Cell Carcinomas ◽  
Relevant Factor ◽  
Cell Type ◽  
Human Carcinogen ◽  
Neoplastic Process

Arsenic is a potent human carcinogen. Around one hundred million people worldwide have potentially been exposed to this metalloid at concentrations considered unsafe. Exposure occurs generally through drinking water from natural geological sources, making it difficult to control this contamination. Arsenic biotransformation is suspected to have a role in arsenic-related health effects ranging from acute toxicities to development of malignancies associated with chronic exposure. It has been demonstrated that arsenic exhibits preference for induction of squamous cell carcinomas in the human, especially skin and lung cancer. Interestingly, keratins emerge as a relevant factor in this arsenic-related squamous cell-type preference. Additionally, both genomic and epigenomic alterations have been associated with arsenic-driven neoplastic process. Some of these aberrations, as well as changes in other factors such as keratins, could explain the association between arsenic and squamous cell carcinomas in humans.

Cell Type Distribution in Histologic Specimens of Primary Lung Cancer

1984 ◽  
Vol 70 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Marco Geddes ◽  
Eva Buiatti ◽  
Adele Seniori Costantini ◽  
Marco Santucci
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Primary Lung Cancer ◽  
Squamous Cell Carcinomas ◽  
Bronchial Biopsy ◽  
Cell Type ◽  
Type Distribution ◽  
Pathology Department ◽  
University Of Florence ◽  
The University

A total of 1986 cases of primary lung cancer, observed in the Pathology Department of the University of Florence during 1971–1981, were analysed by age, sex, year of diagnosis, source of specimen, and cell type. Adenocarcinomas occurred more frequently in females and at younger ages and were diagnosed mainly from surgically obtained specimens. In contrast, squamous cell carcinomas developed more often in males and at older ages, and were chiefly diagnosed by bronchial biopsy. Over the 11-year period of study, a significant increase in the percentage of squamous cell carcinomas and a consequent decrease in the percentage of adenocarcinomas occurred both in females and in males, independent of changes in the specimen sources.

Carcinoma of the Nasal Septum: Experience with 85 Cases

1982 ◽  
Vol 90 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Charles W. Beatty ◽  
Bruce W. Pearson ◽  
Eugene B. Kern
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Squamous Cell ◽  
Nasal Septum ◽  
Surgical Excision ◽  
Squamous Cell Carcinomas ◽  
Cell Type ◽  
Predominant Cell Type ◽  
Choice Of Treatment ◽  
Initial Choice

A review of 85 Mayo Clinic patients with carcinoma of the nasal septum revealed squamous cell carcinoma (58 patients) to be the predominant cell type, with adenocarcinoma (12 patients) and malignant melanoma (7 patients) being next in frequency. Twenty-five (29%) of the 85 patients had metastatic disease. Twenty percent (17) of the patients had another malignancy at some time during their lives. The study suggests that tobacco smoking may have a role in the etiology of squamous cell carcinomas of the nasal septum. In most patients, wide surgical excision was the initial choice of treatment.

scholarly journals Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues

2018 ◽  
Vol 143 (12) ◽  
pp. 3061-3070 ◽  
Author(s):  
Sebastian Marwitz ◽  
Lena Heinbockel ◽  
Swetlana Scheufele ◽  
Christian Kugler ◽  
Martin Reck ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Squamous Cell Carcinomas ◽  
Small Cell Lung ◽  
Epigenetic Age ◽  
Fountain Of Youth

CHRONIC EXPOSURE TO ARSENIC VIA DRINKING WATER AND EVALUATION OF HEALTH EFFECTS IN 91 MUNICIPALITIES OF THE LAZIO REGION, ITALY

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Daniela D’Ippoliti ◽  
Paola Michelozzi ◽  
Manuela De Sario ◽  
Claudia Marino ◽  
Adele Lallo ◽  
...  
Keyword(s):  
Drinking Water ◽  
Health Effects ◽  
Chronic Exposure ◽  
Lazio Region

scholarly journals Expression of endogenous xenotropic retrovirus by methylcholanthrene-induced squamous cell carcinoma of the mouse respiratory tract.

1979 ◽  
Vol 150 (6) ◽  
pp. 1567-1570 ◽  
Author(s):  
P Ebenstein ◽  
B Kinder ◽  
D O Bankole ◽  
F F Richards ◽  
M Y Armstrong
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Squamous Cell ◽  
Murine Leukemia Virus ◽  
Human Lung ◽  
Leukemia Virus ◽  
Squamous Cell Carcinomas ◽  
Human Lung Cancer ◽  
Induction System ◽  
Murine Leukemia

As a model for human lung cancer, squamous cell carcinomas were induced by 3-methylcholanthrene in mouse tracheas which had been explanted to a subcutaneous site. The tumors that developed were examined for both ecotropic and xenotropic infectious murine leukemia virus (MuLV). From all squamous carcinomas--six out of six--a xenotropic MuLV was isolated. From some of the fibrosarcomas that occurred incidentally in our induction system, ecotropic MuLV was isolated. However, in the fibrosarcomas, no xenotropic MuLV at all was found.

scholarly journals Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus

2005 ◽  
Vol 118 (3) ◽  
pp. 714-720 ◽  
Author(s):  
Yan Cui ◽  
Hal Morgenstern ◽  
Sander Greenland ◽  
Donald P. Tashkin ◽  
Jenny Mao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Xeroderma Pigmentosum ◽  
Squamous Cell Carcinomas ◽  
Xeroderma Pigmentosum Group G

p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?

2002 ◽  
Vol 198 (1) ◽  
pp. 100-109 ◽  
Author(s):  
Giuseppe Pelosi ◽  
Felice Pasini ◽  
Catharina Olsen Stenholm ◽  
Ugo Pastorino ◽  
Patrick Maisonneuve ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor.

1995 ◽  
Vol 13 (8) ◽  
pp. 1893-1903 ◽  
Author(s):  
J S Lee ◽  
A Yoon ◽  
S K Kalapurakal ◽  
J Y Ro ◽  
J J Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Small Cell Lung Cancer ◽  
Squamous Cell ◽  
Small Cell ◽  
Squamous Cell Carcinomas ◽  
Small Cell Lung ◽  
Survival Difference ◽  
Favorable Prognostic Factor

PURPOSE Mutation of the p53 gene is one of the most common genetic abnormalities found in lung cancer. The purpose of this study was to evaluate the prognostic value of p53 oncoprotein expression in patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS We studied 156 resected primary NSCLCs by the immunohistochemical staining technique, using the p53 antibody DO7. There were 81 adenocarcinomas, 16 large-cell carcinomas, and 59 squamous cell carcinomas; stages were I in 67, II in 30, and III in 59 cases. For each tumor, the percentage of p53 positivity was calculated by scoring a minimum of 1,000 cells on an arbitrary intensity scale of 0 to 3+. RESULTS Overall, 103 (66%) tumors expressed p53 in more than 0.1% of cells, and squamous cell carcinomas tended to express more p53 than adenocarcinomas. Since 50% positivity marked the most distinct change in overall survival duration (P = .0008), we divided the cases into three groups, as follows: p53-negative (< or = 0.1%, n = 53), low p53 (0.1% to 50%, n = 54), and high p53 (> 50%, n = 49). Overall, patients in the high-p53 group survived longer than those in the low or negative groups, with respective median survival durations of more than 65, 26, and 33 months (P = .002). The survival difference among the three groups was statistically significant for non-squamous cell (P = .008), but not for squamous cell (P = .17) carcinomas. Among lymph node-negative patients, the survival difference between groups was not statistically significant. However, among lymph node-positive patients (n = 78), more than 65% of the high-p53 group survived for more than 70 months, while the median survival durations for the low and negative groups were 21 and 18 months, respectively (P = .001). A Cox regression analysis with multiple covariates showed that p53 positivity in more than 50% of tumor cells was an independent prognostic factor for better outcome. CONCLUSION These results suggest that high expression of the p53 oncoprotein is a favorable prognostic factor in a subset of patients with NSCLC.

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