Cell Type Distribution in Histologic Specimens of Primary Lung Cancer

1984 ◽  
Vol 70 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Marco Geddes ◽  
Eva Buiatti ◽  
Adele Seniori Costantini ◽  
Marco Santucci
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Primary Lung Cancer ◽  
Squamous Cell Carcinomas ◽  
Bronchial Biopsy ◽  
Cell Type ◽  
Type Distribution ◽  
Pathology Department ◽  
University Of Florence ◽  
The University

A total of 1986 cases of primary lung cancer, observed in the Pathology Department of the University of Florence during 1971–1981, were analysed by age, sex, year of diagnosis, source of specimen, and cell type. Adenocarcinomas occurred more frequently in females and at younger ages and were diagnosed mainly from surgically obtained specimens. In contrast, squamous cell carcinomas developed more often in males and at older ages, and were chiefly diagnosed by bronchial biopsy. Over the 11-year period of study, a significant increase in the percentage of squamous cell carcinomas and a consequent decrease in the percentage of adenocarcinomas occurred both in females and in males, independent of changes in the specimen sources.

scholarly journals Induction of Human Squamous Cell-Type Carcinomas by Arsenic

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Victor D. Martinez ◽  
Daiana D. Becker-Santos ◽  
Emily A. Vucic ◽  
Stephen Lam ◽  
Wan L. Lam
Keyword(s):  
Lung Cancer ◽  
Drinking Water ◽  
Health Effects ◽  
Squamous Cell ◽  
Chronic Exposure ◽  
Squamous Cell Carcinomas ◽  
Relevant Factor ◽  
Cell Type ◽  
Human Carcinogen ◽  
Neoplastic Process

Arsenic is a potent human carcinogen. Around one hundred million people worldwide have potentially been exposed to this metalloid at concentrations considered unsafe. Exposure occurs generally through drinking water from natural geological sources, making it difficult to control this contamination. Arsenic biotransformation is suspected to have a role in arsenic-related health effects ranging from acute toxicities to development of malignancies associated with chronic exposure. It has been demonstrated that arsenic exhibits preference for induction of squamous cell carcinomas in the human, especially skin and lung cancer. Interestingly, keratins emerge as a relevant factor in this arsenic-related squamous cell-type preference. Additionally, both genomic and epigenomic alterations have been associated with arsenic-driven neoplastic process. Some of these aberrations, as well as changes in other factors such as keratins, could explain the association between arsenic and squamous cell carcinomas in humans.

Cell Type Accuracy of Bronchial Biopsy Specimens in Primary Lung Cancer

CHEST Journal ◽  
1996 ◽  
Vol 109 (5) ◽  
pp. 1199-1203 ◽  
Author(s):  
Juan J. Soler Cataluña ◽  
Miguel Perpiñá ◽  
José V. Greses ◽  
Victor Calvo ◽  
José D. Padilla ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Bronchial Biopsy ◽  
Cell Type ◽  
Biopsy Specimens

Cyfra 21–1 in Lung Cancer: Comparison with Cea, Ca 125, Scc and Nse Serum Levels

1994 ◽  
Vol 9 (2) ◽  
pp. 96-101 ◽  
Author(s):  
R. Molina ◽  
C. Agusti ◽  
J.M. Mañe ◽  
X. Filella ◽  
J. Jo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Healthy Subjects ◽  
Residual Disease ◽  
Primary Lung Cancer ◽  
Serum Levels ◽  
Squamous Cell Carcinomas ◽  
Histological Type ◽  
Ca 125 ◽  
Active Cancer

CYFRA 21–1, CEA, CA 125, SCC and NSE serum levels were determined in 50 healthy subjects and in 189 patients with primary lung cancer (101 with locoregional disease, 68 with recurrence and 20 patients with no evidence of residual disease (NED). Abnormal CYFRA 21–1 serum levels were found in 53.6% (90/168) of the patients with active cancer. Neither healthy subjects nor NED patients had abnormal serum levels. CYFRa 21–1 serum concentrations were significantly higher in patients with active cancer than in healthy subjects or in NED patients (p < 0.0001). CYFRA 21–1 sensitivity was related to tumor histology with abnormal levels in 64.7% of patients with NSCLC and in 30% of patients with SCLC (P <0.0001). In NSCLC, serum CYFRA 21–1 concentrations were also related to histological type, the highest values being found in squamous cell carcinomas and LCLC and the lowest in adenocarcinomas (p < 0.04). There was also a clear relationship between CYFRA 21–1 and tumor extension, with significantly higher values in patients with metastases than in those without metastases (p < 0.0001). Abnormal CEA values were found in 49.1%, CA 125 in 39%, SCC in 27.8% and NSE in 21.3% of the patients with active cancer. With respect to histological type, CYFRA was elevated in 68.3% of squamous cell carcinomas (CEA: 46.7%, SCC: 50%, CA 125:31.7%, NSE: 11.7%), in 54.8% of adenocarcinomas (CEA: 62%, SCC: 26.2%, CA 125: 59.5%, NSE: 9.5%), in 78.6% of LCLC (CEA: 64.3%, SCC: 28.6%, CA 125: 78.6%, NSE: 7.1%) and in 30% of SCLC (CEA: 37.7%, SCC: 3.8%, CA 125:20.8%, NSE: 45.3%). In summary, CYFRA 21–1 is the most sensitive tumor marker in patients with lung cancer, especially in NSCLC patients.

scholarly journals The Descriptive Epidemiology of Primary Lung Cancer in an Alberta Cohort with a Mutivariate Analysis of Survival to Two Years

2003 ◽  
Vol 10 (8) ◽  
pp. 435-441 ◽  
Author(s):  
Sandor J Demeter ◽  
Chester Chmielowiec ◽  
Wayne Logus ◽  
Pauline Benkovska-Angelova ◽  
Philip Jacobs ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
American Literature ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Lung Cancer ◽  
Case Fatality ◽  
Nonsmall Cell Lung Cancer ◽  
Small Cell ◽  
The Impact

BACKGROUND: Lung cancer contributes significantly to cancer morbidity and mortality. Although case fatality rates have not changed significantly over the past few decades, there have been advances in the diagnosis, staging and management of lung cancer.OBJECTIVE: To describe the epidemiology of primary lung cancer in an Alberta cohort with an analysis of factors contributing to survival to two years.PATIENTS AND METHODS: Six hundred eleven Albertans diagnosed with primary lung cancer in 1998 were identified through the Alberta Cancer Registry. Through a chart review, demographic and clinical data were collected for a period of up to two years from the date of diagnosis.RESULTS: The mean age at diagnosis was 66.5 years. The majority of cases (92%) were smokers. Adenocarcinoma, followed by squamous cell carcinoma, were the most frequent nonsmall cell lung cancer histologies. Adenocarcinoma was more frequent in women, and squamous cell carcinoma was more frequent in men. The overall two- year survival rates for nonsmall cell, small cell and other lung cancers were 24%, 10% and 13%, respectively. In multivariate analysis, stage, thoracic surgery and chemotherapy were significantly associated with survival to two years in nonsmall cell carcinoma; only stage and chemotherapy were significant in small cell carcinoma.CONCLUSIONS: This study provides a Canadian epidemiological perspective, which generally concurs with the North American literature. Continued monitoring of the epidemiology of lung cancer is essential to evaluate the impact of advances in the diagnosis, staging and management of lung cancer. Further clinical and economic analysis, based on data collected on this cohort, is planned.

Carcinoma of the Nasal Septum: Experience with 85 Cases

1982 ◽  
Vol 90 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Charles W. Beatty ◽  
Bruce W. Pearson ◽  
Eugene B. Kern
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Squamous Cell ◽  
Nasal Septum ◽  
Surgical Excision ◽  
Squamous Cell Carcinomas ◽  
Cell Type ◽  
Predominant Cell Type ◽  
Choice Of Treatment ◽  
Initial Choice

A review of 85 Mayo Clinic patients with carcinoma of the nasal septum revealed squamous cell carcinoma (58 patients) to be the predominant cell type, with adenocarcinoma (12 patients) and malignant melanoma (7 patients) being next in frequency. Twenty-five (29%) of the 85 patients had metastatic disease. Twenty percent (17) of the patients had another malignancy at some time during their lives. The study suggests that tobacco smoking may have a role in the etiology of squamous cell carcinomas of the nasal septum. In most patients, wide surgical excision was the initial choice of treatment.

scholarly journals Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues

2018 ◽  
Vol 143 (12) ◽  
pp. 3061-3070 ◽  
Author(s):  
Sebastian Marwitz ◽  
Lena Heinbockel ◽  
Swetlana Scheufele ◽  
Christian Kugler ◽  
Martin Reck ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Squamous Cell Carcinomas ◽  
Small Cell Lung ◽  
Epigenetic Age ◽  
Fountain Of Youth

scholarly journals Expression of endogenous xenotropic retrovirus by methylcholanthrene-induced squamous cell carcinoma of the mouse respiratory tract.

1979 ◽  
Vol 150 (6) ◽  
pp. 1567-1570 ◽  
Author(s):  
P Ebenstein ◽  
B Kinder ◽  
D O Bankole ◽  
F F Richards ◽  
M Y Armstrong
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Squamous Cell ◽  
Murine Leukemia Virus ◽  
Human Lung ◽  
Leukemia Virus ◽  
Squamous Cell Carcinomas ◽  
Human Lung Cancer ◽  
Induction System ◽  
Murine Leukemia

As a model for human lung cancer, squamous cell carcinomas were induced by 3-methylcholanthrene in mouse tracheas which had been explanted to a subcutaneous site. The tumors that developed were examined for both ecotropic and xenotropic infectious murine leukemia virus (MuLV). From all squamous carcinomas--six out of six--a xenotropic MuLV was isolated. From some of the fibrosarcomas that occurred incidentally in our induction system, ecotropic MuLV was isolated. However, in the fibrosarcomas, no xenotropic MuLV at all was found.

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