scholarly journals Synthesis, Characterization and Antimicrobial Activity of Mixed Schiff Base Ligand Complexes of Co(II), Ni(II), Cu(II) and Zn(II)

2011 ◽  
Vol 8 (3) ◽  
pp. 1258-1263 ◽  
Author(s):  
A. K. Mapari ◽  
M. S. Hate ◽  
K. V. Mangaonkar
Keyword(s):  
Antimicrobial Activity ◽  
Thermogravimetric Analysis ◽  
Schiff Bases ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Spectral Studies

The mixed ligand complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff basesN-(2-hydroxy-1-naphthylidene)-4-methylaniline (L1H) andN-(2-hydroxybenzylidene)-2,3-dimethylaniline (L2H) have been synthesized and characterized. The resulting complexes were characterized by elemental analysis, thermogravimetric analysis, magnetic moment measurements, conductivity measurements,1H NMR, IR, UV-visible and ESR spectral studies. The Schiff bases acts as bidentate monobasic ligands, coordinating through deprotonated phenolic oxygen and azomethine nitrogen atoms. The complexes are non-electrolytic in DMSO. The presence of the two coordinated water molecules in these complexes was indicated by IR spectra and thermogravimetric analysis of the complexes. From the analytical and spectral data the stoichiometry of these complexes have been found to be [M(L1)(L2)(H2O)2] {where M = Co(II) , Ni(II), Cu(II) and Zn(II)}. It is found that Co(II), Ni(II), Cu(II) and Zn(II) complexes exhibited octahedral geometry. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion method. It is found that the metal complexes have higher antimicrobial activity than the free ligand.

scholarly journals Bioinorganic Relevance of Some Cobalt(II) Complexes with Thiophene-2-glyoxal Derived Schiff Bases

2009 ◽  
Vol 6 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Prashant Singh ◽  
Shanu Das ◽  
Rajesh Dhakarey
Keyword(s):  
Spectral Data ◽  
Schiff Bases ◽  
Metal Ion ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Carbonyl Oxygen ◽  
Azomethine Nitrogen ◽  
Ligand Field ◽  
Filter Paper Disc ◽  
Electronic Spectral Data

Complexes of Co(II) with two new Schiff bases TEAB [2-hydroxy-4-{[2-oxo-2-(thiophen-2-yl)ethylidene]amino}benzoic acid] and TEPC [N-[2-oxo-2-(thiophen-2-yl)ethylidene]pyridine-3-carboxamide] have been synthesized and characterized with the help of elemental analysis, magnetic, mass,1H-NMR,13C-NMR, IR and electronic spectral data. IR spectra manifest the coordination of the ligand to the metal ion through the carbonyl oxygen, azomethine nitrogen and thienyl sulphur atoms. With the help of electronic spectral data various ligand field parameters were also calculated. All these studies reveal the distorted octahedral Co(II) complexes. Synthesized compounds have also been screened against some micro organismsviz, Escherichia coli, Proteus vulgaris, Aspergillus nigerandAspergillus flavuswith the help of ‘filter paper disc’ technique. It has been observed that the antimicrobial activities of metal complexes are higher than that of the free ligand.

scholarly journals Synthesis, Characterization and Biological Evaluation of Fe(III) and Cu(II) Complexes with 2,4-Dinitrophenyl hydrazine and Thiocyanate Ions

2019 ◽  
Vol 31 (4) ◽  
pp. 780-784
Author(s):  
P. Manimaran ◽  
S. Balasubramaniyan
Keyword(s):  
Antioxidant Activity ◽  
Metal Complexes ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
Diffusion Method ◽  
Spectral Studies

The metal complexes of Fe(III) and Cu(II) were prepared by using 2,4-dinitrophenyl hydrazine (DNPH) and thiocyanate (SCN) with stirrer refluxed for about 6 h. The prepared Fe(III) and Cu(II) complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility and electronic spectrum, FT-IR spectral studies. The result suggested the octahedral geometry for Fe(III) and Cu(II) complexes. Powder X-ray diffraction indicate the crystalline nature of the metal complexes. The antimicrobial activities of the Fe(III) and Cu(II) complexes were tested with various micro organisms by disc diffusion method. The antimicrobial results indicate that the metal complexes are highly active with compared to the free ligand. The in vitro antioxidant activity of the free ligand and its metal complexes was assayed by radical scavenging activity (DPPH). The result proposed that Fe (III) and Cu(II) complexes exhibited strong antioxidant activity than that of the ligand.

scholarly journals Synthesis, characterisation and antimicrobial activities of mixed ligand complexes of Mn (II), Fe (II) and Co(II) containing N,N'-bis (o-anisaldehyde) p-phenylenediamine (tetradentate schiff base) and gylcine

2018 ◽  
Vol 11 (1) ◽  
pp. 32-36
Author(s):  
I.T. Siraj ◽  
M Sule
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Mixed Ligand Complex ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Ligand Complex ◽  
Tetradentate Schiff Base

Complexes of Mn(II), Fe(II) and Co(II) containing N, N’-bis[o-anisaldehyde]p-phenylenediamine tetradentate Schiff base as primary ligand and glycine as secondary bidentate ligand have been synthesized by reflux in 1:1:1 mole ratio and characterized both analytically and spectroscopically. Molar conductance measurement (69.02 to 86.30Ω–1 cm2 mol–1) of the complexes indicated they are weak electrolyte and magnetic susceptibility measurement shows values in range of 4.53 to 5.59BM indicating their paramagnetism. The infrared data suggested that the Schiff base coordinated via the two nitrogen atoms of the azomethine groups (1628 to 1680 cm-1) and the oxygen atoms of the adjacent methoxy groups (1341 to 1389 cm-1), while glycine coordinated via the nitrogen atom of the amino group (3060-3324 cm-1) and the oxygen atom of the carboxylate anion. Based on the analytical and spectroscopic data the complexes may be assigned an octahedral geometries and molecular formulae of the form [M(L)Gly], where M = Mn, Fe and Co, L=Schiff base and Gly = glycine. The Schiff base and its mixed ligand complexes were screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella typhi, Mucor inducus and Aspergillus fumigatus. The complexes exhibited enhanced antimicrobial activity (10mm to 18mm) at 60 µg/disc as compared to 10mm activity of the uncoordinated Schiff base at the same concentration.Keywords: Mixed ligand complex; Schiff base, Glycine, p-phenylenediamine, o-anisaldehyde

scholarly journals Hypercoordinated Organosilicon(IV) and Organotin(IV) Complexes: Syntheses, Spectral Studies, and Antimicrobial Activity In Vitro

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Kiran Singh ◽  
Parvesh Puri ◽  
Yogender Kumar ◽  
Chetan Sharma
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Bases ◽  
Structural Features ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Nmr Studies ◽  
Trigonal Bipyramidal ◽  
Elemental Analyses

This paper deals with the syntheses and structural features of some new diorganosilicon(IV) and diorganotin(IV) complexes having general formulae (CH3)2MCl(L1), (CH3)2MCl(L2), (CH3)2M(L1)2, and (CH3)2M(L2)2 with new Schiff bases (M = Si and Sn). The Schiff bases HL1 and HL2 have been derived from the condensation of 3-bromobenzaldehyde with 4-amino-3-ethyl-5-mercapto-1,2,4-triazole and 4-amino-5-mercapto-3-propyl-1,2,4-triazole, respectively. The compounds have been characterized by the elemental analyses, molar conductance, and spectral (UV, IR, 1H, 13C, 29Si, and 119Sn NMR) studies. The resulting complexes have been proposed to have trigonal bipyramidal and octahedral geometries. In vitro antimicrobial activities of the compounds have been carried out.

scholarly journals Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone

2009 ◽  
Vol 74 (8-9) ◽  
pp. 927-938 ◽  
Author(s):  
Paulmony Tharmaraj ◽  
Deivasigamani Kodimunthiri ◽  
Clarence Sheela ◽  
Shanmuga Priya
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Free Ligand ◽  
Esr Spectra ◽  
Octahedral Geometry ◽  
Diffusion Method ◽  
Spectral Studies ◽  
Conductivity Measurements ◽  
Hydrazone Ligand ◽  
Square Planar

A new series of Cu(II), Co(II) and Ni(II) complexes with the 1-(2- -hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol-1- -yl)methyl]hydrazone ligand, C21H22N4O (LH), were synthesized by the reaction of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, hydrazone with (3,5-dimethyl- 1H-pyrazol-1-yl)methanol and characterized. The nature of the bonding and geometry of the complexes were deduced from elemental analysis, IR, electronic and 1H-NMR spectroscopy, and magnetic susceptibility and conductivity measurements. The studies indicated square-planar, tetrahedral and octahedral geometry for the copper(II), cobalt(II) and nickel(II) complexes, respectively. The ESR spectra of the copper(II) complex in acetonitrile at 300 and 77 K were recorded and their salient features are reported. The electrochemical behavior of the copper (II) complex was studied by cyclic voltammetry. The antimicrobial activity of the ligand and its metal complexes were studied against the following strains of microorganism: Staphylococcus aureus, Salmonella enterica typhi, Escherichia coli and Bacillus subtilis by the well diffusion method. Metal complexes showed enhanced antimicrobial activity compared with that of the free ligand.

scholarly journals Synthesis, spectroscopic, biological activities and DFT calculations of nickel(II) mixed-ligand complexes of tridentate Schiff bases

2020 ◽  
Vol 45 (1) ◽  
pp. 18
Author(s):  
Abidemi Iyewumi Demehin ◽  
Mary Adelaide Oladipo ◽  
Banjo Semire
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Biological Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Elemental Analysis Data ◽  
Biological Studies

Ni(II) mixed-ligand complexes of [NiLNH3] (where L= N-salicylidene-o-aminophenol (L1), N-(5-methoxysalicylidene-o-aminophenol) (L2) and N-(2-hydroxy-1-naphthalidene)-o-aminophenol) (L3) containing ONO tridentate Schiff bases and ammonia were synthesized and characterized by elemental analysis, infrared, ultraviolet-visible, proton and carbon-13 spectroscopies. Theoretical calculations were also performed on the optimized structures of the Ni(II) mixed-ligand complexes. The Infrared and ultraviolet-visible spectra of the complexes were calculated, and the results compared with the corresponding experimental spectra to augment the experimental structural identification. The elemental analysis data confirmed the formation of 1:1:1 [metal: Schiff base: ammonia] molar ratio. The NMR spectra showed that the Schiff bases coordinated to the Ni(II) ion via the two deprotonated phenolic oxygen and azomethine nitrogen atoms. The biological studies showed that the complexes exhibited higher antibacterial and antioxidant activities than the free Schiff base ligands.

scholarly journals Synthesis of New Mixed-Ligand Complexes of Molybdenum (IV) and Tungsten(IV): Characterization, Structure, Thermal and Anti-microbial Studies

2019 ◽  
Vol 11 (1) ◽  
pp. 43
Author(s):  
Festus Sunday Fabiyi ◽  
Friday O. Nwosu
Keyword(s):  
1H Nmr ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi ◽  
And Tungsten

Six new mixed-ligand complexes of Mo(IV) and W(IV) ions have been prepared and characterized. The three new complexes of Mo(IV) ions have the molecular formulae MoC12N2O5H18, MoC15N2O5H22 and MoC14N2O6H19 , while the W(II) ions are WC12N2O5H18, WC15N2O5H22 and WC14N2O6H19. The structures of the complexes were deduced from their ir, 1H nmr, and mass spectral studies. All the complexes were found to exhibit octahedral structures. Their antimicrobial activities against some bacteria and fungi species were found to be moderate.

scholarly journals Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies

2018 ◽  
Vol 69 (11) ◽  
pp. 3169-3177 ◽  
Author(s):  
Karunganathan Sakthikumar ◽  
Murugesan Sankarganesh ◽  
Jeyaraj Dhaveethu Raja ◽  
Liviu Mitu
Keyword(s):  
Dna Cleavage ◽  
Free Ligand ◽  
Dna Interaction ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Water Soluble ◽  
Mixed Ligand Complexes ◽  
Molar Ratio ◽  
Spectral Techniques

A new series of water soluble mixed ligand complexes [MII(L)(bpy)AcO].nH2O M = Cu, (n=1) (1); Co (2), Mn (3), Ni (4) (n=4) and Zn (5) (n=2) have been synthesized from 2-(2-Morpholinoethylimino)methyl)phenol Schiff base ligand (HL) and 2,2�-bipyridine in a 1:1:1 molar ratio. The resulting complexes were characterized by spectral techniques. The spectral data of these complexes suggest an octahedral geometry. In vitro antioxidant activity results of DPPH assay, hydroxyl radical, super oxide and nitric oxide for complexes (1-5) were compared with ligand (HL) and in vitro antimicrobial activities of all compounds were examined against selected bacterial and fungal strains which indicate that the complexes exhibit higher antimicrobial activity than free ligand (HL). Gel electrophoresis results indicated that, complexes (1) and (2) have exhibited more DNA cleavage efficiency than others. The intrinsic binding constant (Kb) values for the complexes (1-5) observed by electronic absorption technique were in the order of (1) ] (4) ] (5) ] (2) ] (3) and DNA binding affinity values for these complexes obtained by viscosity measurements were in the order of ethidium bromide ] (1) ] (2) ] (3) ] (4) ] (5).

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