scholarly journals Efficacy and Tolerability of a Combined Moxifloxacin/Dexamethasone Formulation for Topical Prophylaxis in Phacoemulsification: An Open-Label Single-Arm Clinical Trial

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Cesar Ramon G. Espiritu ◽  
Mary Ellen A. Sy ◽  
Tommee Lynne G. Tayengco
Keyword(s):  
Visual Acuity ◽  
Day Treatment ◽  
Prednisolone Acetate ◽  
Eye Drops ◽  
Infection Prophylaxis ◽  
Ocular Pain ◽  
Open Label ◽  
Iol Implantation ◽  
Asian Patients ◽  
Corrected Visual Acuity

Background. The use of a fixed-combination antibiotic corticosteroid for infection prophylaxis in Asian patients undergoing phacoemulsification has not been reported.Methods. A 15-day, open-label, single-arm trial of 64 patients for phacoemulsification with intraocular lens (IOL) implantation is described. Patients applied moxifloxacin 0.5%/dexamethasone 0.1% (Vigadexa) eye drops four times daily before and until 15 days after surgery. Anterior chamber (AC) reaction, visual acuity, ocular pain and signs, and intraocular pressure (IOP) were assessed at baseline and on postoperative days 1, 3, 8, and 15.Results. At day 15, 55 (91.7%) patients scored 0 (<5 cells) in AC reaction. No surgery-related infection occurred. Mean best-corrected visual acuity improved 0.5 logMAR from baseline to 0.0 logMAR (P<.0001). Mean IOP remained at 12-13 mm Hg over the 15-day treatment. Only 2 patients (3.1%) reported minimum ocular pain. Two (3.1%) patients were shifted to prednisolone acetate for severe inflammation. At the end of the study period, 8.3% were given fluorometholone for 1 week for AC reaction grade >0. No drug-related adverse event was reported.Conclusion. Following phacoemulsification and IOL implantation, the topical combination moxifloxacin 0.5%/dexamethasone 0.1% was effective in preventing infection and controlling inflammation and was well tolerated.

scholarly journals Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy

2015 ◽  
Vol 6 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Bettina Hohberger ◽  
Michael Rudolph ◽  
Antonio Bergua
Keyword(s):  
Visual Acuity ◽  
Choroidal Neovascularization ◽  
Combined Therapy ◽  
Retinal Pigment ◽  
Posterior Pole ◽  
Prednisolone Acetate ◽  
Eye Drops ◽  
Punctate Inner Choroidopathy ◽  
Anti Vegf ◽  
Systemic Medication

Purpose: Choroidal neovascularization (CNV) associated with punctate inner choroidopathy (PIC) is a rare clinical entity, yet still a challenge for medical treatment. A case of a young myopic woman developing CNV secondary to unilateral PIC is presented. Clinical morphology, diagnostic procedure and follow-up are reported. Case Report: A 29-year-old woman presented with multiple yellowish dots at the posterior pole. No other signs of inflammation could be seen. Angiography with fluorescein yielded hyperfluorescent signals in the affected areas with a diffuse leak, and SD-OCT showed a slightly elevated retinal pigment epithelial layer, consistent with the diagnosis of PIC. Additionally a classic CNV was observed. Results: Anti-inflammatory therapy with local prednisolone acetate eye drops in combination with intravitreal injection of anti-vascular endothelial growth factor (VEGF, bevacizumab) yielded an increased best-corrected visual acuity. As CNV reappeared, systemic medication with prednisone and azathioprine in combination with two further intravitreal injections of anti-VEGF stabilized CNV and increased visual acuity again. Conclusion: Combined therapy of immunosuppression with intravitreal anti-VEGF injections can be considered as therapeutic strategy in the management of recurrent CNV associated with PIC.

scholarly journals Cataract Surgery and Uveitis

2016 ◽  
Vol 9 (3) ◽  
Author(s):  
Mumtaz Hussain ◽  
Muhammad Moin ◽  
Nazir Ahmad Aasi ◽  
Muhammad Waqas ◽  
Jawaid Mughal
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
General Hospital ◽  
Cataract Extraction ◽  
Extracapsular Cataract Extraction ◽  
Iol Implantation ◽  
Corrected Visual Acuity ◽  
Best Corrected Visual Acuity

The study of 30 patients was performed at Lahore General Hospital, and Institute Of Ophthalmology Mayo Hospital, Lahore from June 1989 to June 2003 for 14 years. Total number of eyes were 34 where 2 patients had both eyes. Age ranged from 12-65 years. Males were 11 and females were 19. all the patients had planned extracapsular cataract extraction with IOL implantation. Total follow up period ranged from 1-5 years and best corrected visual acuity in these patients after surgery was 6/12 to 6/6. Post operatively, eyes had vitreous membranes and glaucomatous reaction.

scholarly journals ND: YAG LASER

2018 ◽  
Vol 25 (12) ◽  
pp. 1848-1851
Author(s):  
Mohammad Alam
Keyword(s):  
Visual Acuity ◽  
Nd:Yag Laser ◽  
Posterior Capsular Opacification ◽  
Eye Drops ◽  
Slit Lamp ◽  
Yag Laser ◽  
Corrected Visual Acuity ◽  
Nd:Yag Laser Capsulotomy ◽  
Department Of Ophthalmology ◽  
Best Corrected Visual Acuity

Objectives: To find out the visual acuity outcome after Nd: YAG laser capsulotomy in posterior capsular opacification in pseudophakic patients after cataract surgery. Study Design: Analytical study. Setting: Department of Ophthalmology Khyber Medical University Institute of Medical Sciences / K.D.A Teaching Hospital Kohat. Period: January 2016 to June 2017. Materials and methods: Special proforma was designed for record of patients. PreNd:YAG laser posterior capsulotomy best corrected visual acuity was checked and noted. Anterior and posterior segments examination was done with slit lamp and indirect slit lamp bimicroscopy. Pupils were dilated with tropicamide eye drops. Nd:YAG laser capsulotomy was done. All these procedure were conducted as out door. Patients were put on topical steroid and antiglaucoma drops for ten days to control inflammation and rise in IOP. Post laser best corrected visual acuity was recorded after one month of laser. Results: Total 92 patients were selected with age range from 21 to 83 years. Out of these patients 43(46.74%) were male and 49(53.26%) were female. Post surgical laser period was from 7 months to 13 years. Prelaser best corrected visual acuity of 6/24-6/36 was present in 59(64.13%) patients, 6/60 in 24(26.08%) patients while 9(9.78%) patients had visual acuity of counting finger (CF). Post laser best corrected visual acuity after one month of 6/6-6/9 was recorded in 43(46.39%) patients ,6/12-6/18 in 27(29.34%), 6/24-6/36 in 13(14.13%)and 6/60 & below in 9(9.71%) patients. Conclusion: Post laser best corrected visual acuity is highly improved with Nd:YAG laser capsulotomy in posterior capsular opacification.

scholarly journals Validation of an Independent Web-Based Tool for Measuring Visual Acuity and Refractive Error (the Manifest versus Online Refractive Evaluation Trial): Prospective Open-Label Noninferiority Clinical Trial.

10.2196/14808 ◽  
2019 ◽  
Vol 21 (11) ◽  
pp. e14808 ◽  
Author(s):  
Robert P L Wisse ◽  
Marc B Muijzer ◽  
Francesco Cassano ◽  
Daniel A Godefrooij ◽  
Yves F D M Prevoo ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Visual Acuity ◽  
Healthy Volunteers ◽  
Refractive Error ◽  
Reference Test ◽  
Open Label ◽  
Web Based ◽  
Corrected Visual Acuity ◽  
Manifest Refraction ◽  
The Web

Background Digital tools provide a unique opportunity to increase access to eye care. We developed a Web-based test that measures visual acuity and both spherical and cylindrical refractive errors. This test is Conformité Européenne marked and available on the Easee website. The purpose of this study was to compare the efficacy of this Web-based tool with traditional subjective manifest refraction in a prospective open-label noninferiority clinical trial. Objective The aim of this study was to evaluate the outcome of a Web-based refraction compared with a manifest refraction (golden standard). Methods Healthy volunteers from 18 to 40 years of age, with a refraction error between –6 and +4 diopter (D), were eligible. Each participant performed the Web-based test, and the reference test was performed by an optometrist. An absolute difference in refractive error of <0.5 D was considered noninferior. Reliability was assessed by using an intraclass correlation coefficient (ICC). Both uncorrected and corrected visual acuity were measured. Results A total of 200 eyes in 100 healthy volunteers were examined. The Web-based assessment of refractive error had excellent correlation with the reference test (ICC=0.92) and was considered noninferior to the reference test. Uncorrected visual acuity was similar with the Web-based test and the reference test (P=.21). Visual acuity was significantly improved using the prescription obtained by using the Web-based tool (P<.01). The Web-based test provided the best results in participants with mild myopia (ie, <3 D), with a mean difference of 0.02 (SD 0.49) D (P=.48) and yielding a corrected visual acuity of >1.0 in 90% (n=77) of participants. Conclusions Our results indicate that Web-based eye testing is a valid and safe method for measuring visual acuity and refractive error in healthy eyes, particularly for mild myopia. This tool can be used for screening purposes, and it is an easily accessible alternative to the subjective manifest refraction test. Trial Registration Clinicaltrials.gov NCT03313921; https://clinicaltrials.gov/ct2/show/NCT03313921.

scholarly journals Validation of an Independent Web-Based Tool for Measuring Visual Acuity and Refractive Error (the Manifest versus Online Refractive Evaluation Trial): Prospective Open-Label Noninferiority Clinical Trial. (Preprint)

2019 ◽  
Author(s):  
Robert P L Wisse ◽  
Marc B Muijzer ◽  
Francesco Cassano ◽  
Daniel A Godefrooij ◽  
Yves F D M Prevoo ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Visual Acuity ◽  
Healthy Volunteers ◽  
Refractive Error ◽  
Reference Test ◽  
Open Label ◽  
Web Based ◽  
Corrected Visual Acuity ◽  
Manifest Refraction ◽  
The Web

BACKGROUND Digital tools provide a unique opportunity to increase access to eye care. We developed a Web-based test that measures visual acuity and both spherical and cylindrical refractive errors. This test is Conformité Européenne marked and available on the Easee website. The purpose of this study was to compare the efficacy of this Web-based tool with traditional subjective manifest refraction in a prospective open-label noninferiority clinical trial. OBJECTIVE The aim of this study was to evaluate the outcome of a Web-based refraction compared with a manifest refraction (golden standard). METHODS Healthy volunteers from 18 to 40 years of age, with a refraction error between –6 and +4 diopter (D), were eligible. Each participant performed the Web-based test, and the reference test was performed by an optometrist. An absolute difference in refractive error of <0.5 D was considered noninferior. Reliability was assessed by using an intraclass correlation coefficient (ICC). Both uncorrected and corrected visual acuity were measured. RESULTS A total of 200 eyes in 100 healthy volunteers were examined. The Web-based assessment of refractive error had excellent correlation with the reference test (ICC=0.92) and was considered noninferior to the reference test. Uncorrected visual acuity was similar with the Web-based test and the reference test (<italic>P</italic>=.21). Visual acuity was significantly improved using the prescription obtained by using the Web-based tool (<italic>P</italic><.01). The Web-based test provided the best results in participants with mild myopia (ie, <3 D), with a mean difference of 0.02 (SD 0.49) D (<italic>P</italic>=.48) and yielding a corrected visual acuity of >1.0 in 90% (n=77) of participants. CONCLUSIONS Our results indicate that Web-based eye testing is a valid and safe method for measuring visual acuity and refractive error in healthy eyes, particularly for mild myopia. This tool can be used for screening purposes, and it is an easily accessible alternative to the subjective manifest refraction test. CLINICALTRIAL Clinicaltrials.gov NCT03313921; https://clinicaltrials.gov/ct2/show/NCT03313921.

TO EVALUATE OUTCOMES OF PHACOEMULSIFICATION ON HARD NUCLEOUS CATARACT PATIENTS

2018 ◽  
pp. 32-36
Author(s):  
Thi My Hanh Le ◽  
Van Nam Phan ◽  
Minh Pham
Keyword(s):  
Visual Acuity ◽  
Clinical Characteristics ◽  
Light Perception ◽  
Iol Implantation ◽  
Corrected Visual Acuity ◽  
Post Operation ◽  
The Mean ◽  
Grade 3 ◽  
Cataract Patients ◽  
Best Corrected Visual Acuity

Purpose: To evaluate the outcomes of phacoemulsification procedure in treatment cataract with hard nucleous. Material and Methods: 54 cataract patients (54 eyes) with nucleous hardness grade 3, 4, 5 had been phacoemulsificated with intraocular len (IOL) implantation at Hue Eye Hospital from July 2016 to March 2017. Collecting data about age, sex, clinical characteristics, visual acuity pre and post operation, variable of event, complications intra and postoperation, variable of technical characteristics such as time and power of phacoemulsification. Results: 54 patients (54 eyes) including 30 females (55.5%) and 24 males (44.5%) were operated and the mean age was 71.85 ± 6.4. Preoperatively, vision acuity was under 1/10 in all eyes, including 32 eyes (59.3%) had vision acuity from light perception to under count finger 2 metter. One day postoperatively, 100% eyes had visual acuity higher than 1/10. One month postoperative, 52 eyes (96.3%) achieve best corrected visual acuity (BCVA) was higher than 5/10. Three months postoperatively, BCVA is higher than 7/10 in 30 eyes (55.6%). Conclusion: Inspite of cataract with hard nucleus, the phacoemulsification procedure with IOL implantation can be performed and it gives a good result. Key words: phacoemulsification, hard nucleous cataract

scholarly journals Treatment of Stable Keratoconus by Cataract Surgery with Toric IOL Implantation

2012 ◽  
Vol 1 (2) ◽  
pp. 128-130
Author(s):  
Tova Lifshitz ◽  
Jaime Levy ◽  
Anry Pitchkhadze
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
Intraocular Lens ◽  
Toric Intraocular Lens ◽  
Toric Iol ◽  
Iol Implantation ◽  
Corrected Visual Acuity ◽  
Uncorrected Visual Acuity ◽  
Cylinder Power ◽  
Best Corrected Visual Acuity

ABSTRACT We present the case of a 73-year-old patient who underwent successful phacoemulsification and toric intraocular lens (IOL) implantation to correct high stable astigmatism due to keratoconus and cataract. Preoperative refraction was −3.25 −4.0 × 98°. A toric IOL (Acrysof SN60T6) with a spherical power of 16.5 D and a cylinder power of 3.75 D at the IOL plane and 2.57 D at the corneal plane was implanted and aligned at an axis of 0°. Uncorrected visual acuity improved from 6/60 to 6/10. Postoperative best corrected visual acuity was 6/6, 6 months after the operation. In conclusion, phacoemulsification with toric IOL implantation can be performed in eyes with keratoconus and cataract. How to cite this article Levy J, Pitchkhadze A, Lifshitz T. Treatment of Stable Keratoconus by Cataract Surgery with Toric IOL Implantation. Int J Kerat Ect Cor Dis 2012;1(2):128-130.

scholarly journals Intravitreal quantum dots for retinitis pigmentosa: a first-in-human safety study

Nanomedicine ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. 617-626
Author(s):  
Timothy L Jackson ◽  
Naresh Mandava ◽  
Hugo Quiroz-Mercado ◽  
Matthew Benage ◽  
Gerardo Garcia-Aguirre ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Visual Acuity ◽  
Retinitis Pigmentosa ◽  
Therapeutic Potential ◽  
Open Label ◽  
Safety Study ◽  
Fellow Eye ◽  
Human Safety ◽  
Corrected Visual Acuity ◽  
Best Corrected Visual Acuity

Background: Studies indicate that electrical stimulation of retinitis pigmentosa (RP) retina is beneficial. Quantum dots (QDs) can convert light to electrical stimulus and therefore may have therapeutic potential for RP. Methods: This was an open-label, fellow eye-controlled, first-in-human safety study. Five adults with end-stage (arm A) and 15 with severe (arm B) RP received one or two intravitreal injections of 0.2 or 2μM cadmium/selenium 655 Alt QDs. Results: No adverse events were attributed to QDs. In arm A, median best corrected visual acuity was unchanged. In arm B, mean best corrected visual acuity improved from 6/398 to 6/177, versus 6/147 to 6/144 in the fellow eye. Conclusion: Intravitreal QDs can be safely administered to patients with RP. Vision appears to benefit and further validating studies are justified.

scholarly journals Distinct Acute Unilateral Fibrinous Anterior Uveitis After Zoledronic Acid Infusion: A Case Report

2021 ◽  
Author(s):  
Klemens Paul Kaiser ◽  
Ferhat Turgut ◽  
Matthias Dieter Becker ◽  
Vita Louisa Sophie Dingerkus
Keyword(s):  
Visual Acuity ◽  
Case Report ◽  
Zoledronic Acid ◽  
Side Effects ◽  
Anterior Uveitis ◽  
Early Treatment ◽  
Eye Drops ◽  
Acid Infusion ◽  
Corrected Visual Acuity ◽  
Best Corrected Visual Acuity

Abstract Purpose: To report a case of a distinct acute unilateral fibrinous anterior uveitis after zoledronic acid infusion.Methods: Case Report.Results: A 68-year-old woman presented with a burning, itching and reddened right eye with visual deterioration for about five days. She had received her first intravenous infusion of zoledronic acid the day before the onset of the symptoms. Her best-corrected visual acuity was 6/24. She was mainly treated with topical corticosteroids (prednisolone 1% eye drops and subconjunctival dexamethasone) and scopolamine 0.25 %. This treatment resulted in a significant improvement of the findings and symptoms within a few days.Conclusions: It is crucial that patients receiving bisphosphonates are accurately informed about the possibility of ocular inflammation, other inflammatory side effects and their symptoms to ensure early treatment.

Effect of Intraocular Lens Biomaterials on the Treatment of Primary Angle Closure Glaucoma

2022 ◽  
Vol 12 (1) ◽  
pp. 139-145
Author(s):  
Jianlian Guo ◽  
Qiang Dong ◽  
Min Liu
Keyword(s):  
Visual Acuity ◽  
Intraocular Lens ◽  
Clinical Stage ◽  
Acute Angle ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Iol Implantation ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Corrected Visual Acuity

To explore the effect of phacoemulsification along with intraocular lens (IOL) implantation on the treatment of primary angle closure glaucoma (PACG), a total of 50 patients (54 eyes) with PCG who had undergone surgery were selected as the research objects, in which, there were 16 eyes with the acute PACG in pre-clinical stage, 20 eyes with acute PACG during acute attack, and 18 eyes with chronic PACG, and all patients received phacoemulsification along with IOL implantation therapy. The patient’s best corrected visual acuity, anterior chamber (AC), anterior depth, intraocular pressure (IOP), visual field, and fundus conditions were measured during the operation, after the operation, and during the follow-up period. The postoperative visual acuity of the patients with three types of PACG was greatly corrected, in which 30 eyes had corrected visual acuity above 0.5, and there were statistically significant differences (SSDs) (P < 0.05); angle closure of 54 eyes had different degrees of improvement, the opening degree of the acute angle closure is better than that of the chronic angle closure, and there were SSDs (P < 0.05); each of 54 eyes showed different degrees of deepening in the central AC, and there were SSDs (P < 0.05); postoperative IOP decreased greatly in all 54 eyes, and there were SSDs (P < 0.05). In conclusion, the IOL implantation based on phacoemulsification can effectively treat the PACG, at the same time reduce IOP, promote angle opening, enhance vision field of the patients, and ultimately achieve the purpose of improving surgical success.

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