scholarly journals A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Shu Hisata ◽  
Yuichiro Kimura ◽  
Naoko Shibata ◽  
Shuichi Ono ◽  
Takao Kobayashi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Prognostic Value ◽  
Respiratory Symptoms ◽  
Immunohistochemical Analysis ◽  
The Other ◽  
Normal Range ◽  
High Resolution Computed Tomography ◽  
Asymptomatic Patients ◽  
Independent Effects

Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution computed tomography (HRCT), were compared with 17 other IPF outpatients having slight respiratory symptoms and honeycombing as well. Although SP-D was increased in both groups, KL-6 was significantly higher in the symptomatic IPF group. When the patients (n=11) having both biomarkers elevated were compared with the other patients (n=6) with only SP-D elevated, the distribution of fibrotic lesions with honeycombing on HRCT was larger and the survival time was shorter in the patients having both biomarkers elevated. Immunohistochemical analysis also differentiated these biomarkers in the lung. These results suggest both a cause and the prognostic value of dissociation of these biomarkers.

scholarly journals Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Virginie Kreutzinger ◽  
Torsten Diekhoff ◽  
Lutz Liefeldt ◽  
Denis Poddubnyy ◽  
Kay Geert A. Hermann ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Secondary Hyperparathyroidism ◽  
Demographic Data ◽  
Joint Space ◽  
Electronic Patient Records ◽  
Retrospective Case ◽  
High Resolution Computed Tomography ◽  
Asymptomatic Patients ◽  
Control Study

AbstractSecondary hyperparathyroidism (sHPT) as a result of chronic kidney disease (CKD) is a common health problem and has been reported to manifest at the sacroiliac joints (SIJ). The aim of this investigation was to systematically assess sacroiliac joint changes in asymptomatic sHPT as detected by high-resolution CT. Included in this IRB-approved retrospective case–control study were 56 patients with asymptomatic sHPT as well as 259 matched controls without SIJ disease. Demographic data were retrieved from electronic patient records. High-resolution computed tomography datasets of all patients were subjected to a structured scoring, including erosions, sclerosis, osteophytes, joint space alterations and intraarticular calcifications. Chi2 tests were used to compare frequencies of lesions. Erosions were significantly more prevalent in patients with sHPT, and were found mainly in the ventral (28.6% vs. 13.9%; p = 0.016) and middle (17.9% vs. 7.7%; p = 0.040) iliac portions of the SIJ. Partial ankylosis was rare in both cohorts (3.6% vs. 5.0%; p > 0.999); complete ankylosis was not observed. Neither extent not prevalence of sclerosis or calcifications differed significantly between groups. Joint lesions reminiscent of sacroiliitis can be found in a substantial portion of asymptomatic patients with secondary hyperparathyroidism. Further investigations into the clinical significance of these findings are warranted.

scholarly journals An Unusual Case of Dengue Fever with Necrotising Pneumonia

2020 ◽  
Author(s):  
Nazeem Fathima ◽  
Balamma Sujatha ◽  
Shami RP Kumar ◽  
S Rajesh
Keyword(s):  
Computed Tomography ◽  
Pleural Effusion ◽  
High Resolution ◽  
Dengue Fever ◽  
Respiratory Symptoms ◽  
Unusual Case ◽  
Left Lung ◽  
Female Child ◽  
High Resolution Computed Tomography ◽  
Thin Walled

Concurrent bacteremia in patients with dengue fever is rarely reported. Two and a half-year-old female child with fever, cough and cold for six days presented to Emergency Room (ER) with tachypnea, tachycardia and hepatomegaly. Investigations revealed dengue fever. Respiratory symptoms probed us to investigate the case further. High-Resolution Computed Tomography (HRCT) thorax showed moderate pleural effusion with collapse consolidation of left lung and a thin walled cavity with septations and fluid in left upper lobe. Child was treated with injection meropenem and vancomycin successfully.

scholarly journals Collapse phenomenon during Chartis collateral ventilation assessment

2016 ◽  
Vol 47 (6) ◽  
pp. 1657-1667 ◽  
Author(s):  
Wolfgang Gesierich ◽  
Konstantinos Samitas ◽  
Frank Reichenberger ◽  
Juergen Behr
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Predictive Value ◽  
Spontaneous Breathing ◽  
Prognostic Value ◽  
Jet Ventilation ◽  
High Resolution Computed Tomography ◽  
Airway Collapse ◽  
Endobronchial Valve ◽  
Collateral Ventilation

Chartis is increasingly used for bronchoscopic assessment of collateral ventilation before endobronchial valve (EBV) treatment for severe emphysema. Its prognostic value is, however, limited by the airway collapse phenomenon. The frequency and clinical significance of the collapse phenomenon remain largely unknown.We performed a retrospective analysis of 92 patients undergoing Chartis evaluation under spontaneous breathing (n=55) or jet ventilation (n=37) from May 2010 to November 2013. Collateral ventilation status (positive/negative/collapse phenomenon/unclear) was reassessed and correlated with high-resolution computed tomography (HRCT) fissure analysis and clinical response.In the absence of the collapse phenomenon, the predictive value of Chartis measurements and HRCT fissural analysis was comparable. The collapse phenomenon was observed in 31.5% of all assessments, and was more frequent in lower lobes (44.9% versus 16.9% in upper lobes) and under jet ventilation (41.4% versus 22.1% under spontaneous breathing). 69.8% of lobes with the collapse phenomenon had complete fissures. Most patients with the collapse phenomenon in the target lobe and complete fissures treated with EBVs were responders (n=11/15). All valve-treated collapse phenomenon patients with fissure defects were nonresponders (n=3).In the absence of the collapse phenomenon Chartis measurement is reliable to predict response to valve treatment. In patients with the collapse phenomenon, treatment decisions should be based on HRCT detection of fissure integrity. Chartis assessment should be performed under spontaneous breathing.

Acute Pulmonary Oxygen Toxicity in Rats: Findings and Lung Density Changes in High Resolution Computed Tomography

2000 ◽  
Vol 42 (3) ◽  
pp. 473
Author(s):  
Dae Sik Ryu ◽  
Kun Sang Kim ◽  
Kil Hyen Kang ◽  
Haing Sup Chung ◽  
Bung Wok Lee ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Oxygen Toxicity ◽  
High Resolution Computed Tomography ◽  
Lung Density
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