scholarly journals Evaluation of Serum Resistin Levels in Periodontal Health and Disease and Effects of Non Surgical Periodontal Therapy on Its Levels

2012 ◽  
Vol 32 (5) ◽  
pp. 289-294 ◽  
Author(s):  
Archana Devanoorkar ◽  
C.D. Dwarakanath ◽  
Gayatri Gundanavar ◽  
Rahul Kathariya ◽  
Sudhir R Patil
Keyword(s):  
Statistical Significance ◽  
Periodontal Therapy ◽  
Control Group ◽  
Periodontal Health ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Nonsurgical Periodontal Therapy ◽  
Health And Disease ◽  
Group 2 ◽  
Group 1

Background: Resistin and adiponectin are the adipokines secreted by adipocytes and various inflammatory cells. These adipokines are known to play an important role in insulin resistance. The aim of this study was to determine the serum resistin levels in periodontal health and disease and also, to determine the effect of nonsurgical periodontal therapy on its levels.Methods: A total of 40 patients (20 Males and 20 Females; age range 20–50 years) participated in the study. Subjects were categorized as healthy (group 1; Controls) and chronic periodontitis (group 2; Study) groups based on their periodontal status. Periodontal parameters (Plaque index (PI), Gingival index (GI), Bleeding index (BI), Probing pocket depth (PPD), Clinical attachment loss (CAL)) together with serum resistin levels were assessed at baseline and between 6–8 weeks following nonsurgical periodontal therapy for subjects in group~2 and only at baseline in group 1. Sera were tested in duplicate (single run), and the results were averaged.Results: Study group showed higher (1.89 ± 1.83 ng/ml) serum resistin levels, compared to control group (1.35 ± 0.70 ng/ml). However, this difference was not statistically significant (P=0.227). Also, resistin levels decreased following nonsurgical periodontal therapy but, this decrease failed to show any statistical significance, with pretreatment levels being 1.89 ± 1.83 ng/ml and post treatment levels being 1.59 ± 1.01 ng/ml (P=0.386).Conclusion: Observations of the present study revealed that there was not much difference in the serum resistin levels between the cases and the controls. Also the decrease in the resistin levels following nonsurgical periodontal therapy did not show any statistical significance.

scholarly journals Comparison of the rate of claw horn growth and wear and sole thickness in dairy cattle housed in a free stall barn with concrete and rubber flooring

2016 ◽  
Author(s):  
Sarel Van Amstel ◽  
Charles Young ◽  
Clare Scully ◽  
Barton Rohrbach
Keyword(s):  
Dairy Cattle ◽  
Milk Production ◽  
Statistical Significance ◽  
Control Group ◽  
Horn Growth ◽  
Significant Difference ◽  
Group 2 ◽  
Concrete Control ◽  
Experimental Group ◽  
Group 1

Background. Thin soles and resulting lameness in cows are often due to abrasive walking surfaces that cause increased wear. The aim of this project was to compare horn growth and wear and sole thickness in cows kept on rubber mats versus concrete in a free-stall barn. Methods. To examine horn growth and wear and sole thickness, we examined two groups (Group 1 kept on concrete [control] and Group 2 on rubber mats) of 12 cows each at 2-week intervals over a 12-week period. The 12 cows in each group were selected to achieve equal parity in each group, as follows: four cows, parity 1; four cows, parity 2; two cows, parity 3; and two cows, parity 4. The four cows from the parity 1 group had the most days in milk in the herd irrespective of milk production. The remaining eight cows had the fewest days in milk (most recently calved) irrespective of milk production. Results. Cows in the control group had a significant increase in claw horn growth over the study period, compared to the control group. Most of this difference in horn growth occurred during the first 2 weeks of the study. There was no significant difference in claw horn wear and sole thickness at 2 weeks or at the end of the study. There was, however, a non-significant difference in wear between cows in the 2 groups at the end of the study, with cows in the control group showing most wear. Cows in the experimental group exhibited significant increases in all parameters (claw length, wear, and growth; sole thickness) when measured at the beginning and end of the trial, whereas cows in the control group showed a significant increase in claw length and sole thickness.Discussion. These findings suggest that there was a compensatory increase in horn production in response to accelerated claw horn wear in the control group. Statistical significance in wear might have been attained between groups at the end of the study if the study had continued over a longer period.

scholarly journals Evaluation of the clinical efficacy of 1.2% atorvastatin by CBCT in the treatment of periodontal intrabony defects: A randomized controlled clinical trial

2019 ◽  
Vol 13 (3) ◽  
pp. 183-191
Author(s):  
Prerna Y. Shirke ◽  
Abhay P. Kolte ◽  
Rajashri A. Kolte ◽  
Pranjali V. Bawanakar
Keyword(s):  
Clinical Trial ◽  
Statistical Significance ◽  
Periodontal Regeneration ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Treat Ment ◽  
Group 2 ◽  
Attachment Level ◽  
Group 1

Background. Atorvastatin (ATV), which belongs to the statin class of drugs, is the formidable inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. This clinical trial evaluated and compared the clinical and radiographic changes in chronic periodontitis (CP) patients, obtained through 1.2% ATV as an adjunct to scaling and root planing (SRP) in the treat-ment of intraosseous defects. Methods. Twenty CP patients, with a minimum of one pair of bilateral intraosseous, were randomly selected for this split-mouth study. Group 1 included 20 sites treated with SRP and subgingival delivery of a placebo gel, whereas an equal number of sites in group 2 were treated by SRP along with subgingival delivery of 1.2% ATV gel. The plaque index (PI), modified sulcus bleeding index (mSBI), probing pocket depth (PPD) and clinical attachment level (CAL) were evaluated at baseline and 3- and 6-month intervals, while the intraosseous defect was assessed at baseline and 6-month interval using cone-beam computed tomography (CBCT). Paired t-test was used to determine statistical significance. Results. A greater reduction in the mean PPD and gain in CAL was found in group 2 compared to group 1 at 3- and 6-month intervals. Furthermore, a significantly greater bone fill was obtained in group 2 (1.70±0.54 mm) compared to group 1 (0.22±0.43 mm) after six months.Conclusion. ATV, as an adjunct to SRP, enhanced periodontal regeneration, as a noninvasive way to treat periodontal in-traosseous defects.

scholarly journals Comparison of the rate of claw horn growth and wear and sole thickness in dairy cattle housed in a free stall barn with concrete and rubber flooring

2016 ◽  
Author(s):  
Sarel Van Amstel ◽  
Charles Young ◽  
Clare Scully ◽  
Barton Rohrbach
Keyword(s):  
Dairy Cattle ◽  
Milk Production ◽  
Statistical Significance ◽  
Control Group ◽  
Horn Growth ◽  
Significant Difference ◽  
Group 2 ◽  
Concrete Control ◽  
Experimental Group ◽  
Group 1

Background. Thin soles and resulting lameness in cows are often due to abrasive walking surfaces that cause increased wear. The aim of this project was to compare horn growth and wear and sole thickness in cows kept on rubber mats versus concrete in a free-stall barn. Methods. To examine horn growth and wear and sole thickness, we examined two groups (Group 1 kept on concrete [control] and Group 2 on rubber mats) of 12 cows each at 2-week intervals over a 12-week period. The 12 cows in each group were selected to achieve equal parity in each group, as follows: four cows, parity 1; four cows, parity 2; two cows, parity 3; and two cows, parity 4. The four cows from the parity 1 group had the most days in milk in the herd irrespective of milk production. The remaining eight cows had the fewest days in milk (most recently calved) irrespective of milk production. Results. Cows in the control group had a significant increase in claw horn growth over the study period, compared to the control group. Most of this difference in horn growth occurred during the first 2 weeks of the study. There was no significant difference in claw horn wear and sole thickness at 2 weeks or at the end of the study. There was, however, a non-significant difference in wear between cows in the 2 groups at the end of the study, with cows in the control group showing most wear. Cows in the experimental group exhibited significant increases in all parameters (claw length, wear, and growth; sole thickness) when measured at the beginning and end of the trial, whereas cows in the control group showed a significant increase in claw length and sole thickness.Discussion. These findings suggest that there was a compensatory increase in horn production in response to accelerated claw horn wear in the control group. Statistical significance in wear might have been attained between groups at the end of the study if the study had continued over a longer period.

Hyperresponsiveness of Cough Receptors in Patients with Bronchial Asthma

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 855-858
Author(s):  
Masato Mitsuhashi ◽  
Hiroyuki Mochizuki ◽  
Kenichi Tokuyama ◽  
Akihiro Morikawa ◽  
Takayoshi Kuroume
Keyword(s):  
Acetic Acid ◽  
Bronchial Asthma ◽  
Statistical Significance ◽  
Healthy Adults ◽  
Control Group ◽  
Asthmatic Patients ◽  
Group 2 ◽  
Irritant Receptors ◽  
Stimulation Of ◽  
Group 1

The hyperresponsiveness of cough receptors was evaluated using the acetic acid inhalation test in healthy adults, patients with bronchial asthma, and children with or without cough. The concentration of acetic acid inducing cough was more than 20% in all 16 healthy adults and 18 children in the control group. There were two groups of asthmatic patients: Those in group 1 showed normal response to more than 20% acetic acid (n = 46), and those in group 2 showed a sensitive reaction to less than 10% (n = 11). Mean age was 9.0 ± 4.2 years in group 1 and 15.1 ± 7.6 years in group 2 (statistical significance, P < .001). Six of 11 asthmatic patients in group 2 were classified as nonallergic asthmatics, whereas only five of 46 patients in group 1 were nonallergic (P < .01). Bronchoconstriction was not induced in any case, in spite of the production of cough. It is suggested that the hyperresponsiveness of individual cough receptors without the stimulation of irritant receptors be evaluated.

scholarly journals Oral microbiota of periodontal health and disease and their changes after nonsurgical periodontal therapy

2018 ◽  
Vol 12 (5) ◽  
pp. 1210-1224 ◽  
Author(s):  
Casey Chen ◽  
Chris Hemme ◽  
Joan Beleno ◽  
Zhou Jason Shi ◽  
Daliang Ning ◽  
...  
Keyword(s):  
Periodontal Therapy ◽  
Oral Microbiota ◽  
Periodontal Health ◽  
Nonsurgical Periodontal Therapy ◽  
Health And Disease

scholarly journals Effects of self-ligating and conventional brackets on halitosis and periodontal conditions

2014 ◽  
Vol 85 (3) ◽  
pp. 468-473 ◽  
Author(s):  
Emine Kaygisiz ◽  
Fatma Deniz Uzuner ◽  
Sema Yuksel ◽  
Levent Taner ◽  
Rana Çulhaoğlu ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Control Group ◽  
Periodontal Health ◽  
Pocket Depth ◽  
Significant Group ◽  
Mouth Rinses ◽  
Conventional Brackets ◽  
Group 3 ◽  
Group 2 ◽  
Control Group Group

ABSTRACTObjective: To evaluate the effects of fixed orthodontic treatment with steel-ligated conventional brackets and self-ligating brackets on halitosis and periodontal health.Materials and Methods: Sixty patients, at the permanent dentition stage aged 12 to 18 years, who had Angle Class I malocclusion with mild-to-moderate crowding were randomly selected. Inclusion criteria were nonsmokers, without systematic disease, and no use of antibiotics and oral mouth rinses during the 2-month period before the study. The patients were subdivided into three groups randomly: the group treated with conventional brackets (group 1, n  =  20) ligated with steel ligature wires, the group treated with self-ligating brackets (group 2, n  =  20), and the control group (group 3, n  =  20). The periodontal records were obtained 1 week before bonding (T1), immediately before bonding (T2), 1 week after bonding (T3), 4 weeks after bonding (T4), and 8 weeks after bonding (T5). Measurements of the control group were repeated within the same periods. The volatile sulfur components determining halitosis were measured with the Halimeter at T2, T3, T4, and T5. A two-way repeated measures of analysis of variance (ANOVA) was used to compare the groups statistically.Results: No statistically significant group × time interactions were found for plaque index, gingival index, pocket depth, bleeding on probing, and halitosis, which means three independent groups change like each other by time. The risk of tongue coating index (TCI) being 2 was 10.2 times higher at T1 than at T5 (P < .001). Therefore, the probability of higher TCI was decreased by time in all groups.Conclusions: The self-ligating brackets do not have an advantage over conventional brackets with respect to periodontal status and halitosis.

scholarly journals Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population

2017 ◽  
Vol 18 (11) ◽  
pp. 1085-1089 ◽  
Author(s):  
Monica J Mahajani ◽  
Varsha A Jadhao ◽  
Pooja S Wankhade ◽  
Emmanuel Samson ◽  
Vishwas D Acharya ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Interleukin 18 ◽  
Periodontal Health ◽  
Group I ◽  
Nonsurgical Periodontal Therapy ◽  
Health And Disease ◽  
Group Ii ◽  
Crevicular Fluid

ABSTRACT Aim The incidence and progression of the periodontal disease depend on periodontal microflora and the multifaceted response of the host, and these interactions are mediated by cytokines and chemokines. Interleukin-18 (IL-18) is a proinflammatory cytokine of the IL-1 superfamily. The aim of the present study was the assessment of the periodontal therapy in IL-18 level in periodontal disease and health. Materials and methods Based on clinical attachment loss (CAL), probing pocket depth (PPD), gingival index (GI), and plaque index (PI) patients were divided into three groups: Group I with healthy patients, group II with chronic periodontitis, and group III with posttreatment patients having periodontitis. Results Mean PI, PPD, CAL, and gingival crevicular fluid (GCF) volume were significantly higher in groups II and III compared with group I. However, there were no significant differences between GI in groups I, II, and III. The total amount of IL-18 in GCF was significantly higher in group II when compared with groups I and III (p < 0.05). Conclusion The present study confirmed that the IL-18 level in GCF was lower in healthy patients, higher in periodontally involved patients, and reduced at baseline, 3 and 6 weeks after nonsurgical periodontal therapy. Clinical significance The IL-18 might be hypothetically beneficial in distinguishing health from disease and monitoring periodontal disease activity. How to cite this article Mahajani MJ, Jadhao VA, Wankhade PS, Samson E, Acharya VD, Tekale PD. Effect of Periodontal Therapy on Crevicular Fluid Interleukin-18 Level in Periodontal Health and Disease in Central Maharashtra (India) Population. J Contemp Dent Pract 2017;18(11):1085-1089.

scholarly journals THE EFFECT OF DIFFERENT IRRIGANTS WITH OR WITHOUT ULTRASONIC ACTIVATION ON ROOT DENTIN MICROHARDNESS

2021 ◽  
Vol 27 (1) ◽  
pp. 3534-3538
Author(s):  
Irina Tsenova-Ilieva ◽  
◽  
Emilia Karova ◽  
Keyword(s):  
Sodium Hypochlorite ◽  
Statistical Significance ◽  
Treatment Success ◽  
Control Group ◽  
Ultrasonic Activation ◽  
Group 4 ◽  
Root Dentin ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Purpose: The aim of this in vitro study was to evaluate the effect of different irrigation regimens of root dentin microhardness. Materials and methods: Twenty extracted, single-rooted, non-endodontically treated upper incisors were decoronated and further sectioned longitudinally in buccolingual direction. The surfaces of all forty samples were polished, evenly distributed into four groups (n=10) and then immersed in the following solutions: group 1: 2% sodium hypochlorite for 2 minutes followed by 17% EDTA for 2 minutes; group 2: 2% sodium hypochlorite for 2 minutes followed by 17% EDTA for 2 minutes, both ultrasonically activated; group 3: 5.25% sodium hypochlorite for 2 minutes followed by 17% EDTA for 2 minutes; group 4: distilled water (control group). Afterwards, the samples were dried and subjected to microhardness testing by using 300g load with a dwell time of 20 seconds. The averaged values of each sample’s Vicker’s hardness numbers were calculated and statistically analyzed. Results: All irrigation regimens significantly decreased the mean hardness of dentin when compared to the control group 4 (p<0.05). Pair-wise comparison between the values of Group 1, Group 2, Group 3 resulted in no statistical significance (p>0.05) regardless of the concentration and the ultrasonic activation of the solutions. Conclusions: The dentin microhardness was decreased regardless of the irrigation protocols used. Additional studies should clarify the clinical relevance of the compromised mechanical properties of dentin tissue and their relationship with the overall treatment success.

scholarly journals Effect of nonsurgical periodontal therapy on the level of salivary antioxidants in patients with generalized moderate-to-severe chronic periodontitis

2019 ◽  
Vol 11 (1) ◽  
pp. 21-27
Author(s):  
Ferena Sayar ◽  
Roya Shariatmadar Ahmadi ◽  
Mostafa Montazeri
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Periodontal Therapy ◽  
Clinical Parameters ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Periodontal Tissues ◽  
Reducing Ability ◽  
Nonsurgical Periodontal Therapy ◽  
Oxidative Agents

Background. In the course of periodontal diseases, polymorphonuclear leukocytes (PMNs) produce oxidative agents and free radicals, thus triggering oxidant-antioxidant disequilibrium in the saliva. Due to the reduction of antioxidant protective effect, oxidative stress is induced, destroying periodontal tissues. This study aimed to investigate the consequences of the non-surgical phase of periodontal therapy on the level ofsalivary antioxidantsin patients with generalized moderate-to-severe chronic periodontitis. Methods. Un-stimulated salivary samples were collected from 43 patients with generalized moderate-to-severe chronic periodontitis for 5 minutes. Clinical parameters, including clinical attachment loss (CAL), bleeding on probing (BoP) and pocket depth (PD), were recorded in each tooth and subsequently, scaling and root planing (SRP) was carried out. After four weeks, salivary samples were collected once again, and the above-mentioned clinical parameters were recorded. Following centrifugation and freezing at a temperature of -80°C, salivary samples were examined simultaneously in a single day, and the level of their antioxidants was measured with ferric reducing ability of plasma (FRAP) method using a spectrophotometer. Results. The concentration of salivary antioxidants significantly increased four weeks following the non-surgical periodontal therapy (P<0.0001). Moreover, the clinical parameters of CAL, BoP and PD showed a significant decrease in 4 weeks as well (P<0.0001). Conclusion. The level of salivary antioxidants in patients with generalized moderate to severe chronic periodontitis significantly increased after etiotropic periodontal therapy, indicating the possible beneficial influence of periodontal therapy on the level of salivary antioxidants in patients suffering from periodontitis.

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