Hyperresponsiveness of Cough Receptors in Patients with Bronchial Asthma

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 855-858
Author(s):  
Masato Mitsuhashi ◽  
Hiroyuki Mochizuki ◽  
Kenichi Tokuyama ◽  
Akihiro Morikawa ◽  
Takayoshi Kuroume
Keyword(s):  
Acetic Acid ◽  
Bronchial Asthma ◽  
Statistical Significance ◽  
Healthy Adults ◽  
Control Group ◽  
Asthmatic Patients ◽  
Group 2 ◽  
Irritant Receptors ◽  
Stimulation Of ◽  
Group 1

The hyperresponsiveness of cough receptors was evaluated using the acetic acid inhalation test in healthy adults, patients with bronchial asthma, and children with or without cough. The concentration of acetic acid inducing cough was more than 20% in all 16 healthy adults and 18 children in the control group. There were two groups of asthmatic patients: Those in group 1 showed normal response to more than 20% acetic acid (n = 46), and those in group 2 showed a sensitive reaction to less than 10% (n = 11). Mean age was 9.0 ± 4.2 years in group 1 and 15.1 ± 7.6 years in group 2 (statistical significance, P < .001). Six of 11 asthmatic patients in group 2 were classified as nonallergic asthmatics, whereas only five of 46 patients in group 1 were nonallergic (P < .01). Bronchoconstriction was not induced in any case, in spite of the production of cough. It is suggested that the hyperresponsiveness of individual cough receptors without the stimulation of irritant receptors be evaluated.

scholarly journals Physical Activity and Life Quality in Patients with Asthma and Osteoarthritis

2021 ◽  
Vol 15 (7) ◽  
pp. 2343-2347
Author(s):  
YU. S. Ivanchuk ◽  
L.V. Tribuntсeva ◽  
A.V. Budnevsky ◽  
N.I. Ostroushko ◽  
YA. S. Shkatova ◽  
...  
Keyword(s):  
Physical Activity ◽  
Asthma Control ◽  
Life Quality ◽  
Sitting Time ◽  
Control Group ◽  
Moderate Activity ◽  
Life Questionnaire ◽  
Asthmatic Patients ◽  
Group 2 ◽  
Group 1

Background. Physical activity is associated with better asthma control and life quality in asthma. Osteoarthritis is one of the less studied comorbidities in asthmatic patients. Methods. The study included 38 patients diagnosed with asthma, 65 patients with asthma and osteoarthritis, and 40 volunteers who did not suffer from asthma and osteoarthritis. During the study, 3 groups were formed: Group 1 consisted of patients with asthma; Group 2 included patients with both asthma and osteoarthritis, Control group consisted of volunteers. Spirometry, Asthma Quality of Life Questionnaire (AQLQ), Asthma Control Test (АСТ) were used in asthmatic patients. International Physical Activity Questionnaire (IPAQ) in its short from was filled by all the participants. Results. Both Group 1 and Group 2 did not engage in vigorous physical activity. Median of MET-min/week total (1825) was significantly less in Group 2 compared with Control and Group 1 (p=0.0000 and p=0.0169, respectively). MET-min/week total had positive correlations with ACT (r=0.50, p<0.05), AQLQ(S) total (r=0.58, p<0.05), AQLQ(S) activity domain (r=0.28, p<0.05), AQLQ(S) emotions domain (r=0.24, p<0.05), AQLQ (S) symptoms domain (r=0.34, p<0.05), FVC (r=0,28, p<0.05), FEV1 (r=0,37, p<0.05), Index Tiffno (r=0,18, p<0.05). Minutes/week sitting time had a negative correlation with ACT values (r=-0.33, p<0.05), AQLQ(S) total values (r=-0.39, p<0.05). Conclusion. Patients with asthma and osteoarthritis spend significantly less time on moderate activity, walking compared with asthmatics not suffering from osteoarthritis; they avoid vigorous activity. Higher physical activity is associated with better life quality, asthma control and lung function, thus paying attention to osteoarthritis in asthmatic patients is crucial. Key words: life quality, physical activity, asthma, osteoarthritis

scholarly journals Comparison of the rate of claw horn growth and wear and sole thickness in dairy cattle housed in a free stall barn with concrete and rubber flooring

2016 ◽  
Author(s):  
Sarel Van Amstel ◽  
Charles Young ◽  
Clare Scully ◽  
Barton Rohrbach
Keyword(s):  
Dairy Cattle ◽  
Milk Production ◽  
Statistical Significance ◽  
Control Group ◽  
Horn Growth ◽  
Significant Difference ◽  
Group 2 ◽  
Concrete Control ◽  
Experimental Group ◽  
Group 1

Background. Thin soles and resulting lameness in cows are often due to abrasive walking surfaces that cause increased wear. The aim of this project was to compare horn growth and wear and sole thickness in cows kept on rubber mats versus concrete in a free-stall barn. Methods. To examine horn growth and wear and sole thickness, we examined two groups (Group 1 kept on concrete [control] and Group 2 on rubber mats) of 12 cows each at 2-week intervals over a 12-week period. The 12 cows in each group were selected to achieve equal parity in each group, as follows: four cows, parity 1; four cows, parity 2; two cows, parity 3; and two cows, parity 4. The four cows from the parity 1 group had the most days in milk in the herd irrespective of milk production. The remaining eight cows had the fewest days in milk (most recently calved) irrespective of milk production. Results. Cows in the control group had a significant increase in claw horn growth over the study period, compared to the control group. Most of this difference in horn growth occurred during the first 2 weeks of the study. There was no significant difference in claw horn wear and sole thickness at 2 weeks or at the end of the study. There was, however, a non-significant difference in wear between cows in the 2 groups at the end of the study, with cows in the control group showing most wear. Cows in the experimental group exhibited significant increases in all parameters (claw length, wear, and growth; sole thickness) when measured at the beginning and end of the trial, whereas cows in the control group showed a significant increase in claw length and sole thickness.Discussion. These findings suggest that there was a compensatory increase in horn production in response to accelerated claw horn wear in the control group. Statistical significance in wear might have been attained between groups at the end of the study if the study had continued over a longer period.

scholarly journals Effects of phenol, glycerin and acetic acid on the liver of guinea pigs

2007 ◽  
Vol 22 (6) ◽  
pp. 436-440 ◽  
Author(s):  
Rogério Saad-Hossne ◽  
William Saad Hossne ◽  
Mario Rubens Guimarães Montenegro
Keyword(s):  
Acetic Acid ◽  
Guinea Pigs ◽  
Hepatic Tissue ◽  
Control Group ◽  
Control Groups ◽  
Median Laparotomy ◽  
Group 2 ◽  
Tissue Recovery ◽  
And Control ◽  
Group 1

PURPOSE: To investigate the histolytic action of a solution composed of phenol, glycerin and acetic acid for irresectable hepatic metastasis. METHODS: Thirty-two (n=32) guinea pigs were randomly distributed into two groups of 16 animals. The animals in group 1 (experimental) and group 2 (control) were redistributed in two subgroups of eight animals each, according to the day of sacrifice (24 hours and four weeks after injection). All the animals were submitted to median laparotomy, which was followed by the injection of solution E and saline into the livers of subjects in both the experimental and control groups, respectively. The animals were evaluated for biochemical and anatomopathological (liver) alterations after 24 hours and four weeks of the experiment. RESULTS: It was observed that solution E produced necrosis limited to the injected area and that hepatic tissue recovery occurred after four weeks with the formation of a small necrosis area. No biochemical parameters were altered either in the experimental or in the control group. CONCLUSION: In view of the obtained results, the possibility of using the proposed solution can be considered in cases of irresectable metastasis.

scholarly journals Evaluation of Serum Resistin Levels in Periodontal Health and Disease and Effects of Non Surgical Periodontal Therapy on Its Levels

2012 ◽  
Vol 32 (5) ◽  
pp. 289-294 ◽  
Author(s):  
Archana Devanoorkar ◽  
C.D. Dwarakanath ◽  
Gayatri Gundanavar ◽  
Rahul Kathariya ◽  
Sudhir R Patil
Keyword(s):  
Statistical Significance ◽  
Periodontal Therapy ◽  
Control Group ◽  
Periodontal Health ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Nonsurgical Periodontal Therapy ◽  
Health And Disease ◽  
Group 2 ◽  
Group 1

Background: Resistin and adiponectin are the adipokines secreted by adipocytes and various inflammatory cells. These adipokines are known to play an important role in insulin resistance. The aim of this study was to determine the serum resistin levels in periodontal health and disease and also, to determine the effect of nonsurgical periodontal therapy on its levels.Methods: A total of 40 patients (20 Males and 20 Females; age range 20–50 years) participated in the study. Subjects were categorized as healthy (group 1; Controls) and chronic periodontitis (group 2; Study) groups based on their periodontal status. Periodontal parameters (Plaque index (PI), Gingival index (GI), Bleeding index (BI), Probing pocket depth (PPD), Clinical attachment loss (CAL)) together with serum resistin levels were assessed at baseline and between 6–8 weeks following nonsurgical periodontal therapy for subjects in group~2 and only at baseline in group 1. Sera were tested in duplicate (single run), and the results were averaged.Results: Study group showed higher (1.89 ± 1.83 ng/ml) serum resistin levels, compared to control group (1.35 ± 0.70 ng/ml). However, this difference was not statistically significant (P=0.227). Also, resistin levels decreased following nonsurgical periodontal therapy but, this decrease failed to show any statistical significance, with pretreatment levels being 1.89 ± 1.83 ng/ml and post treatment levels being 1.59 ± 1.01 ng/ml (P=0.386).Conclusion: Observations of the present study revealed that there was not much difference in the serum resistin levels between the cases and the controls. Also the decrease in the resistin levels following nonsurgical periodontal therapy did not show any statistical significance.

scholarly journals Comparison of the rate of claw horn growth and wear and sole thickness in dairy cattle housed in a free stall barn with concrete and rubber flooring

2016 ◽  
Author(s):  
Sarel Van Amstel ◽  
Charles Young ◽  
Clare Scully ◽  
Barton Rohrbach
Keyword(s):  
Dairy Cattle ◽  
Milk Production ◽  
Statistical Significance ◽  
Control Group ◽  
Horn Growth ◽  
Significant Difference ◽  
Group 2 ◽  
Concrete Control ◽  
Experimental Group ◽  
Group 1

Background. Thin soles and resulting lameness in cows are often due to abrasive walking surfaces that cause increased wear. The aim of this project was to compare horn growth and wear and sole thickness in cows kept on rubber mats versus concrete in a free-stall barn. Methods. To examine horn growth and wear and sole thickness, we examined two groups (Group 1 kept on concrete [control] and Group 2 on rubber mats) of 12 cows each at 2-week intervals over a 12-week period. The 12 cows in each group were selected to achieve equal parity in each group, as follows: four cows, parity 1; four cows, parity 2; two cows, parity 3; and two cows, parity 4. The four cows from the parity 1 group had the most days in milk in the herd irrespective of milk production. The remaining eight cows had the fewest days in milk (most recently calved) irrespective of milk production. Results. Cows in the control group had a significant increase in claw horn growth over the study period, compared to the control group. Most of this difference in horn growth occurred during the first 2 weeks of the study. There was no significant difference in claw horn wear and sole thickness at 2 weeks or at the end of the study. There was, however, a non-significant difference in wear between cows in the 2 groups at the end of the study, with cows in the control group showing most wear. Cows in the experimental group exhibited significant increases in all parameters (claw length, wear, and growth; sole thickness) when measured at the beginning and end of the trial, whereas cows in the control group showed a significant increase in claw length and sole thickness.Discussion. These findings suggest that there was a compensatory increase in horn production in response to accelerated claw horn wear in the control group. Statistical significance in wear might have been attained between groups at the end of the study if the study had continued over a longer period.

scholarly journals The place of neurotrophic therapy in the concept of stimulation of secondary angiogenesis in acute focal cerebral ischemia

2019 ◽  
Vol 85 (4) ◽  
pp. 18-26
Author(s):  
V.S. Lychko
Keyword(s):  
Endothelial Cells ◽  
Cerebral Ischemia ◽  
Brain Tissue ◽  
Focal Cerebral Ischemia ◽  
Control Group ◽  
Average Area ◽  
Group 3 ◽  
Group 2 ◽  
Stimulation Of ◽  
Group 1

The features of changes in the structural and functional characteristics of brain tissue were studied in 60 outbred male Wistar rats during modelling of acute focal cerebral ischemia (AFCI) in the dynamics of treatment with human cryopreserved cord blood serum (CCBS). Electronic and optical microscopic examination of the sensorimotor area of the cerebral cortex was performed. All animals were divided into three groups: the first (control) group consisted of intact rats without trauma and treatment; the second group consisted of animals after modelling AFCI without treatment; third group consisted of rats after modelling AFCI, which were injected by CCBS. Each group consisted of 20 animals. Material for morphological examination was taken after administration of CCBS solution to animals with the model of AFCI at 12, 24, 72 hours and 7th days after the start of the experiment. The average area of perivascular spaces, which is an indicator of vasogenic oedema in rats of group 2 was 45 times higher than in rats of group 1. In contrast, in rats of group 3 with CCBS, this figure was exceeded 37 times. The average area of pericellular spaces, indicating the degree of cytotoxic oedema, in animals of group 2 on the 7th day after AFCI was almost 23 times higher than the results of group 1. This figure in rats of group 3 was increased 20 times compared with data in group 2. Against the background of the use of this drug, there were signs of reactive changes in endothelial cells in the form of an increase in the number of ribosomes and polysomes in the cytoplasm, a decrease in the degree of perivascular oedema of brain tissue by 21.4 %. The surface area of endothelial cells in the zone of AFCI on the 7th day of the experiment in animals that additionally received CCBS was (1483.00±26.48) μm2, which indicates a positive anti-inflammatory effect of the drug. On the 7th day of the experiment in group 3 rats by optical microscopy was found to increase the density of cerebral capillaries compared with group 2, which indicates the stimulation of the restoration of the ultrastructure of damaged capillaries, increase their density, the formation of new capillaries under the components of CCBS.

scholarly journals Study on the characteristics of microcirculation in the site of pressure ulcer in patients with spinal cord injury

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110287
Author(s):  
Gong Huiming ◽  
Wang Yuming ◽  
Yang Mingliang ◽  
Liu Changbin ◽  
Huang Qiuchen ◽  
...  
Keyword(s):  
Pressure Ulcer ◽  
Imaging System ◽  
Healing Time ◽  
Healthy Adults ◽  
Control Group ◽  
Observation Group ◽  
Significant Difference ◽  
Cord Injury ◽  
Group 2 ◽  
Group 1

To investigate the characteristics of pressure ulcer microcirculation in SCI patients with pressure ulcer, and to provide evidence for the treatment of pressure ulcer in patients with SCI. Group 1 ( n = 12) SCI patients with pressure ulcer, 23 pressure ulcers were included. Group 2 ( n = 15) SCI patients without pressure ulcer and the control group ( n = 16) healthy adults. The application of laser Doppler perfusion imaging system (Moor FLPI) detector to the microcirculation perfusion of the sacrum area of the control group, the observation group 2 and the pressure ulcer site of the observation group 1, record the microcirculation perfusion (PU), The data of microcirculation perfusion (PU) were compared and analyzed. The correlation between microcirculation perfusion and healing time of pressure ulcer was analyzed. (1) The microcirculation perfusion was highest in the pressure ulcer center. (2) SCI patients and healthy adults had no significant difference of microcirculation perfusion at sacrococcygeal skin. (3) The lower the microcirculation perfusion of the pressure ulcer center, the longer the healing time of pressure ulcer. The healing time and the microcirculation perfusion of pressure ulcer center was negatively correlated. Microcirculation perfusion detection is a noninvasive and effective method for the determination of the scope of pressure ulcer, detection and direction judgment of pressure ulcer sinus tract, monitoring and guidance of pressure ulcer treatment, and prediction of the healing time of pressure ulcer.

scholarly journals THE EFFECT OF DIFFERENT IRRIGANTS WITH OR WITHOUT ULTRASONIC ACTIVATION ON ROOT DENTIN MICROHARDNESS

2021 ◽  
Vol 27 (1) ◽  
pp. 3534-3538
Author(s):  
Irina Tsenova-Ilieva ◽  
◽  
Emilia Karova ◽  
Keyword(s):  
Sodium Hypochlorite ◽  
Statistical Significance ◽  
Treatment Success ◽  
Control Group ◽  
Ultrasonic Activation ◽  
Group 4 ◽  
Root Dentin ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Purpose: The aim of this in vitro study was to evaluate the effect of different irrigation regimens of root dentin microhardness. Materials and methods: Twenty extracted, single-rooted, non-endodontically treated upper incisors were decoronated and further sectioned longitudinally in buccolingual direction. The surfaces of all forty samples were polished, evenly distributed into four groups (n=10) and then immersed in the following solutions: group 1: 2% sodium hypochlorite for 2 minutes followed by 17% EDTA for 2 minutes; group 2: 2% sodium hypochlorite for 2 minutes followed by 17% EDTA for 2 minutes, both ultrasonically activated; group 3: 5.25% sodium hypochlorite for 2 minutes followed by 17% EDTA for 2 minutes; group 4: distilled water (control group). Afterwards, the samples were dried and subjected to microhardness testing by using 300g load with a dwell time of 20 seconds. The averaged values of each sample’s Vicker’s hardness numbers were calculated and statistically analyzed. Results: All irrigation regimens significantly decreased the mean hardness of dentin when compared to the control group 4 (p<0.05). Pair-wise comparison between the values of Group 1, Group 2, Group 3 resulted in no statistical significance (p>0.05) regardless of the concentration and the ultrasonic activation of the solutions. Conclusions: The dentin microhardness was decreased regardless of the irrigation protocols used. Additional studies should clarify the clinical relevance of the compromised mechanical properties of dentin tissue and their relationship with the overall treatment success.

scholarly journals Evaluation of analgesic (in vivo) activity of Ariflex liniment in comparison with diclofenac gel by acetic acid induced writhing model

2021 ◽  
Vol 10 (8) ◽  
pp. 943
Author(s):  
Sanjay U. Nipanikar ◽  
Sohan S. Chitlange
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Control Group ◽  
Single Animal ◽  
Group 3 ◽  
The Difference ◽  
Group 2 ◽  
Control Group Group ◽  
Group 1

Background: Adverse effects of available medications for osteoarthritis (OA) and rheumatoid arthritis (RA) necessitate development of safer and effective alternative medicinal substitutes. The present study was conducted to evaluate analgesic activity of Ariflex liniment (conceptualized and developed by Ari Healthcare Pvt. Ltd.) in comparison with diclofenac gel by using acetic acid induced writhing model.Methods: Albino mice of either sex weighing 20-25 g were taken and divided into 3 groups with 5 animals in each group, i.e., group 1 (control group), group 2 (diclofenac gel) and group 3 (Ariflex liniment). After 1 hour of topical application of study drugs writhing was induced in mice using intra-peritonial injection of 1% acetic acid in volume of 0.1 ml/10 g body weight. Then the writhing episodes were recorded for 30 minutes and results were noted.Results: In the control group, the total number of  writhes were 260±29.73 (mean±S. E. M.). The total number of writhes was 12.17±11.81 (mean ± S. E. M.) in diclofenac group. In Ariflex liniment group, not a single animal felt pain, hence there were no writhes recorded. When compared to control group, the difference in number of writhes was statistically significant. The analgesic activity of Ariflex liniment was found to be superior to that of diclofenac gel used as standard drug.Conclusions: It can be concluded that Ariflex liniment possesses analgesic activity.

scholarly journals The Effect of Restraint Stress on the Reactivation of Colitis in Acetic Acid-Induced Ulcerative Colitis Rat

2020 ◽  
pp. 73-82 ◽  
Author(s):  
S. F. Ige ◽  
O. T. Adio
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Restraint Stress ◽  
Antioxidant Activities ◽  
Inflammatory Cells ◽  
Control Group ◽  
Stress Group ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim: To evaluate the effect of restraint stress on the reactivation of ulcerative colitis in rats that have been chemically-induced with ulcerative colitis after allowing progression of natural healing to take place. Study Design: 36 animals were used for this study, and were divided into three groups; control (group 1), colitis alone (group 2) and colitis + restraint stress (group 3). Methodology: 36 healthy female wistar rats of weight of 170±20 were used. Colitis was induced by intra-rectal administration of 1 mL/100 g body weight of 7% acetic acid. Fourteen days post colitis induction, colitis + restraint stress group animals were exposed to restraint stress for six consecutive days while animals in colitis alone group were not. Colon levels of Malondialdehyde (MDA), Glutathione (GSH) concentration, Superoxide dismutase (SOD), Catalase (CAT) and Myeloperoxidase (MPO) activities were measured spectrophometrically. Histological assessment was also done on the colon tissues. Place and Duration of Study: Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria, between April 2019 and August 2019. Results: Colitis caused significant increase in the levels of GSH, SOD, CAT and MPO on the 3rd day. On the 14th day, group 2 showed lowered level of antioxidant activities (SOD and CAT) when compared with the 3rd day, while on the 20th day, group 3 animals exhibited increased levels of antioxidant activities (as well as increase in  MDA and MPO) when compared to group 2 and group 1. Histological examination revealed cyst in the mucosal layer, infiltration of inflammatory cells and dilation of vessels in the colitis + restraint stress on the 20th day post colitis induction. Results are considered significant when p≤0.05. Conclusion: The results of this study showed that restraint stress is capable of reactivating and inhibiting colitis healing in acetic acid-induced ulcerative colitis rats.

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