scholarly journals Nitroglycerin for Management of Retained Placenta: A Multicenter Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Maria Bullarbo ◽  
Hans Bokström ◽  
Håkan Lilja ◽  
Elisabeth Almström ◽  
Nina Lassenius ◽  
...  
Keyword(s):  
Placebo Group ◽  
Adverse Effects ◽  
Clinical Experience ◽  
Statistical Significance ◽  
Clinical Importance ◽  
The Other ◽  
Retained Placenta ◽  
Sequential Administration ◽  
The Difference ◽  
To Receive

The primary aim was to determine if sequential administration of oxytocin and nitroglycerin is effective for management of retained placenta when performed by obstetricians with no experience of the method. Secondary aims were to examine possible adverse effects of nitroglycerin. One hundred and five women with retained placenta were randomly selected to receive either 1 mg nitroglycerin or placebo tablets sublingually if intravenous oxytocin had failed to expel the placenta. At two of the hospitals some of the midwives were familiar with the use of nitroglycerin. The other midwives and all the participating obstetricians had no clinical experience of the method. In the treatment group, detachment of placenta following nitroglycerin occurred in 37.3% of the women compared to 20.4% in the placebo group (P=0.056). In the two hospitals with some experience of the method, placenta was removed in 9 of 19 (47.4%) women in the nitroglycerin group compared to 3 of 17 (15.0%) women in the placebo group. No adverse effects of clinical importance were registered. Although the difference between the two groups did not reach statistical significance, the higher success rate in the two hospitals with some experience could indicate that clinical experience is of importance in order to achieve placental detachment.

scholarly journals Involvement of the Inconstant Bursa of the Fifth Metatarsophalangeal Joint in Psoriatic Arthritis: A Clinical and Ultrasonographic Study

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Giovanni Ciancio ◽  
Stefania Volpinari ◽  
Maria Fotinidi ◽  
Federica Furini ◽  
Ilaria Farina ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Healthy Subjects ◽  
Statistical Significance ◽  
Metatarsophalangeal Joint ◽  
Metatarsal Bone ◽  
The Other ◽  
Control Group ◽  
Asymptomatic Patients ◽  
Seronegative Spondyloarthritis ◽  
The Difference

Objective. To evaluate the involvement of the bursa located next to the head of the 5th metatarsal bone in patients with psoriatic arthritis (PsA) in comparison with the other seronegative spondyloarthritis (SpA).Methods. All patients with PsA seen during a period of 24 months were enrolled. The control group included healthy subjects and patients with the other SpA. All subjects underwent clinical and ultrasound (US) examination of the lateral surface of the 5th metatarsal.Results. 150 PsA patients (88 M; 62 F), 172 SpA (107 M; 65 F), and 95 healthy controls (58 M; 37 F) were evaluated. Based on clinical and US evaluation, bursitis was diagnosed in 17/150 (11.3%) PsA patients but in none of the SpA (P<0.0001) and healthy (P=0.0002) controls. In detecting bursitis, US was more sensitive than clinical examination, although the difference did not reach statistical significance (P=0.09).Conclusion. The bursa of the 5th metatarsophalangeal joint appears to be involved in PsA more frequently than by chance. If confirmed by other studies, this finding could be considered as a distinctive clinical sign of PsA, useful for differential diagnosis with the other SpA. In asymptomatic patients, US proved to be more sensitive in the detection of bursitis.

Pirenzepine in Non-Ulcer Dyspepsia: A Double-Blind Multicentre Trial

1990 ◽  
Vol 18 (1) ◽  
pp. 16-20 ◽  
Author(s):  
P.M. Smith ◽  
A.H. Troughton ◽  
F. Gleeson ◽  
J. Walters ◽  
C.F. McCarthy
Keyword(s):  
Abdominal Pain ◽  
Placebo Group ◽  
Adverse Effects ◽  
Multicentre Study ◽  
Multicentre Trial ◽  
Nausea And Vomiting ◽  
Double Blind ◽  
Non Ulcer Dyspepsia ◽  
Upper Abdominal ◽  
To Receive

In a double-blind multicentre study to compare pirenzepine with placebo in non-ulcer dyspepsia, 71 patients were randomized to receive 50 mg pirenzepine or placebo given orally twice daily for 4 weeks. The trial was not completed by five patients in the pirenzepine group and six in the placebo group. There were no significant differences between the groups in respect to changes in total symptoms (upper abdominal pain, nausea and vomiting, early satiety and postprandial bloating, eructation and pyrosis) scores and outcome, although 27/35 (77%) patients receiving pirenzepine were cured or improved compared with 22/36 (61%) receiving the placebo. Adverse effects were reported by 13 (37%) patients treated with pirenzepine and by six (17%) treated with placebo, seven withdrawing due to adverse effects.

scholarly journals The role of oral mifepristone in pre-induction cervical ripening at term

2019 ◽  
Vol 8 (11) ◽  
pp. 4337
Author(s):  
Uma H. Chourasia ◽  
Mudita Kamlesh Jain ◽  
Juzar I. Fidvi
Keyword(s):  
Placebo Group ◽  
Labor Induction ◽  
Cervical Ripening ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Bishop Score ◽  
The Difference ◽  
Pg E2 ◽  
To Receive

Background: Planned induction of labor is an established part of modern obstetrics and is used as a definite form of treatment where continuation of pregnancy would be detrimental to the health of mother or fetus. The objective of this study was to evaluate the effect of mifepristone in pre-induction cervical ripening and labor induction.Methods: A total of 200 pregnant women at term with Bishop Score 4 or less were selected for this prospective randomized placebo-controlled study. The sample was equally divided into study group to receive 200 mg of mifepristone and control group to receive placebo orally for 2 days. Bishop score was assessed at every 24 hours interval till patient entered in spontaneous labor or 72 hours after 1st dose. Women who did not enter labor spontaneously, labor induction was planned with per vaginal insertion of prostaglandin (PG) E2 analogue, Dinoprostone gel 2.5 mg or PGE1 analogue Tab. Misoprostol 25 µg.Results: Ninety-six subjects in the study group and eighty-one in the control achieved successful ripening of cervix and the difference was statistically significant. Sixty-eight of study group and thirty-nine of placebo group entered in spontaneous active labor within 72 hours. Requirement of oxytocin as adjuvant treatment was significantly lower in the study group. Nineteen women of study group and fifteen of control group delivered within 24 hours, and eighty-one of study group and sixty-two of placebo delivered in 48 hours. The mean induction delivery interval was 35.53±13.67 hours in the study group, whereas it was significantly prolonged in the placebo group 50.49±20.92 hours. Eighty-two subjects of study group and seventy-eight of the control group delivered vaginally, the differences were statistically not significant.Conclusions: Mifepristone was found to be an effective agent for cervical priming prior to labor induction in women at term and significantly reduces the induction delivery interval compared with placebo.

Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis

Parasitology ◽  
1980 ◽  
Vol 81 (1) ◽  
pp. 157-168 ◽  
Author(s):  
R. G. Slighter ◽  
A. Yarinsky ◽  
H. P. Drobeck ◽  
D. M. Bailey
Keyword(s):  
Single Dose ◽  
Adverse Effects ◽  
Total Dose ◽  
Statistical Significance ◽  
Parent Compound ◽  
The Other ◽  
Daily Administration ◽  
Intestinal Amoebiasis ◽  
Tissue Changes

SUMMARYA novel tetrahydroquinolinyl ester, quinfamide, administered orally in multiple doses for 3 days had an ED50, of 0·25 mg/kg/day (total dose 0·75 mg/kg) for eradicating Entamoeba criceti in hamsters in several tests. It was significantly more active by direct comparison than 3 commercially available amoebicides and at least as active as 2 other esters of the parent compound, 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinonnol. After administration of a single dose, ED50, calculations for quinfamide averaged 0·9 mg/kg. Quinfamide was considerably more active than the other tetrahydroquinolinols, diloxanide furoate and teclozan, and it was approximately 1·5 times more active than etofamide; a statistical significance between the latter 2 drugs could be demonstrated in one of 4 tests. Administered prophylactically, quinfamide was shown to protect hamsters from re-infection with E. criceti. It also inhibited propagation of E. histolytica in vitro at a concentration of 20 /tg/ml. No adverse effects were noted in rodents after a single dose as high as 10 g/kg. Daily administration to monkeys of doses up to 500 mg/kg for as long as 37 days produced no pharmacological aberrations during or after medication; haematological studies and urine analyses were normal and no gross or microscopical tissue changes attributable to quinfamide were observed. No toxicity was revealed following acute (2 g/kg) and chronic (500 mg/kg/day × 31 days) administration of the drug to dogs and rats, respectively.

scholarly journals The Religion of War and Peace: Better Understanding of International Conflict

2003 ◽  
Author(s):  
Armand Abecassis
Keyword(s):  
Social Group ◽  
International Conflict ◽  
The Other ◽  
War And Peace ◽  
Binary Logic ◽  
Spiritual Meaning ◽  
The Bible ◽  
Living Together ◽  
The Difference ◽  
To Receive

PEACE: Is peace the cessation of war? The Binary Logic, The History: War is organized and collective, War is a balance of strengths. Can politics alone create a foundation of peace? Is peace only security? WAR: Is the difference the cause of violence? War is linked to living together as a social group. War: Is the hidden threat in the differences between the nations? War:”Is the midwife of societies”.The problem of terrorism: Is peace the obliteration of the differences? THE MEADING OF CONFLICTS: The conflict is permanent and necessary. Peace is not a cessation of conflict. Peace exists only with, through, and owing to conflicts .PEACE AS A DIALECTIC BETWEEN JUSTICE AND LOVE: The spiritual meaning of love. Humility and responsibility. The relation to the other. THE LESSONS OF THE EIGHT WELLS OF THE BIBLE: From war to love. To give and to receive.

scholarly journals Do androgens enhance the response to antithymocyte globulin in patients with aplastic anemia? A prospective randomized trial

Blood ◽  
1985 ◽  
Vol 66 (1) ◽  
pp. 184-188 ◽  
Author(s):  
RE Champlin ◽  
WG Ho ◽  
SA Feig ◽  
DJ Winston ◽  
C Lenarsky ◽  
...  
Keyword(s):  
Placebo Group ◽  
Confidence Interval ◽  
Aplastic Anemia ◽  
Antithymocyte Globulin ◽  
Response Rates ◽  
Severe Aplastic Anemia ◽  
Actuarial Survival ◽  
The Difference ◽  
To Receive ◽  
Historical Controls

We analyzed the effect of antithymocyte globulin (ATG) with or without androgens in 121 patients with aplastic anemia. Fifty-three patients with moderate to severe aplastic anemia were prospectively randomized to receive ATG with or without oral androgens. Eleven of 26 patients (42%) receiving ATG plus androgen responded, including three complete and eight partial responses. Twelve of 27 patients (44%) receiving ATG plus placebo responded, including five complete and seven partial responses. The difference in response rates was not significant (P greater than .9). Survival was also comparable in the two groups; for patients with severe aplastic anemia, actuarial survival at two years was 55% +/- 24% (95% confidence interval) in patients receiving ATG plus androgen compared with 50% +/- 24% in the ATG plus placebo group (P = .65). Furthermore, results in both groups were indistinguishable from those obtained in 68 historical controls receiving ATG without androgens. These data indicate that androgens are not required in order to respond to antithymocyte globulin and the addition of androgens, as used in this trial, did not significantly improve response rates to ATG treatment.

scholarly journals Impact of intraoperative Cone-Beam Computed Tomography use on patient satisfaction after closed nasal reduction

2021 ◽  
Vol 4 ◽  
pp. 77-84
Author(s):  
C. Bruehlmann ◽  
M. Blumer ◽  
M.B. Soyka
Keyword(s):  
Computed Tomography ◽  
Patient Satisfaction ◽  
Cone Beam Computed Tomography ◽  
Intraoperative Imaging ◽  
Statistical Significance ◽  
Clinical Importance ◽  
Cone Beam ◽  
The Difference ◽  
And Function ◽  
Female Subjects

Background: The aim of the study was to assess, whether there is a difference in aesthetic and functional patient satisfaction between closed nasal reductions with intraoperative Cone-Beam Computed Tomography (CBCT) and without using intraoperative medical imaging. Methods: A monocentric, retrospective cohort study of 43 patients (20 patients treated with intraoperative CBCT and 23 patients treated without intraoperative imaging) was conducted. Subjective postoperative aesthetic and functional aspects of the nose were assessed. Additionally, questions comparing the aesthetics and function of the nose before and after the accident and on the desire of revision surgery were asked. Results: Both the SCHNOS-C and total SCHNOS score in the non-CBCT group were higher than the respective scores of the CBCT-group. The comparison of SCHNOS-C between male subjects of the two groups showed no statistical significance. The comparison of SCHNOS-C between male and female subjects over both groups showed significantly higher scores for female subjects. Conclusions: Patients undergoing surgery with intraoperative CBCT imaging showed better aesthetical outcomes than patients, treated without intraoperative imaging. However, the difference showed no clinical importance, so that both strategies appear to have comparable outcomes regarding postoperative aesthetics and function of the nose. Gender instead of the different strategies could contribute to the demonstrated differences. Female subjects seem to be less satisfied with the aesthetics of their nose postoperatively, potentially being more sensitive to remaining nasal deformities after surgery.

scholarly journals Do androgens enhance the response to antithymocyte globulin in patients with aplastic anemia? A prospective randomized trial

Blood ◽  
1985 ◽  
Vol 66 (1) ◽  
pp. 184-188 ◽  
Author(s):  
RE Champlin ◽  
WG Ho ◽  
SA Feig ◽  
DJ Winston ◽  
C Lenarsky ◽  
...  
Keyword(s):  
Placebo Group ◽  
Confidence Interval ◽  
Aplastic Anemia ◽  
Antithymocyte Globulin ◽  
Response Rates ◽  
Severe Aplastic Anemia ◽  
Actuarial Survival ◽  
The Difference ◽  
To Receive ◽  
Historical Controls

Abstract We analyzed the effect of antithymocyte globulin (ATG) with or without androgens in 121 patients with aplastic anemia. Fifty-three patients with moderate to severe aplastic anemia were prospectively randomized to receive ATG with or without oral androgens. Eleven of 26 patients (42%) receiving ATG plus androgen responded, including three complete and eight partial responses. Twelve of 27 patients (44%) receiving ATG plus placebo responded, including five complete and seven partial responses. The difference in response rates was not significant (P greater than .9). Survival was also comparable in the two groups; for patients with severe aplastic anemia, actuarial survival at two years was 55% +/- 24% (95% confidence interval) in patients receiving ATG plus androgen compared with 50% +/- 24% in the ATG plus placebo group (P = .65). Furthermore, results in both groups were indistinguishable from those obtained in 68 historical controls receiving ATG without androgens. These data indicate that androgens are not required in order to respond to antithymocyte globulin and the addition of androgens, as used in this trial, did not significantly improve response rates to ATG treatment.

THE EFFECT OF HYPOPHYSECTOMY ON THE NUMBER OF OOCYTES IN THE ADULT ALBINO RAT

1953 ◽  
Vol 9 (3) ◽  
pp. 307-311 ◽  
Author(s):  
D. L. INGRAM
Keyword(s):  
Statistical Significance ◽  
The Other ◽  
Physiological Significance ◽  
Albino Rat ◽  
Litter Mate ◽  
Other Hand ◽  
The Mean ◽  
The Difference ◽  
Rate Of Decline

A comparison of the number of oocytes in fourteen pairs of hypophysectomized and litter-mate control rats showed that the number was greater in nine of the fourteen comparisons, and less in only five. This ratio is not significantly different from one of 7: 7. The mean total number of oocytes was, on the other hand, about 20 % greater in the operated animals, the statistical significance of the difference falling between P = 0·05–0·02. If any physiological significance attaches to this difference, the most likely explanation is that the rate of decline in the number of oocytes is less after removal of the pituitary than in normal animals.

scholarly journals Bowel preparation in intravenous urography doesn’t have an impact on the quality of urinary tract image

2017 ◽  
Vol 16 (1) ◽  
pp. 107-114
Author(s):  
Yuyun Yueniwati ◽  
Ari Eko Laksono
Keyword(s):  
Urinary Tract ◽  
Adverse Effects ◽  
Bowel Preparation ◽  
Medical Science ◽  
Intravenous Urography ◽  
The Other ◽  
X Ray ◽  
Intestinal Gas ◽  
The Difference

Purpose: The procedure of bowel preparation before intravenous urography (IVU) is still a controversial debate and it varies in each health center. Preparation is believed to reduce residual feces and intestinal gas thus improving the quality of visualization of the urinary tract. On the other hand, many radiology and urology studies did not mention the need for preparation before IVU procedure. Preparation before IVU, especially giving laxative agent, gives many adverse effects to the patient. The purpose of this study was to know the difference in quality visualization of the urinary tract in IVU patients with and without preparation in Saiful Anwar hospital Malang.Materials and Methods: A total of 20 patients participated in this study and they were divided into two groups in which each group consists of 10 patients with and without preparation before IVU. Abdominal x-ray and IVU were performed on all patients. Urinary tract visualization quality assessment was done through two methods of assessing the quality of the image by the European Commission Guidelines and of assessing the residue of feces/ intestinal gas based on Dadkhah’s studies.Results: Results showed the total score of image quality and the residue of feces/intestinal gas was not significantly different in the abdominal plain photo of IVU patients with and without preparation (Mann-Whitney test (p=1.000) and Independent T-test (p=0.5111)).Conclusions: In conclusion, there was no difference in the quality of visualization of the urinary tract in IVU patients with and without preparation in Saiful Anwar hospital Malang.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.107-114

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