scholarly journals Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Gregory J. Zilinskas ◽  
Abdolrasoul Soleimani ◽  
Elizabeth R. Gillies
Keyword(s):  
Drug Delivery ◽  
Ethylene Oxide ◽  
Graft Copolymers ◽  
Nile Red ◽  
Biological Properties ◽  
Amphiphilic Copolymers ◽  
Drug Molecules ◽  
Poly Ethylene Oxide ◽  
Model Drug ◽  
Poly Ethylene

Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.

A comparison of covalent and noncovalent strategies for paclitaxel release using poly(ester amide) graft copolymer micelles

2015 ◽  
Vol 93 (4) ◽  
pp. 399-405 ◽  
Author(s):  
Abdolrasoul Soleimani ◽  
Mahmoud M. Abd Rabo Moustafa ◽  
Aneta Borecki ◽  
Elizabeth R. Gillies
Keyword(s):  
Ethylene Oxide ◽  
Graft Copolymer ◽  
Drug Carriers ◽  
Prolonged Release ◽  
Amphiphilic Copolymers ◽  
Release Rates ◽  
Drug Molecules ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Micelles formed from amphiphilic copolymers are promising for the delivery of drug molecules, potentially leading to enhanced properties and efficacies. Critical aspects of these systems include the use of biocompatible, biodegradable polymer backbones as well as the ability to control the incorporation of drugs and their release rates. In this work, a poly(ester amide)–poly(ethylene oxide) graft copolymer with paclitaxel conjugated via ester linkages was prepared and assembled into micelles. For comparison, micelles with physically encapsulated paclitaxel were also prepared. The release rates of these two systems were studied, and the micelles with covalently conjugated paclitaxel exhibited a prolonged release of the drug in comparison to the noncovalent system, which rapidly released the payload. In vitro studies suggested that the poly(ester amide)–poly(ethylene oxide) copolymers were nontoxic, whereas the toxicities of the drug-loaded micelles were dependent on their release rates. Overall, these systems are promising for further development as anticancer drug carriers.

scholarly journals Poloxamer Hydrogels for Biomedical Applications

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 671 ◽  
Author(s):  
Eleonora Russo ◽  
Carla Villa
Keyword(s):  
Drug Delivery ◽  
Ethylene Oxide ◽  
Propylene Oxide ◽  
Biomedical Application ◽  
Aqueous Environment ◽  
Molecular Weights ◽  
Long Time ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Concentration Threshold

This review article focuses on thermoresponsive hydrogels consisting of poloxamers which are of high interest for biomedical application especially in drug delivery for ophthalmic, injectable, transdermal, and vaginal administration. These hydrogels remain fluid at room temperature but become more viscous gel once they are exposed to body temperature. In this way, the gelling system remains at the topical level for a long time and the drug release is controlled and prolonged. Poloxamers are synthetic triblock copolymers of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO), also commercially known as Pluronics®, Synperonics® or Lutrol®. The different poloxamers cover a range of liquids, pastes, and solids, with molecular weights and ethylene oxide–propylene oxide weight ratios varying from 1100 to 14,000 and 1:9 to 8:2, respectively. Concentrated aqueous solutions of poloxamers form thermoreversible gels. In recent years this type of gel has arouse interest for tissue engineering. Finally, the use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC). This property is exploited for drug delivery and different therapeutic applications.

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