scholarly journals Infantile Myofibroma Eroding into the Frontal Bone: A Case Report and Review of Its Histopathologic Differential Diagnosis

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Aatish Thennavan ◽  
Venkadasalapathi Narayanaswamy ◽  
Thanvir Mohammed Niazi ◽  
Lakshmi Rao ◽  
Raghu Radhakrishnan
Keyword(s):  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Neck Region ◽  
Final Diagnosis ◽  
Muscle Actin ◽  
Radiological Findings ◽  
Head And Neck Region ◽  
Spindle Cell Tumours ◽  
Myofibroblastic Differentiation ◽  
Infantile Myofibroma

Infantile myofibroma is a rare and benign tumour of children presenting in the head and neck region. Rendering a final diagnosis of infantile myofibroma can be challenging in the light of nonspecific clinical, radiological findings and its histopathological similarities with a number of neoplasms especially spindle cell tumours. In this paper we discuss a case of infantile myofibroma in a 2-month-old infant, enumerating the various differential entities that have to be eliminated in reaching its specific diagnosis and highlighting the importance of immunopositivity to vimentin and smooth muscle actin (SMA) in establishing its myofibroblastic differentiation.

Rhabdomyoma of the base of the tongue

2003 ◽  
Vol 117 (6) ◽  
pp. 503-507 ◽  
Author(s):  
Yutaka Fukuda ◽  
Hiro-Oki Okamura ◽  
Tetsuo Nemoto ◽  
Seiji Kishimoto
Keyword(s):  
Striated Muscle ◽  
Smooth Muscle Actin ◽  
Neck Region ◽  
Magnetic Resonance Images ◽  
Tumour Cells ◽  
Muscle Actin ◽  
Immunohistochemical Examination ◽  
Head And Neck Region ◽  
Contrast Enhanced ◽  
Base Of The Tongue

The histopathological and imaging findings of a rhabdomyoma of the base of the tongue were studied. An immunohistochemical examination of the tumour cells showed positiveimmunostaining for myoglobin, desmin, and striated muscle actin, but negative immunostaining for smooth muscle actin. Electron microscopy showed many glycogen granules and mitochondria in the tumour cells. The T2-weighted and contrast-enhanced magnetic resonance images (MRI) clearly delineated morphological features of this tumour, but T1-weighted MRI and computed tomography (CT) images showed no important features. These findings are typical for an adult extracardiac rhabdomyoma located in the head and neck region, and they will be useful for diagnosis of this tumour.

Pediatric Angiosarcoma of Soft Tissue: A Rare Clinicopathologic Entity

2010 ◽  
Vol 134 (3) ◽  
pp. 481-485 ◽  
Author(s):  
Lobna Ayadi ◽  
Abdelmajid Khabir
Keyword(s):  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Kaposi Sarcoma ◽  
Neck Region ◽  
Epithelioid Hemangioendothelioma ◽  
Vascular Tumors ◽  
Clinical Settings ◽  
Vascular Differentiation ◽  
Head And Neck Region ◽  
Poorly Differentiated

Abstract Angiosarcomas are rare tumors that predominantly affect adults and elderly patients. Although angiosarcomas are well described in a variety of clinical settings, they have been poorly studied in children and little is known about their biology, natural history, or optimal treatment. Childhood angiosarcomas are exceedingly rare. The head and neck region and mediastinum seem to be the preferred locations. Most tumors are high-grade tumors. Vasoformative architecture is not always obvious on light microscopy requiring the benefit of immunohistochemical study. The differential diagnosis includes Kaposi sarcoma, epithelioid hemangioendothelioma, hemangiopericytoma, and spindle cell hemangioendothelioma whose prognosis is different. Complete resection is required for patients with localized tumors. Malignant vascular tumors are rare in children in the first 2 decades of life and when they do occur they seem to be more aggressive than in adults. Pathologic diagnosis is difficult particularly in poorly differentiated angiosarcomas requiring immunohistochemical study to confirm vascular differentiation.

scholarly journals Spindle Cell Hemangioendothelioma of the Temporal Muscle Resected with Zygomatic Osteotomy: A Case Report of an Unusual Intramuscular Lesion Mimicking Sarcoma

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tomohiro Minagawa ◽  
Takeshi Yamao ◽  
Ryuta Shioya
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Spindle Cell ◽  
Neck Region ◽  
Benign Neoplasm ◽  
Low Grade ◽  
Temporal Muscle ◽  
Head And Neck Region

Spindle cell hemangioendothelioma (SCH) was originally described by Weiss and Enzinger (1986) as a low-grade angiosarcoma resembling both cavernous hemangioma and Kaposi's sarcoma. Recent studies suggest that SCH is a benign neoplasm or reactive lesion accompanying a congenital or acquired vascular malformation. Most SCHs present as one or more nodules affecting the dermis or subcutis of the distal extremities. Few reports describe SCH of the head and neck region; even fewer note intramuscular SCH. Here, we describe a case of SCH involving the temporal muscle mimicking soft tissue sarcoma, who had a successful surgical treatment with a coronal approach and zygomatic osteotomy.

Five Cases of Spindle Cell Carcinoma of the Head and Neck Region

2018 ◽  
Vol 111 (8) ◽  
pp. 557-563
Author(s):  
Hiyori Takahashi ◽  
Kenichi Watanabe ◽  
Masayuki Shirakura ◽  
Yohei Honkura ◽  
Daisuke Yamauchi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Spindle Cell ◽  
Neck Region ◽  
Spindle Cell Carcinoma ◽  
Head And Neck Region

Spindle Cell Epithelioma of the Vagina Shows Immunohistochemical Staining Supporting Its Origin From a Primitive/Progenitor Cell Population

2001 ◽  
Vol 125 (4) ◽  
pp. 547-550
Author(s):  
Henry Skelton ◽  
Kathleen J. Smith
Keyword(s):  
Progenitor Cell ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Progesterone Receptors ◽  
Myoepithelial Cells ◽  
Muscle Actin ◽  
Estrogen And Progesterone Receptors ◽  
Progenitor Cell Population ◽  
Mixed Tumors

Abstract Spindle cell epitheliomas of the vagina (SCEVs) coexpresses epithelial and mesenchymal markers and were first described as a “mixed tumors of the vagina.” However, unlike mixed tumors of other organs, which are believed to originate from myoepithelial cells, SCEVs neither immunohistochemically nor ultrastructurally show features of myoepithelial cells. The present expanded battery of immunohistochemical stains is presented on this rare tumor, including cytokeratin AE1/AE3, CK7, CK20, S100 protein, epithelial membrane antigen, α-smooth muscle actin, desmin, CD34, CD99, Bcl-2, vimentin, estrogen and progesterone receptors, and Ki-67. There was minimal expression of α-smooth muscle actin and negative staining with S100 protein, with coexpression of cytokeratins and vimentin and expression of estrogen and progesterone receptors, as previously reported in SCEVs. In addition, diffuse expression of CD34, CD99, and Bcl-2 immunohistochemical stains was found, which has not previously been reported. The coexpression of CD34, CD99, and Bcl-2 in SCEVs is consistent with its origin from a primitive/progenitor cell population.

Eight Cases of Spindle Cell Carcinoma Arising in the Head and Neck Region

2021 ◽  
Vol 156 (0) ◽  
pp. 61-65
Author(s):  
Yuki Yamaguchi ◽  
Seiji Hosokawa ◽  
Junya Kita ◽  
Daiki Mochizuki ◽  
Atushi Imai ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Spindle Cell ◽  
Neck Region ◽  
Spindle Cell Carcinoma ◽  
Head And Neck Region

Primary monophasic breast synovial sarcoma in a female patient

2021 ◽  
Vol 14 (8) ◽  
pp. e242313
Author(s):  
Quan Do ◽  
Vatsala Katiyar ◽  
Andrea Breaux ◽  
Vikas Singh
Keyword(s):  
Synovial Sarcoma ◽  
Soft Tissues ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
Neck Region ◽  
Fusion Transcript ◽  
Spindle Cell Carcinoma ◽  
Head And Neck Region ◽  
Immunohistochemistry Staining ◽  
Uncommon Location

Synovial sarcoma (SS) is a rare soft tissue sarcoma usually arising in the deep soft tissues of the limbs, trunk, and head and neck region. Due to its rarity, diagnosis can be difficult to establish, especially when it involves an uncommon location like the breast. In this case report, we describe a young woman who was found to have primary SS of the breast. Initial immunohistochemistry staining was focally positive for cytokeratin and S100 and she was misdiagnosed with atypical spindle cell carcinoma. Due to the unusual presentation, further testing was performed which showed TLE1 and epithelial membrane antigen positivity, establishing the diagnosis of SS of the breast. A FISH was later sent out and was positive for SS18-SSX fusion transcript. This case highlights the importance of considering rare histopathology in breast lesions and using additional staining and cytogenetics to confirm diagnosis.

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