Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients

One challenging feature of head and neck pathology is that a dizzying array of sarcomatoid lesions occurs here ranging all the way from reactive to malignant and very aggressive. This makes accurate diagnosis critical. These lesions are quite diverse with great clinical and biological heterogeneity. Some are malignant while many others are benign or simply reactive in nature. For example; at mucosal sites, a well known lesion is spindle cell carcinoma (SpCC), which are overtly malignant, and the differential diagnosis then includes a number of different malignant spindle cell lesions. However, there are several benign or even non-neoplastic lesions that can sometimes be difficult to discern from SpCC, e.g. Nodular fasciitis, Proliferative myositis, Cellular schwannoma, Benign fibrous histiocytoma, Carcino sarcoma, Sarcomatoid melanoma. Fracture callus, etc. Aim of Study: There is a diagnostic challenge to the oral pathologists to differentiate dizzying array of sarcoma like lesions from other similar microscopic simulates ranging all the way from reactive to malignant and very aggressive. This article aims to review the sarcomatoid lesions of the head and neck region with emphasis on differential diagnosis histologically and immunohistochemicaly.

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Spindle Cell Carcinoma in Head and Neck Region

10.53350/pjmhs211593028 ◽

2021 ◽

Vol 15 (9) ◽

pp. 3028-3030

Author(s):

Samar Nazir ◽

Athar Khan ◽

Muhammad Ilyas ◽

Safia . ◽

Muhammad Ali ◽

...

Keyword(s):

Oral Cavity ◽

Cell Carcinoma ◽

Head And Neck ◽

Spindle Cell ◽

Neck Region ◽

Spindle Cell Carcinoma ◽

Clinicopathological Characteristics ◽

Female Ratio ◽

Male Predominance ◽

Younger Age

Objective: The aim of this study was to evaluate clinicopathological characteristics, treatment and outcomes of spindle cell carcinoma. Study Design: Retrospective study Place and Duration: Multi-centric (MMDC, Multan and Dow university of Health Sciences, Karachi) Nov 2020-July 2021. Methods: There were 40 patients of both genders were presented in this study, patients were aged between 20-70 years. Patients detailed demographics were recorded after taking informed written consent. Patients with primary tongue disease comprised 17 of 40, 13 had primary paranasal sinus disease, 5 had primary hypopharynx disease, 3 had basic vocal cord disease and 2 had primary soft palate and floor of mouth disease. At least 28 people were treated with the goal of becoming entirely repaired (19 patients required surgery only and eight were treated with combined modality). The remaining 12 patients were given palliative care as a last resort. Results: Mean age of the patients was 27.77±4.49 years with mean BMI 25.19±7.64 kg/m2. Male predominance was seen, with a male to female ratio of 4:1. The oral cavity is the most commonly affected region, followed by the oropharynx. Surgery is the first line of treatment, followed by adjuvant radiotherapy, depending on the indications for treatment. The shortest follow-up period was 11 months, while the longest was 31 months. Only five patients were presented with a recurrence of their condition. Conclusion: The diagnosis of spindle cell carcinoma is difficult, and histology in conjunction with immunohistochemistry is required for an accurate diagnosis to be made. The oral cavity appears to be the most common place in the younger age group in the current study, which is consistent with findings from prior studies. It is necessary to do additional research to determine the geographic diversity in clinicopathological characteristics, as well as the optimal treatment regimen for this rather rare entity. Keywords: Spindle Cell Carcinoma, Head and Neck, Young age, Treatment, Outcomes

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A Case Report of Spindle Cell Carcinoma with Osteoid and Cartilage Formation in the Tongue

Reports ◽

10.3390/reports4010005 ◽

2021 ◽

Vol 4 (1) ◽

pp. 5

Author(s):

Sawako Ono ◽

Takuma Makino ◽

Hiroyuki Yanai ◽

Hotaka Kawai ◽

Kiyofumi Takabatake ◽

...

Keyword(s):

Case Report ◽

Cell Carcinoma ◽

Head And Neck ◽

Spindle Cell ◽

Spindle Cell Carcinoma ◽

Cartilage Formation ◽

And Cartilage

Spindle cell carcinoma (SCSCC) with osteoid and/or cartilage formation in the head and neck is rare; only one case was reported in the tongue. Herein, we report an SCSCC with osteoid and cartilage formation of the tongue developed in an 85-year-old man, and then review the report.

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Mucosal Adenoid Squamous Cell Carcinoma of the Head and Neck

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949610500515 ◽

1996 ◽

Vol 105 (5) ◽

pp. 409-413 ◽

Cited By ~ 25

Author(s):

Alfio Ferlito ◽

Kenneth O. Devaney ◽

Christopher M. Milroy ◽

Alessandra Rinaldo ◽

Antonino Carbone

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Adenosquamous Carcinoma ◽

Neck Region ◽

Metastatic Adenocarcinoma ◽

Head And Neck Region ◽

Adenoid Cystic ◽

Basaloid Squamous

Adenoid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. The lesion is histologically distinctive and it is usually localized on the skin of the head and neck region; it only rarely involves the mucosal sites. The differential diagnoses include adenosquamous carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, basaloid squamous cell carcinoma, and metastatic adenocarcinoma. Surgery is the treatment of choice. The biologic behavior of this neoplasm is more aggressive when it involves mucosal areas, and the prognosis seems worse than that of conventional squamous cell carcinoma.

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