scholarly journals Henoch-Schönlein purpura

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Natalia Zdanowska ◽  
Agnieszka Owczarczyk-Saczonek ◽  
Waldemar Placek
Keyword(s):  
Surgical Intervention ◽  
Systemic Vasculitis ◽  
Bowel Perforation ◽  
Careful Monitoring ◽  
Henoch Schonlein Purpura ◽  
Life Threatening ◽  
Adults And Children ◽  
The Central Nervous System ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

<p>Henoch-Schönlein purpura (HSP) is an acute, systemic vasculitis which usually occurs in young adults and children. The skin involvement may lead to the manifestation of symptoms associated with vasculitis in intestines, kidneys, and the central nervous system. The incidence of bowel perforation in course of HSP is very seldom and it occurs about 10 days after the appearance of the first symptoms. We present a 23-year-old male patient with jejunal intussusception in the course of HSP. The patient was operated urgently with resection of part of the small intestine. Adults rarely suffer from the occurrence of abdominal pain and fever, but sometimes they require careful monitoring and surgical intervention because misdiagnosis can be life threatening.</p><p class="Standard"> </p>

scholarly journals Adult Onset Henoch-Schonlein Purpura and Intussusception: A Rare Presentation

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Mridula Krishnan ◽  
Joseph Nahas
Keyword(s):  
Unusual Case ◽  
Surgical Intervention ◽  
Gastrointestinal Symptoms ◽  
Adult Onset ◽  
Henoch Schonlein Purpura ◽  
Rare Presentation ◽  
Prompt Treatment ◽  
Life Threatening ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

We present an unusual case of a young 26-year-old male who was diagnosed with Henoch-Schonlein Purpura (HSP). Initial presentation was primarily mild gastrointestinal symptoms, which progressed to a life threatening intussusception and subsequently resolved with prompt glucocorticoid use rather than typical surgical intervention. Of importance, the patient’s initial gastrointestinal symptoms without associated skin manifestations made the diagnosis difficult. In conclusion, it is important to recognize uncommon presentations of HSP as it may lead to life threatening complications and surgical intervention may be avoided with prompt treatment.

Life-threatening complications of Henoch-Schönlein purpura: diffuse alveolar haemorrhage, venous thrombosis and bowel ischaemia

2020 ◽  
Vol 13 (9) ◽  
pp. e235905
Author(s):  
Kezreen Kaur Dhaliwal ◽  
Nur Atikah Lile ◽  
Chou Luan Tan ◽  
Chong Hong Lim
Keyword(s):  
Venous Thrombosis ◽  
Systemic Vasculitis ◽  
Alveolar Haemorrhage ◽  
Diffuse Alveolar Haemorrhage ◽  
Henoch Schonlein Purpura ◽  
Bowel Ischaemia ◽  
Life Threatening ◽  
Schonlein Purpura ◽  
Purpuric Rash ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a common systemic vasculitis occurring in children. Making a diagnosis of HSP is often straightforward, managing its complications can be difficult. Diffuse alveolar haemorrhage (DAH), bowel ischaemia and venous thrombosis are rare complications of this disorder. We present a case of a 15-year-old teenage girl presenting with typical purpuric rash of HSP, developed DAH, bowel ischaemia and venous thrombosis. She was successfully treated with pulse methylprednisolone, intravenous Ig and intravenous cyclophosphamide.

Prednisolone with Artesunate Effect on Henoch Schonlein Purpura with Malaria Condition

2019 ◽  
Author(s):  
Pavani Thota
Keyword(s):  
Menstrual Cycle ◽  
Autoimmune Disease ◽  
Female Patient ◽  
Past History ◽  
Systemic Vasculitis ◽  
Bowel Perforation ◽  
Hormonal Changes ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch Schonlein Purpura (HSP) is the common form of systemic vasculitis which is mostly seen in children and rarely in adults. It is clinically characterized by the symptoms of palpable purpura, joint pains, abdominal pain, nephritis, bowel perforation rarely CNS involved. HSP has incidence of 15 casesin 1,00,000 childrensper year. The etiology of the disease remains unclear but antigens such as infective agents, vaccination, drugs, insects and foods can trigger this autoimmune disease. The hormonal changes such as usage of oral contraceptives, during menstrual cycle, during pregnancy & hormones like dehydro-epiandrosterone, testosterone and estrogen also triggers autoimmune disease. Here we report a case of female patient affected with HSP which is triggered due to hormonal changes. A 12 years female patient admitted in hospital with complaints of restricting to walk, swelling of legs since 2 days, petechial rash, pain over arm and forearm, burning sensation in legs, rash started over ankle region which started spreading since 1 day. Then after admitting in hospital she was suffered with on and off fever and was diagnosed as malaria. On examination of past history she had hypothyroidism 1 year back and under medication for 6 months. She attained puberty but with abnormal menstrual cycle for 3 months. Based on these conditions it was finally diagnosed as HSP with malaria. The condition was treated with corticosteroids and antimalarial drugs. During the treatment we observed adverse effects- swelling in scalp and peripheral neuropathy due to prednisolone and increase in rashes due to artesunate.

scholarly journals 017 Pulmonary renal syndrome in Henoch-Schönlein purpura: a life-threatening complication

Rheumatology ◽  
2018 ◽  
Vol 57 (suppl_3) ◽  
Author(s):  
Katherine Clarke ◽  
Elena Kurteva ◽  
Neil Sebire ◽  
Muthana Al-Obaidi ◽  
Muthana Al-Obaidi
Keyword(s):  
Henoch Schonlein Purpura ◽  
Life Threatening ◽  
Pulmonary Renal Syndrome ◽  
Life Threatening Complication ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Steroid Effects on the Course of Abdominal Pain in Children With Henoch-Schonlein Purpura

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1018-1021
Author(s):  
NORMAN D. ROSENBLUM ◽  
HARLAND S. WINTER
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Symptom ◽  
Systemic Vasculitis ◽  
Skin Lesions ◽  
Intestinal Bleeding ◽  
Controlled Trials ◽  
Henoch Schonlein Purpura ◽  
Intestinal Lesions ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura is a systemic vasculitis of unknown cause that is characterized primarily by abdominal pain, arthritis, and purpuric skin lesions. Abdominal pain is the most common gastrointestinal symptom, but intestinal bleeding and intussusception may occur. Previous studies have supported the use of steroids in managing the abdominal pain of Henoch-Schonlein purpura.1,2 Because there are no controlled trials using steroids in this disease, their value in affecting the intestinal lesions of Henoch-Schonlein purpura remains unknown. The purpose of this retrospective study was to assess the effect of corticosteroids on the outcome of abdominal pain in children with Henoch-Schonlein purpura. PATIENTS AND METHODS

scholarly journals Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenjia Chai ◽  
Xiaolin Wang ◽  
Wei Wang ◽  
Hui Wang ◽  
Wenjun Mou ◽  
...  
Keyword(s):  
Nk Cells ◽  
Systemic Vasculitis ◽  
Metabolic Reprogramming ◽  
Healthy Children ◽  
Henoch Schonlein Purpura ◽  
Reduced Frequency ◽  
Activating Receptors ◽  
Innate Lymphocytes ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis of the childhood. However, its mechanisms and pathogenesis still need more exploration. Natural killer (NK) cells are innate lymphocytes, and there is a growing appreciation that cellular metabolism is important in determining the immune responsiveness of lymphocytes. Thus, we aimed to analyze the NK cells phenotype and explore the association between glucose metabolism and NK cells function in HSP patients. Results A total number of 64 HSP patients and 34 healthy children were included. The HSP patients were divided into two groups according to whether accompanied with nephritis or not. NK cells in HSP patients without nephritis showed a reduced frequency in peripheral blood, a down-regulated expression of activating receptors both NKp30 and NKp46, and an attenuated cytotoxic function against tumor cells. In addition, the function impairment of NK cells was shown to exacerbate in HSPN. Our data further revealed an aberrant metabolic reprogramming of NK cells in HSP patients. Upon stimulation with cytokines (IL-15, IL-12 and IL-2), NK cells from healthy controls switched to an elevated glycolysis rate to support their effector function. By contrast, the glycolysis rate of activated NK cells in HSP group was not significantly up-regulated from the resting level possibly owing to the inhibition of mTORC1. Conclusions Our study found that HSP patients were accompanied with dysfunction of NK cells. We concluded that the dysfunction of NK cells in HSP patients was induced with a decreased glycolysis rate and suggested that metabolic reprogramming of NK cells might be a player in the pathogenesis of HSP.

scholarly journals Intestinal Infarction and Portal Vein Thrombosis in a Patient with Henoch Schonlein Purpura

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Mekdess Abebe ◽  
Asha Patnaik ◽  
Frederick Miller ◽  
Heidi Roppelt ◽  
Nand K. Wadhwa ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Therapeutic Intervention ◽  
Systemic Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Vein Thrombosis ◽  
Schonlein Purpura ◽  
Benign Course ◽  
Henoch Schönlein Purpura

Henoch Schonlein purpura is a systemic vasculitis that commonly affects children and teenagers but also affects adults of all ages. In most instances it has a benign course. Organ involvement, particularly in adults, and notably the kidneys and gastrointestinal tract may require therapeutic intervention and may have a less favorable outcome. We report a case of a 58-year-old man who presented with purpura and who rapidly developed catastrophic intestinal vasculitis, leading to his demise.

scholarly journals Not Just A Rash!

2010 ◽  
Vol 9 (1) ◽  
pp. 27-29
Author(s):  
MA Fox ◽  
◽  
JA Fox ◽  
Al-Shamma S ◽  
Leiper K ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Systemic Vasculitis ◽  
Gastrointestinal Haemorrhage ◽  
Henoch Schonlein Purpura ◽  
Classic Case ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein Purpura (HSP) is the most common systemic vasculitis in childhood and can present in adults. It is a self-limiting disease characterised by a tetrad of manifestations including the mandated typical cutaneous hallmark. We present a classic case of HSP complicated by gastrointestinal haemorrhage associated with hidradenitis suppurativa.

scholarly journals Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Jisup Kim ◽  
Sung-Eun Choi ◽  
Keum Hwa Lee ◽  
Hyeon Joo Jeong ◽  
Jae Il Shin ◽  
...  
Keyword(s):  
Systemic Vasculitis ◽  
Renal Involvement ◽  
International Study ◽  
Clinical Parameters ◽  
M2 Macrophages ◽  
Henoch Schonlein Purpura ◽  
Severe Manifestation ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular crescents. Macrophages, categorized as M1 or M2, frequently infiltrate in various glomerular and tubulointerstitial diseases and infiltration of specific subtypes is associated with disease progression. Therefore, to identify whether infiltration of M1 or M2 macrophages has clinical significance, we quantified the subtypes of macrophages in 49 HSPN specimens and correlated the counts with histologic features and clinical parameters. Higher tubulointerstitial M2 counts were associated with chronic renal failure (CRF), ISKDC classes III-IV, and crescents (P<0.001, 0.002, 0.001). Glomerular M2 counts were significantly related to ISKDC classes III-IV and crescents (area under curve, AUC 0.804, 0.833). Tubulointerstitial M2 counts were associated with CRF, ISKDC classes III-IV, and crescents (AUC 0.872, 0.778, 0.830). Tubulointerstitial M2 counts also revealed higher AUC than tubulointerstitial M1 counts for CRF (P=0.036) and ISKDC classes III-IV (P=0.047). Glomerular M2 counts revealed higher AUC than glomerular M1 counts for ISKDC classes III–IV (P=0.024). Tubulointerstitial M2 counts were the most powerful parameter for CRF (AUC 0.872) and revealed even higher AUC than ISKDC classification (AUC 0.716) with borderline significance (P=0.086) for CRF. In summary, tubulointerstitial M2 counts were a superior parameter to tubulointerstitial M1 counts and even to ISKDC classification indicating the presence of CRF.

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