Alterations in Nitric Oxide Synthase in the Aged CNS
2012 ◽
Vol 2012
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pp. 1-7
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Keyword(s):
Aging is associated with neuronal loss, gross weight reduction of the brain, and glial proliferation in the cortex, all of which lead to functional changes in the brain. It is known that oxidative stress is a critical factor in the pathogenesis of aging; additionally, growing evidence suggests that excessive nitric oxide (NO) production contributes to the aging process. However, it is still unclear how NO plays a role in the aging process. This paper describes age-related changes in the activity of NADPH-diaphorase (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS), in many CNS regions. Understanding these changes may provide a novel perspective in identifying the aging mechanism.
2004 ◽
Vol 370
(2-3)
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pp. 175-179
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Localization of the cGMP-dependent protein kinases in relation to nitric oxide synthase in the brain
1999 ◽
Vol 17
(1)
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pp. 45-55
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Keyword(s):
2008 ◽
Vol 294
(3)
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pp. L582-L591
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2008 ◽
Vol 89
(4)
◽
pp. 241-250
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2004 ◽
Vol 287
(2)
◽
pp. F231-F235
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2007 ◽
Vol 293
(1)
◽
pp. L212-L221
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2011 ◽
Vol 10
(4)
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pp. 395-400
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