scholarly journals Limited Value of KAI1/CD82 Protein Expression as a Prognostic Marker in Human Gastric Cancer

2012 ◽  
Vol 32 (6) ◽  
pp. 337-342 ◽  
Author(s):  
Maximilian Knoener ◽  
Till Krech ◽  
Florian Puls ◽  
Ulrich Lehmann ◽  
Hans Kreipe ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Expression ◽  
Tumor Growth ◽  
Prognostic Marker ◽  
Metastatic Lymph Node ◽  
Surface Glycoprotein ◽  
Human Gastric Cancer ◽  
Cell Surface Glycoprotein ◽  
Gastric Carcinomas ◽  
Tumor Growth And Metastasis

The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n= 271) with amean clinical follow-up time of 48months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negativeversuspositive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p= 0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p= 0.0222), metastatic lymph node involvement (p= 0.0018) and a higher clinical tumor stage (p= 0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p= 0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.

scholarly journals RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer

2019 ◽  
Vol 25 ◽  
pp. 4025-4034 ◽  
Author(s):  
Hongmei Yong ◽  
Wei Zhao ◽  
Xueyi Zhou ◽  
Zhenyun Liu ◽  
Qi Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Rna Binding ◽  
Binding Motif ◽  
Human Gastric Cancer ◽  
Tumor Growth And Metastasis

scholarly journals Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 302 ◽  
Author(s):  
Xin Zhang ◽  
Yao Qin ◽  
Zhaohai Pan ◽  
Minjing Li ◽  
Xiaona Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Protein Expression ◽  
Cell Cycle Arrest ◽  
Phase Cell ◽  
G1 Phase ◽  
Therapeutic Effects ◽  
Human Gastric Cancer ◽  
Expression Levels ◽  
Cycle Arrest

The main chemical component of cannabis, cannabidiol (CBD), has been shown to have antitumor properties. The present study examined the in vitro effects of CBD on human gastric cancer SGC-7901 cells. We found that CBD significantly inhibited the proliferation and colony formation of SGC-7901 cells. Further investigation showed that CBD significantly upregulated ataxia telangiectasia-mutated gene (ATM) and p53 protein expression and downregulated p21 protein expression in SGC-7901 cells, which subsequently inhibited the levels of CDK2 and cyclin E, thereby resulting in cell cycle arrest at the G0–G1 phase. In addition, CBD significantly increased Bax expression levels, decreased Bcl-2 expression levels and mitochondrial membrane potential, and then upregulated the levels of cleaved caspase-3 and cleaved caspase-9, thereby inducing apoptosis in SGC-7901 cells. Finally, we found that intracellular reactive oxygen species (ROS) increased after CBD treatment. These results indicated that CBD could induce G0–G1 phase cell cycle arrest and apoptosis by increasing ROS production, leading to the inhibition of SGC-7901 cell proliferation, thereby suggesting that CBD may have therapeutic effects on gastric cancer.

scholarly journals Interleukin-23A is associated with tumor growth in Helicobacter-pylori-related human gastric cancer

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Changming Liu ◽  
Ying Zhang ◽  
Jie Zhan ◽  
Yuanyuan Zhao ◽  
Qijun Wan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Tumor Growth ◽  
Human Gastric Cancer

scholarly journals Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 57187-57200 ◽  
Author(s):  
Feng Wang ◽  
Dunke Zhang ◽  
Jingxin Mao ◽  
Xiao-Xue Ke ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Human Gastric Cancer

scholarly journals Loss of MTUS1 in gastric cancer promotes tumor growth and metastasis

Neoplasma ◽  
2014 ◽  
Vol 61 (02) ◽  
pp. 128-135 ◽  
Author(s):  
X. Li ◽  
H. Liu ◽  
T. Yu ◽  
Z. Dong ◽  
L. Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis
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