The Role of TNPO3 in HIV-1 Replication
Keyword(s):
TNPO3, transportin-SR2 or Tnp3, a member of the karyopherin β superfamily of proteins, is important for the ability of human immunodeficiency virus (HIV-1) to achieve productive infection, as TNPO3 depletion in human cells leads to a dramatic reduction of infection. Here we describe and discuss recent findings suggesting that TNPO3 assists HIV-1 replication in the nucleus and in fact that TNPO3 may assist PIC maturation in the nucleus. In addition, the viral determinant for the requirement of TNPO3 in HIV-1 infection is discussed. This paper summarizes the most significant recent discoveries about this important host factor and its role in HIV-1 replication.
2010 ◽
Vol 299
(3)
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pp. F664-F673
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Keyword(s):
2001 ◽
Vol 75
(17)
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pp. 7925-7933
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2000 ◽
Vol 74
(24)
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pp. 11811-11824
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1997 ◽
Vol 8
(5)
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pp. 290-293
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