Mature Ovarian Teratoma with Carcinoid Tumor in a 28-Year-Old Patient

Introduction. Coexistence of carcinoid tumor inside a mature cystic teratoma is an extremely rare phenomenon, especially in young women. We present the case of a 28-year-old woman diagnosed with a right ovarian carcinoid and treated uneventfully with conservative surgical approach.Case Report. A 28-year-old woman, gravid 0, parity 0, presented to our department for her annual gynecological examination and Pap smear test. During her examination, a mobile cystic mass was detected in the right lower abdomen. Ultrasound indicated a right ovarian mass 10.5 × 6.3 cm, confirmed by CT scan. Further investigation revealed AFP levels (1539 ng/mL). The ovarian mass was excised by laparoscopy, leaving intact the remaining right ovary. Frozen sections showed a mature cystic teratoma. However, paraffin sections revealed the presence of a small carcinoid within the teratoma’s gastric-type mucosa. The patient was set to a close followup. Nine months postoperatively, ultrasound pelvis imaging and CT scan of the abdomen as well as serum tumor markers have shown no evidence of recurrence disease.Conclusion. Despite the weak evidence, fertility spare surgical approach for women wanting to preserve their genital tract might be a reasonable option.

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Carcinoid tumor arising from a retroperitoneal mature cystic teratoma

Pediatrics & Neonatology ◽

10.1016/j.pedneo.2017.11.016 ◽

2018 ◽

Vol 59 (5) ◽

pp. 520-522

Author(s):

Po-Wei Huang ◽

Yen-Lin Liu ◽

James S. Miser ◽

Chii-Hong Lee ◽

Chun-Yu Kao ◽

...

Keyword(s):

Carcinoid Tumor ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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A carcinoid tumor arising from a mature cystic teratoma in a 25-year-old patient: a case study

World Journal of Surgical Oncology ◽

10.1186/s12957-016-0867-8 ◽

2016 ◽

Vol 14 (1) ◽

Cited By ~ 7

Author(s):

Joo-Yeon Kim

Keyword(s):

Carcinoid Tumor ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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Squamous Cell Carcinoma Transformation of Mature Cystic Teratoma of Ovary: A Case Report and Review of Surgical Approach

Indian Journal of Gynecologic Oncology ◽

10.1007/s40944-020-00432-5 ◽

2020 ◽

Vol 18 (3) ◽

Author(s):

Sundeep Kumar ◽

Preeti Arora

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Surgical Approach ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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Primary Ovarian Carcinoid Tumor with a Mature Cystic Teratoma: A Case Report

JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY ◽

10.5180/jsgoe.35.1_175 ◽

2019 ◽

Vol 35 (1) ◽

pp. 175-179

Author(s):

Satoshige Wagatsuma ◽

Syuko Miyahara

Keyword(s):

Case Report ◽

Carcinoid Tumor ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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A mature cystic teratoma adherent to the vaginal wall: a case report

Journal of International Medical Research ◽

10.1177/0300060520971495 ◽

2020 ◽

Vol 48 (11) ◽

pp. 030006052097149

Author(s):

Jian Qiu ◽

Jiewei Xu ◽

Guorong Yao ◽

Mingyue Cao ◽

Fengjia Zhu ◽

...

Keyword(s):

Preoperative Evaluation ◽

Cystic Teratoma ◽

Large Mass ◽

Vaginal Wall ◽

Ovarian Teratoma ◽

Pelvic Cavity ◽

Anatomical Location ◽

Gynecological Examination ◽

Magnetic Resonance Imaging Mri ◽

Left Front

We present the case of a woman diagnosed with a teratoma adherent to the vaginal wall. The patient had been misdiagnosed with an ovarian teratoma 8 years previously at her local hospital, but no mass was found in the pelvic cavity during cesarean section. She therefore attended our institution for further examination. Transvaginal ultrasonography, magnetic resonance imaging (MRI), and computed tomography (CT) revealed a large mass on the left side at the bottom of the pelvis, near the side of the vagina, mainly composed of greasy and cystic elements. Gynecological examination showed the mass protruding into the left side of the vaginal wall. The patient therefore underwent vaginal wall incision. During surgery, we found a mass adherent to the vaginal wall, located on the left front of the rectum. Surgery was completed successful with no complications. This case highlights the need for careful preoperative evaluation of teratomas with unusual locations. MRI and CT may be useful for identifying the origin of the tumor and determining its relationship with the surrounding tissues. Surgery should be based on the characteristics and anatomical location of the tumor to minimize damage to other tissues and organs.

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Coexistence of endometriosis in women with mature cystic ovarian teratoma may not be rare.

10.21203/rs.2.21971/v1 ◽

2020 ◽

Author(s):

Heesuk Chae

Keyword(s):

Early Stage ◽

Cystic Teratoma ◽

Operation Time ◽

Mature Cystic Teratoma ◽

Ovarian Teratoma ◽

Advanced Stage ◽

Clinicopathologic Features ◽

Complex Group ◽

The Mean ◽

Group Serum

Abstract Background We investigated the incidence of endometriosis in women with mature cystic ovarian teratoma and analyzed the clinicopathologic features of this occurrence. Methods From January 2017 through December 2018, we retrospectively studied 71 women who had undergone cystectomy for mature cystic ovarian teratoma (n = 55, teratoma group) and coexistence of endometriosis and mature cystic ovarian teratoma (n = 16, complex group). Serum anti-Müllerian hormone (AMH) levels were measured preoperatively and one month after surgery. Results Sixteen (22.54%) patients had coexistence of endometriosis and mature cystic ovarian teratoma (complex group); 55 patients had mature cystic teratoma alone (teratoma group). Early-stage endometriosis (stage I) was present in eight patients and advanced-stage endometriosis (stage III or IV) was present in eight. In five cases (31.25%), the coexistence of endometrioma and mature cystic teratoma in the same ovary was observed. The mean operation time was significantly shorter in the teratoma group than in the complex group (61.02 ± 22.74 vs. 86.31 ± 35.35 min, p = 0.007). The complex group had more dysmenorrhea (43.8% vs. 7.3%, p = 0.002) and a significantly higher rate of decrease in serum anti-Müllerian hormone (AMH) levels (33.06 ± 24.92 vs. 16.31 ± 28.17%, p = 0.048). Conclusion(s) The prevalence of coexisting endometriosis and mature cystic ovarian teratoma may be underestimated. Patients with this rare concurrence may present with worsening dysmenorrhea and damage to ovarian reserve after surgery may be greater in patients with coexisting endometriosis than in patients with mature cystic teratoma alone.

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A Case of Early-Stage Ovarian Carcinoid Tumor Metastasized to the Liver

Case Reports in Obstetrics and Gynecology ◽

10.1155/2012/961087 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Seiji Kanayama ◽

Yoshihiko Yamada ◽

Yasuhito Tanase ◽

Shoji Haruta ◽

Akira Nagai ◽

...

Keyword(s):

Liver Metastases ◽

Carcinoid Tumor ◽

Early Stage ◽

Cystic Teratoma ◽

Hepatic Arterial Infusion ◽

Abnormal Uterine Bleeding ◽

Mature Cystic Teratoma ◽

Maximum Diameter ◽

Pathology Report ◽

Multiple Liver Metastases

We report a case of ovarian carcinoid tumor that recurred with multiple liver metastases and was successfully treated with chemoembolization. A 76-year-old woman was admitted to our hospital presented with abdominal distension and abnormal uterine bleeding for about 6 months. She presented with hyperestrogenic and androgenic manifestations such as vaginal bleeding with endometrial hyperplasia and hirsutism. Magnetic resonance (MR) imaging revealed a large solid and cystic ovarian tumor of 17 cm at maximum diameter. On the basis of the clinical diagnosis of sex cord stromal tumor containing a mature cystic teratoma, she underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. The pathology report revealed that the mass in the left ovary was a carcinoid tumor, insular type, with mature cystic teratoma. Two years after surgical treatment, multiple liver metastases were revealed by abdominal CT. Hepatic arterial infusion of cisplatin was performed for 2 courses, and multiple metastatic nodules have remarkably reduced. No established chemotherapy or radiation therapy treatments are currently available for recurrent or advanced carcinoid tumors. Our paper suggests that chemoembolization with cisplatin may be effective in treatment of patients with multiple liver metastases of ovarian carcinoid tumor.

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