Coexistence of endometriosis in women with mature cystic ovarian teratoma may not be rare.

2020 ◽  
Author(s):  
Heesuk Chae
Keyword(s):  
Early Stage ◽  
Cystic Teratoma ◽  
Operation Time ◽  
Mature Cystic Teratoma ◽  
Ovarian Teratoma ◽  
Advanced Stage ◽  
Clinicopathologic Features ◽  
Complex Group ◽  
The Mean ◽  
Group Serum

Abstract Background We investigated the incidence of endometriosis in women with mature cystic ovarian teratoma and analyzed the clinicopathologic features of this occurrence. Methods From January 2017 through December 2018, we retrospectively studied 71 women who had undergone cystectomy for mature cystic ovarian teratoma (n = 55, teratoma group) and coexistence of endometriosis and mature cystic ovarian teratoma (n = 16, complex group). Serum anti-Müllerian hormone (AMH) levels were measured preoperatively and one month after surgery. Results Sixteen (22.54%) patients had coexistence of endometriosis and mature cystic ovarian teratoma (complex group); 55 patients had mature cystic teratoma alone (teratoma group). Early-stage endometriosis (stage I) was present in eight patients and advanced-stage endometriosis (stage III or IV) was present in eight. In five cases (31.25%), the coexistence of endometrioma and mature cystic teratoma in the same ovary was observed. The mean operation time was significantly shorter in the teratoma group than in the complex group (61.02 ± 22.74 vs. 86.31 ± 35.35 min, p = 0.007). The complex group had more dysmenorrhea (43.8% vs. 7.3%, p = 0.002) and a significantly higher rate of decrease in serum anti-Müllerian hormone (AMH) levels (33.06 ± 24.92 vs. 16.31 ± 28.17%, p = 0.048). Conclusion(s) The prevalence of coexisting endometriosis and mature cystic ovarian teratoma may be underestimated. Patients with this rare concurrence may present with worsening dysmenorrhea and damage to ovarian reserve after surgery may be greater in patients with coexisting endometriosis than in patients with mature cystic teratoma alone.

Advanced stage squamous cell carcinoma arising from mature cystic teratoma of the ovary

2001 ◽  
Vol 80 (1) ◽  
pp. 84-84 ◽  
Author(s):  
Ruey–Jien Chen ◽  
Po-Ta Huang ◽  
Ming-Chieh Lin ◽  
Su-Cheng Huang ◽  
Song-Nan Chow ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Advanced Stage

scholarly journals Advanced Mucinous Adenocarcinoma Arising from a Mature Cystic Teratoma: A Case Report and Literature Review

2016 ◽  
Vol 9 (2) ◽  
pp. 331-337
Author(s):  
Aki Miyasaka ◽  
Tadaaki Nishikawa ◽  
Eito Kozawa ◽  
Masanori Yasuda ◽  
Keiichi Fujiwara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Literature Search ◽  
Abdominal Mass ◽  
Cystic Teratoma ◽  
Figo Stage ◽  
Mature Cystic Teratoma ◽  
Advanced Stage ◽  
Review Of The Literature ◽  
Progressive Course

Purpose: To describe the postoperative progressive course of advanced-stage adenocarcinoma arising from a mature cystic teratoma (MCT) and review the literature regarding this disease. Methods: A 59-year-old woman visited our hospital with an abdominal mass. Laparotomy showed enlargement of the left ovary and dissemination throughout the abdominal and pelvic cavities. The diagnosis was FIGO stage IIIB adenocarcinoma arising from a MCT. We report this case in detail with a review of the literature. Results: A literature search yielded 9 cases of stage III adenocarcinoma with malignant transformation. Six of these 9 patients died within 12 months after diagnosis. Of the 8 patients who underwent postoperative chemotherapy, 3 survived for over 39 months. The review indicates that prognosis of adenocarcinoma is as poor as that for squamous cell carcinoma arising from a MCT. Conclusions: In general, as with this case, prognosis of advanced adenocarcinoma associated with a MCT is poor. However, we should be aware that not all patients are resistant to chemotherapy.

scholarly journals A Case of Early-Stage Ovarian Carcinoid Tumor Metastasized to the Liver

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Seiji Kanayama ◽  
Yoshihiko Yamada ◽  
Yasuhito Tanase ◽  
Shoji Haruta ◽  
Akira Nagai ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Carcinoid Tumor ◽  
Early Stage ◽  
Cystic Teratoma ◽  
Hepatic Arterial Infusion ◽  
Abnormal Uterine Bleeding ◽  
Mature Cystic Teratoma ◽  
Maximum Diameter ◽  
Pathology Report ◽  
Multiple Liver Metastases

We report a case of ovarian carcinoid tumor that recurred with multiple liver metastases and was successfully treated with chemoembolization. A 76-year-old woman was admitted to our hospital presented with abdominal distension and abnormal uterine bleeding for about 6 months. She presented with hyperestrogenic and androgenic manifestations such as vaginal bleeding with endometrial hyperplasia and hirsutism. Magnetic resonance (MR) imaging revealed a large solid and cystic ovarian tumor of 17 cm at maximum diameter. On the basis of the clinical diagnosis of sex cord stromal tumor containing a mature cystic teratoma, she underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. The pathology report revealed that the mass in the left ovary was a carcinoid tumor, insular type, with mature cystic teratoma. Two years after surgical treatment, multiple liver metastases were revealed by abdominal CT. Hepatic arterial infusion of cisplatin was performed for 2 courses, and multiple metastatic nodules have remarkably reduced. No established chemotherapy or radiation therapy treatments are currently available for recurrent or advanced carcinoid tumors. Our paper suggests that chemoembolization with cisplatin may be effective in treatment of patients with multiple liver metastases of ovarian carcinoid tumor.

scholarly journals Successful Laparoscopic Resection of 7 mm Ovarian Mature Cystic Teratoma Associated with Anti-NMDAR Encephalitis

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Masaru Hayashi ◽  
Emi Motegi ◽  
Koichi Honma ◽  
Nobuhide Masawa ◽  
Hideki Sakuta ◽  
...  
Keyword(s):  
Cystic Teratoma ◽  
Antibody Test ◽  
Mature Cystic Teratoma ◽  
Ovarian Teratoma ◽  
Cystic Tumor ◽  
Macroscopic Appearance ◽  
Abdominal Image ◽  
Nmdar Encephalitis ◽  
Disturbance Of Consciousness ◽  
The Right

Anti-NMDAR (N-methyl-D-aspartate receptor) encephalitis is an immune-mediated encephalitis. It has been predominantly described in young women and is commonly associated with an ovarian teratoma. We report a case of anti-NMDAR encephalitis associated with a 7 mm ovarian teratoma that was completely resected by laparoscopic surgery. An 18-year-old woman suddenly presented with personality changes requiring her admission to the department of neurology. After that, she also showed involuntary movements, disturbance of consciousness, and central hypoventilation. As an abdominal image revealed the possibility of a right ovarian teratoma of5×7 mm, a laparoscopic operation was performed. The macroscopic appearance of the right ovary did not show any abnormalities; nevertheless, we performed a partial resection of the right ovary, with reference to the image diagnosis, in order to spare the ovarian reserve. The22×22 mm partially resected ovary contained an intact5×7 mm cystic tumor. The pathological diagnosis was mature cystic teratoma with components of brain tissue. An anti-NMDAR-antibody test proved positive in both serum and cerebrospinal fluid 1 month after the surgery. From these results, she was diagnosed with anti-NMDAR encephalitis. By the administration of cyclophosphamide in addition to the operation, she recovered drastically without any of the symptoms shown before.

scholarly journals Clinical Features and Survival Outcome of Patients with Malignant Transformation Arising in Mature Cystic Teratoma: A 20-Year Experience at Multicenter Institution and Literature Review on 342 Cases

2020 ◽  
Author(s):  
Tian Wang ◽  
Runfeng Yang ◽  
Shixuan Wang ◽  
Mingfu Wu
Keyword(s):  
Malignant Transformation ◽  
Medical Center ◽  
Abdominal Mass ◽  
Young Patients ◽  
Cystic Teratoma ◽  
Disease Free Survival ◽  
Mature Cystic Teratoma ◽  
Published Data ◽  
Platinum Based Chemotherapy ◽  
The Mean

Abstract Background: To analyze the clinicopathologic characteristics and prognosis in malignant transformation of mature cystic teratoma (MT-MCT).Methods: We retrospectively reviewed 23 patients (cohort 3) diagnosed with MT-MCT from the medical center (Tongji Hospital and Hubei cancer hospital), between January 1990 to June 2020. Cohort 2 was obtained from the PubMed, CNKI, Web of Science, and MEDLINE database, between January 1990 to June 2020. Cohort 3 was based on the surveillance, epidemiology, and results registry (SEER) database, between January 1975 and December 2016. Results: Among 3865 cases diagnosed with mature cystic teratoma, the incidence of MT-MCT is 23 (0.59%). The mean age of 23 patients was 50.6 years (median 49.0, range 24 to71 years). Patients mainly had abdominal pain (21.7%) or complained about an abdominal mass (30.4%). The mean tumor size was 11.6 cm (median 11.9, range 5.2 to 14.8 cm). According to the FIGO stage, eight patients were in stage I (34.8%), two cases were in stage II (8.6%), III (47.8%), and IV (8.7%), respectively. Most patients were diagnosed with squamous cell carcinoma (91.3%). Most patients received total hysterectomy, salpingo-oophorectomy, and omentectomy. Five patients (21.7%) received lymphadenectomy. Platinum-based chemotherapy and radiotherapy were selectively used for patients after surgical resection. The mean of disease-free survival was 27.3 months (median 22.0, range 3.0 to 67.0 months). According to the published data analysis of 342 cases, the 1-, 3-, and 5-year overall survival rates were 53.2%, 33.1%, and 23.2%, respectively. The young patients (＜55 years) showed better prognosis. Conclusion: MT-MCT has an aggressive clinical course, with poor long-term prognosis. The high incidence in postmenopausal women should not be ignored. The effectiveness of adjuvant chemotherapy or radiotherapy after surgery is needed to elucidate in the future.

scholarly journals Mature Ovarian Teratoma with Carcinoid Tumor in a 28-Year-Old Patient

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Stamatios Petousis ◽  
Ioannis Kalogiannidis ◽  
Chrysoula Margioula-Siarkou ◽  
Alexandros Traianos ◽  
Dimosthenis Miliaras ◽  
...  
Keyword(s):  
Ct Scan ◽  
Carcinoid Tumor ◽  
Surgical Approach ◽  
Pap Smear ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Ovarian Teratoma ◽  
Ovarian Mass ◽  
Gynecological Examination ◽  
Gastric Type

Introduction. Coexistence of carcinoid tumor inside a mature cystic teratoma is an extremely rare phenomenon, especially in young women. We present the case of a 28-year-old woman diagnosed with a right ovarian carcinoid and treated uneventfully with conservative surgical approach.Case Report. A 28-year-old woman, gravid 0, parity 0, presented to our department for her annual gynecological examination and Pap smear test. During her examination, a mobile cystic mass was detected in the right lower abdomen. Ultrasound indicated a right ovarian mass 10.5 × 6.3 cm, confirmed by CT scan. Further investigation revealed AFP levels (1539 ng/mL). The ovarian mass was excised by laparoscopy, leaving intact the remaining right ovary. Frozen sections showed a mature cystic teratoma. However, paraffin sections revealed the presence of a small carcinoid within the teratoma’s gastric-type mucosa. The patient was set to a close followup. Nine months postoperatively, ultrasound pelvis imaging and CT scan of the abdomen as well as serum tumor markers have shown no evidence of recurrence disease.Conclusion. Despite the weak evidence, fertility spare surgical approach for women wanting to preserve their genital tract might be a reasonable option.

scholarly journals Collision Glial Neoplasms Arising in an Ovarian Mature Cystic Teratoma: A Rare Event

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Abdelrazak Meliti ◽  
Bayan Hafiz ◽  
Haneen Al-Maghrabi ◽  
Abdulrahim Gari
Keyword(s):  
Germ Cell ◽  
English Literature ◽  
Rare Event ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Single Type ◽  
Ovarian Teratoma ◽  
Histopathologic Finding ◽  
Children And Young Adults ◽  
Benign Ovarian Neoplasm

Germ cell neoplasms represent around 20% of all ovarian tumors. They most frequently affect children and young adults. Mature cystic teratoma is a common benign ovarian neoplasm comprising about 95% and is made up of all three germ cell embryonic layers. By definition, mature cystic teratoma may be derived from any of the three germ cell lines. On the other hand, immature teratomas contain primitive neuroepithelial elements. However, it is quite uncommon in the English literature to have a neuroepithelial glial neoplasm arising in a mature cystic teratoma of an adolescent. Interestingly enough, all published cases described a single type of glial neoplasm arising in mature ovarian teratoma. Herein, the authors discuss a unique case of concomitant occurrence of two different glial neoplasms, namely pilocytic astrocytoma and subependymoma arising in an ovarian mature cystic teratoma. To the best of our knowledge, this is the first reported case with such a distinctive histopathologic finding.

scholarly journals Malignant transformation arising in mature cystic teratoma

2016 ◽  
Vol 6 (12) ◽  
pp. 981-984 ◽  
Author(s):  
P Sherpa ◽  
R Baral ◽  
TK Kansakar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Single Case ◽  
Cystic Teratoma ◽  
Cross Sectional Study ◽  
Mature Cystic Teratoma ◽  
Cross Sectional ◽  
The Mean

Background: The prognosis of patients with malignant transformation arising within mature cystic teratoma is poor. However, preoperative diagnosis is dif cult due to its rarity. The aim of this study was to evaluate the clinical and histopathological characteristics of such malignancies. Materials and Methods: A retrospective cross sectional study on a series of cases was performed in the Department of Pathology, Patan Academy of Health Sciences, Patan Hospital, Lalitpur, Nepal from April 2011 to March 2016. Data from the histopathology database were analyzed using SPSS version 16.0. Results: Mature cystic teratoma comprised 230 cases (57.6%) out of total 399 cases of ovarian neoplasms. Malignant transformation was noted in 7 (3%) of the mature cystic teratoma. The mean age at diagnosis of patients with malignant transformation of mature cystic teratoma was 47.57 years. The size of the tumors ranged from 7-14cm. The mean diameter of tumor was 10.28cm. There was signi cant difference in age between mature cystic teratoma and malignant transformations arising within mature cystic teratoma. No signi cant association was noted in tumor size. Torsion was noted in a single case. Squamous cell carcinoma was the most common malignant tumor seen in 5 cases. The TNM stage distribution was T1aNx for 4 cases, T2aNx for one case and T3aNx for 2 cases. Conclusion: Squamous cell carcinoma is the most common malignancy arising in mature cystic teratoma. Advanced age is a signi cant risk factor for malignant transformation in mature cystic teratoma. 

scholarly journals Mature Cystic Teratoma in Douglas’ Pouch

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Kenji Ohshima ◽  
Anna Umeda ◽  
Ayako Hosoi ◽  
Toshiya Yamamoto ◽  
Satoru Munakata
Keyword(s):  
Squamous Epithelium ◽  
Laparoscopic Resection ◽  
Ovarian Neoplasms ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Ovarian Teratoma ◽  
Pathologic Diagnosis ◽  
First Case ◽  
Stratified Squamous Epithelium ◽  
Douglas Pouch

Mature cystic teratoma is one of the most common ovarian neoplasms, but extragonadal teratoma is rare. Teratoma in Douglas’ pouch is extremely rare, and only 12 cases have been reported since the first case was described in 1978. We report a 20-year-old woman with a multicystic mass in Douglas’ pouch that was treated via laparoscopic resection. The tumor consisted of cysts lined by stratified squamous epithelium with an accumulation of keratin debris and various mature tissues. No immature elements or malignancy was found in the tumor, confirming the pathologic diagnosis of a mature cystic teratoma. The teratoma contained no ovarian tissues and both of the ovaries were intact on laparoscopy. These findings suggest that the teratoma originated primarily in Douglas’ pouch rather than being caused by autoamputation of a previously existing ovarian teratoma. This is the first case that simultaneously showed normal ovaries and a teratoma in Douglas’ pouch on laparoscopy.

Short-term and long-term outcomes of laparoscopic pylorus-preserving gastrectomy.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 181-181
Author(s):  
Haruna Onoyama ◽  
Haruhiko Cho ◽  
Ryouki Oohinata,
Keyword(s):  
Weight Loss ◽  
Distal Gastrectomy ◽  
Early Stage ◽  
Operation Time ◽  
Postoperative Recurrence ◽  
Middle Part ◽  
Significant Difference ◽  
Hospital Deaths ◽  
The Mean ◽  
And Function

181 Background: Distal gastrectomy is still a standard surgical procedure for early gastric cancer locating in the middle third of the stomach. Laparoscopic pylorus-preserving gastrectomy (LPPG) is promising method which can achieve both minimally invasive and function-preserving outcomes; however, the advantage of PPG against laparoscopic distal gastrectomy (LDG) has not been clarified. Methods: This study examined the clinical outcomes of 71 patients who underwent LPPG for cT1 N0 GC located in the middle part of the stomach and 168 patients who underwent LDG with BillrothI reconstruction for cT1 N0 GC located in the middle or lower part of the stomach between September 2006 and December 2014. Surgical outcomes of LPPG were retrospectively compared with those of LDG. Results: The pathological T- and N-stage of the two groups were similar. There was no significant difference in the mean number of resected lymph nodes (37 in LPPG and 33 in LDG). Operation time was longer in LPPG than LDG (248min:LPPG, 228min:LDG) and blood loss were higher in LPPG than LDG (72ml:LPPG, 54ml:LDG). Postoperative hospital stay was longer in LPPG than LDG (13days:LPPG, 11days:LDG). There was no difference in the surgical complications (12.7%:LPPG, 9.5%:LDG) and no mortality occurred(no in-hospital deaths). Only one case of LDG was died of postoperative recurrence. The mean weight loss rate in 3 years after gastrectomy was lower in LPPG than in LDG (7.7% and 10.4%, respectively). Conclusions: LPPG is an acceptable and favorable operative method with possible prevention of weight loss for clinically diagnosed early stage GC.

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