scholarly journals Ulcerative Cutaneous Lesions Synchronously Present with the Diagnosis of Primary Lung Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Khaldoon Shaheen ◽  
Abdul Hamid Alraiyes ◽  
Motaz Baibars ◽  
Ama Paintsil ◽  
M. Chadi Alraies
Keyword(s):  
Lung Cancer ◽  
Skin Biopsy ◽  
Primary Lung Cancer ◽  
Clinical Information ◽  
Skin Lesions ◽  
Skin Metastasis ◽  
Cutaneous Lesions ◽  
Skin Metastases ◽  
History Of

The percentage of patients with lung cancer that develop skin metastases is low. The diagnosis is usually made using clinical information and skin biopsy in patients with suspicious skin lesions and history of smoking or lung cancer. The prognosis for patients having lung cancer with skin metastasis is very poor. We describe findings in a 70-year-old man with lung cancer with skin metastases. Interestingly, multiple skin lesions were the first manifestation of the underlying lung cancer. The prognosis for patients having lung cancer with skin metastasis is thus very poor.

scholarly journals Scrotal Skin Metastases Revealing a Prostatic Adenocarcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Idriss Ziani ◽  
Zayd El Boukili El Makhoukh ◽  
Ahmed Ibrahimi ◽  
Omar Bellouki ◽  
Jihane Benahmed ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Skin Biopsy ◽  
Past History ◽  
Skin Lesions ◽  
Prostate Adenocarcinoma ◽  
Cutaneous Metastasis ◽  
Skin Metastasis ◽  
Scrotal Skin ◽  
Cutaneous Lesions ◽  
Skin Metastases

Introduction. Prostate cancer is the most common cancer in men. Cutaneous metastasis from prostate cancer is an unusual clinical finding. Scrotal skin metastasis revealing a prostate adenocarcinoma is even rarer. Case Report. We report the case of a 78-year-old patient, who initially consulted for nonspecific scrotal skin lesions evolving for 4 months. Patient’s past history revealed urinary disorders. Physical examination and PSA levels led to perform a prostate biopsy, and the diagnosis of prostate adenocarcinoma was made. Bone scintigraphy showed that the cancer has spread to the bones. Imaging studies showed that the cutaneous lesions were limited to the scrotal wall. Cutaneous metastasis was suspected and was proven on skin biopsy. The patient received second-generation hormone therapy with good clinical and biological outcomes. Discussion. Based on literature review of nearly 2,500 skin metastases, we found that only 436 were spreading from the genitourinary tract. Skin metastasis from prostate adenocarcinoma is a rare entity with a low incidence rate (0.36%). Conclusion. Skin metastases, and especially in the scrotum, are exceptional in prostate cancer. However, in any patient with a prostate adenocarcinoma, nonspecific cutaneous lesions should lead to perform skin biopsy in order to identify and initiate treatment of cutaneous metastases.

Predicting factors for early and long-term mortality after thoracotomy in patients with primary lung cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e18562-e18562
Author(s):  
Cynthia van Arkel ◽  
Daphne Dumoulin ◽  
Bart van Straten ◽  
Joost ter Woorst ◽  
Saskia Houterman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Regression Analysis ◽  
Primary Lung Cancer ◽  
Early Mortality ◽  
Predicting Factors ◽  
Time Period ◽  
History Of ◽  
Long Term Mortality

e18562 Background: To determine factors predicting early and long term mortality in patients who underwent a thoracotomy because of primary lung cancer. Methods: Data of patients who underwent a thoracotomy in the Catharina Hospital Eindhoven between 1 January 1995 and 1 January 2011 have been collected retrospectively from the medical files. Early mortality was defined as mortality <30 days after surgery. Last date of follow up was 1 January 2013. Patients were divided in three periods according to date of surgery (1: 1995-1999, 2: 2000-2004 and 3: 2005-2010). Predicting factors for early mortality were assessed with uni- and multivariate logistic regression analysis. For long term mortality and survival predicting factors were assessed using the Cox proportional hazards model and Kaplan-Meier survival curves. Results: In total 501 patients underwent a thoracotomy due to primary lung cancer. Overall 30 day mortality was 5.8% (n=29). Early mortality was 3.0% for lobectomy (n=289), 0.2% for bilobectomy (n=29) and 11% for pneumonectomy (n=109). Multivariate analysis showed that age over 70 (p=0.002), pneumonectomy (p=0.008) and a pre-operative VO2max of <15 ml/kg/min (p=0.02) were significant predictors of early mortality. With respect to long term survival, 308 (62%) patients had died at the end of the follow-up period. Median survival time was 44 months, with an overall 5- and 10- year survival of 45% and 27% respectively. The 5- and 10-year survival for stage I, II and III-IV was 61% and 37%; 46% and 30%;16% and 6.6%, respectively (p<0.0001, log rank test). Finally Cox regression analysis showed that stage (stage I (HR 0.30; 95% CI 0.22-0.42), stage II (HR 0.38; 95% CI 0.26-0.57) compared to stage III-IV, FEV1% ≤70% (HR 1.57; 95% CI 1.61-2.11), a history of cerebrovascular disease (CVD) (HR 1.97; 95% CI 1.20-3.23) and surgery in an earlier time period (1 (HR 1.50; 95% CI 1.04-2.17); 2 (HR 1.46; 95% CI 1.05-2.02) compared to 3) were significant predictors of long term mortality. Conclusions: In this cohort age, pneumonectomy and pre-operative VO2max are significant predictors of early mortality. Significant predictors of long term mortality are disease stage, FEV1%, a history of CVD and surgery in an earlier time period.

scholarly journals Ileo-psoas muscle metastasis from pulmonary carcinoma

1970 ◽  
Vol 2 (3) ◽  
pp. 251-253 ◽  
Author(s):  
S Parajuli ◽  
RB Basnet ◽  
A Tuladhar
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Psoas Muscle ◽  
Excisional Biopsy ◽  
Heavy Smoking ◽  
Pulmonary Carcinoma ◽  
Muscle Metastasis ◽  
Unusual Phenomenon ◽  
History Of ◽  
Tomography Scan

Metastatic disease to muscle is rare and may be misdiagnosed when it is the presenting symptom, particularly in the absence of a known primary tumor. Skeletal muscle metastasis as a mode of presentation of primary lung cancer is an unusual phenomenon. Here, we report a case of ileo-psoas muscle metastasis from lung cancer as the initial clinical manifestation in a 58 year-old male with a personal history of heavy smoking. Excisional biopsy of the mass in the ileo-psoas muscle revealed metastatic adenocarcinoma. Computed tomography scan of the chest for a primary search was done and found to be pulmonary carcinoma. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6033 JPN 2012; 2(3): 251-253

scholarly journals Case Report: Mastocytosis: The Long Road to Diagnosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Tiago Azenha Rama ◽  
Diana Martins ◽  
Nuno Gomes ◽  
Jorge Pinheiro ◽  
Ana Nogueira ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Case Report ◽  
Mast Cells ◽  
Allergic Sensitization ◽  
Skin Lesions ◽  
Normal Serum ◽  
Cutaneous Lesions ◽  
History Of ◽  
Exercise Induced ◽  
Low Prevalence

Mastocytosis is a heterogeneous group of disorders characterized by expansion and accumulation of clonal mast cells. Patients mainly present with either cutaneous lesions, anaphylaxis, or both. Its low prevalence and unusual features often hinder its diagnosis for several years. We report the case of an 18-year-old male who was referred to our department with a long-standing history of atypical skin lesions, allergic rhinitis, exercise-induced bronchoconstriction and what was believed to be food-related flushing and anaphylaxis, that was later diagnosed with mastocytosis. This case illustrates the need to consider investigating for mastocytosis when recurrent anaphylaxis is present, especially in the presence of atypical skin lesions, even if normal serum basal tryptase levels and allergic sensitization are present.

scholarly journals Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

2019 ◽  
Vol 2019 ◽  
pp. 1-23
Author(s):  
Qi Shen ◽  
Wen-xiang Wang ◽  
Qiu-ping Xu ◽  
Wen-min Xiong ◽  
Zhi-qiang Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Primary Lung Cancer ◽  
Case Control ◽  
Single Nucleotide ◽  
History Of ◽  
Control Study ◽  
History Of Cancer ◽  
Lung Cancer Susceptibility

The purpose of the current study is to explore the contribution of single-nucleotide polymorphisms (SNPs) of REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 to the risk of lung cancer. A questionnaire survey was used to obtain basic information of the included subjects. A case control study was performed in 1121 patients and 1121 controls. All subjects were subjected to blood sampling for genomic DNA extraction and genotyping of the cancer stem cell-associated gene SNPs, including REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 by real-time PCR. The association with the risk of primary lung cancer and interaction with environmental factors were assessed using unconditional logistic regression for the odds ratios and corresponding 95% confidence intervals. The genotype frequency distribution of OCT4 rs13409 loci was statistically significant, but there was no significant difference in the rest of the loci between lung cancer patients and healthy controls. The OCT4 gene was also related with lung cancer susceptibility in the genetic model after adjusting for lung cancer-related factors. Despite the presence of the dominant or recessive model, the four loci polymorphisms were associated with pollution near the place of residence, house type, worse ventilation situation, smoking, passive smoking, cooking oil fumes (COF), and family history of cancer, which increased the risk of lung cancer. Nonmarried status, 18.5≤BMI, COF, smoking, passive smoking, family history of cancer, and history of lung disease were independent risk factors of lung cancer susceptibility. Additionally, college degree or above, no pollution near the place of residence, protective genotype 1 or 2, and well ventilation can reduce the occurrence of lung cancer. There is an interaction between the four loci and environmental factors, and OCT4 rs13409 is a risk factor of primary lung cancer.

Prostate adenocarcinoma and cutaneous metastases

2020 ◽  
pp. 205141582095475
Author(s):  
Jeff John ◽  
Tanya Wantenaar ◽  
John Lazarus ◽  
Ken Kesner
Keyword(s):  
Prostate Cancer ◽  
Skin Lesions ◽  
Prostate Adenocarcinoma ◽  
Cutaneous Lesions ◽  
Cutaneous Metastases ◽  
Primary Malignancy ◽  
Level Of Evidence ◽  
History Of ◽  
Adenocarcinoma Of The Prostate ◽  
Nodular Lesions

Prostate cancer is the second most frequently diagnosed cancer in men and the fifth leading cause of mortality worldwide. Men of African descent with prostate adenocarcinoma tend to present late with advanced, aggressive and often metastatic disease. Cutaneous metastases are extremely rare, with the incidence reported to be as low as 0.36%. We report a case of prostate adenocarcinoma with cutaneous metastases. A 69-year-old African male known to the urology unit, with metastatic adenocarcinoma of the prostate, presented with a two-week history of pale-to-purple large nodular lesions on the skin of his left hemiscrotum and smaller nodules on the penile shaft. Punch biopsies of the scrotal nodules revealed metastatic prostate adenocarcinoma. Bilateral orchidectomy and excision of the cutaneous lesions were performed. Although cutaneous metastases are rare, more so in patients with adenocarcinoma of the prostate, any skin lesions in patients with a known primary malignancy should raise a suspicion of metastasis. All physicians should therefore have a low threshold for the biopsy of any unusual skin lesion in patients with known prostate cancer. Level of evidence: 5.

scholarly journals Ulcerative skin metastases of primary lung cancer

2014 ◽  
Vol 45 (1) ◽  
pp. 135-135
Author(s):  
A. Pircher ◽  
G. Gastl ◽  
I. Heidegger
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Skin Metastases

scholarly journals Lower Extremity Cutaneous Lesions as the Initial Presentation of Metastatic Adenocarcinoma of the Colon

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Dhyan Rajan ◽  
Mitanshu Shah ◽  
Pooja Raghavan ◽  
Shanza Mujeeb ◽  
Sadat Rashid ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Metastatic Disease ◽  
Skin Lesions ◽  
Initial Presentation ◽  
Cutaneous Lesions ◽  
Cutaneous Metastases ◽  
Surgical Incision ◽  
History Of ◽  
Adenocarcinoma Of The Colon ◽  
New Skin

Cutaneous metastases from colorectal cancers are rare and are usually present on the abdominal wall or previous surgical incision sites. Remote cutaneous lesions have been reported, however, often occur in the setting of widespread metastatic disease including other visceral secondaries. We present a case of lower extremity cutaneous metastases as the first sign of metastatic disease in a patient with adenocarcinoma of the colon. This case illustrates that new skin lesions may be the initial presentation of metastatic disease in a patient with a history of cancer.

scholarly journals Ulcerative Skin Metastasis Lesion in Non-Small Cell Lung Cancer

2020 ◽  
Vol 16 (2) ◽  
pp. 106-112
Author(s):  
Jaehyun Bae ◽  
Dongkeun Jun ◽  
Jeenam Kim ◽  
Hyungon Choi ◽  
Donghyeok Shin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surgical Resection ◽  
Perforator Flap ◽  
Skin Lesions ◽  
Metastatic Lesion ◽  
Cutaneous Metastasis ◽  
Skin Metastasis ◽  
Superior Gluteal Artery ◽  
Patients With Cancer ◽  
Venous Ulcers

Venous ulcers, ischemic wounds and skin lesions from autoimmune diseases are some examples of unhealing wounds. Practitioners treating such wounds should consider the possibility of skin metastasis of neoplasms, especially in patients with cancer. Treatment of cutaneous metastasis in cancer must include both surgical resection and chemotherapy. Here we present a patient who had lung cancer with skin metastasis. Though incidence of metastasis from lung cancer is known to be as low as 1% to 12%, its prognosis is poor. Also, the clinical features of these skin lesions tend to vary, often resulting in them being misdiagnosed as benign lesions. The diagnosis of malignancy for this particular case was delayed. After the metastatic lesion was diagnosed as such, surgical resection was performed and the defect caused by wide excision was covered by a superior gluteal artery perforator flap. Though the patient was administered an anticancer drug, the wound healed well after the operation.

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