scholarly journals Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Stephanie Hui-Su Lim ◽  
Sharon Mary Wilson ◽  
Arnagretta Hunter ◽  
Jane Hill ◽  
Philip Beale
Keyword(s):  
Takotsubo Cardiomyopathy ◽  
Rectal Adenocarcinoma ◽  
Chemotherapeutic Agents ◽  
Mural Thrombus ◽  
Rare Occurrence ◽  
Thromboembolic Complications ◽  
Chemotherapeutic Drug ◽  
Review Of The Literature ◽  
Potential Toxicity ◽  
Clinical Phenomenon

Takotsubo cardiomyopathy is a rare but increasingly recognized phenomenon, which can occur as a side-effect of chemotherapeutic agents, in particular, the antimetabolite 5-fluorouracil. We describe a case of delayed Takotsubo cardiomyopathy after 3 weeks of adjuvant 5-fluorouracil for resected rectal adenocarcinoma in a 66-year-old female, supported by angiographic, electrocardiographic, and echocardiographic features. As a complication, she developed an apical mural thrombus with subsequent cerebral thromboembolic events and was successfully anticoagulated to make a full recovery. We present a review of the literature on Takotsubo cardiomyopathy secondary to 5-fluorouracil and the rare occurrence of thromboembolic complications. As this is a significant clinical phenomenon which involves a multispeciality approach to management, oncologists and cardiologists need to recognize it as a potential toxicity of a widely administered chemotherapeutic drug.

scholarly journals Palpable Penile Metastases: A Bizarre Presentation of Rectal Adenocarcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Liza Cholin ◽  
Sarah Perz ◽  
Furman Mahmood ◽  
Saleem Zafar
Keyword(s):  
Poor Prognosis ◽  
Rectal Adenocarcinoma ◽  
Initial Presentation ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Penile Metastases

Metastasis to the penis is an uncommon occurrence, with only about 370 cases reported in the literature to date. The majority of the primary tumors are genitourinary in origin. We report on a patient with undiagnosed disseminated rectal adenocarcinoma, who first presented with lesions of the corporal bodies. A review of the literature indicates that corporeal metastasis as an initial presentation of malignancy is an extremely rare occurrence and carries a very poor prognosis.

Squamous Differentiation in a Sarcomatoid Chromophobe Renal Cell Carcinoma: An Unusual Case Report With Review of the Literature

2008 ◽  
Vol 132 (10) ◽  
pp. 1672-1674
Author(s):  
Seethalakshmi Viswanathan ◽  
Sangeeta B. Desai ◽  
S. R. Prabhu ◽  
Mahul B. Amin
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Unusual Case ◽  
Chromophobe Renal Cell Carcinoma ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Squamous Differentiation ◽  
Unusual Case Report

Abstract We describe an extremely rare occurrence of a squamous differentiation in a sarcomatoid chromophobe renal cell carcinoma in a 45-year-old woman with nodal and lung metastasis at presentation. The tumor on histology showed all 3 components intimately admixed with each other, which to the best of our knowledge is the first such case to be reported in the literature. The renal pelvis was smooth walled and uninvolved. Kidney-specific cadherin was positive in the chromophobe renal cell carcinoma areas and negative in the sarcomatoid and squamous areas.

scholarly journals The Promise of Integrins as Effective Targets for Anticancer Agents

2002 ◽  
Vol 2 (3) ◽  
pp. 124-130 ◽  
Author(s):  
William L. Rust ◽  
Stephen W. Carper ◽  
George E. Plopper
Keyword(s):  
Monoclonal Antibodies ◽  
Drug Design ◽  
Cell Surface ◽  
Signaling Pathways ◽  
Anticancer Agents ◽  
Chemotherapeutic Agents ◽  
Migration And Invasion ◽  
Chemotherapeutic Drug ◽  
Cellular Processes ◽  
Adenovirus Vectors

This review will briefly describe integrin function, address why integrins are attractive targets for chemotherapeutic drug design, and discuss some ongoing studies aimed at inhibiting integrin activity. Integrins are cell surface heterodimeric receptors. They modulate many cellular processes including: growth, death (apoptosis), adhesion, migration, and invasion by activating several signaling pathways. Many potential chemotherapeutic agents target integrins directly (eg, polypeptides, monoclonal antibodies, adenovirus vectors). These agents may be clinically useful in controlling the metastatic spread of cancer.

Idiopathic Bilateral Auricular Ossificans: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (12) ◽  
pp. 1432-1434 ◽  
Author(s):  
Whitney A. High ◽  
Matthew J. Larson ◽  
Mai P. Hoang
Keyword(s):  
Radiographic Examination ◽  
Ectopic Calcification ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Routine Testing ◽  
Elastic Cartilage ◽  
Addison Disease ◽  
Pathologic Findings ◽  
History Of ◽  
The Right

Abstract Petrification of the auricle results in a rigid and immalleable ear. The etiology of such a finding is usually ectopic calcification. The condition has been associated with injurious processes, such as cold injury, and with various endocrinopathies, including Addison disease. In a significant number of cases, ossification occurs without knowledge of the precipitating cause or event. True auricular ossification is a rare occurrence, with only 12 histologically confirmed cases in the literature. We herein present the clinical and pathologic findings of another case. A 60-year-old man with diet-controlled diabetes presented with a 10-year history of slowly and insidiously stiffened auricles. He denied any precipitating historical events. Routine testing did not demonstrate systemic abnormalities. Radiographic examination revealed opacities consistent with bony structure in the auricles of the ears, with the right more prominent than the left. Histologic sampling demonstrated ossification with deposition of trabecular bone in proximity to normal elastic cartilage.

scholarly journals Tibial Tuberosity Fracture in an Elderly Gentleman: An Unusual Injury Pattern

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Emma Brown ◽  
Mohammad Taaha Sohail ◽  
Jonathan West ◽  
Benjamin Davies ◽  
Georgios Mamarelis ◽  
...  
Keyword(s):  
Rare Case ◽  
Avulsion Fracture ◽  
Left Knee ◽  
Injury Pattern ◽  
Tibial Tuberosity ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Tibial Tuberosity Fracture ◽  
Unusual Injury

Avulsion fracture of the tibial tuberosity is an infrequent injury in adolescents and an extremely rare occurrence in adults. We describe the case of an 86-year-old gentleman presenting after a fall, sustaining injury to the left knee. Radiographs of the left knee showed avulsion fracture of the tibial tuberosity. The purpose of this study was to present a rare case of tibial tuberosity avulsion fracture in an adult, the treatment performed, and the challenges faced. The case is discussed with the review of the literature.

scholarly journals Bobble-head doll syndrome: report of 2 cases and a review of the literature, with video documentation of the clinical phenomenon

2018 ◽  
Vol 21 (3) ◽  
pp. 236-246 ◽  
Author(s):  
Bryan Renne ◽  
Stefan Rueckriegel ◽  
Sudheesh Ramachandran ◽  
Julia Radic ◽  
Paul Steinbok ◽  
...  
Keyword(s):  
Signs And Symptoms ◽  
Visual Disturbance ◽  
Autism Spectrum ◽  
Head Movements ◽  
Third Ventriculostomy ◽  
Review Of The Literature ◽  
Suprasellar Cyst ◽  
Clinical Phenomenon ◽  
Video Documentation ◽  
Head Rotations

Bobble-head doll syndrome (BHDS) is a rare pediatric movement disorder presenting with involuntary 2- to 3-Hz head movements. Common signs and symptoms also found on presentation include macrocephaly, ataxia, developmental delay, optic disc pallor or atrophy, hyperreflexia, tremor, obesity, endocrinopathy, visual disturbance or impairment, headache, and vomiting, among others. The syndrome is associated with suprasellar cysts, third ventricular cysts, or aqueductal obstruction, along with a few other less common conditions. The cause of involuntary head motions is not understood. Treatment is surgical. The authors present 2 cases of BHDS. The first is a 14-year-old boy with BHDS associated with aqueductal obstruction and triventricular hydrocephalus secondary to a tectal tumor. He was successfully treated by endoscopic third ventriculostomy, and all symptoms resolved immediately in the recovery room. This case is unusual in its late age of symptom onset, the primacy of lateral (“no-no”) involuntary head rotations, and the associated tectal tumor. The second case is a 7.5-year-old girl with BHDS associated with a suprasellar cyst. She was successfully treated with an endoscopic fenestration but preexisting endocrinopathy persisted, and the patient was diagnosed with autism spectrum disorder at age 12 years. This second case is more typical of BHDS. A comprehensive and up-to-date review of the literature of BHDS and video documentation of the phenomenon are presented.

scholarly journals Unusual case of locally advanced and metastatic paratesticular liposarcoma: a case report and review of the literature

2015 ◽  
Vol 87 (1) ◽  
pp. 87 ◽  
Author(s):  
Stefano Chiodini ◽  
Lorenzo G. Luciani ◽  
Tommaso Cai ◽  
Alberto Molinari ◽  
Luca Morelli ◽  
...  
Keyword(s):  
Lower Limb ◽  
Unusual Case ◽  
Locally Advanced ◽  
Rapid Progression ◽  
Nodal Metastases ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Favourable Evolution ◽  
The Right ◽  
Paratesticular Liposarcoma

Liposarcoma accounts for 20% of all sarcomas and is a rare occurrence in the paratesticular region. We present the case of a 66-year-old man with a massive liposarcoma of the right scrotum invading the lower limb and the abdominal wall skin. The case concerns an unusually large and aggressive liposarcoma (25 cm), presenting with multiple lung and nodal metastases. The patient had an unfavourable evolution with rapid progression of metastases, although there were no signs of local disease. In this case, a wide local excision was performed in order to obtain local control of the disease. Even though paratesticular sarcomas might have a more favourable evolution, the association with lung involvement carries an ominous prognosis. Diagnosis of paratesticular sarcoma should be kept in mind in case of irregular necrotic masses in the inguinal and scrotal region.

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