scholarly journals Palpable Penile Metastases: A Bizarre Presentation of Rectal Adenocarcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Liza Cholin ◽  
Sarah Perz ◽  
Furman Mahmood ◽  
Saleem Zafar
Keyword(s):  
Poor Prognosis ◽  
Rectal Adenocarcinoma ◽  
Initial Presentation ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Penile Metastases

Metastasis to the penis is an uncommon occurrence, with only about 370 cases reported in the literature to date. The majority of the primary tumors are genitourinary in origin. We report on a patient with undiagnosed disseminated rectal adenocarcinoma, who first presented with lesions of the corporal bodies. A review of the literature indicates that corporeal metastasis as an initial presentation of malignancy is an extremely rare occurrence and carries a very poor prognosis.

scholarly journals Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Stephanie Hui-Su Lim ◽  
Sharon Mary Wilson ◽  
Arnagretta Hunter ◽  
Jane Hill ◽  
Philip Beale
Keyword(s):  
Takotsubo Cardiomyopathy ◽  
Rectal Adenocarcinoma ◽  
Chemotherapeutic Agents ◽  
Mural Thrombus ◽  
Rare Occurrence ◽  
Thromboembolic Complications ◽  
Chemotherapeutic Drug ◽  
Review Of The Literature ◽  
Potential Toxicity ◽  
Clinical Phenomenon

Takotsubo cardiomyopathy is a rare but increasingly recognized phenomenon, which can occur as a side-effect of chemotherapeutic agents, in particular, the antimetabolite 5-fluorouracil. We describe a case of delayed Takotsubo cardiomyopathy after 3 weeks of adjuvant 5-fluorouracil for resected rectal adenocarcinoma in a 66-year-old female, supported by angiographic, electrocardiographic, and echocardiographic features. As a complication, she developed an apical mural thrombus with subsequent cerebral thromboembolic events and was successfully anticoagulated to make a full recovery. We present a review of the literature on Takotsubo cardiomyopathy secondary to 5-fluorouracil and the rare occurrence of thromboembolic complications. As this is a significant clinical phenomenon which involves a multispeciality approach to management, oncologists and cardiologists need to recognize it as a potential toxicity of a widely administered chemotherapeutic drug.

scholarly journals Pancreatic Cancer Exposome Profile to Aid Early Detection and Inform Prevention Strategies

2021 ◽  
Vol 10 (8) ◽  
pp. 1665
Author(s):  
Maria J. Monroy-Iglesias ◽  
Saoirse Dolly ◽  
Debashis Sarker ◽  
Kiruthikah Thillai ◽  
Mieke Van Hemelrijck ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Immune Responses ◽  
Inflammatory Markers ◽  
Poor Prognosis ◽  
Associated Factors ◽  
Review Of The Literature ◽  
Prevention Strategies ◽  
Factors Influencing ◽  
Detection Strategies

Pancreatic cancer (PCa) is associated with a poor prognosis and high mortality rate. The causes of PCa are not fully elucidated yet, although certain exposome factors have been identified. The exposome is defined as the sum of all environmental factors influencing the occurrence of a disease during a life span. The development of an exposome approach for PCa has the potential to discover new disease-associated factors to better understand the carcinogenesis of PCa and help with early detection strategies. Our systematic review of the literature identified several exposome factors that have been associated with PCa alone and in combination with other exposures. A potential inflammatory signature has been observed among the interaction of several exposures (i.e., smoking, alcohol consumption, diabetes mellitus, obesity, and inflammatory markers) that further increases the incidence and progression of PCa. A large number of exposures have been identified such as genetic, hormonal, microorganism infections and immune responses that warrant further investigation. Future early detection strategies should utilize this information to assess individuals’ risk for PCa.

scholarly journals Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid

2021 ◽  
Vol 18 (15) ◽  
pp. 7819
Author(s):  
Mateusz Kozłowski ◽  
Katarzyna Nowak ◽  
Agnieszka Kordek ◽  
Aneta Cymbaluk-Płoska
Keyword(s):  
Clinical Case ◽  
Ovarian Neoplasms ◽  
Treatment Guidelines ◽  
Case Reports ◽  
Review Of The Literature ◽  
Pharmacological Treatments ◽  
International Database ◽  
Primary Tumors ◽  
Fertility Sparing ◽  
Oncological Centers

Carcinosarcoma, leiomyosarcoma, melanoma and carcinoid as primary tumors in the ovary are extremely rare. In this paper, the authors reviewed the literature from 2010 to 2021, based on specific criteria, to analyze the treatment of these rare ovarian neoplasms. We also aimed to verify whether modern therapies have been found in recent years. For this article, 80 papers were finally selected. The vast majority of the articles were clinical case reports. Despite single mentions of new potential pharmacological treatments, surgery (radical or fertility-sparing) is definitely the mainstay of treatment. There are currently no treatment guidelines for these tumors. A review of the literature has revealed the use of various adjuvant treatments. We, therefore, believe that a more detailed understanding of the biology of these tumors is necessary in order to find new target points for treatment. We would like to emphasize the importance of creating an international database of rare ovarian tumors which would make it possible to gather data from various oncological centers and enable further research into these neoplasms.

scholarly journals Supraclavicular lymph node metastases from distant primary tumors: Case reports and review of the literature

2021 ◽  
Vol 81 ◽  
pp. 105720
Author(s):  
Youssef Oukessou ◽  
Yassir Hammouda ◽  
Khadija El Bouhmadi ◽  
Redallah Larbi Abada ◽  
Mohamed Roubal ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Case Reports ◽  
Review Of The Literature ◽  
Supraclavicular Lymph Node ◽  
Primary Tumors ◽  
Node Metastases

scholarly journals Small Cell Ovarian Cancer in Adolescents: Report of Two Cases and Review of the Literature

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
M. Rovithi ◽  
A. G. Pallis ◽  
A. Kalykaki ◽  
E. Lagoudaki ◽  
L. Giannikaki ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Combination Chemotherapy ◽  
Poor Prognosis ◽  
Relevant Literature ◽  
Malignant Neoplasm ◽  
Standard Of Care ◽  
Small Cell ◽  
Review Of The Literature

Ovarian small cell carcinoma is a rare and highly malignant neoplasm carrying a poor prognosis. Although combination chemotherapy remains the cornerstone of treatment due to the rarity of these tumors, no regimen can be recommended as standard of care although in the majority of cases platinum-based regimens are used. Herein, we report two cases of small cell carcinoma of the ovaries along with a review of the relevant literature.

scholarly journals Adrenergic cardiomyopathy and cardiogenic shock as initial presentation of pheochromocytoma. A case report and review of the literature

2018 ◽  
Vol 49 ◽  
pp. 145-148 ◽  
Author(s):  
Esther Gil-Barrionuevo ◽  
José Maria Balibrea ◽  
Enric Caubet ◽  
Oscar Gonzalez ◽  
Ramón Vilallonga ◽  
...  
Keyword(s):  
Case Report ◽  
Cardiogenic Shock ◽  
Initial Presentation ◽  
Review Of The Literature

Malignant Rhabdoid Tumor of the Kidney in an Adult: A Case Report and Review of the Literature

2003 ◽  
Vol 127 (9) ◽  
pp. e371-e373 ◽  
Author(s):  
Hong Qi Peng ◽  
Albert E. Stanek ◽  
Saul Teichberg ◽  
Barry Shepard ◽  
Ellen Kahn
Keyword(s):  
Case Report ◽  
Aggressive Behavior ◽  
Poor Prognosis ◽  
Renal Tumor ◽  
Adult Population ◽  
Rhabdoid Tumor ◽  
Malignant Rhabdoid Tumor ◽  
Review Of The Literature ◽  
Electron Microscopic ◽  
Rhabdoid Tumors

Abstract Malignant rhabdoid tumor of the kidney is an uncommon renal tumor in children. The tumor has aggressive behavior and a poor prognosis and is extremely rare in adults; only 3 cases of renal rhabdoid tumors have been reported in adults. We describe here the microscopic, immunohistochemical, and electron microscopic characteristics of another case in a 38-year-old woman. This case reinforces the importance of recognizing this entity in the adult population.

Squamous Differentiation in a Sarcomatoid Chromophobe Renal Cell Carcinoma: An Unusual Case Report With Review of the Literature

2008 ◽  
Vol 132 (10) ◽  
pp. 1672-1674
Author(s):  
Seethalakshmi Viswanathan ◽  
Sangeeta B. Desai ◽  
S. R. Prabhu ◽  
Mahul B. Amin
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Unusual Case ◽  
Chromophobe Renal Cell Carcinoma ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Squamous Differentiation ◽  
Unusual Case Report

Abstract We describe an extremely rare occurrence of a squamous differentiation in a sarcomatoid chromophobe renal cell carcinoma in a 45-year-old woman with nodal and lung metastasis at presentation. The tumor on histology showed all 3 components intimately admixed with each other, which to the best of our knowledge is the first such case to be reported in the literature. The renal pelvis was smooth walled and uninvolved. Kidney-specific cadherin was positive in the chromophobe renal cell carcinoma areas and negative in the sarcomatoid and squamous areas.

scholarly journals Unusual Metastases Site of Thyroid Papillary Carcinoma: A Case Report and Review of the Literature

2020 ◽  
pp. 1-2
Author(s):  
Hicham Ngham
Keyword(s):  
Poor Prognosis ◽  
Radioactive Iodine ◽  
Subcutaneous Tissue ◽  
Review Of The Literature ◽  
Unusual Site ◽  
Thyroid Papillary ◽  
Scalp Metastasis ◽  
Unusual Metastases ◽  
Skull Lesion

Thyroid carcinoma with cranial scalp metastasis is an unusual site. Although these metastases have poor prognosis, early diagnosis and administration of accurate therapy using radioactive iodine seems likely to improve the survival rate and the quality of life. We report a case of a 50-years old woman presented to our ENT department with a slowly evolving lesion in the subcutaneous tissue of the skull occurred 10 years after right lobo-isthmectomy. The treatment was based on resection of the skull lesion as well as thyroid totalization and radioactive iodine

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