scholarly journals Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Aysegul Alpay ◽  
Nilgün Solak Tekin ◽  
Ishak Özel Tekin ◽  
H. Cevdet Altinyazar ◽  
Rafet Koca ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Thyroid Autoantibodies ◽  
Thyroid Function Tests ◽  
Control Groups ◽  
Autologous Plasma ◽  
Autologous Serum Skin Test ◽  
Autoimmune Urticaria ◽  
And Control

Previous studies indicate that 25–45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62%) patients and 5 (10%) control patients had positive ASST; 21 (42%) patients and 3 (6%) control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASSTP<0.001; APSTP<0.001). Thirteen (26%) patients and 5 (10%) control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TGP=0.317; anti-TPOP=0.269). We consider that the ASST and APST can both be used asin vivotests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU.

scholarly journals Association between chronic spontaneous urticaria and thyroid autoimmunity: a case control study from a tertiary care centre

2017 ◽  
Vol 3 (1) ◽  
pp. 64 ◽  
Author(s):  
Olasseri K. Reena Mariyath ◽  
Manikoth P. Binitha ◽  
Vadakke P. Anilakumari ◽  
George Biju ◽  
Pappinisseri K. Nikhila ◽  
...  
Keyword(s):  
Skin Test ◽  
Thyroid Function ◽  
Antibody Level ◽  
Thyroid Autoimmunity ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Thyroid Peroxidase ◽  
Thyroid Function Tests ◽  
Autologous Serum Skin Test ◽  
Antibody Levels

<p class="abstract"><strong>Background:</strong> The exact etiology of chronic spontaneous urticaria is unknown in the majority of patients. A subset of chronic spontaneous urticaria can be autoimmune and may be associated with thyroid autoimmunity<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> Serum anti thyroid peroxidase (anti-TPO) antibody level and thyroid function tests (TFT) including triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) levels were estimated in 100patients with chronic spontaneous urticaria and 50 controls. Autologous serum skin test (ASST) was done in 84 chronic urticaria patients and 21 patients with high anti-TPO antibody.<strong></strong></p><p class="abstract"><strong>Results:</strong> High anti-TPO antibodies and abnormal thyroid function were seen in 24 (24%) patients each. High anti-TPO antibody levels were seen in nine (18%) and abnormal TFT in 11 (22%) controls. Abnormal TSH was seen in 22 patients (22%) and 6 (12%) controls. Autologous serum skin test was positive in 53 patients with chronic spontaneous urticaria. It was positive in 16 and negative in five out of 21 patients with high anti-TPO antibody levels<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> Though there was a slight increase in abnormal anti-TPO antibody level and thyroid dysfunction in patients with chronic spontaneous urticaria compared to controls, it was not statistically significant<span lang="EN-IN">.</span></p>

scholarly journals Chronic urticaria: a clinico-etiological study and autologous serum skin test role in chronic idiopathic urticaria

2021 ◽  
Vol 7 (4) ◽  
pp. 552
Author(s):  
Purnachandra Badabagni ◽  
Sruthi Thammineedi ◽  
Ramadevi Birudala
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Thyroid Function Tests ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Physical Urticaria ◽  
Autoimmune Urticaria ◽  
Number Of Patients

<p class="abstract"><strong>Background:</strong> Appearance of wheals daily for more than six weeks is chronic urticarial (CU). No cause is identified in about 50-70% of chronic urticaria patients and are labelled as chronic idiopathic urticaria (CIU). The aim of the present study is to study the clinical and etiological pattern of chronic urticaria and to find out the incidence of autoimmune urticaria by performing autologous serum skin test (ASST) in patients with CIU.</p><p class="abstract"><strong>Methods:</strong> This was a cross sectional study enrolling 100 chronic urticaria patients satisfying including and excluding criteria. The study was done for a period of 1 year. ASST was done in all the CIU patients after recording detailed history, complete physical and systemic examination.</p><p class="abstract"><strong>Results:</strong> Most of the patients (33%) were in 21-30 years age group with female preponderance (66%). Students (38%) followed by house wives (27%) were majorly involved. 21% patients had history of atopy and 8% had abnormal thyroid function tests. Causative factors noticed in 46% patients and remaining were idiopathic (54%). Infections (32.6%) constituted the major etiological factor followed by physical urticaria (30.4%), food (23.9%), medication (11%) and inhalants (2.1%). In infective agents, 46.6% were bacterial followed by helminthic (33.3%). In 29.6% of CIU patients, the ASST was positive indicating auto-immune urticaria.</p><p class="abstract"><strong>Conclusions:</strong> The etiology cannot be identified in most number of patients and hence they were labelled as CIU and the common causative agents observed were infections followed by physical urticaria, food and medication. ASST is considered as the relevant screening test to detect autoimmune urticaria.</p>

scholarly journals Autologous serum skin test in 250 patients of chronic spontaneous urticaria at tertiary care hospital in Gujarat

2019 ◽  
Vol 5 (3) ◽  
pp. 466
Author(s):  
Sonal Gaurang Patel ◽  
Rima Rakesh Joshi ◽  
Raksha Maganlal Patel
Keyword(s):  
Skin Test ◽  
Tertiary Care ◽  
Cost Effective ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Care Hospital ◽  
In Vivo Test ◽  
Autologous Serum Skin Test ◽  
Autoimmune Urticaria

<p class="abstract"><strong>Background:</strong> Chronic urticaria (CU) is defined as urticaria persisting daily as or almost daily for more than 6 weeks and affecting 0.1% of the population. In chronic autoimmune urticaria, immunoglobulin G (lgG) auto antibodies react to the alpha subunit of the high-affinity lgE receptor (FceR1) on dermal mast cells and basophils, leading to chronic stimulation of these cells. This results in the release of histamine and other inflammatory mediators which cause urticaria and angioedema. More than half of the patients have autoimmune urticaria. ASST is the only in vivo test to detect autoimmune urticaria. The aim was to study the frequency of ASST positivity among patients with chronic spontaneous urticaria and to identify the clinical and laboratory parameters associated with positive ASST.</p><p class="abstract"><strong>Methods:</strong> The present study is prospective observational study of chronic spontaneous urticaria. ASST was performed in 250 patients fulfilling exclusion and inclusion criteria. Baseline investigations (CBC, ESR, urine, stool, RBS and CRP) were done for all the patients whereas specific investigations (ANA, Thyroid Profile, IgE, Anti H.Pylori IgG and skin biopsy) were done in selected cases.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 250 patients examined, 60% had positive autologous serum skin test suggestive of autoimmune urticaria. H. pylori antibodies were significantly higher (29%) in ASST positive patients. While antinuclear antibody (ANA) was positive in 4% and thyroid antibodies were present in 7% of patients with positive ASST. Serum IgE was elevated in 32% ASST positive patients.</p><p class="abstract"><strong>Conclusions:</strong> ASST is an easy, simple and cost effective screening test for chronic autoimmune urticaria.</p>

scholarly journals Association between Clinico-epidemiological Features in Chronic Urticaria with Autologous Serum Skin Test: A Cross-sectional Observational Study

2021 ◽  
Author(s):  
Usha Rani Tirupathi ◽  
Bhagya Rekha Manchiryala ◽  
Sruthi Kareddy
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Autologous Serum ◽  
Clinical Test ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Epidemiological Features ◽  
Chronic Inducible Urticaria ◽  
Autoimmune Urticaria ◽  
Significant Difference

Introduction: Urticaria is a frequent and heterogeneous skin disease characterised by the development of wheals (hives), angioedema, or both. Chronic urticaria is characterised by the occurrence of wheals lasting less than 24 hours, with or without angioedema occurring daily or almost daily lasting more than six weeks. The two subtypes of chronic urticaria are Chronic Spontaneous Urticaria (CSU) and Chronic Inducible Urticaria (CIU). Autologous Serum Skin Test (ASST) is the simplest and the best in-vivo clinical test for the detection of basophil histamine- releasing activity. ASST has a sensitivity of approximately 70% and a specificity of 80%. Aim: To study the association between clinico-epidemiological features of CSU with positive and negative ASST. Materials and Methods: The cross-sectional study was conducted on 80 clinically diagnosed cases of CSU attending the Department of Dermatology Venereology Leprology Outpatient Department at Mahatma Gandhi Memorial Hospital (Kakatiya Medical College), Warangal, Telangana, India; during the period of January 2016 to September 2017. The detailed history was taken; complete physical and cutaneous examination and laboratory investigations like Complete Blood Picture (CBP), Absolute Eosinophil Count (AEC), Erythrocytic Sedimentation Rate (ESR), Thyroid Function Test (TFT) were carried out. ASST was done and read after 30 minutes. Chi- square test was applied and the results analysed using Statistical Package for the Social Sciences (SPSS) version 10.0. Results: Out of total 80 patients included in the study, ASST was positive in 36 (45%) and negative in 44 (55%). ASST positive patients showed longer duration of the disease with increased frequency of attacks and longer duration of wheals. However, both ASST positive and negative groups did not show statistically significant difference in the age of occurrence, gender, angioedema, dermographism. Conclusion: Autoimmune urticaria has no distinctive clinical features. ASST positive, autoimmune urticaria patients have more severe disease with greater impact on quality of life. Thus, they may need more aggressive treatment.

scholarly journals Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients

2021 ◽  
Vol 4 (1) ◽  
pp. 24-29
Author(s):  
Mahvira Chow Liana Herman Adil ◽  
Nopriyati Nopriyati ◽  
Desi Oktariana ◽  
Yuli Kurniawati ◽  
Gita Dwi Prasasty
Keyword(s):  
Quality Of Life ◽  
Skin Test ◽  
Outpatient Clinic ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Bivariate Analysis ◽  
Female Group ◽  
Cross Sectional ◽  
Autologous Serum Skin Test

Several studies regarding the quality of life of chronic spontaneous urticaria patients based on Autologous Serum Skin Test (ASST) results have shown a variety of results. This study aims to determine the correlation between the quality of life and ASST results in chronic spontaneous urticaria patients at Dermatology and Venereology (DV) Outpatient Clinic of Dr. Mohammad Hoesin Hospital Palembang. This analytic observational study with a cross-sectional design used secondary data in the form of medical records. 76 samples met the inclusion criteria from 110 samples of chronic spontaneous urticaria patients at DV outpatient clinic. The distribution of chronic spontaneous urticaria patients was highest in the 17-25 year age group (23.7%) and the female group (64.5%). The majority of chronic spontaneous urticaria patients had negative ASST results (52.6%). The effect of chronic spontaneous urticaria on the decline in quality of life was mostly moderate (35.5%). The bivariate analysis between DLQI score and ASST results with a value of p = 0.307 or p> 0.05 showed no significant correlation between the quality of life and ASST results.

IL‐6 and IL‐1β expression is increased in autologous serum skin test of patients with chronic spontaneous urticaria

Allergy ◽  
2019 ◽  
Vol 74 (12) ◽  
pp. 2522-2524
Author(s):  
Laurence Montjoye ◽  
Mathilde Choteau ◽  
Anne Herman ◽  
Emilie Hendrickx ◽  
Paméla Chéou ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Autologous Serum Skin Test

scholarly journals Autologous Serum Skin Test as a Diagnostic Aid in Chronic Idiopathic Urticaria

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Hayder R. Al-Hamamy ◽  
Ammar F. Hameed ◽  
Asaad S. Abdulhadi
Keyword(s):  
Skin Test ◽  
Clinical Features ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Test Results ◽  
Autologous Serum Skin Test ◽  
Autoimmune Urticaria ◽  
Number Of Patients ◽  
Significant Difference ◽  
The Face

Background. Chronic urticaria is defined as urticaria persisting daily for more than six weeks. A significant number of patients had autoimmune basis where autologous serum skin test is widely used for detection of chronic autoimmune urticaria. Objectives. To estimate the frequency of autoimmune urticarial in Iraqi patients utilizing the autologous serum skin test and to evaluate its results with the variable clinical features of chronic idiopathic urticaria. Methods. In this prospective study, 54 patients with chronic idiopathic urticaria were investigated with autologous serum skin test where its results were examined with the different clinical parameters of chronic autoimmune urticaria. Results. Twenty two patients (40.7%) out of 54 patients with chronic idiopathic urticarial had positive autologous serum skin test. Statistical analysis of the clinical variables did not show a significant difference between patients with positive and negative autologous serum skin test except for the distribution of wheals on the face and extremities which was significantly associated with positive autologous serum skin test results (P value 0.004). Conclusion. Autologous serum skin test is a simple, office-based test for detecting chronic autoimmune urticaria patients who have no distinctive clinical features differentiating them from chronic idiopathic urticaria patients.

scholarly journals What Basophil Testing Tells Us About CSU Patients – Results of the CORSA Study

2021 ◽  
Vol 12 ◽  
Author(s):  
João Marcelino ◽  
Katrine Baumann ◽  
Per Stahl Skov ◽  
Maria Conceição Pereira Santos ◽  
Inga Wyroslak ◽  
...  
Keyword(s):  
Disease Activity ◽  
Poor Response ◽  
Basophil Activation Test ◽  
Cross Sectional Study ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Total Serum ◽  
Thyroid Autoantibodies ◽  
Cross Sectional ◽  
Autologous Serum Skin Test

Basophil testing is the most effective single approach for diagnosing type-IIb autoimmune chronic spontaneous urticaria (TIIbaiCSU). A positive basophil test has been linked to long disease duration, higher disease activity, a poor response to antihistamines and omalizumab, and a better response to cyclosporine and fenebrutinib. As of now it is unclear what other features are connected to a positive basophil test in chronic spontaneous urticaria (CSU). We aimed to identify features of basophil test-positive CSU patients. We performed a cross-sectional study of 85 CSU patients. Basophil testing was done with the basophil activation test (BAT) and the basophil histamine release assay (BHRA). Data were analysed using SPSS: Student’s t-test, Chi-square test, Odds Ratio, Spearman’s correlation test. Of 85 CSU patients, 44% and 28% tested positive with the BAT and BHRA, respectively. These patients showed higher disease activity and impact, lower levels of disease control and total serum IgE, as well as higher rates of having a positive autologous serum skin test (ASST), angioedema, nocturnal symptoms, symptoms for &gt;5 days/week, and thyroid autoantibodies. The ASST, by itself, was not a good predictor of basophil test results, but it predicted a positive basophil test in up to 100% of cases when combined with angioedema, thyroid autoantibodies or low IgE. In conclusion, a positive basophil test is linked to known features of TIIbaiCSU and novel characteristics including nocturnal symptoms. Further studies on basophil test-positive and -negative CSU patients can help to better understand CSU endotypes and to develop better management approaches.

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