scholarly journals Chinese Herbal Medicine on Dyslipidemia: Progress and Perspective

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Ming Guo ◽  
Yue Liu ◽  
Zhu-Ye Gao ◽  
Da-zhuo Shi
Keyword(s):  
Cardiovascular Diseases ◽  
Chinese Herb ◽  
Term Treatment ◽  
Lipid Lowering ◽  
Favorable Effect ◽  
Beneficial Effects ◽  
Long Term Treatment ◽  
Lipid Lowering Agents ◽  
Hypolipidemic Drugs

Dyslipidemia is an independent risk factor of cardiovascular diseases. The statins are a milestone in the primary and second prevention of cardiovascular diseases and significantly improved its prognosis. Along with the long-term treatment with statins in combination with other hypolipidemic drugs or alone, its safety has attracted a particular attention in clinic, such as the elevation of transaminase and rhabdomyolysis, which have raised an idea of developing the other types of lipid-lowering agents from botanic materials. Traditional Chinese medicine (TCM) has been used in clinical practice for more than 2000 years in China and showed some beneficial effects for human health and many diseases. Recently, many studies demonstrated a favorable effect of TCM for treating dyslipidemia; however, its mechanism remains unclear or totally unknown. The progress and perspective of studies on dyslipidemia with single Chinese herb and its monomers or effective extracts during the past 10 years are discussed in the present review.

scholarly journals Oral pravastatin prolongs survival time of scrapie-infected mice

2009 ◽  
Vol 90 (7) ◽  
pp. 1775-1780 ◽  
Author(s):  
Vito Vetrugno ◽  
Michele Angelo Di Bari ◽  
Romolo Nonno ◽  
Maria Puopolo ◽  
Claudia D'Agostino ◽  
...  
Keyword(s):  
Water Solubility ◽  
Cholesterol Biosynthesis ◽  
Term Treatment ◽  
Lipid Lowering ◽  
High Dose ◽  
Protective Effects ◽  
Survival Times ◽  
Beneficial Effects ◽  
Long Term Treatment

Statins are potent inhibitors of HMG–CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase in the cholesterol-biosynthesis pathway. They are either lipophilic (e.g. simvastatin) or hydrophilic [e.g. pravastatin (PRV)] compounds, considered mainly for long-term treatment of hypercholesterolaemic individuals. Beneficial effects of statins are not related exclusively to their lipid-lowering action; they also possess cholesterol-independent, pleiotropic effects (e.g. anti-inflammatory and antioxidant). Recent studies revealed that simvastatin treatment increased survival significantly in scrapie-infected mice. Although PRV treatment results in measurable drug levels in the mouse brain, the anti-prion effect of this compound has not been investigated. Therefore, we aimed to test the potential therapeutic action of PRV in a murine scrapie model. Our study showed that high-dose and long-term oral PRV treatment prolonged survival times of strain 139A scrapie-infected mice significantly (194 versus 177 days) in the absence of any obvious toxicity, suggesting that protective effects of statins may be independent of absolute solvent or water solubility of the drug.

scholarly journals Lipid-Lowering Effects of Tetradecylthioacetic Acid in Antipsychotic-Exposed, Female Rats: Challenges with Long-Term Treatment

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50853 ◽  
Author(s):  
Silje Skrede ◽  
Johan Fernø ◽  
Bodil Bjørndal ◽  
Wenche Rødseth Brede ◽  
Pavol Bohov ◽  
...  
Keyword(s):  
Term Treatment ◽  
Female Rats ◽  
Lipid Lowering ◽  
Tetradecylthioacetic Acid ◽  
Long Term Treatment

Peripheral Neurostimulation for Treatment of Intractable Occipital Neuralgia

Neurosurgery ◽  
2006 ◽  
Vol 58 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Konstantin V. Slavin ◽  
Hrachya Nersesyan ◽  
Christian Wess
Keyword(s):  
Pain Syndrome ◽  
Good Alternative ◽  
Term Treatment ◽  
Long Term Results ◽  
Intractable Pain ◽  
Occipital Neuralgia ◽  
Beneficial Effects ◽  
Long Term Treatment ◽  
Patient Reported

Abstract OBJECTIVE: Medically intractable pain caused by occipital neuralgia (ON) can be very difficult to control with traditional pain management. Peripheral nerve stimulation (PNS) may serve as a good alternative to destructive surgical manipulations used currently for the treatment of severe ON. METHODS: We analyzed records of 14 consecutive patients (9 women and 5 men; mean age, 43.3 yr) with intractable ON treated with PNS during the period from April 2002 to November 2004. Five patients had unilateral and nine had bilateral PNS electrodes inserted for trial, which was considered successful if patient reported at least 50% decrease of pain on the visual analogue scale. Ten patients proceeded with system internalization, and their long-term results were analyzed. RESULTS: At the time of the last follow-up examination (5–32 mo, mean 22 mo), seven patients (70%) with implanted PNS systems continue to experience beneficial effects of stimulation, including adequate pain control, continuous employment, and decrease in oral pain medications intake. Two patients had their systems explanted because of loss of stimulation effect or significant improvement of pain, and one patient had part of his hardware removed because of infection. CONCLUSION: Overall, the beneficial effect from chronic stimulation in our series persisted in more than half of the patients for whom procedure was considered and in 80% of those who significantly improved during the trial and proceeded with internalization. Thus, chronic PNS may be a safe and relatively effective method for long-term treatment of chronic pain syndrome in patients with medically intractable ON.

Sign in / Sign up

Export Citation Format

Share Document