Cobalt(II) Chloride Hexahydrate as an Efficient and Inexpensive Catalyst for the Preparation of Biscoumarin Derivatives

Cobalt(II) chloride hexahydrate (CoCl2·6H2O) has been found to be an efficient catalyst for the one-pot synthesis of biscoumarin derivatives through a combination of aromatic aldehydes and 4-hydroxycoumarin in aqueous media at 70°C. Several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were used in the reaction and in all cases the desired products were synthesized successfully. The present approach offers remarkable advantages such as short reaction times, excellent yields, straightforward procedure, easy purification, environment friendliness, and low catalyst loading.

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Synthesis of 2,4-diamino-6-aryl-5-pyrimidinecarbonitrile promoted by amino-functionalized CoFe2O4@SiO2 nanoparticles under conventional heating, microwave and ultrasound irradiations

Zeitschrift für Naturforschung B ◽

10.1515/znb-2017-0114 ◽

2018 ◽

Vol 73 (1) ◽

pp. 17-21 ◽

Cited By ~ 7

Author(s):

Samaneh Barkhordarion-Mohammadi ◽

Javad Safaei-Ghomi

Keyword(s):

Guanidine Hydrochloride ◽

Aromatic Aldehydes ◽

Sio2 Nanoparticles ◽

Conventional Heating ◽

Catalyst Loading ◽

Reaction Conditions ◽

One Pot ◽

Efficient Catalyst ◽

The One ◽

Low Catalyst Loading

AbstractAmino-functionalized CoFe2O4@SiO2 nanoparticles have been used as an efficient catalyst for the preparation of 2,4-diamino-6-arylpyrimidine-5-carbonitrile derivatives by the one-pot reaction of aromatic aldehydes, malononitrile, and guanidine hydrochloride under conventional heating, microwave, and ultrasound irradiations. This method provides several advantages including mild reaction conditions, the reusability of the catalyst and low catalyst loading, and the use of microwave and ultrasonic irradiation as a valuable and powerful tool.

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TiO2 Nanoparticles as an Efficient Catalyst for the One-pot Preparation of Tetrahydrobenzo[c]acridines in Aqueous Media

Zeitschrift für Naturforschung B ◽

10.5560/znb.2013-2323 ◽

2013 ◽

Vol 68 (4) ◽

pp. 362-366 ◽

Cited By ~ 12

Author(s):

Shahrzad Abdolmohammadi ◽

Mahdieh Mohammadnejad ◽

Faezeh Shafaei

Keyword(s):

Ammonium Acetate ◽

Titanium Dioxide Nanoparticles ◽

Aqueous Media ◽

Aromatic Aldehydes ◽

Catalytic Amount ◽

One Pot ◽

Efficient Catalyst ◽

The One ◽

Work Up ◽

Operational Simplicity

A series of tetrahydrobenzo[c]acridinone derivatives have been prepared by a one-pot fourcomponent reaction of 1-naphthol, aromatic aldehydes, dimedone, and ammonium acetate in aqueous media using a catalytic amount of titanium dioxide nanoparticles (TiO2 NPs). The advantages of this novel protocol include the excellent yields, operational simplicity, short reaction time, easy work-up, reusability of the catalyst and an environmentally friendly procedure.

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Leucine: green and efficient catalyst for the synthesis of 4H-chromenes

JOURNAL OF ADVANCES IN CHEMISTRY ◽

10.24297/jac.v10i9.6168 ◽

2017 ◽

Vol 10 (9) ◽

pp. 3197-3202 ◽

Cited By ~ 2

Author(s):

Davood Azarifar ◽

Younes Abbasi ◽

Omolbanin Badalkhani

Keyword(s):

Amino Acid ◽

Condensation Reaction ◽

Reaction Times ◽

Aromatic Aldehydes ◽

One Pot ◽

Efficient Catalyst ◽

Naturally Occurring ◽

The One ◽

High Yields ◽

Work Up

Leucine, a naturally occurring Î±-amino acid, has been found as an effective catalyst to effect the one-pot three-component condensation reaction between aromatic aldehydes, malononitrile and 5,5-dimethyl-1,3-cyclohexanedione (dimedone). Various 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives are conveniently prepared by these reactions in excellent yields. High yields, short reaction times, simple work-up, use of green and naturally occurring catalyst and solvent are the main merits of the present protocol.

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K2CO3: A Mild and Efficient Catalyst for the Synthesis of Pyran Annulated Heterocyclic Systems by Grinding Method Under Solvent-Free Conditions

Acta Chemica Iasi ◽

10.1515/achi-2017-0014 ◽

2017 ◽

Vol 25 (2) ◽

pp. 163-178 ◽

Cited By ~ 1

Author(s):

Reza Heydari ◽

Rohollah Rahimi ◽

Mehrnoosh Kangani ◽

Afshin Yazdani-Elah-Abadi ◽

Mojtaba Lashkari

Keyword(s):

Room Temperature ◽

Reaction Times ◽

Aromatic Aldehydes ◽

Solvent Free ◽

Synthetic Methods ◽

One Pot ◽

Efficient Catalyst ◽

Grinding Method ◽

Solvent Free Conditions ◽

The One

Abstract The potassium carbonate was applied as a green and efficient catalyst for the one-pot synthesis of pyran annulated heterocyclic systems, via the condensation between aromatic aldehydes, malononitrile and dimedone/1-naphtole by a grinding method at room temperature and solvent-free conditions. Short reaction times, environmentally friendly procedure and excellent yields are the main advantages of this procedure which makes it more economic than other environmentally synthetic methods.

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CeCl3·7H2O as mild and efficient catalyst for the one-pot multicomponent synthesis of 8-aryl-7,8-dihydro[1,3]dioxolo[4,5-g]chromen-6-ones

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc2010139 ◽

2011 ◽

Vol 76 (4) ◽

pp. 235-241 ◽

Cited By ~ 4

Author(s):

Li-Qiang Wu ◽

Wei-Lin Li ◽

Fu-Lin Yan

Keyword(s):

Aromatic Aldehydes ◽

Environmentally Benign ◽

Multicomponent Synthesis ◽

One Pot ◽

Efficient Catalyst ◽

Solvent Free Conditions ◽

Three Component Reaction ◽

The One ◽

High Yields ◽

Work Up

A series of new 8-aryl-7,8-dihydro[1,3]dioxolo[4,5-g]chromen-6-ones were synthesized via a three-component reaction of 3,4-methylenedioxyphenol, aromatic aldehydes and Meldrum’s acid in the presence of CeCl3·7H2O under solvent-free conditions. The method provided several advantages such as easy work-up, high yields and environmentally benign procedure.

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An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones

E-Journal of Chemistry ◽

10.1155/2008/132879 ◽

2008 ◽

Vol 5 (4) ◽

pp. 688-695 ◽

Cited By ~ 11

Author(s):

Taoues Boumoud ◽

Boudjemaa Boumoud ◽

Salah Rhouati ◽

Ali Belfaitah ◽

Abdelmadjid Debache ◽

...

Keyword(s):

Reaction Times ◽

Aromatic Aldehydes ◽

One Pot ◽

First Derivative ◽

Target Molecules ◽

The One ◽

High Yields

The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)2, as a recycling catalyst, from a diversity of aromatic aldehydes, β-ketoesters and urea. The reaction was carried out in refluxing acetonitrile and afforded the target molecules in good to excellent yields. The method offers several advantages including high yields of the products, short reaction times and easy experimental workup procedure

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Silica-supported ZnCl2 — A highly active and reusable heterogeneous catalyst for the one-pot synthesis of dihydropyrimidinones–thiones

Canadian Journal of Chemistry ◽

10.1139/v07-018 ◽

2007 ◽

Vol 85 (3) ◽

pp. 197-201 ◽

Cited By ~ 15

Author(s):

Raman Gupta ◽

Monika Gupta ◽

Satya Paul ◽

Rajive Gupta

Keyword(s):

Zinc Chloride ◽

Biginelli Reaction ◽

Catalyst Loading ◽

Reaction Conditions ◽

One Pot ◽

Highly Active ◽

Chloride Catalyst ◽

Biginelli Compounds ◽

The One ◽

Low Catalyst Loading

A novel silica-supported zinc chloride catalyst was prepared and investigated for the Biginelli reaction. The key features of the catalyst include rapid reaction with 100% conversion of aldehyde, good catalyst recyclability, and high stability under the reaction conditions (passes hot filtration test successfully). A low catalyst loading (12 mol% of ZnCl2) was required to achieve a quantitative reaction. Other catalysts such as SiO2–AlCl2, SiO2–AlCl2–ZnCl2 were also prepared and their activity was compared with SiO2–ZnCl2 for the Biginelli reaction.Key words: silica gel, zinc chloride, Biginelli compounds, heterogeneous catalysis, reusability.

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A Suitable One-Pot Synthesis of 3,4-Dihydropyrano[3,2-c]Chromenes Using Magnetic Nanoparticles Tag: Piperidinium Benzene-1,3-Disulfonate Ionic Liquid as a Novel, Green, Efficient and Reusable Catalyst in Aqueous Medium

Current Organic Synthesis ◽

10.2174/1570179414666170203150629 ◽

2017 ◽

Vol 14 (6) ◽

pp. 904-911 ◽

Cited By ~ 3

Author(s):

Ramin Ghorbani-Vaghei ◽

Jafar Mahmoodi ◽

Yaser Maghbooli ◽

Azadeh Shahriari

Keyword(s):

Ionic Liquid ◽

Magnetic Nanoparticles ◽

Reaction Times ◽

Catalytic Amount ◽

High Yield ◽

Reusable Catalyst ◽

One Pot ◽

Efficient Catalyst ◽

Water Solvent ◽

The One

Background: The synthesis of 3,4-dihydropyrano[3,2-c]chromenes via the one-pot three-component reactions of various aldehydes, malononitrile, and 4-hydroxycumarin at 60 °C in water as a solvent by the magnetic nanoparticles tag: piperidinium benzene-1,3-disulfonate ionic liquid as a green and efficient catalyst. Some benefits of the presented technique are significant cost impact, impressive catalysis and the ability to reuse of the catalyst. The current procedure offers high yield, short reaction times, neat reaction and simple reusable catalyst. Objective: A magnetic nanoparticles tag: piperidinium benzene-1,3-disulfonate ionic liquid as a green, efficient, reusable and heterogeneous catalyst was used for the synthesis of 3,4-dihydropyrano[3,2-c]chromenes. Method: We have described an efficient and green process for the synthesis of the one-pot three-component synthesis of 3,4-dihydropyrano[3,2-c]chromenes from the reaction between 4-hydroxy-coumarin with malononitrile and aldehydes in the presence of catalytic amount of magnetic nanoparticles tag: piperidinium benzene-1,3-disulfonate ionic liquid as a novel and powerful nano ionic liquid with good to excellent yields and in a short reaction time in water solvent at 60 °C. Result: The main advantage of this process is the simplicity of the work-up and the products can be isolated without chromatography. Conclusion: We suggest that the method has also various additional advantages such as low loading of catalyst, clean reaction, which makes it a suitable and noteworthy approach for the synthesis of 3,4- dihydropyrano[3,2-c]chromenes.

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