scholarly journals Intraductal Papillary Neoplasms of the Bile Duct

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Masayuki Ohtsuka ◽  
Hiroaki Shimizu ◽  
Atsushi Kato ◽  
Hideyuki Yoshitomi ◽  
Katsunori Furukawa ◽  
...  
Keyword(s):  
Bile Duct ◽  
Molecular Genetic ◽  
Intraepithelial Neoplasia ◽  
Mucinous Carcinoma ◽  
Tumor Location ◽  
Tubular Adenocarcinoma ◽  
Superficial Spreading ◽  
Genetic Changes ◽  
Intraductal Papillary Neoplasm ◽  
Radiologic Findings

Intraductal papillary neoplasm of the bile duct (IPNB) is a rare variant of bile duct tumors characterized by papillary growth within the bile duct lumen and is regarded as a biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas. IPNBs display a spectrum of premalignant lesion towards invasive cholangiocarcinoma. The most common radiologic findings for IPNB are bile duct dilatation and intraductal masses. The major treatment of IPNB is surgical resection. Ultrasonography, computed tomography, magnetic resonance image, and cholangiography are usually performed to assess tumor location and extension. Cholangioscopy can confirm the histology and assess the extent of the tumor including superficial spreading along the biliary epithelium. However, pathologic diagnosis by preoperative biopsy cannot always reflect the maximum degree of atypia, because IPNBs are often composed of varying degrees of cytoarchitectural atypia. IPNBs are microscopically classified into four epithelial subtypes, such as pancreatobiliary, intestinal, gastric, and oncocytic types. Most cases of IPNB are IPN with high-grade intraepithelial neoplasia or with an associated invasive carcinoma. The histologic types of invasive lesions are either tubular adenocarcinoma or mucinous carcinoma. Although several authors have investigated molecular genetic changes during the development and progression of IPNB, these are still poorly characterized and controversial.

scholarly journals A Resected Case of Mucinous Adenocarcinoma of the Duodenum, Mimicking Intraductal Papillary Neoplasm of the Bile Duct

2015 ◽  
Vol 100 (11-12) ◽  
pp. 1443-1448
Author(s):  
Norio Kubo ◽  
Hideki Suzuki ◽  
Norihiro Ishii ◽  
Mariko Tsukagoshi ◽  
Akira Watanabe ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Transverse Colon ◽  
Extrahepatic Bile Duct ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Mucinous Carcinoma ◽  
Villous Tumor ◽  
Intraductal Papillary Neoplasm ◽  
The Common ◽  
Papillary Neoplasm

Duodenum mucinous carcinoma is very rare, and the prognosis of the patient is very bad, especially when the tumor is invasive to other organs. In this case, duodenum carcinoma was invasive to common bile duct and transverse colon. Mucinous fluid, which was secreted from a duodenum tumor, was found in the dilatated bile duct. The intraductal papillary neoplasm of the bile duct was considered a differential diagnosis. We performed aggressive resection and had a good prognosis. A 74-year-old woman received a diagnosis of cholangitis and was treated with antibiotic drugs. Endoscopic retrograde cholangiopancreatography revealed a defect in the lower common bile duct with the mucoid fluid. We suspected intraductal papillary neoplasm of the bile duct, but no malignant cells were detected. One year later, gastrointestinal fiberscopy revealed a villous tumor in the postbulbar portion of the duodenum; adenocarcinoma was detected in biopsy specimens. Computed tomography revealed dilatation of the duodenum with an enhanced tumor, and dilatation of both the common and intrahepatic bile ducts. Magnetic resonance cholangiopancreatography revealed that the duodenum was connected with the common bile duct and ascending colon. We resected the segmental duodenum, extrahepatic bile duct, left lobe of liver, a partial of the transverse colon, and associated lymph nodes. Although the advanced duodenal carcinoma had poor prognosis, the patient was alive, without recurrence, 5 years after the operation.

Impact of Tumor Location on Postoperative Outcome of Intraductal Papillary Neoplasm of the Bile Duct

2019 ◽  
Vol 43 (5) ◽  
pp. 1313-1322 ◽  
Author(s):  
Takatsugu Matsumoto ◽  
Keiichi Kubota ◽  
Hiroyuki Hachiya ◽  
Yuhki Sakuraoka ◽  
Takayuki Shiraki ◽  
...  
Keyword(s):  
Bile Duct ◽  
Postoperative Outcome ◽  
Tumor Location ◽  
Intraductal Papillary Neoplasm ◽  
Papillary Neoplasm

Recurrence After Resection for Intraductal Papillary Neoplasm of Bile Duct (IPNB) According to Tumor Location

2019 ◽  
Vol 24 (4) ◽  
pp. 804-812 ◽  
Author(s):  
Yunghun You ◽  
Seong Ho Choi ◽  
Dong Wook Choi ◽  
Jin Seok Heo ◽  
In Woong Han ◽  
...  
Keyword(s):  
Bile Duct ◽  
Tumor Location ◽  
Intraductal Papillary Neoplasm ◽  
Papillary Neoplasm

Updates on Precancerous Lesions of the Biliary Tract: Biliary Precancerous Lesion

2016 ◽  
Vol 140 (11) ◽  
pp. 1285-1289 ◽  
Author(s):  
Sanaz Ainechi ◽  
Hwajeong Lee
Keyword(s):  
Bile Duct ◽  
Biliary Tract ◽  
Precancerous Lesions ◽  
Precancerous Lesion ◽  
Intraepithelial Neoplasia ◽  
Precursor Lesions ◽  
Invasive Adenocarcinoma ◽  
Intraductal Papillary Neoplasm ◽  
Pathologic Features ◽  
Mechanisms Of Carcinogenesis

Precursor lesions of invasive adenocarcinoma of the bile duct (cholangiocarcinoma) have been increasingly recognized during the past decade because of the results of multiple studies on the carcinogenesis of cholangiocarcinoma, technologic advancements in diagnostic imaging modalities, and an increase in the volume of elective procedures. The two main precursor lesions of cholangiocarcinoma that have evolved are biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. These lesions demonstrate histomorphologic similarities to pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm of the pancreas, respectively, whereas mechanisms of carcinogenesis and risk of progressive disease appear distinct. An enhanced understanding of the clinical presentation and pathologic features of precursor lesions of the biliary tract and use of the correct terminology will facilitate efficient communication between surgeons, oncologists, and pathologists and improve quality of patient care.

Intraductal papillary neoplasm of the bile duct: Radiologic findings in a new disease

2020 ◽  
Vol 62 (1) ◽  
pp. 28-37
Author(s):  
D. Rodríguez Vargas ◽  
M.J. Parada Blázquez ◽  
B. Vargas Serrano
Keyword(s):  
Bile Duct ◽  
New Disease ◽  
Intraductal Papillary Neoplasm ◽  
Radiologic Findings ◽  
Papillary Neoplasm

scholarly journals Biliary Intraepithelial Neoplasia in Non-biliary Cirrhosis—Report From 100 Explanted Livers: A Single Center Experience

2019 ◽  
Vol 12 ◽  
pp. 2632010X1987693 ◽  
Author(s):  
Maryam Zarei ◽  
Alireza Shasaeefar ◽  
Kurosh Kazemi ◽  
Masoud Dehghani ◽  
Seyed-Ali Malekhosseini ◽  
...  
Keyword(s):  
Bile Duct ◽  
Intraepithelial Neoplasia ◽  
Biliary Cirrhosis ◽  
Multistep Carcinogenesis ◽  
Biliary Intraepithelial Neoplasia ◽  
Single Center Experience ◽  
Intraductal Papillary Neoplasm ◽  
Main Pathway ◽  
Papillary Neoplasm ◽  
Bile Duct Dysplasia

Background: Intrahepatic cholangiocarcinoma is a highly malignant tumor with a very short 5-year survival. Multistep carcinogenesis has been suggested as the main pathway for the development of this tumor. Main suggested precursors have been (1) biliary intraepithelial neoplasia (BilIN) and (2) intraductal papillary neoplasm of bile duct (IPNB). The former is flat and does not produce grossly and radiologically detectable mass lesion, but the latter produces grossly identifiable lesion. Objectives: The development of bile duct dysplasia (BilIN) in chronic biliary diseases has been investigated and proved, but the incidence of BilIN in non-biliary causes of cirrhosis such as hepatitis B and non-alcoholic steatohepatitis has very rarely been investigated. In this study, we have tried to find out the prevalence of BilIN in non-biliary cirrhosis. Patients and Methods: During the study period (2017-2018) in 100 explanted livers with the diagnosis of non-biliary cirrhosis, thorough sampling (at least 20 sections) was performed, and pathologic sections were studied for the presence of BilIN. Results: In the 100 studied livers with different diagnoses of non-biliary causes of cirrhosis, 31% of cases showed BilIN-1 and 2% of cases showed BiliIN-2. No case of BilIN-3 has been identified. Discussion and Conclusions: Non-biliary causes of cirrhosis should be considered as precursors of cholangiocarcinoma (BilIN); however, the incidence of this occurrence is low.

Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

1990 ◽  
Vol 48 (3) ◽  
pp. 252-253
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Wu Jifeng ◽  
Chen Xiaolin
Keyword(s):  
Gastric Cancer ◽  
Intestinal Metaplasia ◽  
Cancer Cells ◽  
Microscopic Observation ◽  
Biological Significance ◽  
Ultrastructural Localization ◽  
Mucinous Carcinoma ◽  
Surface Glycoprotein ◽  
Tubular Adenocarcinoma ◽  
Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

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