scholarly journals Synthesis, Spectroscopic Characterization, and Biological Evaluation Studies of 5-Bromo-3-(((hydroxy-2-methylquinolin-7-yl)methylene)hydrazono)indolin-2-one and Its Metal (II) Complexes

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Kuruba Siddappa ◽  
Nabiya Sultana Mayana
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Stability Constants ◽  
Dna Cleavage ◽  
Thermal Studies ◽  
Mixed Solvents ◽  
Free Ligand ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Ph Titration

The Schiff base ligand 5-bromo-3-(((8-hydroxy-2-methylquinolin-7-yl)methylene)hydrazono)indolin-2-one (BHMQMHI) was preparedviacondensation of 5-bromo-3-hydrazonoindolin-2-one and 7-formyl-8-hydroxy-2-methylquinoline and its Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) complexes have been synthesized and characterized by elemental analysis, conductance data, magnetic susceptibility measurements, IR, UV-Vis, mass spectrometry,1H NMR, ESR, XRD, and thermal studies. By these spectral studies it is found that Co(II), Ni(II), and Cu(II) complexes have exhibited octahedral geometry whereas the Zn(II), Cd(II), and Hg(II) complexes have exhibited tetrahedral geometry. Potentiometric studies have been carried out on complexes of Schiff base (BHMQMHI) with Cu(II), Co(II), and Ni(II). Calvin-Bjerrum pH-titration technique as used by Irving and Rossotti has been applied to determine stability constants in mixed solvents at25 ± 1°C. The present study reports the protonation constants of this ligand and stability constants of its metal complexes in dioxane-water (50%, v/v) mixtures. Metal-ligand stability constants fall in the order of Cu(II) > Co(II) > Ni(II) which is in agreement with those reported by Irving stability order. The Schiff base (BHMQMHI) and its metal complexes have been screened for theirin vitroantibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activities of all the complexes were studied by agarose gel electrophoresis method. In addition, the free ligand along with its complexes has been studied for their antioxidant activity.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

scholarly journals Synthesis, Characterization and Biological Evaluation of Fe(III) and Cu(II) Complexes with 2,4-Dinitrophenyl hydrazine and Thiocyanate Ions

2019 ◽  
Vol 31 (4) ◽  
pp. 780-784
Author(s):  
P. Manimaran ◽  
S. Balasubramaniyan
Keyword(s):  
Antioxidant Activity ◽  
Metal Complexes ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
Diffusion Method ◽  
Spectral Studies

The metal complexes of Fe(III) and Cu(II) were prepared by using 2,4-dinitrophenyl hydrazine (DNPH) and thiocyanate (SCN) with stirrer refluxed for about 6 h. The prepared Fe(III) and Cu(II) complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility and electronic spectrum, FT-IR spectral studies. The result suggested the octahedral geometry for Fe(III) and Cu(II) complexes. Powder X-ray diffraction indicate the crystalline nature of the metal complexes. The antimicrobial activities of the Fe(III) and Cu(II) complexes were tested with various micro organisms by disc diffusion method. The antimicrobial results indicate that the metal complexes are highly active with compared to the free ligand. The in vitro antioxidant activity of the free ligand and its metal complexes was assayed by radical scavenging activity (DPPH). The result proposed that Fe (III) and Cu(II) complexes exhibited strong antioxidant activity than that of the ligand.

scholarly journals Synthesis, Characterization, Antimicrobial, DNA Cleavage, andIn VitroCytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Nagesh Gunvanthrao Yernale ◽  
Mruthyunjayaswamy Bennikallu Hire Mathada
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Biological Activities ◽  
Artemia Salina ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Pyramidal Geometry

A novel Schiff base ligandN-(4-phenylthiazol-2yl)-2-((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide(L)obtained by the condensation ofN-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3-carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR,1H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand(L)behaves as tridentate ONS donor and forms the complexes of type [ML(Cl)2] with square pyramidal geometry. The Schiff base ligand(L)and its metal complexes have been screenedin vitrofor their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study thein vitrocytotoxicity properties for the ligand and its metal complexes againstArtemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation.

scholarly journals Synthesis, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from 4-Nitrobenzene-1,2-diamine and 5-Chloroisatin

2020 ◽  
Vol 32 (9) ◽  
pp. 2324-2328
Author(s):  
NETRA PAL SINGH ◽  
KAUSHAL KUMAR ◽  
GAJENDRA KUMAR ◽  
ANUROOP KUMAR
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Magnetic Moments ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi

A series of transition metal complexes of the type [MLX2], where M = Mn(II), Fe(II), Co(II), Ni(II), X = Cl–/CH3COO– and L = Schiff base derived from 4-nitrobenzene-1,2-diamine and 5-chloroisatin have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-visible, magnetic moments measurement, 1H & 13C NMR and mass spectral studies. On the basis of physico-chemical studies and spectral evaluation, an octahedral geometry have been proposed for all metal(II) complexes. The antimicrobial activity of ligand and its metal complexes have been additionally screened against bacteria and fungi. Metal(II) complexes show good activity as compared to ligand towards studied microorganisms and also metal complexes checked for their catalytic properties for benzoylation of phenol.

scholarly journals Synthesis, Characterization of Metal Complexes of Schiff Base derived from Pyrrole-2-carbaldehyde and 4-Methoxy Aniline and their Biological Studies

2020 ◽  
Vol 32 (12) ◽  
pp. 3012-3018
Author(s):  
A. Charles ◽  
R. Krishnaveni ◽  
K. Sivara
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Dna Cleavage ◽  
Thermal Studies ◽  
Salmonella Typhi ◽  
Spectroscopic Techniques ◽  
Dna Cleavage Activity ◽  
Biological Studies ◽  
Staphylococcus Epidermis ◽  
Coordinated Water

The metal complexes of Fe(II), Co(II) and Ni(II) have been synthesized from N-((1H-pyrrol-2- yl)methylene)-4-methoxyaniline. The synthesized Schiff base and its metal complexes were structurally characterized based on IR, NMR, UV-vis spectroscopic techniques. The presence of coordinated water molecules were confirmed by thermal studies. All the synthesized compounds were screened for their antibacterial (Escherichia coli, Bacillus substilis, Salmonella typhi, Staphylococcus epidermis) and antifungal (Aspergillus flavus) and DNA cleavage activity.

Synthesis, spectral characterization and some biological studies of transition metal complexes with Schiff base ligand containing N,O and S as donor atoms

2017 ◽  
Vol 13 (9) ◽  
pp. 6513-6519
Author(s):  
Anil Kumar M R ◽  
Shanmukhappa S ◽  
Rangaswamy B E ◽  
Revanasiddappa M
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Schiff Base Complexes ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Biological Studies

Transition metal complexes of Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II) have been synthesized with the Schiff base ligand 5-Sub-N-(2-mercaptophenyl)salicylideneimine. Elemental analysis of these complexes suggest that these metal ions forms complexes of type ML(H2O)stoichiometry for Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II). The ligand behaves as tridentate and forms coordinate bonds through O, S and N atoms. Magnetic susceptibility, IR, UV – Visible, Mass and ESR spectral studies suggest that Cu(II), Ni(II) complexes posses square planar geometry, whereas Co(II), Zn(II), Cd(II) and Mn(II) complexes posses tetrahedral geometry. The complexes were tested for their antimicrobial activity against the bacterial strains Staphylococcus aureus and Bacillus subtilis.The Schiff base metal complexes evaluated for their antifungal activity against the fungi A. niger and C. oxysporum. The DNA cleavage studies of Schiff base complexes werestudied using Calf – Thymus DNA by agarose gel electrophoresis method.

scholarly journals Spectroscopic, thermal and antibacterial studies on Mn(II) and Co(II) complexes derived from thiosemicarbazone

2009 ◽  
Vol 74 (8-9) ◽  
pp. 907-915 ◽  
Author(s):  
Sulekh Chandra ◽  
Monika Tyagi ◽  
Moamen Refat
Keyword(s):  
Magnetic Susceptibility ◽  
Thermogravimetric Analysis ◽  
Metal Complexes ◽  
Thermal Studies ◽  
Free Ligand ◽  
Antibacterial Properties ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Antibacterial Studies

Mn(II) and Co(II) complexes having the general composition [M(L)2X2] (where L = 2-pyridinecarboxaldehyde thiosemicarbazone, M = Mn(II) and Co(II), X = Cl- and - NO3 ) were synthesized. All the metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, mass, IR, EPR, electronic spectral studies and thermogravimetric analysis (TG). Based on the spectral studies, an octahedral geometry was assigned for all the complexes. Thermal studies of the compounds suggest that the complexes are more stable than the free ligand. This fact was supported by the kinetic parameters calculated using the Horowitz-Metzger (H-M) and Coats-Redfern (C-R) equations. The antibacterial properties of the ligand and its metal complexes were also examined and it was observed that the complexes are more potent bactericides than the free ligand.

scholarly journals Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Suman Malik ◽  
Suparna Ghosh ◽  
Bharti Jain ◽  
Archana Singh ◽  
Mamta Bhattacharya
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Elemental Analysis Data ◽  
Central Metal

The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.

scholarly journals Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions

2020 ◽  
Vol 71 (4) ◽  
pp. 47-58
Author(s):  
Noreen Mazhar ◽  
Mehwish Aftab ◽  
Tariq Mahmud ◽  
Muhammadasim Raza Basra ◽  
Mansoor Akhtar ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Protein Denaturation ◽  
Condensation Reaction ◽  
Free Ligand ◽  
Biological Evaluation ◽  
Divalent Metal ◽  
Anti Inflammatory

A new Schiff base ligand (L) and its transition divalent metal complexes were prepared by the condensation reaction; Reaction was carried out at 70-80 oC by refluxing equimolar ratio of toluidine and aldehyde by continuous stirring for 5-6 hours. Synthesized ligand and Ni(II), Fe(II), Co(II), Mn(II) and Zn(II) bimetallic complexes were characterized by using FT-IR, UV-visible spectroscopy, AAS, Single crystal X-ray analysis, 1H-NMR, molar conductance. Compounds were screened against two fungus Candida glabrata and Candida albicans by agar tube dilution protocol. In vivo anti-inflammatory activity via induced paw edema method and in vitro results by heat induced protein denaturation method were checked. Synthesized compounds were also showed antioxidant activity by using DPPH (diphenylpicrylhydrazyl) and Trolox was used as standard. These studies show that ligand and almost all metal complexes are reactive towards biological assays against reported standard drugs. Zn-L indicates more activeness for antioxidant activity and free ligand while Co-L recognized as more effective anti-inflammatory drug.

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