scholarly journals Receptors of Hypothalamic-Pituitary-Ovarian-Axis Hormone in Uterine Myomas

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Danuta Plewka ◽  
Jacek Marczyński ◽  
Michał Morek ◽  
Edyta Bogunia ◽  
Andrzej Plewka
Keyword(s):  
Estrogen Receptor ◽  
Cell Nucleus ◽  
Receptor Expression ◽  
Reproductive Age ◽  
Fsh Receptor ◽  
Uterine Myomas ◽  
Gnrh Receptors ◽  
Local Feedback ◽  
Uterine Glands ◽  
Cytoplasmic Location

In this study the expression of GnRH, FSH, LH, ER-α, ER-β, and PR receptors was examined in uterine myomas of women in reproductive and perimenopausal age. In cases of GnRH and tropic hormones a membranous and cytoplasmic immunohistochemical reaction was detected, in cases of ER-αand PR the reaction was located in cell nucleus, and in the case of ER-βit manifested also a cytoplasmic location. In some of the examined cases the expression was detected in endometrium, myocytes, and endothelium of blood vessels, in uterine glands and myoma cells. In myometrium the level of GnRH and LH receptors increases with age, whereas the level of progesterone and both estrogen receptors decreases. In myomas of women in reproductive age, independently of their size, expression of GnRH, FSH, and LH receptors was more pronounced than in myometrium. In women of perimenopausal age, independently of myoma size, expression of LH and estrogenαreceptors was higher while expression of GnRH receptors was lower than in myometrium. FSH receptor expression was not observed. Expression of estrogen receptorβwas not affected by age of the woman or size of myoma. Analysis of obtained results indicates on existing in small myomas local feedback axis between GnRH-LH-progesterone.

Changes in the Serum Levels of Estradiol and Changes in Expression of Estrogen Receptor Alpha in the Bone Tissue of Ovariectomized Wistar Rats

2022 ◽  
Vol 6 (1) ◽  
pp. 01-05
Author(s):  
Armine V. Grigoryan ◽  
Alexander B. Blazhev ◽  
Tatyana M. Betova ◽  
Aneliya A. Dimitrova
Keyword(s):  
Estrogen Receptor ◽  
Bone Tissue ◽  
Wistar Rats ◽  
Receptor Expression ◽  
Reproductive Age ◽  
Ovariectomized Rats ◽  
Aromatase Activity ◽  
Estrogen Receptor Expression ◽  
Serum Estradiol ◽  
Estradiol Levels

Estradiol is an estrogen steroid hormone and is produced basically within the follicles of the ovaries. The decrease in serum estrogens concentration at menopause disrupts the metabolic balance, changes the lipid profile leading to visceral obesity, which caused an increase in serum estradiol levels, through aromatase activity. Estrogen deficiency also is a reason for the development of osteoporosis.We investigated the serum estradiol levels and changes in bone alpha estrogen receptor expression in ovariectomized rats. For this purpose, we used 20 female Wistar rats at reproductive age - 2 months divided into 2 groups: group 1 (G1)-10 animals were ovariectomized and group 2 (G2)-10 of which were sham-operated. All animals of G1 showed weight gain compared to group G2. The results showed that the values of serum 17β-estradiol in rats of G1 statistically increased compared to G2 (p <0.05). Immunohistochemical analysis revealed no difference in estrogen receptor expression between the both groups. Histomorphological analysis of femur from G1 showed the presence of pronounced osteoporosis. Ovariectomy led to the development of obesity, which caused an increase in serum estradiol levels, through aromatase activity, but this process did not prevent bone tissue from developing osteoporosis.

Association of antimullerian hormone with the size of the appendix testis, the androgen and estrogen receptors and their expression in the appendix testis, in congenital cryptorchidism

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Xenophon Sinopidis ◽  
Eirini Kostopoulou ◽  
Andrea Paola Rojas-Gil ◽  
Antonios Panagidis ◽  
Eleni Kourea ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Receptor Expression ◽  
Testicular Descent ◽  
Antimullerian Hormone ◽  
Mullerian Ducts ◽  
Score Method ◽  
Antimüllerian Hormone ◽  
Unilateral Cryptorchidism ◽  
Appendix Testis

Abstract Objectives Antimullerian hormone (AMH) causes regression of the mullerian ducts in the male fetus. The appendix testis (AT) is a vestigial remnant of mullerian duct origin, containing both androgen (AR) and estrogen (ER) receptors. The role of both AMH and AT in testicular descent is yet to be studied. We investigated the possible association of AMH with AT size, the AR and ER, and their expression in the AT, in congenital cryptorchidism. Methods A total of 26 patients with congenital unilateral cryptorchidism and 26 controls with orthotopic testes were investigated, and 21 ATs were identified in each group. AMH and insulin-like three hormone (INSL3) concentrations were measured with spectrophotometry. AR and ER receptor expression was assessed with immunohistochemistry using monoclonal antibodies R441 for AR and MAB463 for ER. For the estimation of receptor expression, the Allred Score method was used. Results AMH concentrations did not present significant differences between patients with congenital cryptorchidism and the controls. Also, no correlation was found between AMH, INSL3, and AT length. Allred scores did not present significant differences. However, expression percentiles and intensity for both receptors presented significant differences. Three children with cryptorchidism and the highest AMH levels also had the highest estrogen receptor scores in the AT. Conclusions No association was found between AMH and the studied major parameters. However, higher AMH concentrations, in combination with higher estrogen receptor scores in the AT, may play a role in cryptorchidism in some children. Larger population samples are needed to verify this observation.

scholarly journals Estrogen Causes Dynamic Alterations in Endothelial Estrogen Receptor Expression

2002 ◽  
Vol 91 (9) ◽  
pp. 814-820 ◽  
Author(s):  
Christopher E. Ihionkhan ◽  
Ken L. Chambliss ◽  
Linda L. Gibson ◽  
Lisa D. Hahner ◽  
Michael E. Mendelsohn ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Receptor Expression ◽  
Estrogen Receptor Expression

Estrogen receptor expression in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma

2004 ◽  
Vol 10 (3) ◽  
pp. 166-168 ◽  
Author(s):  
Fábio Ramôa Pires ◽  
Danyel Elias da Cruz Perez ◽  
Oslei Paes de Almeida ◽  
Luiz Paulo Kowalski
Keyword(s):  
Estrogen Receptor ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Mucoepidermoid Carcinoma ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Adenoid Cystic

Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer

2015 ◽  
Vol 68 (10) ◽  
pp. 839-843 ◽  
Author(s):  
Francisco E Vera-Badillo ◽  
Martin C Chang ◽  
Gordana Kuruzar ◽  
Alberto Ocana ◽  
Arnoud J Templeton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Lymph Node ◽  
Androgen Receptor ◽  
Statistical Significance ◽  
Multivariable Analysis ◽  
Recurrence Score ◽  
Receptor Expression ◽  
Ki 67 ◽  
Node Negative

BackgroundThe mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.MethodsThe associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.ResultsAnalysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1–53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=−0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.ConclusionsAR is associated with lower RS, but not with Ki-67.

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