scholarly journals Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Z. A. Elkabbany ◽  
R. T. Hamza ◽  
N. H. Mahmoud

Because ghrelin is one of the key hormones in regulating feeding behavior and caloric status, it was suggested that ghrelin behavior might be closely associated with malnutrition state of patients with chronic liver disease (CLD). Thus, we aimed to assess serum ghrelin levels in children with CLD and its relation to anthropometric parameters and severity of CLD. Forty CLD patients were studied in comparison to 40 controls. All subjects were subjected to history, anthropometric, and laboratory assessment of liver functions and serum acylated ghrelin. Ghrelin was higher in patients than controls being higher with progress of Child’s grade and with deterioration of liver functions. Hyperghrelinemia was detected in 62.5% of cases. Ghrelin correlated negatively with body mass index standard deviation score (BMISDS (r=-0.95,P<0.001)), triceps skin fold thickness (TSFT (r=-0.88,P<0.001)), and subscapular skin fold thickness (SSFT (r=0.83,P<0.001)) percentiles. In conclusion, hyperghrelinemia may represent a compensatory mechanism trying to overcome malnutrition state complicating CLD and can be used as a parameter for early detection and assessment of the severity of malnutrition in children with CLD.

2020 ◽  
Vol 7 (7) ◽  
pp. 2201
Author(s):  
Manik C. Gedam ◽  
Yogesh D. Mankar ◽  
Devdas S. Samala ◽  
Leena Y. Ingale ◽  
Lavanya L. ◽  
...  

Background: The aims and objectives of this article were to compare the advantages, disadvantages associated with percutaneous endoscopic gastrostomy (PEG) and nasogastric (NG) tube and also to compare complications, to measure the outcomes in terms of hospital stay, mortality and improvement in nutritional status.Methods: In this prospective and interventional study 25 patients were selected in each group on an alternate basis. Study was conducted on cases of traumatic brain injury and cerebrovascular accident patients admitted in Department of General Surgery, IGGMC for a period of November 2013- November 2015 with a need to provide prolonged enteral nutritional support. Each patient was assessed by a dietician and received a standard enteral feeding according to their body weight. The main outcome was measures at 4 weeks were complications (tube dislodgement, aspiration pneumonia, tube blockade and peristomal infections) and nutritional status.Results: The anthropometric parameters (mid arm circumference, biceps skin fold thickness and triceps skin fold thickness) and serum albumin showed a rise in PEG group at 4 weeks when compared to baseline (0 week) whereas they showed a decline in NG group at follow up (4 weeks). The NG group has got higher mortality 4 (17%) when compared to PEG group 2 (7%) due to aspiration pneumonia. Hence, PEG is better tolerated with lesser complications better nutritional support as assessed by the anthropometric parameters at 4 weeks.Conclusions: We conclude that whenever feasible percutaneous endoscopic gastrostomy (PEG) feeding is a choice over nasogastric (NG) feeding in patients requiring long term enteral support.


Author(s):  
Gautam Mehta ◽  
Bilal Iqbal

1. Jaundice is a marker of severity of liver disease, as well as a consequence of decompensation. Yellow discolouration is not usually seen until the serum bilirubin is >40μmol/L (twice the upper limit of normal), although the earliest signs of jaundice can be detected in the periphery of the conjunctivae, or in the buccal mucosa. Remember, there are other causes of jaundice in liver disease, such as Zieve’s syndrome (haemolysis and hyperlipidaemia in alcohol misuse), or biliary obstruction. 2. Cachexia can be established by demonstrating muscle and fat loss. Wasting of the temporalis muscle is an early sign of generalized muscle atrophy. A reduced triceps skin-fold thickness is a marker of loss of fat stores. This can be demonstrated by palpating for redundant skin over the triceps area between your thumb and forefingers. 3. Anaemia is most reliably demonstrated by looking for conjunctival pallor. This is thought to be more sensitive than looking for pallor of skin creases, nails, or other mucosal membranes. If there is no evidence of anaemia, it is an important negative to mention to the examiner. The principal causes of anaemia in chronic liver disease are blood loss from portal hypertensive gastropathy, alcohol excess causing bone marrow suppression and poor nutrition. 4. Other gastrointestinal (GI) causes of clubbing include inflammatory bowel disease (IBD), coeliac disease, GI lymphoma and rare causes of malabsorption such as tropical sprue and Whipple’s disease. 5. Leuconychia is a non-specific finding which is associated with hypoalbuminaemia as well as other conditions such as heart failure, renal disease, Hodgkin’s lymphoma (HL) and diabetes mellitus (see Case 8—Nephrotic Syndrome). 6. Palmar erythema reflects the vasodilated state of cirrhosis. Other causes of palmar erythema include hypercapnoea, rheumatoid arthritis, thyrotoxicosis, pregnancy, fever, and exercise. 7. Spider naevi are vascular lesions, with a central arteriole that supplies smaller surrounding vessels. Generally, the number and size correlate with the severity of liver disease, although they may occur in normal individuals and pregnancy. Spider naevi, palmar erythema, gynaecomastia, and loss of body hair are thought to be the consequence of altered sex hormone metabolism, and an increase in the oestradiol:free testosterone ratio.


Body mass index (BMI) acts as a casual factor for developing many diseases such as cardiovascular, breast cancer, heart, diabetes etc. The article presents the impacts of BMI on gestational diabetes Pima Indian heritage women with at least 21 years old. It is established here that mean BMI is larger for gestational diabetes mellitus (GDM) women (P=0.0007) than normal. Mean BMI is directly linked with triceps skin fold thickness (TSFT) (P<0.0001), and it is not related with age (P=0.5185), while it is inversely linked with their joint interaction effect TSFT*Age (P=0.0023). In addition, mean BMI is partially inversely linked with insulin (P=0.1813), and it is partially directly linked with diabetes pedigree function (PDF) (P=0.1601). Variance of BMI is larger for normal women (P<0.0001) than GDM women. It is inversely linked with glucose (P<0.0001), and it is not associated with the number of pregnancies (NOP) (P=0.5494), while it is directly linked with their joint interaction effect Glucose*NOP (P=0.0434). Mean and variance of BMI show many complex impacts on GDM women. Gestational women must care on BMI along with TSFT and glucose levels.


2013 ◽  
Vol 3 (3-4) ◽  
pp. 103-111
Author(s):  
A. N. Izuora ◽  
B. A. Animasahun ◽  
U. Nwodo ◽  
N. M. Ibeabuchi ◽  
O. F. Njokanma ◽  
...  

2003 ◽  
Vol 82 (1) ◽  
pp. 53-58 ◽  
Author(s):  
J.A. Morais ◽  
G. Heydecke ◽  
J. Pawliuk ◽  
J.P. Lund ◽  
J.S. Feine

It is unclear whether mandibular implant overdentures improve the nutritional state of edentulous patients better than conventional dentures. In a randomized clinical trial, we tested for post-treatment differences in nutritional status between patients with mandibular two-implant retained overdentures and those with conventional complete dentures. Edentulous subjects (ages 65–75 yrs) received two-implant mandibular overdentures (IOD, n = 30) or conventional dentures (CD, n = 30). Measures of nutritional state were gathered before and 6 mos after treatment. Significant improvements in anthropometric parameters were detected in the IOD but not in the CD group, for percent body fat (p = 0.011) and skin-fold thickness at the biceps, subscapularis, and abdomen (p < 0.05), with significant decreases in waist circumference (p < 0.0001) and waist-hip ratio (p = 0.001). Significant increases were seen in concentrations of serum albumin (p = 0.015), hemoglobin (p = 0.01), and B12 (p = 0.01). No significant between-group differences were found. These results suggest that low-cost IOD treatment may improve the nutritional state of edentulous people.


2019 ◽  
Vol 6 (5) ◽  
pp. 2116
Author(s):  
Vairamuthu G. S. ◽  
Thangavel A.

Background: Studies in India shown high body fat indices were strongly associated with hypertension in Indian children, but such studies mostly not done in southern states of India. So, authors include children in Tamilnadu measure body fat indices and blood pressure to find which body fat index correlates closely with hypertension.Methods: Standing height was measured using stadiometer. Weight was measured using electronic scale. WC measured in standing position, by a stretch resistant.  WC above 90th centile will be considered as Adipose. Waist to height ratio optimal cut-off value is 0.44 for children. TSFT recorded using Harpenden caliper, on the non-dominant upper arm. Wrist circumference measured using stretch resistant tape.Results: In this study 2000 children were participated. More hypertensives are seen in 10 to 12 years(62) and 16 to 18 years(31).Increased weight correlated with hypertension. Study indicates waist circumference is significantly correlated with systolic BP p<0.003, diastolic BP p<0.000. This study shows significant correlation p<0.003 for systolic and p<0.000 for diastolic BP with triceps skin fold thickness estimation. In multivariate analysis with systolic blood pressure and diastolic blood pressure shows very strong correlation with waist circumference, waist to height ratio and triceps skin fold thickness.Conclusions: In this study we investigate the correlation between body fat indices and blood pressure correlation was statistically analyzed which shows that waist circumference, waist to height ratio and triceps skin fold thickness were strongly correlated with systolic and diastolic BP.


2019 ◽  
Vol 16 (01) ◽  
pp. 21-26
Author(s):  
Manju Dhandapani ◽  
Sivashanmugam Dhandapani ◽  
Meena Agarwal ◽  
Alka Chutani ◽  
Bhawani S. Sharma ◽  
...  

Abstract Aim Nutritional demand after traumatic brain injury is increased due to hypermetabolic response. The present study was undertaken to assess nutritional status with anthropometric indices, factors associated, and their prognostic role following severe head injury (SHI). Method A total of 114 patients in age group 20 to 60 years, admitted within 24 hours of SHI, with Glasgow Coma Scale of 4 to 8, and with no serious systemic disorder were enrolled for the study. Of these, 67 were prospectively assessed weekly till 21 days for changes in mid arm circumference (MAC), mid arm muscle circumference (MAMC), and triceps skin fold thickness (TSF). They were studied in relation to other factors and outcome was assessed at 3 months. Results The percentage fall at 3 weeks for MAC, MAMC, and TSF were 14, 10, and 37%, respectively. The percentage of fall in MAMC was the earliest, and was significantly greater in patients with surgical intervention, tracheostomy, prolonged fever, delayed enteral feeding, and greater caloric deficit. Admission MAMC < 90% of standard was significantly associated with unfavorable outcome (odds ratio 5.9 [95% confidence interval 1.3–27.8], p = 0.01). Unfavorable outcome was significantly more frequent in patients who had at least 15% fall in MAC (85.7 vs. 41.9%, p = 0.03), or 10% fall in MAMC (68.8 vs. 38.2%, p = 0.04) at 2 weeks, compared with others. Fall in TSF had no significant association with outcome at 3 months. In multivariate analysis, MAMC fall had significant independent association with unfavorable outcome. Conclusion Bedside anthropometry (especially MAMC) is efficient in identifying patients with nutrition depletion with significant influence on outcome at 3 months.


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