scholarly journals Antenatal Diagnosis of Alobar Holoprosencephaly

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Rajesh Raman ◽  
Geetha Mukunda Jagadesh

A twenty-year-old second gravida presented to the department of radiodiagnosis for routine obstetric ultrasound examination. Ultrasonography revealed a live fetus of 17 weeks with absent falx, fused thalami, monoventricle, proboscis, and cyclopia. Fetal MRI was performed and the findings were confirmed. Even though ultrasonography is diagnostic in the detection of fetal anomalies, MRI plays a vital role due to its multiplanar capability and excellent soft tissue resolution. The importance of presenting this classical case of alobar holoprosencephaly is to sensitize the clinicians and radiologists to the imaging manifestations of holoprosencephaly and to stress the importance of early diagnosis. If diagnosed in utero at an early stage of pregnancy, termination can be performed and maternal psychological trauma of bearing a deformed fetus can be avoided.

2019 ◽  
Vol 6 (5) ◽  
pp. 2198
Author(s):  
Manjushri Waikar ◽  
Anamika Singh

 Holoprosencephaly (HPE) is a structural malformation of the brain that results from the complete or incomplete noncleavage of the forebrain/ prosencephalon of the embryo into 2 hemispheres1. We present a case of twenty-five year-old primigravida presented to the Outpatient department of Obstetrics for routine checkup and diagnosed with Alobar holoprosencephaly on 2nd level USG. Fetal MRI was performed and the findings were confirmed. Even though ultrasonography is diagnostic in the detection of fetal anomalies, MRI plays a vital role due to its multiplanar capability and excellent soft tissue resolution. The purpose of publishing this case is to sensitize the clinicians to the classical features of holoprosencephaly on various imaging modalities and to stress the importance of its detection before 20 weeks of gestation so as to allow for legal medical termination and alleviate maternal psychological trauma of bearing a deformed fetus.


Author(s):  
Ahmed RG

Background: The complications of the SARS-CoV-2 infection and its COVID-19 disease on mothers and their offspring are less known. Objective: The aim of this review was to determine the transmission, severity, complications of SARS-CoV-2 infection during the pregnancy. This review showed the influence of COVID-19 disease on the neonatal neurogenesis. Owing to no specific vaccines or medicines that were reported for the treatment of COVID-19 disease, this review suggested some control strategies like treatments (medicinal plants, antiviral therapy, cellular therapy, and immunotherapy), nutrition uptake, prevention, and recommendations. Discussion: This overview showed in severely states that SARS-CoV-2 infection during the early stage of pregnancy might increase the risk of stress, panic, and anxiety. This disorder can disturb the maternal immune system, and thus causing a neurodevelopmental disturbance. This hypothesis may be depending on the severity and intensity of the SARS-CoV-2 infection during pregnancy. However, vertical transmission of SARS-CoV-2 from dams to their fetuses is absent until now. Conclusion: During this global pandemic disease, maintaining safety during pregnancy, vaginal delivery, and breastfeeding may play a vital role in a healthy life for the offspring. Thus, international and national corporations should be continuing for perinatal management, particularly during the next pandemic or disaster time.


2021 ◽  
Vol 23 (1) ◽  
pp. 33-49 ◽  
Author(s):  
Sally Griffin

Practical relevance: Abdominal ultrasound plays a vital role in the diagnostic work-up of many cats presenting to general and specialist practitioners. Ultrasound examination of the adrenal glands can provide important information pertaining to several conditions including hyperaldosteronism and hyperadrenocorticism. Clinical challenges: Despite ultrasonography being a commonly used modality, many practitioners are not comfortable performing an ultrasound examination or interpreting the resulting images. Even for the experienced ultrasonographer, differentiating between incidental findings, such as adrenal mineralisation, and clinically significant pathological changes can be challenging. Aim: This review, part of an occasional series on feline abdominal ultrasonography, discusses the ultrasonographic examination of the normal and diseased adrenal glands. Aimed at general practitioners who wish to improve their knowledge of and confidence in feline abdominal ultrasound, this review is accompanied by high-resolution images and videos available online as supplementary material. Equipment: Ultrasound facilities are readily available to most practitioners, although the use of ultrasonography as a diagnostic tool is highly dependent on operator experience. Evidence base: Information provided in this article is drawn from the published literature and the author’s own clinical experience.


1996 ◽  
Vol 89 (3) ◽  
pp. 155P-158P ◽  
Author(s):  
P S J Malone

When used as a screening procedure, ultrasound examination of the fetal urinary tract seldom leads to beneficial interventions. There is also a cost in terms of parental anxiety and unnecessary investigation and treatment. A formal screening programme would therefore be unjustified. However, screening of women for obstetric purposes will continue to reveal fetal abnormalities, and a strategy for dealing with these is needed. Antenatal treatments remain experimental; for most of the common conditions postnatal treatment has no urgency; and, in cases of minor abnormality detected by ultrasound, the best course may be to do nothing.


2020 ◽  
Vol 32 (06) ◽  
pp. 2050047
Author(s):  
Ayesha Sohail ◽  
Muhammad Idrees ◽  
Maria Sajjad ◽  
Sahrish Iftikhar ◽  
Sümeyye Tunc

In the field of epidemiology, not only the disease and the carriers, but also the surrounding environment and the associated stresses play a vital role. Environmental stresses in a novel habitat may facilitate adaptive shifts. Organisms living under environmental stresses often experience higher mutation rates and display greater phenotypic and genetic variation. There is controversial evidence available in the literature about the impact of environmental stresses on the organisms and the resulting variation in mutation rates and the immune responses. In nature, “selection” and the high energetic costs of stress usually reduce this variation. The prior knowledge of the interaction between the stress and disease epidemics may help to control the disease spread at an early stage. A mathematical model of epidemiology, specifically focusing on the vector borne diseases, with environmental stress is reported in this paper. The model is validated with the aid of stability analysis. During this research, a set of parametric values is obtained using reverse engineering. For this purpose, the parametric evaluation is reported with the help of Monte Carlo Markov Chain (MCMC) reverse engineering. Among other factors, the environmental stresses are also responsible for different dynamics of the same disease, in different continents of the world. The proposed research methodology will help in forecasting the epidemiological problems such as the current threat of coronavirus.


2020 ◽  
Vol 12 (14) ◽  
pp. 5652
Author(s):  
Yongquan Li ◽  
Rui Li ◽  
Wenqi Ruan ◽  
Chih-Hsing Liu

Following regional tourism cooperation, the promotion of balanced sustainable development has begun to play a vital role in the tourism industry. Using the West Coast of the Strait urban agglomeration, China, as an example, this study uses a data envelopment analysis (DEA) to analyzes the nonlinear relationship between tourism economic contact intensity and tourism industry efficiency by constructing a mixed effect model. The results show the following: (1) In the early stage of regional tourism cooperation, the efficiency of the tourism industry will decrease with an increase in the intensity of tourism economic contact. As regional cooperation tends towards a stable stage, the efficiency of the tourism industry will continue to increase with the strengthening of the intensity of tourism economic contact. (2) The regional economic level harms the efficiency of the tourism industry. The urbanization level has a positive effect on the efficiency of the tourism industry. (3) The level of opening up and transportation development in the region will not only bring tourism resources or tourists, but also lead them to flow out. They have no significant impacts on the efficiency of the tourism industry.


Author(s):  
Marguerite Lisa Bartholomew

ABSTRACT Obstetric ultrasound is unlike any other form of medical imaging. The expectations of the provider performing the ultrasound are dramatically different from those of the woman receiving the ultrasound. Ultrasound providers are often put into situations where the practice of medicine is superseded by expectations of a pregnant woman and her family who see themselves as consumers of ‘medictainment’ rather than patients. Women come to obstetric ultrasound with the primary expectation to hear the simple news that their baby is normal and most wish to know the fetal sex as a secondary piece of information. They would also like to have information ahead of time about what to expect from an ultrasound examination experience. Ultrasound physicians are charged with the task of identifying something wrong, providing a definitive diagnosis, and communicating it in a balanced and relatively unemotional manner, while at the same time being beneficent and respectful of patient autonomy. Patients may not want to find out that something is wrong, but when there is, they want direct, compassionate communication, and a plan of action. How to cite this article Bartholomew ML. Obstetric Ultrasound: Balancing Recommendations with Expectations. Donald School J Ultrasound Obstet Gynecol 2016;10(1):14-22.


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