scholarly journals The Regulatory Role of Activating Transcription Factor 2 in Inflammation

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Tao Yu ◽  
Yong Jun Li ◽  
Ai Hong Bian ◽  
Hui Bin Zuo ◽  
Ti Wen Zhu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Leucine Zipper ◽  
Regulatory Role ◽  
Neurological Development ◽  
Potential Applications ◽  
Inflammatory Drugs ◽  
Activating Transcription Factor ◽  
And Function ◽  
Potential Inhibitors

Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA-binding proteins and is widely distributed in tissues including the liver, lung, spleen, and kidney. Like c-Jun and c-Fos, ATF2 responds to stress-related stimuli and may thereby influence cell proliferation, inflammation, apoptosis, oncogenesis, neurological development and function, and skeletal remodeling. Recent studies clarify the regulatory role of ATF2 in inflammation and describe potential inhibitors of this protein. In this paper, we summarize the properties and functions of ATF2 and explore potential applications of ATF2 inhibitors as tools for research and for the development of immunosuppressive and anti-inflammatory drugs.

scholarly journals Identification of human myometrial target genes of the c-Jun NH2-terminal kinase (JNK) pathway: the role of activating transcription factor 2 (ATF2) and a novel spliced isoform ATF2-small

2005 ◽  
Vol 34 (1) ◽  
pp. 19-35 ◽  
Author(s):  
Jarrod Bailey ◽  
G Nicholas Europe-Finner
Keyword(s):  
Transcription Factor ◽  
Stress Responses ◽  
Leucine Zipper ◽  
Target Genes ◽  
Mitogen Activated Protein Kinase ◽  
Human Myometrium ◽  
Suppression Subtractive Hybridisation ◽  
Jnk Pathway ◽  
Activating Transcription Factor

Activating transcription factor 2 (ATF2), a ubiquitously expressed member of the basic region leucine zipper (bZIP) family of transcription factors activated by mitogen activated protein kinase (MAPK) pathways, is important in the mediation of cellular stress responses, development and transformation. We have previously reported the differential expression of active ATF2 in the human myometrium throughout pregnancy and labour, and identified and partially characterized a novel splice variant ATF2-small (ATF2-sm). To further understand the role of these factors in the myometrium, we have used gene microarrays to define the target genes in cultured myometrial cells stably-transfected with ATF2 and ATF2-sm cDNAs. Many of the genes identified appear to have potential roles in regulating myometrial function and include proteins involved in G-protein receptor signalling, cytokine signalling, transcriptional regulation, cell-cycle control, formation of the extracellular matrix and cytoskeletal architecture. ATF2 was found to affect the expression of 204 genes; 113 being up-regulated and 91 down-regulated whereas the novel ATF2-sm factor altered the expression of 55 genes; expression was increased in 29 cases and decreased in 26. A further 25 genes affected by ATF2-sm were identified by suppression subtractive hybridisation (SSH). Notably, the genes affected by ATF2 and ATF2-sm appear to belong to discrete groups: only two genes were affected by both factors.

scholarly journals A Pivotal Role of the Basic Leucine Zipper Transcription Factor bZIP53 in the Regulation of Arabidopsis Seed Maturation Gene Expression Based on Heterodimerization and Protein Complex Formation

2009 ◽  
Vol 21 (6) ◽  
pp. 1747-1761 ◽  
Author(s):  
Rosario Alonso ◽  
Luis Oñate-Sánchez ◽  
Fridtjof Weltmeier ◽  
Andrea Ehlert ◽  
Isabel Diaz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Complex Formation ◽  
Protein Complex ◽  
Leucine Zipper ◽  
Pivotal Role ◽  
Basic Leucine Zipper ◽  
Arabidopsis Seed ◽  
Protein Complex Formation

scholarly journals The Potential Applications of Peroxisome Proliferator-Activated ReceptorδLigands in Assisted Reproductive Technology

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Jaou-Chen Huang
Keyword(s):  
Assisted Reproductive Technology ◽  
Reproductive Function ◽  
Reproductive Technology ◽  
Embryonic Cell ◽  
Preimplantation Embryos ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Potential Applications ◽  
And Function

Peroxisome proliferator-activated receptorδ(PPARδ, also known as PPARβ) has ubiquitous distribution and extensive biological functions. The reproductive function of PPARδwas first revealed in the uterus at the implantation site. Since then, PPARδand its ligand have been discovered in all reproductive tissues, including the gametes and the preimplantation embryos. PPARδin preimplantation embryos is normally activated by oviduct-derived PPARδligand. PPARδactivation is associated with an increase in embryonic cell proliferation and a decrease in programmed cell death (apoptosis). On the other hand, the role of PPARδand its ligand in gamete formation and function is less well understood. This review will summarize the reproductive functions of PPARδand project its potential applications in assisted reproductive technology.

Anti-inflammatory drugs and tumor necrosis factor-α production from monocytes: role of transcription factor NF-κB and implication for rheumatoid arthritis therapy

2004 ◽  
Vol 501 (1-3) ◽  
pp. 199-208 ◽  
Author(s):  
Luisa Lavagno ◽  
Gabriele Gunella ◽  
Claudio Bardelli ◽  
Simona Spina ◽  
Luigia Grazia Fresu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Transcription Factor ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine

FEBS Journal ◽  
2014 ◽  
Vol 281 (7) ◽  
pp. 1892-1900 ◽  
Author(s):  
Akira Sato ◽  
Kentaro Nakama ◽  
Hiroki Watanabe ◽  
Akito Satake ◽  
Akihiro Yamamoto ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Activating Transcription Factor 3 ◽  
Activating Transcription Factor ◽  
Transcription Factor 3

THE ROLE OF ACTIVATING TRANSCRIPTION FACTOR-2 IN SKELETAL GROWTH CONTROL

2003 ◽  
Vol 85 ◽  
pp. 133-136 ◽  
Author(s):  
PHYLLIS LUVALLE ◽  
QIN MA ◽  
FRANK BEIER
Keyword(s):  
Transcription Factor ◽  
Growth Control ◽  
Skeletal Growth ◽  
Activating Transcription Factor

scholarly journals BATF acts as an essential regulator of IL-25–responsive migratory ILC2 cell fate and function

2020 ◽  
Vol 5 (43) ◽  
pp. eaay3994 ◽  
Author(s):  
Mindy M. Miller ◽  
Preeyam S. Patel ◽  
Katherine Bao ◽  
Thomas Danhorn ◽  
Brian P. O’Connor ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Fate ◽  
Leucine Zipper ◽  
Mucosal Barrier ◽  
Nippostrongylus Brasiliensis ◽  
Cell Hyperplasia ◽  
Basic Leucine Zipper ◽  
Tuft Cell ◽  
Group 2 ◽  
And Function

A transitory, interleukin-25 (IL-25)–responsive, group 2 innate lymphoid cell (ILC2) subset induced during type 2 inflammation was recently identified as iILC2s. This study focuses on understanding the significance of this population in relation to tissue-resident nILC2s in the lung and intestine. RNA-sequencing and pathway analysis revealed the AP-1 superfamily transcription factor BATF (basic leucine zipper transcription factor, activating transcription factor–like) as a potential modulator of ILC2 cell fate. Infection of BATF-deficient mice with Nippostrongylus brasiliensis showed a selective defect in IL-25–mediated helminth clearance and a corresponding loss of iILC2s in the lung characterized as IL-17RBhigh, KLRG1high, BATFhigh, and Arg1low. BATF deficiency selectively impaired iILC2s because it had no impact on tissue-resident nILC2 frequency or function. Pulmonary-associated iILC2s migrated to the lung after infection, where they represented an early source of IL-4 and IL-13. Although the composition of ILC2s in the small intestine was distinct from those in the lung, their frequency and IL-13 expression remained dependent on BATF, which was also required for optimal goblet and tuft cell hyperplasia. Findings support IL-25–responsive ILC2s as early sentinels of mucosal barrier integrity.

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