Giant Malignant Phyllodes Tumour of Breast

The term phyllodes tumour includes lesions ranging from completely benign tumours to malignant sarcomas. Clinically phyllodes tumours are smooth, rounded, and usually painless multinodular lesions indistinguishable from fibroadenomas. Percentage of phyllodes tumour classified as malignant ranges from 23% to 50%. We report a case of second largest phyllodes tumour in a 35-year-old lady who presented with swelling of right breast since 6 months, initially small in size, that progressed gradually to present size. Examination revealed mass in the right breast measuring36×32 cms with lobulated firm surface and weighing 10 kgs. Fine needle aspiration cytology was reported as borderline phyllodes; however core biopsy examination showed biphasic neoplasm with malignant stromal component. Simple mastectomy was done and specimen was sent for histopathological examination which confirmed the core biopsy report. Postoperatively the patient received chemotherapy and radiotherapy. The patient is on follow-up for a year and has not shown any evidence of metastasis or recurrence.

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MON-482 Thyroid Tuberculosis - An Unlikely Diagnosis

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.719 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Alexandra Novais Araújo ◽

Tânia Matos ◽

Ema Nobre ◽

Maria Joao Bugalho

Keyword(s):

Lymph Node ◽

Fine Needle Aspiration ◽

Histopathological Examination ◽

Extrapulmonary Tuberculosis ◽

Needle Aspiration ◽

Tuberculous Infection ◽

Rare Presentation ◽

Adequate Treatment ◽

Fine Needle ◽

The Right

Abstract Background: Mycobacterium tuberculosis (MTB) is an aerobic bacillus responsible for the most cases of tuberculous infection. Approximately one-third of the world’s population is infected. Tuberculosis (TB) of the thyroid gland is an unusual diagnosis with an estimated prevalence of 0.1 to 0.6%. The thyroid TB can mimic different pathologies (thyroid neoplasms, lymphoma, infectious or granulomatous thyroiditis, Graves’ disease or bacterial abscess) and the diagnosis can be easily disregarded, especially in non-endemic countries and if the patient doesn’t have systemic symptoms. The fine needle aspiration and histopathological examination, with acid-fast bacilli staining and TB culture, are the gold standard exams. Clinical Case: A 71-year-old female was referred to our Endocrinology department after a diagnosis of nodular thyroid disease. She had complaints of slight cervical discomfort, with 6 months of duration. She hadn’t personal or familiar relevant antecedents. At observation, a movable, elastic and non-tender nodule of 15mm at the right superior thyroid lobe was identified. Blood tests including a thyroid profile were normal. The neck ultrasound showed, at the right lobe of the thyroid, multiple solid nodules; the dominant had 18mm, was heterogeneous and had multiple calcifications. Moreover, lymph nodes with suspicious ultrasonographic features along the right internal jugular chain were reported. The patient underwent fine-needle aspiration (FNA) of the suspicious thyroid nodule and one lymph node. Results were respectively: non-diagnostic (Bethesda I) and reactive pattern. FNA was repeated on a different occasion and results were similar. Due to ultrasound suspicious of malignancy, a total thyroidectomy was performed and a lymph node from level IV was sampled for extemporaneous examination. Necrotizing granulomas were documented; the Ziehl-Neelson staining (ZNS) was negative; material was sent to microbiology. Following this finding, ganglion emptying was not performed. The thyroid histology showed tuberculoid type granulomas with lymphoid border and central necrosis. However, the ZNS was negative. The diagnosis was definitely established by a positive culture of the lymph node tissue and molecular detection, by polymerase chain reaction (PCR), of MTB. Pulmonary involvement was excluded and she started antituberculous agents planned for 9 months (rifampicin and isoniazid during 9 months and ethambutol and pyrazinamide for 2 months). Conclusion: Thyroid TB is a rare presentation of extrapulmonary tuberculosis. In presence of systemic or specific complaints or history of exposition the diagnosis may be suspected and confirmatory tests requested in order to ensure an adequate treatment. However, sometimes, histopathology remains a key step and the use of cultures improves the sensitivity and specificity of TB tests.

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Regional Nodal Metastasis of Humeral Chondrosarcoma in a Dog

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6198 ◽

2015 ◽

Vol 51 (5) ◽

pp. 346-351 ◽

Cited By ~ 1

Author(s):

Mandy Meindel ◽

Lisa Pohlman ◽

Brad DeBey ◽

Mary Lynn Higginbotham ◽

Rachel Moon

Keyword(s):

Lymph Nodes ◽

Histopathological Examination ◽

Bone Lesion ◽

Prognostic Indicator ◽

Needle Aspiration ◽

Nodal Metastasis ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

History Of ◽

The Right

A 6 yr old castrated male English springer spaniel was evaluated with a 1 mo history of progressive right forelimb lameness with recent swelling around the elbow joint. Physical examination findings included lameness of the right forelimb, muscle atrophy around the right shoulder, grade 2/6 heart murmur, and moderate dental disease. Results of a complete blood cell count and serum biochemical analysis were unremarkable with the exception of a mildly increased alkaline phosphatase (368 U/L; reference range, 128–328 U/L). Radiographs of the right elbow revealed a mixed lytic and proliferative osseous lesion most consistent with either neoplasia or infection. Thoracic radiographs and the echocardiogram were unremarkable. Fine-needle aspiration of the bone lesion was performed. The cytological diagnosis was chondrosarcoma. The right forelimb was amputated and the axillary lymph nodes were collected. Histopathological examination of the bone lesion and axillary lymph nodes revealed chondrosarcoma with metastasis to the lymph nodes. Lymph node metastasis of chondrosarcoma is rare and needs to be further evaluated as a prognostic indicator.

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CYTOLOGICAL EXPERIENCE OF PAEDIATRIC RETROPERITONEAL GANGLIONEUROMA- A RARE CASE REPORT

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703786 ◽

2014 ◽

Vol 04 (02) ◽

pp. 144-146

Author(s):

Harish S. Permi ◽

Sandeep Rai ◽

Padma Shetty ◽

Sunil Kumar Y. ◽

Kiran H. S. ◽

...

Keyword(s):

Schwann Cells ◽

Ganglion Cells ◽

Histopathological Examination ◽

Needle Aspiration ◽

Posterior Mediastinum ◽

Sympathetic Ganglia ◽

Rare Case Report ◽

Mantle Layer ◽

Needle Aspiration Cytology ◽

The Right

Abstract:Ganglioneuroma is a benign tumor that originates from primordial neural crest cells which migrate from the mantle layer of the developing spinal cord to the sympathetic ganglia, adrenal medulla, and other sites. The most affected anatomical sites are the posterior mediastinum, retroperitoneum, adrenal gland, head and neck. It occurs most commonly in children over 10 years of age and consists of ganglion and Schwann cells. We report a case of 9 – year- old male child who presented with mass per abdomen in the right hypochondrium. Fine needle aspiration cytology showed mature ganglion cells and cluster of Schwann cells suggestive of Ganglioneuroma. Cytology diagnosis was confirmed by histopathological examination of tru-cut biopsy and subsequently excised specimen. On regular follow he is doing fine without any symptoms.

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Supraclavicular nerve schwannoma: a rare differential diagnosis for a neck lump

International Surgery Journal ◽

10.18203/2349-2902.isj20190842 ◽

2019 ◽

Vol 6 (3) ◽

pp. 1010

Author(s):

Adarsh P. Shah ◽

Raj Bhutiani

Keyword(s):

Middle Eastern ◽

Systemic Disease ◽

Needle Aspiration ◽

Excision Biopsy ◽

Benign Schwannoma ◽

Supraclavicular Fossa ◽

Rare Differential Diagnosis ◽

Needle Aspiration Cytology ◽

Benign Tumours ◽

The Right

Supraclavicular schwannomas are very rare benign tumours. We present the case of a 30-year-old middle-eastern man who complained of a gradually enlarging, asymptomatic 2cm non-tender swelling in the right supraclavicular fossa. There were no other symptoms suggestive of systemic disease. Ultrasound imaging was suggestive of an abnormal lymph node, but fine needle aspiration cytology of the lump was inconclusive. Subsequent urgent excision biopsy of the lump on histology revealed it to be a benign schwannoma. On post-operative follow-up, the patient did not have any neurological deficit.

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Lymphoepithelial cyst of submandibular gland, a clinical dilemma- case report

International Surgery Journal ◽

10.18203/2349-2902.isj20171648 ◽

2017 ◽

Vol 4 (5) ◽

pp. 1818

Author(s):

Robin Cheereth ◽

Dheeraj Eldho Paulose ◽

George Abraham Ninan

Keyword(s):

Submandibular Gland ◽

Histopathological Examination ◽

Neck Region ◽

Needle Aspiration ◽

Great Difficulty ◽

Interesting Case ◽

Lymphoepithelial Cyst ◽

Submandibular Region ◽

Maxilla And Mandible ◽

The Right

Swellings of the head and neck region present great difficulty in accurate diagnosis as well as proper management. Swelling associated with the maxilla and mandible has a tendency to be provisionally diagnosed as orofacial space infections, which is the most common cause for acute swelling in this region. Fine needle aspiration cytology (FNAC), ultrasonogram and computed tomography can be used in supporting diagnosis. It usually occurs due to the process of lymphocyte-induced cystic ductular dilatation and the confirmatory diagnosis is always made postoperatively by histopathological examination. The mainstay in the treatment of a lymphoepithelial cyst remains the surgical approach, which includes complete enucleation of the cyst along with total excision of the involved salivary gland. Here we present an interesting case of swelling in the right submandibular region which was provisionally diagnosed as submandibular space infection, but later proven histopathologically as a lymphoepithelial cyst of the submandibular gland.

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P1704 An unusual mass in the right heart

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.1067 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

A Wojtkowska ◽

W Brzozowski ◽

M Prasal ◽

S Lukasik ◽

E Czekajska-Chehab ◽

...

Keyword(s):

Smooth Muscle ◽

Inferior Vena ◽

Histopathological Examination ◽

Vena Cava ◽

Premenopausal Women ◽

Iliac Vein ◽

Intravenous Leiomyomatosis ◽

Right Heart ◽

Benign Tumours ◽

The Right

Abstract A 39 year old patient after removal of the uterus, the left oviduct and the right appendages due to Tu (massive fibroids). The histopathological examination revealed: leiomyomatosis intravascularis masiva (multifocal, intravenous smooth muscle cell hyperplasia without necrosis, cellular atypia and mitotic activity. Vascular invasion within the uterus, parametrium, mesovarium, perinodule tissues). The patient was admitted to the Gynaecology Clinic on the 9th postoperative day due to pain in the right lumbar region. The angio-CT of the thoracic, abdominal and pelvic cavities revealed a tumour/thrombus in the right internal iliac vein, common iliac vein and inferior vena cava (VCI). Then, the patient underwent transesophageal echocardiography (TEE) and transthoracic echocardiography (TTE) revealing an additional mass in the VCI entering the right atrium (RA), periodically passing through the tricuspid valve to the right ventricle (RV). The mass was of irregular shape, free-floating and did not obstruct the right ventricle inflow. Due to a suspicion of thrombus, an attempt at pharmacological treatment was initiated: initially LMWH at a therapeutic dose, followed by UFH iv. (controlled by APTT). Follow-up echocardiography: the image has not changed, the mass is still in the same location. The patient then underwent a surgical treatment: the pathological mass with a length of 35 cm was removed from VCI and RA with extracorporeal circulation. The histopathological examination confirmed: numerous foci of intravenous leiomyomatosis in the form of smooth muscle hyperplasia penetrating into the light of numerous vessels, mainly venous. Discussion Uterine fibroids are the most common benign tumours of the reproductive tract in premenopausal women, they are also the most common cause of hysterectomy. They are formed as a result of benign proliferation of myometrial smooth muscle cells. A special, though very rare, form is intravenous leiomyomatosis (IVL) - caused by abnormal growth of benign tumours, arising from smooth muscle, into venous vessels. Although histopathologically they are benign tumours, due to the possible invasion of large vessels they can be highly "aggressive" and extend into the heart chambers and pulmonary arteries (intracardiac leiomyomatosis - ICLM). Possible symptoms of ICLM: dyspnoea (30-37%), peripheral oedema (20-28%), chest pain (12-30%), palpitation (10-17%), fainting (11%). Approximately 13% of patients have no symptoms at all. In the differential diagnosis of masses in the right heart cavities, the following should be taken into account : thrombus, myxoma, metastases of malignant neoplasms, in particular renal cancer, as well as: liver cancer, adrenal cancer, lymphoma, leiomyosarcoma. Conclusion IVL should be taken into account as a differential diagnosis in case of a free-floating mass in the right heart chambers, originating from the inferior vena cava, among premenopausal women with a history of hysterectomy. Abstract P1704 Figure. mass in the right atrium

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Meibomian adenoma in a Syrian hamster (Mesocricetus auratus

Veterinární Medicína ◽

10.17221/7184-vetmed ◽

2013 ◽

Vol 58 (No. 12) ◽

pp. 641-644 ◽

Cited By ~ 1

Author(s):

A. Demirutku ◽

Y. Devecioglu ◽

E. Eravci ◽

I. Firat ◽

F. Yildirim

Keyword(s):

Syrian Hamster ◽

Histopathological Examination ◽

Mesocricetus Auratus ◽

Faculty Research ◽

Upper Eyelid ◽

Research And Practice ◽

Healing Wound ◽

Benign Tumours ◽

The Right ◽

Veterinary Faculty

A two-year old male Syrian hamster (Mesocricetus auratus) was brought to the Surgery Clinic at the Istanbul University, Veterinary Faculty, Research and Practice Hospital, with a non-healing wound on the right upper eyelid. An ulcerated, bleeding wound was observed and diagnosed as an eyelid mass. The eyelid mass was excised and submitted for histopathological examination, which resulted in a diagnosis of meibomian adenoma. After excision of the mass, the right upper eyelid became deformed and adopted an abnormal shape. The surgical site was examined two weeks later. No abnormality was observed and the appearance of the right eyelid had returned to normal. Although there are many reports on benign tumours such as polyps, adenomas, haemangiomas and papillomas in hamsters, to the authors’ knowledge, this is the first report on a meibomian adenoma in a Syrian hamster which was resolved by surgery.

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Extra skeletal soft tissue chondroma (ESSC) of right thumb- a benign tumour diagnosed by FNAC – a rare case report

International Journal of Human and Health Sciences (IJHHS) ◽

10.31344/ijhhs.v2i3.48 ◽

2018 ◽

Vol 2 (3) ◽

pp. 164

Author(s):

Tirthankar Chakraborty ◽

Kabyasree Jana ◽

Pratima Mondal ◽

Sanjusree Das ◽

Tapan Kumar Ghosh ◽

...

Keyword(s):

Soft Tissue ◽

Histopathological Examination ◽

Surgical Excision ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Rare Case Report ◽

Malignant Lesions ◽

Needle Aspiration Cytology ◽

Benign Tumours ◽

Hands And Feet

Extra skeletal soft tissue chondroma (ESSC) is very rare slowly growing benign tumours usually occur in hands and feet. Lesion must be differentiated from other benign and malignant lesions in these locations by clinical, radiological, cytological and histopathological examination for proper management of such benign entity. A case is presenting here in a thirty five years old lady suffering from similar type of lesion over right thumb diagnosed preoperatively by fine needle aspiration cytology because of rarity. Diagnosis was confirmed by surgical excision and histopathological examination.International Journal of Human and Health Sciences Vol. 02 No. 03 July’18. Page : 164-166

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Popliteal artery thrombosis secondary to a tibial osteochondroma

VASA ◽

10.1024/0301-1526/a000101 ◽

2011 ◽

Vol 40 (3) ◽

pp. 251-255 ◽

Cited By ~ 4

Author(s):

Gruber-Szydlo ◽

Poreba ◽

Belowska-Bien ◽

Derkacz ◽

Badowski ◽

...

Keyword(s):

Case Report ◽

Magnetic Resonance Angiography ◽

Popliteal Artery ◽

Doppler Ultrasonography ◽

Histopathological Examination ◽

Previous History ◽

Plain Radiography ◽

Artery Thrombosis ◽

History Of ◽

The Right

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

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