scholarly journals Vitamin D Status in Women with Gestational Diabetes Mellitus during Pregnancy and Postpartum

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Pleskačová ◽  
Vendula Bartáková ◽  
Lukáš Pácal ◽  
Katarína Kuricová ◽  
Jana Bělobrádková ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Normal Glucose Tolerance ◽  
Vitamin D Status ◽  
Early Postpartum ◽  
Pregnancy And Postpartum

Of many vitamin D extraskeletal functions, its modulatory role in insulin secretion and action is especially relevant for gestational diabetes mellitus (GDM). The aims of the present study were to determine midgestational and early postpartum vitamin D status in pregnant women with and without GDM and to describe the relationship between midgestational and postpartum vitamin D status and parallel changes of glucose tolerance. A total of 76 pregnant women (47 GDM and 29 healthy controls) were included in the study. Plasma levels of 25(OH)D were measured using an enzyme immunoassay. Vitamin D was not significantly decreased in GDM compared to controls during pregnancy; however, both groups of pregnant women exhibited high prevalence of vitamin D deficiency. Prevalence of postpartum 25(OH)D deficiency in post-GDM women remained significantly higher and their postpartum 25(OH)D levels were significantly lower compared to non-GDM counterparts. Finally, based on the oGTT repeated early postpartum persistent glucose abnormality was ascertained in 15% of post-GDM women; however, neither midgestational nor postpartum 25(OH)D levels significantly differed between subjects with GDM history and persistent postpartum glucose intolerance and those with normal glucose tolerance after delivery.

scholarly journals Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland

2021 ◽  
Author(s):  
Kristin S. Magnusdottir ◽  
Ellen A. Tryggvadottir ◽  
Ola K. Magnusdottir ◽  
Laufey Hrolfsdottir ◽  
Thorhallur I. Halldorsson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Vitamin D Status ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25Ohd Concentration

Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. Objective: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. Design: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. Results: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). Conclusion: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in this study.

scholarly journals Comparison of Serum Lipid Profile between Gestational Diabetes Mellitus and Pregnant Women with Normal Glucose Tolerance

2020 ◽  
Vol 08 (06) ◽  
pp. 148-159
Author(s):  
Mahmudul Hossain ◽  
A. K. M. Shahidur Rahman ◽  
Samira Mahjabeen ◽  
Mohona Zaman ◽  
Mohaiminul Abedin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Normal Glucose Tolerance ◽  
Serum Lipid Profile ◽  
Normal Glucose

scholarly journals Maternal Vitamin D Status in Gestational Diabetes Mellitus Women

2021 ◽  
pp. 55-63
Author(s):  
Zainedeen Nassar ◽  
Mazen Alzaharna
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Gaza Strip ◽  
Density Lipoprotein ◽  
Vitamin D Status

Aims: To assess vitamin D status among Gestational Diabetes Mellitus pregnant women in Gaza Strip. Study Design: Case control study. Place and Duration of Study: Samples were collected from pregnant women attending primary health care centers, Gaza, Gaza Strip. Methodology: The study comprised 90 participants, 45 GDM pregnant women and 45 apparently healthy pregnant women. Serum vitamin D and insulin levels were measured by ELISA, fasting blood glucose (FBG), 2 h oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), triglycerides (TG), cholesterol, high-density lipoprotein (HDL), phosphorus and calcium were determined chemically. Blood pressure was measured. Body mass index (BMI) and low-density lipoprotein (LDL) were calculated. Ethical approval was acquired from Helsinki committee. All data was analyzed using the SPSS program. Results: The average vitamin D in GDM cases was lower than that in controls (P=0.031). There was an increase in the average of FBG, OGTT, HbA1c and insulin levels in GDM cases versus controls (P<0.001). The average levels of serum cholesterol, TG and LDL were significantly higher in cases as compared to controls. The average systolic and diastolic blood pressure levels were higher in GDM cases in relation to controls. Pearson correlation test showed a significant negative correlation between vitamin D and the parameters: BMI, glucose, OGTT, HbA1c and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Conclusion: Vitamin D was lower in GDM women compared to controls. Low vitamin D status may be associated with insulin resistance and act as a risk factor for GDM.

Study of vitamin D receptor gene methylation and the risk of gestational diabetes mellitus in Iranian pregnant women

Gene Reports ◽  
2021 ◽  
Vol 22 ◽  
pp. 100978
Author(s):  
Pooneh Mokarram ◽  
Golzar Rahmannezhad ◽  
Mehran Erfani ◽  
Mohammad Reza Rezvanfar ◽  
Farideh Jalali Mashayekhi
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Methylation

scholarly journals Relationship of Early Vitamin D Concentrations and Gestational Diabetes Mellitus in Indian Pregnant Women

2019 ◽  
Vol 6 ◽  
Author(s):  
Pratibha Dwarkanath ◽  
Ponnusamy Vinotha ◽  
Tinku Thomas ◽  
Siji Joseph ◽  
Annamma Thomas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Relationship Of

scholarly journals Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus

2019 ◽  
Vol 41 (07) ◽  
pp. 425-431
Author(s):  
Thais Walverde Siqueira ◽  
Edward Araujo Júnior ◽  
Rosiane Mattar ◽  
Silvia Daher
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Vitamin ◽  
Vdr Gene ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and women with GDM (GDM group) (n = 79), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide/cetyltrimethylammonium bromide (DTAB/CTAB) method, and genotyping was performed by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results. Results There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60 ± 8.89 ng/mL versus 23.60 ± 10.68 ng/mL; p = 0.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p = 0.41). Conclusion There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.

scholarly journals Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort

2019 ◽  
Vol 21 (8) ◽  
pp. 1895-1905 ◽  
Author(s):  
Jin Xia ◽  
Yiqing Song ◽  
Shristi Rawal ◽  
Jing Wu ◽  
Stefanie N. Hinkle ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Longitudinal Study ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Status
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