scholarly journals Structural and Population Polymorphism of RT-Like Sequences in Avian SchistosomesTrichobilharzia szidati(Platyhelminthes: Digenea: Schistosomatidae)

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
S. K. Semyenova ◽  
G. G. Chrisanfova ◽  
A. S. Guliaev ◽  
A. P. Yesakova ◽  
A. P. Ryskov
Keyword(s):  
Host Specificity ◽  
Lymnaea Stagnalis ◽  
Strong Association ◽  
Snail Host ◽  
New Members ◽  
East Europe ◽  
Causative Agents ◽  
History Of ◽  
Avian Schistosomes ◽  
Parasite Evolution

Recently we developed the genus-specific markers of the avian schistosomes of the genusTrichobilharzia, the causative agents of human cercarial dermatitis. The 7 novel genome sequences ofT. franki, T. regenti, andT. szidatirevealed similarity with genome repeat region of African schistosomeSchistosoma mansoni. In the present work we analyzed the 37 newT. szidatisequences to study intragenome variability and host specificity for the parasite from three localities of East Europe. DNAs were isolated from cercariae or single sporocysts obtained from 6 lymnaeid snailsLymnaea stagnalisandL. palustrisfrom Belarus and Russia. All sequences formed three diverged groups, one of which consists of the sequences with multiple deletions; other groups involved two paralogous copies with stop codons and frameshift mutations. Strong association between geographical distribution and snail host specificity cannot be established. All studied sequences have homology with the reverse transcriptase domain (RT) of Penelope-like elements (PLE) ofS. mansoniandS. japonicumand new members of RT family were identified. We proposed that three diverged groups RT sequences ofT. szidatiare results of duplication or transposition of PLE during parasite evolution. Implications of the retroelement dynamics in the life history of avian schistosomes are discussed.

Factor V Leiden Is Associated with Repeated and Recurrent Unexplained Fetal Losses

1997 ◽  
Vol 77 (05) ◽  
pp. 0822-0824 ◽  
Author(s):  
Elvira Grandone ◽  
Maurizio Margaglione ◽  
Donatella Colaizzo ◽  
Marina d'Addedda ◽  
Giuseppe Cappucci ◽  
...  
Keyword(s):  
Protein C ◽  
Strong Association ◽  
Activated Protein C ◽  
Fetal Loss ◽  
Factor V Leiden ◽  
Factor V ◽  
Significant Difference ◽  
History Of ◽  
Fv Leiden ◽  
Caucasian Women

SummaryActivated protein C resistance (APCR) is responsible for most cases of familial thrombosis. The factor V missense mutation Arg506>Gln (FV Leiden) has been recognized as the commonest cause of this condition. Recently, it has been suggested that APCR is associated with second trimester fetal loss. We investigated the distribution of FV Leiden in a sample (n = 43) of Caucasian women with a history of two or more unexplained fetal losses. A group (n = 118) of parous women with uneventful pregnancies from the same ethnical background served as control. We found the mutation in 7 cases (16.28%) and 5 controls (4.24%; p = 0.011). A statistically significant difference between women with only early fetal loss vs those with late events (p = 0.04) was observed. Our data demonstrate a strong association between FV Leiden and fetal loss. Furthermore, they indicate that late events are more common in these patients.

scholarly journals Violence and depression among pregnant women in Egypt

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hanan M. Ghoneim ◽  
Mohamed Elprince ◽  
Tamer Yehia M. Ali ◽  
Waleed F. Gharieb ◽  
Amal A. Ahmed
Keyword(s):  
Intimate Partner Violence ◽  
Sexual Violence ◽  
Partner Violence ◽  
Strong Association ◽  
Depression Scale ◽  
Intimate Partner ◽  
University Hospital ◽  
P Value ◽  
Significant Difference ◽  
History Of

Abstract Background Depression is a serious mental health disorder that might affect women in the childbearing period. Incidences increase during pregnancy as well as after delivery. Its association with intimate partner violence (defined as physical, sexual, or psychological harm by a current or former partner) has been reported in many countries. Data about this sensitive issue are lacking in Egypt. The aim of the study was to determine the relation between intimate partner violence and depression during pregnancy. Methods This was a case control study conducted at the outpatient clinics in Suez Canal University hospital, from January 2019 to March 2020. The study included two groups, the study group included women exposed to violence during the current pregnancy and a control one included women with no history of violence. Both groups were recruited according to the predetermined inclusion criteria (women aged 18-45 years, continuous marital relationship, no history of depression in current or previous pregnancies, and singleton pregnancy). Women were asked to complete the Arabic validated NorVold Domestic Abuse Questionnaire (measuring four types of abuse: emotional, physical, sexual, and violence in the health care system, the last one being excluded). Depression was evaluated using the Arabic validated form of the Edinburgh Postnatal Depression Scale (comprises 10 questions that represent patients’ feelings in the last 7 days). The main outcome measure was to assess the association between intimate partner violence and depression. Results We recruited 158 women in each group. Both groups were matched in their demographic characters. Although emotional violence was reported prominently among women exposed to IPV 87.9% (139/158), it was not significantly reported in depressed women (P value 0.084). Physical and sexual violence were significantly reported among depressed women (P value 0.022 and 0.001, respectively). There was a significant difference between women exposed to violence and those who were not exposed to violence in the total depression scores (13.63 ± 5.47 and 10.65 ± 5.44, respectively with a p value < 0.001). Emotional (p value < 0.001) and sexual violence (mild and severe with p value of 0.026 and 0.002 respectively) had significant roles as risk factors for depression during pregnancy in single regression and after control of other confounders. Conclusion There was a strong association between intimate partner violence and depression during pregnancy.

Anxiety disorders and substance abuse

2016 ◽  
Vol 33 (S1) ◽  
pp. S384-S384
Author(s):  
I. Prieto Sánchez ◽  
M.D.L.C. Ramírez Domínguez ◽  
S. Fernández León ◽  
M. Reina Domínguez ◽  
N. Garrido Torres ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Dual Diagnosis ◽  
Behavioral Problems ◽  
Strong Association ◽  
Epidemiological Studies ◽  
Distinctive Features ◽  
Other Substances ◽  
History Of ◽  
Competing Interest ◽  
Substance Disorder

IntroductionPatients with anxiety disorders are more vulnerable to develop other comorbid conditions. In particular, large epidemiological studies show a strong association between different anxiety disorders and substance use disorders.ObjectivesTo show the prevalence of major anxiety disorders and the consumption of different substances. As well as the particular characteristics of this dual diagnosis and treatments that have proven more effective.MethodsExhaustive review of all the material published on this topic in the recent years.ConclusionsNearly 24% of patients with anxiety disorder suffer from a comorbid substance disorder use in their lifetime (17.9% diagnosis of alcohol abuse or dependence diagnosis and 11.9% of abuse or dependence on other drugs). Dual patients show a number of distinctive features, such as more frequency in males, family history of alcohol or other substances abuse and behavioral problems, early parental loss among others.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Bat coronavirus phylogeography in the Western Indian Ocean

2019 ◽  
Author(s):  
Léa Joffrin ◽  
Steven M. Goodman ◽  
David A. Wilkinson ◽  
Beza Ramasindrazana ◽  
Erwan Lagadec ◽  
...  
Keyword(s):  
Indian Ocean ◽  
Phylogenetic Analyses ◽  
Strong Association ◽  
Western Indian Ocean ◽  
Reunion Island ◽  
High Genetic Diversity ◽  
Soil Fertilization ◽  
Réunion Island ◽  
History Of ◽  
Bat Coronavirus

AbstractBats provide key ecosystem services such as crop pest regulation, pollination, seed dispersal, and soil fertilization. Bats are also major hosts for biological agents responsible for zoonoses, such as coronaviruses (CoVs). The islands of the Western Indian Ocean are identified as a major biodiversity hotspot, with more than 50 bat species. In this study, we tested 1,013 bats belonging to 36 species from Mozambique, Madagascar, Mauritius, Mayotte, Reunion Island and Seychelles, based on molecular screening and partial sequencing of the RNA-dependent RNA polymerase gene. In total, 88 bats (8.7%) tested positive for coronaviruses, with higher prevalence in Mozambican bats (20.5% ± 4.9%) as compared to those sampled on islands (4.5% ± 1.5%). Phylogenetic analyses revealed a large diversity of α- and β-CoVs and a strong signal of co-evolution between CoVs and their bat host species, with limited evidence for host-switching, except for bat species sharing day roost sites.ImportanceThis is the first study to report the presence of coronaviruses (CoVs) in bats in Mayotte, Mozambique and Reunion Island, and in insectivorous bats in Madagascar. Eight percent of the tested bats were positive for CoVs, with higher prevalence in continental Africa than on islands. A high genetic diversity of α- and β-CoVs was found, with strong association between bat host and virus phylogenies, supporting a long history of co-evolution between bats and their associated CoVs in the Western Indian Ocean. These results highlight that strong variation between islands does exist and is associated with the composition of the bat species community on each island. Future studies should investigate whether CoVs detected in these bats have a potential for spillover in other hosts.

scholarly journals Puzzle Out the Reason behind Habitual Miscarriage

2020 ◽  
pp. 92-98
Author(s):  
Waqas Ahmad ◽  
Shahid Bilal ◽  
Sarah Azhar ◽  
Muhammad Aitmaud Uddolah Khan ◽  
Nasima Iqbal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Maternal Age ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Multinomial Logistic Regression ◽  
Strong Association ◽  
Multinomial Logistic Regression Model ◽  
Multiple Risk Factors ◽  
Bivariate Correlation ◽  
History Of

Aims: As no data is available in Pakistan so the aim of current study is to find out the link of multiple risk factors with recurrent pregnancy loss (RPL) in Pakistan. Study Design: Case control study. Place and Duration of Study: Study conducted in Obstetrics and Gynecology Clinic of Benazir Bhutto Hospital, Holy Family Hospital Rawalpindi and Polyclinic Hospital Islamabad from November 2018 to April 2019. Methodology: Subjects were investigated on the basis of an in depth Performa. For data analysis Statistical package for social sciences version-20 was used. Beside this, height in cm, weight in kg and blood pressure in mmHg were recorded. All the statistical calculations were performed by using SPSS 20. For association analysis of qualitative variables Spearman bivariate correlation was calculated while for numerical variables ANOVA was applied. Multinomial logistic regression model was used and the odd ratio and relative risk were calculated. Results: Among cases 91.34% were having spontaneous miscarriage and majority (64.86%) were during first trimester. Spearman bivariate correlation reported a strong association of recurrent pregnancy loss with the risk factors including family history, smoking, obesity, history of hypertension and history of diabetes, having highly significant p-values, on the hand, significant association of maternal age with the frequency of recurrent pregnancy loss was found but not with the paternal age and parity. The multinomial logistic regression model showed that smokers were19.012 times more prone to develop recurrent pregnancy loss. Conclusion: The multiple risk factors including maternal age, obesity, smoking, family history, body mass index, hypertension and diabetes have a strong association with the recurrent pregnancy loss. So keeping these risk factors in mind a careful evaluation of each pregnancy is necessary to reduce the risk of recurrent pregnancy loss.

scholarly journals Genetic Structure and Phylogeography of Tuber magnatum Populations

Diversity ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 44 ◽  
Author(s):  
Beatrice Belfiori ◽  
Valentina D’Angelo ◽  
Claudia Riccioni ◽  
Marco Leonardi ◽  
Francesco Paolocci ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Ectomycorrhizal Fungus ◽  
Northern Italy ◽  
East Europe ◽  
East European ◽  
South East Europe ◽  
Tuber Magnatum ◽  
Mediterranean Countries ◽  
History Of ◽  
Glacial Expansion

The ectomycorrhizal fungus Tuber magnatum produces the white truffle appreciated worldwide for its unique aroma. With respect to other Tuber spp. of economic interest, T. magnatum presents a narrower geographical range. This species has, in fact, long been considered endemic to Italy. However, over the last few decades several reports have documented the presence of white truffles in different Mediterranean countries and in particular in various areas of south-east Europe. In this study, samples from several Pannonian and Balkan countries such as Hungary, Serbia, Romania, Bulgaria and Greece have been collected and genotyped with microsatellite markers and the data merged with those available for Italian populations. Our objectives were to test whether Italian and south-east European populations are differentiated and to evaluate the genetic diversity of T. magnatum all over its distributional range. We show the genetic structure of T. magnatum populations with the differentiation of four main groups: northern Italy, central-northern Italy, southern Italy and the Balkan/Pannonian region. The present study allowed us to refine the evolutionary history of T. magnatum and track the possible post-glacial expansion route of this species. The assessment of T. magnatum’s genetic structure is not only of scientific relevance, but it is also important for the conservation and market traceability of this prestigious fungus.

scholarly journals Factors influencing Ludwig’s Angina

2015 ◽  
Vol 20 (1) ◽  
pp. 5-7 ◽  
Author(s):  
Sharfuddin Mahmud ◽  
Rojibul Haque ◽  
Abdullah Al Mamun ◽  
Rafiul Alam ◽  
Siddiqur Rahman ◽  
...  
Keyword(s):  
Systemic Disease ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Tooth Cleaning ◽  
Clinical Presentations ◽  
Poor Nutritional Status ◽  
Causative Agents ◽  
History Of ◽  
Response Method

Introduction: Ludwig‘s angina is a rapidly progressive, potentially fulminant cellulitis involving the sub-lingual, submental and sub-mandibular spaces. It typically originates from an infected or recently extracted tooth, most commonly the lower second and third molars. Besides, poor nutritional status, lack of proper medical supports are still major predisposing factors in developing Ludwig‘s angina in countries like Bangladesh. Aim: Our study aimed to observe etiological factors, clinical presentations, causative agents and treatment response. Method: We carried out a cross sectional study among 26 patients with Ludwig‘s angina admitted in the department of ENT and Head-neck surgery in Mitford Hospital from January- December-2012. Results: In this study we found that males are predominantly affected than females (22 males and 4 females, ratio-5.5:1) with odontogenic infection (15, 57%) as source. We found history of recent tooth extraction in 5 cases (19.2%) & organism was isolated from pus culture, Klebsiella in 5 cases (19.2%) out of 13 cases. In this study we found tooth cleaning habit of patients by tooth brush18 cases (69.2%). We elicited underlying systemic disease mainly Diabetes Mellitus in 4 cases (15.3%) and Chronic renal failure in some of our cases but could not reach in a conclusion as to whether systemic illness predisposes to Ludwig‘ angina. Conclusion: Our study suggests that prompt and thorough clinical evaluation and definitive care will considerably improve patient condition and reduce morbidity and mortality. DOI: http://dx.doi.org/10.3329/bjo.v20i1.22010 Bangladesh J Otorhinolaryngol; April 2014; 20(1): 5-7

scholarly journals Increased Levels of Galactose-Deficient Anti-Gal Immunoglobulin G in the Sera of Hepatitis C Virus-Infected Individuals with Fibrosis and Cirrhosis

2007 ◽  
Vol 82 (3) ◽  
pp. 1259-1270 ◽  
Author(s):  
Anand S. Mehta ◽  
Ronald E. Long ◽  
Mary Ann Comunale ◽  
Mengjun Wang ◽  
Lucy Rodemich ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Immunoglobulin G ◽  
Antigen Recognition ◽  
Noninvasive Detection ◽  
Altered Glycosylation ◽  
Causative Agents ◽  
Immunoglobulin Molecule ◽  
History Of

ABSTRACT Hepatitis B and C viruses are major causative agents of liver fibrosis, cirrhosis, and liver cancer. Using comparative glycoproteomics, we identified a glycoprotein that is altered both in amount and in glycosylation as a function of liver fibrosis and cirrhosis. Specifically, this altered glycoprotein is an immunoglobulin G (IgG) molecule reactive to the heterophilic alpha-Gal epitope [Galα-1-3Galβ1-(3)4GlcNAc-R]. While similar changes in glycosylation have been observed in several autoimmune diseases, the specific immunoglobulins and their antigen recognition profiles were not determined. Thus, we provide the first report identifying the specific antigenic recognition profile of an immunoglobulin molecule containing altered glycosylation as a function of liver disease. This change in glycosylation allowed increased reactivity with several fucose binding lectins and permitted the development of a plate-based assay to measure this change. Increased lectin reactivity was observed in 100% of the more than 200 individuals with stage III or greater fibrosis and appeared to be correlated with the degree of fibrosis. The reason for the alteration in the glycosylation of anti-Gal IgG is currently unclear but may be related to the natural history of the disease and may be useful in the noninvasive detection of fibrosis and cirrhosis.

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