scholarly journals Long-Term Outcomes of Sacrococcygeal Germ Cell Tumors in Infancy and Childhood

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Rangsan Niramis ◽  
Maitree Anuntkosol ◽  
Veera Buranakitjaroen ◽  
Achariya Tongsin ◽  
Varaporn Mahatharadol ◽  
...  
Keyword(s):  
Germ Cell ◽  
Distant Metastasis ◽  
Malignant Tumors ◽  
Tumor Resection ◽  
Germ Cell Tumors ◽  
Type I ◽  
Patient Death ◽  
Long Term Outcomes ◽  
Infancy And Childhood

Purpose. The aim of this study was to evaluate long-term outcomes of sacrococcygeal germ cell tumors (SC-GCTs) over a 15-year period.Materials and Methods. A retrospective review was conducted of all pediatric patients treated for SC-GCTs at our hospital from 1998 to 2012.Results. Fifty-seven patients were treated for SC-GCTs with the most common in Altman’s classification type I. Age at surgery ranged from one day to 5.6 years. Tumor resection and coccygectomy were primarily performed in about 84% of the cases. Pathology revealed mature, immature, malignant sacrococcygeal teratomas (SCTs), and endodermal sinus tumors (ESTs) in 41 (72%), 4 (77%), 6 (10.5%), and 6 (10.5%), respectively. Recurrence of discase occurred in 3 of 41 patients with mature teratomas (7.3%); 2 recurrences with mature teratomas and one recurrence with EST. Five of 6 malignant SCTs and 3 of 6 ESTs responded well to the treatment. Alpha-fetoprotein (AFP) level was elevated in both malignant teratomas and ESTs. No immediate patient death was noted in any of the 57 cases, but 4 patients with malignant tumors and distant metastasis succumbed at home within 2 years of the initial treatment.Conclusion. Benign SCTs have a significant recurrence rate of approximately 7%. Close follow-up with serial AFP level monitoring should be done for 5 years after initial tumor resection and coccygectomy. The survival rate for malignant SC-GCTs with distant metastasis was unfavorable in the present study.

Long-term outcomes of accelerated BEP (bleomycin, etoposide, cisplatin) for advanced germ cell tumors: updated analysis of an Australian multicenter phase II trial.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e16056-e16056
Author(s):  
Peter S. Grimison ◽  
Martin R. Stockler ◽  
Andrew James Martin ◽  
Luke Buizen ◽  
Nicola Jane Lawrence ◽  
...  
Keyword(s):  
Germ Cell ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Germ Cell Tumors ◽  
Long Term Outcomes ◽  
Multicenter Phase

scholarly journals Assessment of prognostic factors in extracranial germ cell tumors in children

2021 ◽  
Vol 67 (6) ◽  
pp. 829-836
Author(s):  
Symbat Salieva ◽  
Riza Boranbayeva ◽  
Bakhram Zhumadullayev ◽  
Ergali Sarsekbayev ◽  
Oleg Bydanov
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Survival Rate ◽  
Germ Cell ◽  
Malignant Tumors ◽  
Survival Rates ◽  
Tumor Resection ◽  
Germ Cell Tumors ◽  
Morphological Structure ◽  
High Sensitivity

Germ cell neoplasms in the group of benign and malignant tumors heterogeneous in morphological structure, clinical features and prognosis. A special characteristic of germ cell tumors is their high sensitivity to platinum-containing chemotherapy, which allows cure of up to 80–90% patients. However 20–25% of patients with a common type have overall survival rate of less than 50%. The aim of the study is to assess the survival rate of children with extracranial germ cell tumors and to identify adverse risk factors. Methods. The study includes 116 children with extracranial germ cell tumors treated from 2013 to September 2009. Treatment consisted of tumor resection and platinum based on platinum chemotherapy. Survival rate was assessed by the Kaplan-Mayer method. Prognostic factors are determined according to IGCCCG, MaGIC, MAKEI, RODO. Results. Overall and event free survival rates were 79±5% and 76±4%, respectively. The worst overall survival had patients with extragonadal tumors, advanced stages of a disease, high initial level of AFP (≥10 000 ng/ml), non-seminoma version of state treasury bills and extra pulmonary metastases. Conclusion. Survival rate in children with extracranial germ cell tumors depends on the prognostic factors. Statistically significant predictors of the poor prognosis were extragonadal localization of a tumor and the AFP level ≥10 000 ng/ml.

scholarly journals Management and long-term outcomes of giant mediastinal germ cell tumors in children

2019 ◽  
Vol 40 (4) ◽  
pp. 515
Author(s):  
Sandeep Agarwala ◽  
Kashish Khanna ◽  
AkshayKumar Bishoi ◽  
Sameer Bakhshi ◽  
Veereshwar Bhatnagar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Long Term Outcomes ◽  
Mediastinal Germ Cell Tumors

Short- and Long-Term Outcomes After Large Pulmonary Resection for Germ Cell Tumors After Bleomycin-Combination Chemotherapy

2006 ◽  
Vol 175 (4) ◽  
pp. 1368-1369
Author(s):  
R.S. Andrade ◽  
K.A. Kesler ◽  
J.L. Wilson ◽  
J.A. Brooks ◽  
B.D. Reichwage ◽  
...  
Keyword(s):  
Germ Cell ◽  
Combination Chemotherapy ◽  
Pulmonary Resection ◽  
Germ Cell Tumors ◽  
Long Term Outcomes ◽  
Short And Long Term

Long-term outcomes of cisplatin-based chemotherapy in patients with stage II-III germ cell tumors: Center 30-year experience of a single center.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 338-338
Author(s):  
Guillermo De Velasco ◽  
Daniel E. Castellano ◽  
Juan Manuel Sepúlveda ◽  
Felipe Villacampa ◽  
Tomas Pascual ◽  
...  
Keyword(s):  
Complete Remission ◽  
Germ Cell ◽  
Molecular Mechanisms ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Stage Ii ◽  
High Dose ◽  
Long Term Outcomes ◽  
Platinum Based Chemotherapy

338 Background: We retrospectively assessed long-term outcomes of cisplatin-based chemotherapy for stage II/IIII germ cell tumors (GCTs) at Medical Oncology Department of 12 Octubre University Hospital, Madrid (Spain). Methods: Two hundred fourteen (214) consecutive males with advanced GCTs of the testis or extragonadal origin who received standard cisplatin-based chemotherapy regimens between 1982 and 2012 were analyzed. Results: Demographic features: Median age 26.4 years (range 14- 72 years). Right and left testicular tumor present in 71 (37%) and 78 (41%) patients respectively and cryptorchidism in 11 (5%). Histology: 12% of the patients had seminomatous and 88% non-seminomatous histology. Stage distribution (TNM): Stage II 105p (49%), Stage III 109 p (51%). Twenty-five primary (11%) were extragonadal. Risk assessment according to IGCCCG - good 115 p (54%) intermediate 34 p (16%) and poor 62 p (29%). All patients received chemotherapy with cisplatin (BEP-73%, EP-15%, BOPM-EPI 5%, PVB 6%, others 1%). Survival analysis: The median follow-up period was 117 months (0 - 329). Totally, 158 patients (74%) achieved complete remission (CR). CR was achieved in 128 p (60%) after induction therapy (first line chemotherapy). Salvage treatment: surgery +/-chemotherapy was given to 72 (33%) and 85 (39%) patients respectively. High-dose chemotherapy (with carboplatin based- schemes at dosage (AUC20) as salvage therapy was performed in 65 patients (30%). Of them 35 p (53.4%) had complete remission of disease without relapse and the median progression free survival was of 47.2 months. Severe AEs were < to 5%, and classically already described renal impairment, ototoxicity and neurophaty with non chemotherapy-related toxic deaths. Conclusions: Improvement of medical management and survival during platinum-based chemotherapy and the development of several regimens for salvage chemotherapy seemed to contribute to improving outcomes of patients with advanced GCTs even for patients with platinum-refractory disease. However, we continue to investigate in the search for genetic and molecular mechanisms that help us change it.

Short- and Long-Term Outcomes after Large Pulmonary Resection for Germ Cell Tumors After Bleomycin-Combination Chemotherapy

2004 ◽  
Vol 78 (4) ◽  
pp. 1224-1228 ◽  
Author(s):  
Rafael S. Andrade ◽  
Kenneth A. Kesler ◽  
Jamison L. Wilson ◽  
Jo Ann Brooks ◽  
Brett D. Reichwage ◽  
...  
Keyword(s):  
Germ Cell ◽  
Combination Chemotherapy ◽  
Pulmonary Resection ◽  
Germ Cell Tumors ◽  
Long Term Outcomes ◽  
Short And Long Term
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