scholarly journals Multifunctional Silica Nanoparticles Modified via Silylated-Decaborate Precursors

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Fatima Abi-Ghaida ◽  
Sébastien Clément ◽  
Ali Safa ◽  
Daoud Naoufal ◽  
Ahmad Mehdi
Keyword(s):  
Silica Nanoparticles ◽  
Solid State Nmr ◽  
Neutron Capture Therapy ◽  
Stöber Method ◽  
Boron Clusters ◽  
New Class ◽  
Boron Neutron Capture ◽  
The Stöber Method ◽  
Luminescent Centers

A new class of multifunctional silica nanoparticles carrying boron clusters (10-vertex closo-decaborate) and incorporating luminescent centers (fluorescein) has been developed as potential probes/carriers for potential application in boron neutron capture therapy (BNCT). These silica nanoparticles were chargedin situwith silylated-fluorescein fluorophoresviathe Stöber method and their surface was further functionalized with decaborate-triethoxysilane precursors. The resulting decaborate dye-doped silica nanoparticles were characterized by TEM, solid state NMR, DLS, nitrogen sorption, elemental analysis, and fluorescence spectroscopy.

A non-surfactant self-templating strategy for mesoporous silica nanospheres: beyond the Stöber method

Nanoscale ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 3657-3662 ◽  
Author(s):  
Zhe Chen ◽  
Bo Peng ◽  
Jia-Qiong Xu ◽  
Xue-Chen Xiang ◽  
Dong-Fang Ren ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Size Distribution ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanospheres ◽  
Stöber Method ◽  
Directed Synthesis ◽  
The Stöber Method ◽  
Surfactant Templates ◽  
Mesoporous Silica Nanospheres

The “pre-Ouzo” structure directed synthesis of mesoporous silica nanoparticles (MSNs) in the absence of surfactant templates probably also explains the origin of highly monodisperse size distribution of classical Stöber silica NPs.

Unraveling the Growth Mechanism of Silica Particles in the Stöber Method: In Situ Seeded Growth Model

Langmuir ◽  
2017 ◽  
Vol 33 (23) ◽  
pp. 5879-5890 ◽  
Author(s):  
Yandong Han ◽  
Ziyang Lu ◽  
Zhaogang Teng ◽  
Jinglun Liang ◽  
Zilong Guo ◽  
...  
Keyword(s):  
Growth Model ◽  
Growth Mechanism ◽  
Silica Particles ◽  
Seeded Growth ◽  
Stöber Method ◽  
The Stöber Method

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

2018 ◽  
Author(s):  
Guillaume Vares ◽  
Vincent Jallet ◽  
Yoshitaka Matsumoto ◽  
Cedric Rentier ◽  
Kentaro Takayama ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Mesoporous Silica Nanoparticles ◽  
Alpha Particles ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

AbstractTreatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron Capture Therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with Gadolinium for magnetic resonance imaging (MRI)in vivo. Chondrosarcoma cells were exposedin vitroto an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers.

Carbaboranes – more than just phenyl mimetics

2015 ◽  
Vol 87 (2) ◽  
pp. 163-171 ◽  
Author(s):  
René Frank ◽  
Verena Ahrens ◽  
Solveig Boehnke ◽  
Sven Hofmann ◽  
Martin Kellert ◽  
...  
Keyword(s):  
Neutron Capture ◽  
Breast Tumour ◽  
Water Soluble ◽  
Propanoic Acid ◽  
Neutron Capture Therapy ◽  
Boron Clusters ◽  
Boron Neutron Capture ◽  
Modified Peptides ◽  
Highly Hydrophobic ◽  
Selective Accumulation

AbstractDicarba-closo-dodecaboranes(12) (C2B10H12, carbaboranes) are highly hydrophobic and stable icosahedral carbon-containing boron clusters. The cage framework of these clusters can be modified with a variety of substituents, both at the carbon and at the boron atoms. Substituted carbaboranes are of interest in medicine as boron neutron capture therapy (BNCT) agents or as pharmacophores. High and selective accumulation in tumour cells is an important requirement for a BNCT agent and is achieved by incorporating boron-rich, water-soluble carbaborane derivatives into breast tumour-selective modified neuropeptide Y, [F7, P34]-NPY. Preliminary studies showed that the receptor binding affinity and signal transduction of the boron-modified peptides were very well retained. Use of carbaboranes as pharmacophores was shown by replacement of Bpa32 (Bpa=benzoylphenylalanine) in the reduced-size NPY analogue [Pro30, Nle31, Bpa32, Leu34]-NPY 28–36 by ortho-carbaboranyl propanoic acid. The inclusion of the carbaborane derivative resulted in a short NPY agonist with an interesting hY2R/hY4R preference. This might be a promising approach in the field of anti-obesity drug development.

scholarly journals Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT

2021 ◽  
Vol 9 ◽  
Author(s):  
Darya Sergeevna Novopashina ◽  
Mariya Alexandrovna Vorobyeva ◽  
Alya Venyaminova
Keyword(s):  
Nucleic Acids ◽  
Boron Content ◽  
Neutron Capture Therapy ◽  
Boron Clusters ◽  
Boron Neutron Capture ◽  
High Boron ◽  
Low Toxicity ◽  
Therapeutic Tools ◽  
Phosphate Diesters ◽  
Oligonucleotide Conjugates

Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-like molecules, such as oligomeric phosphate diesters, bearing one or multiple boron clusters permits to create potential high boron-loaded agents for BNCT with good bioavailability, specifically interacting with nucleic acids inside the cell. Here, we shortly review the strategies and solutions in the design of oligonucleotide conjugates with boron clusters in light of the requirements for effective BNCT and future prospects of their practical use.

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