scholarly journals A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Omer Alici ◽  
Musa Kemal Keles ◽  
Alper Kurt
Keyword(s):  
Differential Diagnosis ◽  
Elderly Women ◽  
Low Grade ◽  
Outer Root Sheath ◽  
Ki 67 ◽  
Morphological Findings ◽  
Root Sheath ◽  
Adnexal Tumor ◽  
Proliferating Trichilemmal Tumor ◽  
Malignant Proliferating Trichilemmal Tumor

Proliferating trichilemmal tumors (PTTs) are neoplasms derived from the outer root sheath of the hair follicle. These tumors, which commonly affect the scalp of elderly women, rarely demonstrate malignant transformation. Although invasion of the tumors into neighboring tissues and being accompanied with anaplasia and necrosis are accepted as findings of malignancy, histological features may not always be sufficient to identify these tumors. The clinical behavior of the tumor may be incompatible with its histological characteristics. Squamous-cell carcinoma should certainly be considered in differential diagnosis because of its similarity in morphological appearance with PTT. Immunostaining for CD34, P53, and Ki-67 is a useful adjuvant diagnostic method that can be used in differential diagnosis aside from morphological findings. In this study, we aimed to present the case of a 52-year-old female patient with clinicopathological features. We reported a low-grade malignant proliferating trichilemmal tumor in this patient and detected no relapse or metastasis in a 24-month period of follow-up.

scholarly journals Atypical Proliferating Trichilemmal Cyst with Malignant Breast Skin Transformation: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Marino Antonio Capurso-García ◽  
Verónica Bautista-Piña ◽  
Alan Pomerantz ◽  
Javier Andrés Galnares-Olalde ◽  
Ruben Blachman-Braun ◽  
...  
Keyword(s):  
Medical Literature ◽  
Elderly Women ◽  
Rare Event ◽  
Skin Neoplasms ◽  
Outer Root Sheath ◽  
Root Sheath ◽  
Pathologic Features ◽  
English Medical Literature ◽  
Malignant Breast ◽  
Proliferating Trichilemmal Tumor

Proliferating trichilemmal tumors (PTTs) are benign adnexal skin neoplasms that arise from the outer root sheath of the hair follicle. These tumors are most commonly observed on the scalp and occur, most of the time, in elderly women. Malignant transformation of these neoplasms is a rare event; less than 50 cases have been reported in the English medical literature. We present the case of a 39-year-old Hispanic woman with a tumor located on the skin of one of her breasts that in her third surgical procedure the histologic examination revealed the presence of a malignant proliferating trichilemmal tumor (MPTT). Furthermore, a review of the medical literature and a discussion of the clinical and pathologic features of this rare entity are provided.

scholarly journals An Unusual Presentation of Proliferating Trichilemmal Tumor Developing in Psoriatic Plaque: A Case Report

2020 ◽  
Vol 1 (3) ◽  
pp. 115-117
Author(s):  
Gökçe Işıl KURMUŞ ◽  
Müzeyyen GÖNÜL ◽  
Filiz CANPOLAT ◽  
Can ERGİN ◽  
Bilgihan AÇIKGÖZ ◽  
...  
Keyword(s):  
Case Report ◽  
Male Patient ◽  
Unusual Case ◽  
Elderly Women ◽  
Benign Neoplasm ◽  
Outer Root Sheath ◽  
Psoriatic Plaque ◽  
Root Sheath ◽  
Trichilemmal Cyst ◽  
Proliferating Trichilemmal Tumor

Proliferating trichilemmal tumor (PTT) is a rare, mostly benign neoplasm which stems from the follicular outer root sheath epithelium. PTT occurs as a subcutaneous cystic nodule slowly enlarging to a larger noduler mass, and is usually localized on the scalp of elderly women. To the best of our knowledge, PTT localized on a psoriatic plaque has not been reported previously. Herein, we report an unusual case of benign PTT arising from a psoriatic plaque on the knee of a 63-year-old male patient. Keywords: proliferating trichilemmal tumor, psoriasis, trichilemmal cyst

The Innermost Cell Layer of the Outer Root Sheath Is Positive with Ki-67

1990 ◽  
Vol 95 (4) ◽  
pp. 393-396 ◽  
Author(s):  
Shunji Miyauchi ◽  
Ken Hashimoto ◽  
Yoshiharu Miki
Keyword(s):  
Cell Layer ◽  
Outer Root Sheath ◽  
Ki 67 ◽  
Root Sheath

scholarly journals Case Report: A rapidly growing cyst on the scalp

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 779
Author(s):  
Emma Short ◽  
Aisling O'Shea ◽  
Krishna Mukkanna ◽  
Girish Patel ◽  
Stefan Docjinov ◽  
...  
Keyword(s):  
Surgical Excision ◽  
Skin Lesions ◽  
Hair Follicles ◽  
The Body ◽  
Low Grade ◽  
Outer Root Sheath ◽  
Rare Tumour ◽  
Suspected Infection ◽  
Root Sheath ◽  
History Of

Trichilemmal carcinoma is a rare tumour derived from the outer root sheath of hair follicles.  It can be difficult to distinguish both clinically and histologically from other skin lesions, particularly squamous cell carcinoma.  We present the case of a 62-year-old female with a 20-year history of three 1-cm cysts on her scalp.  Over a six-month period, a cyst overlying the occiput had become painful and grown in size.  The general practitioner and subsequently local emergency department suspected infection.  The lesion was incised, and the patient was treated with oral antibiotics.  At the time of surgical excision, the lesion measured 3 x 4 cm. Microscopic examination identified rounded dermal lobules of squamous epithelium with trichilemmal keratinization, in keeping with a pre-existing pilar cyst.  There were areas with nuclear pleomorphism, mitoses and an infiltrative architecture.  A diagnosis of trichilemmal carcinoma arising in a pilar cyst was made.  Trichilemmal carcinomas are considered to be a low-grade tumour, but they have the potential to spread to lymph nodes and to metastasise to distant sites in the body, therefore adequate excision and appropriate follow-up are required.

scholarly journals A Case of Basal Cell Carcinoma with Outer Hair Follicle Sheath Differentiation

2015 ◽  
Vol 7 (3) ◽  
pp. 352-357
Author(s):  
Masazumi Onishi ◽  
Kazuhiro Takahashi ◽  
Fumihiko Maeda ◽  
Toshihide Akasaka
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Basal Cell ◽  
Outer Root Sheath ◽  
Root Sheath ◽  
Old Japanese ◽  
Peripheral Palisading ◽  
Follicle Differentiation ◽  
Proliferating Trichilemmal Tumor

A 70-year-old Japanese man presented at our hospital with an asymptomatic, blackish, irregularly shaped plaque with a gray nodule in the periphery on his left lower leg. The lesion had been present for 10 years and had recently enlarged, associated with bleeding. Histopathologically, the tumor consisted of three distinct parts: The first part showed massive aggregation of basophilic basaloid cells with peripheral palisading and abundant melanin granules, and was diagnosed as solid-type basal cell carcinoma. The second part showed aggregation of clear cells with squamous eddies, and was diagnosed as proliferating trichilemmal tumor. The third part showed reticular aggregation of basaloid cells with infundibular cysts in the papillary dermis, and was diagnosed as infundibulocystic basal cell carcinoma. We diagnosed this tumor as basal cell carcinoma with various forms of hair follicle differentiation, including differentiation into the outer root sheath.

Chordoid Glioma: Clinicopathologic Profile and Differential Diagnosis of an Uncommon Tumor

2004 ◽  
Vol 128 (11) ◽  
pp. e141-e145 ◽  
Author(s):  
Anna Maria Buccoliero ◽  
Adele Caldarella ◽  
Pasquale Gallina ◽  
Nicola Di Lorenzo ◽  
Antonio Taddei ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Glial Fibrillary Acidic Protein ◽  
Neuron Specific Enolase ◽  
Acidic Protein ◽  
Low Grade ◽  
Ki 67 ◽  
Cranial Trauma ◽  
Chordoid Glioma ◽  
Clinicopathologic Profile ◽  
Protein Immunoreactivity

Abstract Chordoid glioma is an uncommon low-grade brain neoplasm arising in the third ventricular region, predominantly in middle-aged women. It characteristically shows chordoma-like histologic features and glial fibrillary acidic protein immunoreactivity. We present a case of chordoid glioma in a previously healthy 56-year-old woman admitted to our hospital because of a cranial trauma subsequent to an incidental fall. Radiologic examinations revealed a well-demarcated, partially cystic, enhancing mass at the level of the lamina terminalis. The lesion was surgically removed. The patient remained alive and well 8 months after the surgery. Histologically, the tumor consisted of clusters and cords of epithelioid cells embedded in a mucinous matrix. Lymphoplasmacytic infiltrates and Russell bodies were prominent. Immunohistochemically, the tumor cells were positive for glial fibrillary acidic protein, neurofilaments, and neuron-specific enolase, suggesting a divergent neuronal and glial differentiation. The Ki-67 index was low. The clinicopathologic profile and the differential diagnosis of this tumor are discussed.

scholarly journals A large helmet-shaped proliferating trichilemmal tumor of the scalp: Is definitive radiotherapy the treatment? A case report

2019 ◽  
Vol 31 (1) ◽  
Author(s):  
Haresh Kunhi Parambeth ◽  
Nava Udhayam ◽  
Shipra Agarwal ◽  
Subhash Gupta ◽  
Prashanth Giridhar ◽  
...  
Keyword(s):  
Volumetric Modulated Arc Therapy ◽  
Elderly Male ◽  
Outer Root Sheath ◽  
Case Presentation ◽  
Root Sheath ◽  
Arc Therapy ◽  
Proliferating Trichilemmal Tumor ◽  
Good Cosmesis ◽  
Slow Growing ◽  
Theoretical Risk

Abstract Background Benign proliferating trichilemmal tumors (PTTs) are a rare entity that arises from the outer root sheath of a hair follicle. They range from a benign PTT that recurs locally to the more aggressive malignant PTT that, in addition to recurring locally, has the potential for metastatic spread. However, as a group, PTTs are slow growing and amenable to surgery. To the best of our knowledge, radical radiotherapy without surgery has been used in only one case in an elderly male patient with good oncological and cosmetic results. Case presentation We present a case of a young unmarried female with a disfiguring PTT of the scalp not amenable to surgery treated successfully with radiotherapy providing good cosmesis. Volumetric modulated arc therapy was used to treat this patient with a dose of 50 Gy in 25 fractions over 5 weeks. A theoretical risk of malignant transformation was explained to the patient. The patient has maintained good cosmesis over the last 12 months with no signs of re-growth. Conclusion In patients with PTT not amenable to surgery, radiotherapy may be an effective alternative providing local control and good cosmesis.

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