scholarly journals Antibodies to Infliximab and Adalimumab in Patients with Rheumatoid Arthritis in Clinical Remission: A Cross-Sectional Study

Arthritis ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Grith P. Eng ◽  
Klaus Bendtzen ◽  
Henning Bliddal ◽  
Michael Stoltenberg ◽  
Marcin Szkudlarek ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Remission ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Infliximab Treatment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gene Assay ◽  
A Cell ◽  
Low Levels

Objective. To investigate if antibodies towards biological TNF-α inhibitors (anti-TNFi Abs) are present in patients with rheumatoid arthritis (RA) in clinical remission and to relate any anti-TNFi Abs to circulating level of TNF-α inhibitor (TNFi). Methods. Patients with RA, treated with infliximab or adalimumab, and in clinical remission (DAS28(CRP) < 2.6) were included from 6 out-patient clinics. In blood samples, presence of anti-TNFi Abs was determined by radioimmunoassay, and concentration of bioactive TNFi was measured by a cell-based reporter gene assay. Results. Anti-TNFi Abs were present in 8/44 patients (18%) treated with infliximab and 1/49 patients (2%) treated with adalimumab (p=0.012). In the former group, anti-TNFi Abs corresponded with low levels of TNFi (p=0.048). Anti-TNFi Ab-positive patients had shorter disease duration at initiation of TNFi therapy (p=0.023) but were similar for the rest of the compared parameters. Conclusions. In RA patients in clinical remission, anti-TNFi Abs occur frequently in patients treated with infliximab, while they occur rarely in patients treated with adalimumab. Presence of anti-infliximab Abs is accompanied by low or undetectable levels of infliximab. These data suggest that continued infliximab treatment may be redundant in a proportion of RA patients treated with infliximab and in clinical remission.

scholarly journals Anti-carbamylated protein antibody isotype pattern differs between palindromic rheumatism and rheumatoid arthritis

2020 ◽  
Vol 12 ◽  
pp. 1759720X2097813
Author(s):  
Raul Castellanos-Moreira ◽  
Sebastian C. Rodriguez-Garcia ◽  
Sonia Cabrera-Villalba ◽  
María José Gomara ◽  
Georgina Salvador ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Duration ◽  
Fetal Calf Serum ◽  
Calf Serum ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sectional Study ◽  
Antibody Isotype ◽  
Cross Sectional ◽  
Palindromic Rheumatism

Background: A restricted response against citrullinated peptides/proteins, with less isotype usage, has been found in palindromic rheumatism (PR) in comparison with rheumatoid arthritis (RA). We hypothesized that this different antibody response may be observed for other post-translational modified proteins. We compared the prevalence and isotype usage of two specificities of anti-carbamylated peptide/protein antibodies (Anti-CarP) in patients with PR and RA. Methods: Cross-sectional study including 54 patients with pure PR and 53 patients with RA, matched by sex, age, disease duration and ACPA. Anti-CarP specificities were determined by home-made enzyme-linked immunosorbent assay tests using a synthetic chimeric fibrin/filaggrin homocitrullinated peptide (CFFHP) and fetal calf serum (FCS) homocitrullinated protein as antigens. IgG, IgA and IgM isotypes were measured. Results: Anti-CarP were positive (CFFHP or FCS) in 24% and 64% of patients with PR and RA, respectively ( p < 0.005). All Anti-CarP isotype proportions were significantly lower in PR than in RA: Anti-CarP-IgG (24% versus 51%), Anti-CarP-IgA (7% versus 34%) and Anti-CarP-IgM (7% versus 36%). Mean titers of Anti-CarP isotypes were also lower in PR. In Anti-CarP positive patients, the isotype distribution differed between PR and RA: IgG Anti-CarP was used in all PR patients and in 79% of RA patients. By contrast, a significantly lower isotype usage of both IgA (31% versus 53%) and IgM (31% versus 56%) was observed in PR patients. No significant differences in clinical or demographic characteristics were observed according to Anti-CarP status in PR patients, except for a higher prevalence of ACPA and higher mean titers of ACPA and rheumatoid factor in Anti-CarP positive patients. Conclusion: Anti-CarP are found in patients with PR but in a lower proportion and with a different isotype usage from in RA, suggesting a distinct B cell response to homocitrullinated antigens in PR.

scholarly journals Frequency of myelin oligodendrocyte glycoprotein antibody in multiple sclerosis

2019 ◽  
Vol 7 (2) ◽  
pp. e649 ◽  
Author(s):  
Álvaro Cobo-Calvo ◽  
Hyacintha d'Indy ◽  
Anne Ruiz ◽  
Nicolas Collongues ◽  
Laurent Kremer ◽  
...  
Keyword(s):  
Disease Duration ◽  
Disease Onset ◽  
Cross Sectional Study ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Sectional Study ◽  
University Hospitals ◽  
Serum Samples ◽  
Cross Sectional ◽  
Mcdonald Criteria ◽  
A Cell

ObjectiveTo address the frequency of myelin oligodendrocyte glycoprotein (MOG) antibody (Ab) in an unselected large cohort of adults with MS.MethodsThis is a cross-sectional study in 2 MS expert centers (Lyon and Strasbourg University Hospitals, France) between December 1, 2017, and June 31, 2018. Patients aged ≥18 years with a definite diagnosis of MS according to 2010 McDonald criteria were tested for MOG-Ab by using a cell-based assay (CBA) in Lyon and subsequently included. Positive samples were tested by investigators blinded to the first result with a second assay in a different laboratory (Barcelona, Spain) by using the same plasmid and secondary Ab.ResultsSerum samples from 685 consecutive patients with MS were analyzed for MOG-Ab. Median disease duration at sampling was 11.5 (interquartile range, 5.8–17.7) years, and 72% were women. Two (0.3%) patients resulted to be MOG-Ab-positive. The 2 patients were women aged 42 and 38 at disease onset and were diagnosed with secondary and primary progressive forms of MS, respectively. This positive result was confirmed by the CBA in Barcelona.ConclusionOur findings indicate that MOG-Ab are exceptional in MS phenotype, suggesting that the MOG-Ab testing should not be performed in typical MS presentation.

scholarly journals A Cross-sectional Study on Electrophysiological Evaluation of Neuropathy in Rheumatoid Arthritis

2021 ◽  
Author(s):  
Ravinder Singh ◽  
PV Sripadma ◽  
Vaibhav Mathur ◽  
Sujata Ganguly
Keyword(s):  
Rheumatoid Arthritis ◽  
Peripheral Neuropathy ◽  
Nerve Conduction ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Nerve Conduction Studies ◽  
Laboratory Evaluation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Subclinical Neuropathy

Introduction: Rheumatoid Arthritis (RA) is a chronic multisystem immune mediated disease. Rheumatoid associated neuropathy causes significant disability and adds to the economic burden. Aim: To assess clinical determinants of peripheral neuropathy (diagnosed electrophysiologically using nerve conduction studies) among patients with RA. Additionally, it was also aimed to study the various patterns of peripheral neuropathy in patients with RA. Materials and Methods: A cross-sectional study was conducted on 100 consecutive adult patients with RA between 01stFebruary, 2020 to 02nd January, 2021 at medicine and neurology departments of SMS Medical College and Hospital, Jaipur, Rajasthan, India. Inclusion and exclusion criteria were followed and eligible patients after appropriate laboratory evaluation underwent nerve conduction studies. Statistical analysis was performed using student’s unpaired t-test and Chi-square test for continuous and categorical variables respectively. Results: Mean age of the study population was 42.4±14.2 years with 88 females and 12 males. Mean duration of RA was 7.0±7.4 years. Nerve conduction studies detected neuropathy in 18 patients, of these only four patients were symptomatic with tingling, pins and needles sensation and numbness. Fourteen patients had subclinical neuropathy. Patients with neuropathy had significantly longer disease duration (p=0.0001), were older (p=0.014) with more joint deformities (p=0.0008). Conclusion: Subclinical neuropathy is not infrequent in RA patients. Those with advanced age, longer disease duration, higher Erythrocyte Sedimentation Rate (ESR), erosions and deformities should be assessed electrophysiologically for neuropathy.

scholarly journals Medication Adherence and Coping Strategies in Patients with Rheumatoid Arthritis: A Cross-Sectional Study

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Carolin Berner ◽  
Ludwig Erlacher ◽  
Karl H. Fenzl ◽  
Thomas E. Dorner
Keyword(s):  
Rheumatoid Arthritis ◽  
Medication Adherence ◽  
Coping Strategies ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Clinical Factors ◽  
Average Income ◽  
Cross Sectional ◽  
Coping With Illness

Objectives. The aim of this study was to determine if strategies for coping with illnesses, demographic factors, and clinical factors were associated with medication adherence among patients with rheumatoid arthritis (RA). Methods. This cross-sectional study was conducted at a Viennese rheumatology outpatient clinic on RA patients. Medication adherence was assessed using the Medication Adherence Report Scale. Strategies for coping with illness were assessed using the Freiburg Questionnaire for Coping with Illness. Results. Half (N=63, 52.5%) of the 120 patients included in the study were considered completely medication adherent. Female sex (odds ratio [OR]: 4.57, 95% confidence interval [CI]: 1.14 – 18.42), older age (54-65 yr vs. <45 yr OR: 9.2, CI:2.0-40.70; >65 yr vs. <45 yr OR 6.93, CI:1,17 – 40.87), middle average income (middle average income vs. lowest income class OR= 0.06, CI= 0.01-0.43), and shorter disease duration (5-10 yr vs. >10 yr OR= 3.53, CI= 1.04-11.95; 1-4 yr vs. >10 yr OR=3.71, CI= 1.02-13.52) were associated with higher medication adherence. Levels of active coping (15.57 vs. 13.47, p=0.01) or diversion and self-encouragement (16.10 vs. 14.37, p=0.04) were significantly higher among adherent as opposed to less adherent participants. However, in multivariate regression models, coping strategies were not significantly associated with adherence. Conclusions. Age, sex, monthly net income, and disease duration were found to be associated with an increased risk for medication nonadherence among patients with RA. Coping strategies such as active coping, diversion, and self-encouragement were associated with adherence in univariate models, but not when adjusted for demographic and clinical factors.

scholarly journals Association between osteoporosis and rheumatoid arthritis in women: a cross-sectional study

2009 ◽  
Vol 127 (4) ◽  
pp. 216-222 ◽  
Author(s):  
Karin Sedó Sarkis ◽  
Mariana Barbieri Salvador ◽  
Marcelo Medeiros Pinheiro ◽  
Raissa Gomes Silva ◽  
Cristiano Augusto Zerbini ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Body Composition ◽  
Linear Regression ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Linear Regression Models ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional

CONTEXT AND OBJECTIVES: Osteoporosis has frequently been observed in patients with rheumatoid arthritis. The present study was undertaken in order to evaluate factors associated with osteoporosis among women with rheumatoid arthritis. DESIGN AND SETTING: Cross-sectional study, carried out in a public hospital in São Paulo. METHODS: The participants were 83 women with rheumatoid arthritis (53.7 ± 10.0 years old). Bone mineral density (BMD) and body composition were measured by dual energy X-ray absorptiometry. The patients were divided into three groups according to BMD: group 1, normal BMD (n = 24); group 2, osteopenia (n = 38); and group 3, osteoporosis (n = 21). Tests were performed to compare differences in means and correlations, with adjustments for age, duration of disease and cumulative corticosteroid. The relationships between clinical factors, physical activity score, dietary intake, body composition and biochemical parameters were analyzed using linear regression models. RESULTS: Mean calcium, vitamin D and omega-6 intakes were lower than the recommendations. Associations were found between BMD and age, disease duration, parathyroid hormone concentration and fat intake. The linear regression model showed that being older, with more years of disease and lower weight were negatively correlated with BMD [Total femur = 0.552 + 0.06 (weight) + 0.019 (total physical activity) - 0.05 (age) - 0.003 (disease duration); R² = 48.1; P < 0.001]. CONCLUSION: The present study indicates that nutritional factors and body composition are associated with bone mass in women with rheumatoid arthritis.

scholarly journals Morphological Parameters in Quadriceps Muscle Were Associated with Clinical Features and Muscle Strength of Women with Rheumatoid Arthritis: A Cross-Sectional Study

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2014
Author(s):  
Leonardo Peterson dos Santos ◽  
Rafaela Cavalheiro do Espírito Santo ◽  
Émerson Pena ◽  
Lucas Denardi Dória ◽  
Vanessa Hax ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Muscle Strength ◽  
Disease Duration ◽  
Muscle Thickness ◽  
Quadriceps Muscle ◽  
Cross Sectional Study ◽  
Pennation Angle ◽  
Morphological Parameters ◽  
Sectional Study ◽  
Cross Sectional

Background: Rheumatoid arthritis (RA) is an autoimmune, inflammatory and chronic disease that may lead to loss of muscle mass, muscle strength and decreased functionality. Our objectives are to assess the quadriceps muscle morphology by ultrasound (MU) and verify its associations with clinical features, muscle strength and physical function in RA patients. Methods: In this cross-sectional study, RA women (≥18 years) were included. Morphological parameters in quadriceps muscle consisted of the muscle thickness and pennation angle of rectus femoris (RF), vastus intermedius (VI) and vastus lateralis (VL). RA activity was measured by a 28-joint disease activity score (DAS28), muscle strength by handgrip and chair stand tests, and physical function by health assessment questionnaire (HAQ), timed-up-and-go (TUG) test and short physical performance battery (SPPB). Results: Fifty-five patients were included (age: 56.73 ± 9.46 years; DAS28: 3.08 ± 1.29). Muscle thickness in RF, VI and VL were negatively associated with age (RF, p < 0.001; VI, p = 0.013; VL, p = 0.002) and disease duration (RF, p < 0.001; VI, p = 0.005; VL, p = 0.001), and were positively associated with handgrip strength (RF, p = 0.015; VI, p = 0.022; VL, p = 0.013). In addition, decreased muscle thickness in VI (p = 0.035) and a smaller pennation angle in RF (p = 0.030) were associated with higher DAS-28 scores. Conclusion: Quadriceps muscle morphology by ultrasound appears to be affected by age, disease duration, disease activity and muscle strength in patients with RA. MU can be a useful method to evaluate the impact of the disease on skeletal muscle.

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