scholarly journals A Rare Case of Paclitaxel and/or Trastuzumab Induced Acute Hepatic Necrosis

2015 ◽  
Vol 2015 ◽  
pp. 1-2 ◽  
Author(s):  
Hiren Mandaliya ◽  
Pinky Baghi ◽  
Amy Prawira ◽  
Mathew K. George
Keyword(s):  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Hepatic Necrosis ◽  
Clinical Findings ◽  
Acute Onset ◽  
Hepatocellular Injury ◽  
Her2 Receptor ◽  
Trastuzumab Therapy ◽  
History Of

Paclitaxel induced mild derangement of liver functions including bilirubin, alkaline phosphatase, and AST has been infrequently noticed in clinical trials. Contrary to Paclitaxel, hepatocellular injury, hepatitis, and liver tenderness are common laboratory and clinical findings with Trastuzumab. However, hepatic failure/necrosis secondary to Paclitaxel or Trastuzumab has never been reported in literature. A 62-year-old lady, previously healthy, was treated with adjuvant therapy for left breast stage II, high grade invasive ductal carcinoma which was node negative, oestrogen receptor negative, progesterone receptor positive, and HER2 receptor positive. After modified radical mastectomy and axillary clearance, she finished four cycles of Doxorubicin/Cyclophosphamide chemotherapy and then commenced on Paclitaxel/Trastuzumab combination chemotherapy. Within twelve hours of first dose of Paclitaxel/Trastuzumab therapy, patient required hospital admission for acute onset respiratory failure. Patient died within 36 hours of therapy and autopsy was suggestive of acute hepatic necrosis without any other significant findings. Detailed investigations were not carried out as event was quick with rapid deterioration. There was no history of prior liver pathology/injury and preliminary investigations for major organ involvement were unremarkable. As per our knowledge, Paclitaxel and/or Trastuzumab induced acute hepatic necrosis has never been reported in literature before, hence difficult to predict.

scholarly journals Bilateral Neuroendocrine Carcinoma of Breast: A Case Report

2021 ◽  
Vol 59 (244) ◽  
pp. 1320-1322
Author(s):  
Sulochana Neupane ◽  
Sanam Dhakal ◽  
Shripad Walawalakar ◽  
Surya Bahadur Parajuli ◽  
Sulav Sapkota
Keyword(s):  
Ductal Carcinoma ◽  
Neuroendocrine Differentiation ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Breast Cancers ◽  
Breast Carcinomas ◽  
Breast Lump ◽  
History Of ◽  
Poorly Differentiated ◽  
Neuroendocrine Carcinomas

Primary neuroendocrine carcinomas of the breast are rare of all breast carcinomas. They may be welldifferentiated, poorly differentiated, or invasive breast cancers with neuroendocrine differentiation. They are staged and treated similarly to conventional breast cancer. Herein, we report a case of invasive ductal carcinoma with neuroendocrine differentiation of the breast in a 73 years female with a history of breast lump initially in the lower inner quadrant of left breast and a month later, similar lump at the same site in right breast. Patient underwent Modified Radical Mastectomy bilaterally followed by adjuvant chemotherapy based on Carboplatin and Etoposide regimen.

scholarly journals Trastuzumab induced radiation recall dermatitis: an interesting case

2018 ◽  
Vol 7 (12) ◽  
pp. 2465
Author(s):  
Anupama C. ◽  
Anuradha H. V. ◽  
Vinayak V. Maka
Keyword(s):  
Ductal Carcinoma ◽  
Growth Factor Receptor ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Interesting Case ◽  
Axillary Lymph ◽  
Radiation Recall ◽  
Skin Reactions ◽  
Radiation Recall Dermatitis ◽  
Recall Dermatitis

Radiation recall dermatitis (RRD) is the appearance of skin reactions in previously irradiated skin which is triggered by the administration of certain drugs. Surgery, chemotherapy, and radiotherapy are the mainstay of treatment in breast cancer. RRD induced by trastuzumab has been rarely reported in India. This is a case report of a 56-year-old woman presented to the medical oncology outpatient department of our hospital with breast lump, and she was diagnosed to have human epidermal growth factor receptor 2 (HER-2/neu) positive invasive ductal carcinoma of left breast of stage T2N3cM0. She was treated with neoadjuvant chemotherapy, and she underwent modified radical mastectomy with axillary lymph node dissection. The treating oncologist was planned to start on adjuvant chemotherapy with injection trastuzumab for every four weeks, for 15 cycles. Patient received first dose of injection trastuzumab (450 mg) intravenously in the right (contralateral) arm and developed painful, swollen, erythematous blisters, and maculopapular rashes following the sharp linear borders of her previous radiation fields. She was reviewed by the medical oncologist and diagnosed as a rare case of RRD and treated with topical betamethasone cream. Causality assessment for RRD to trastuzumab was done using Naranjo and WHO-UMC scale and found to be in the category of probable and probable/ likely respectively.

scholarly journals Nodular Scleritis Revealing Metastasis of Breast Cancer: Diagnosis Not to Be Neglected

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Belghmaidi Sarah ◽  
Ghazza Ahmed ◽  
Boutgayout Saloua ◽  
Hajji Ibtissam ◽  
Moutaouakil Abdeljalil ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Breast Cancer Diagnosis ◽  
Left Breast ◽  
Histopathological Study ◽  
Ophthalmological Examination ◽  
Secondary Tumor ◽  
Systemic Corticosteroids ◽  
Anterior Scleritis ◽  
History Of

We report the case of ocular metastasis in a 48-year-old woman presenting left eye redness and pain. The patient was followed in another health institution for nodular scleritis and received systemic corticosteroids with moderate improvement. Medical history revealed that she was diagnosed three years ago with invasive ductal carcinoma of the left breast treated by tumorectomy with ganglion dissection. An ophthalmological examination found a hard scleral nodule with vascular architectural disorganization. A biopsy was performed, and the histopathological study revealed the presence of secondary tumor proliferation of poorly differentiated carcinoma of mammary cancer. This case report shows the fact that any unusual ocular presentation, even one simulating anterior scleritis, in a patient with a history of breast cancer should raise suspicion of metastasis.

scholarly journals Reminder of an important clinical lesson: breast cancer metastasis to the parotid gland

2019 ◽  
Vol 12 (10) ◽  
pp. e226494
Author(s):  
Amisha Jakharia-Shah ◽  
Hugh Wheatley ◽  
Matthew Beesley
Keyword(s):  
Parotid Gland ◽  
Facial Nerve ◽  
Cancer Metastasis ◽  
Ductal Carcinoma ◽  
Primary Tumour ◽  
Breast Cancer Metastasis ◽  
Her2 Receptor ◽  
Significant Family History ◽  
History Of ◽  
The Right

A 59-year-old woman presented to an otolaryngology clinic with an 8-week history of a painless lump over her left parotid gland. Her medical history included an invasive ductal carcinoma (33 mm) and a ductal carcinoma in situ (70 mm) of the right breast, for which she had a mastectomy and various adjuvant therapies. The primary tumour presented 8 years prior to the metachronous metastasis. This patient was a non-smoker and had no significant family history. Post-superficial parotidectomy pathology revealed the parotid gland tumour to be oestrogen receptor-positive and HER2 receptor-positive, thus ruling out the initial differential diagnosis of a pleomorphic adenoma. A consequential total parotidectomy with a posterolateral neck dissection was performed with sparing of the facial nerve. The patient recovered well having only encountered a self-resolving salivary fistula. She portrayed no signs of facial nerve palsy and subsequent imaging scans showed no abnormalities.

scholarly journals Synchronous breast and colon cancer: the importance of multidisciplinary team cancer meetings

2019 ◽  
Vol 12 (12) ◽  
pp. e232680
Author(s):  
Hussain Adnan Abdulla ◽  
Raed Almarzooq ◽  
Amal Alrayes
Keyword(s):  
Colon Cancer ◽  
Multidisciplinary Team ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Radical Mastectomy ◽  
Right Hemicolectomy ◽  
Left Breast ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Ascending Colon

A 58-year-old female patient presented with left breast lump. Mammography and ultrasonography were performed, which reported lesions suspicious of malignancy in the left breast and axilla. Core biopsy of the lesions revealed invasive ductal carcinoma with axillary lymph node metastasis. Staging CT scan (thorax, abdomen and pelvis) identified a coexisting neoplasm in the ascending colon. Colonoscopy was performed and the tumour in the ascending colon was biopsied. Histopathological examination revealed adenocarcinoma. In the multidisciplinary team cancer meeting, it was decided to treat the breast cancer first and then the colon cancer, followed by adjuvant chemotherapy. In the first operation, left modified radical mastectomy was performed. Two weeks after her initial operation, the patient underwent laparoscopic right hemicolectomy. Postoperatively, the patient did not develop any complications and was referred to oncology for chemotherapy.

Retrospective analysis on patients with male breast cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19681-19681
Author(s):  
A. M. Alvarez ◽  
M. N. Gandur Quiroga ◽  
G. Cinat ◽  
J. Iturbe ◽  
T. Said Nissi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Radical Mastectomy ◽  
Male Breast ◽  
History Of ◽  
The Media ◽  
Histological Characteristics ◽  
Breast Lumps

19681 Background: Male breast cancer is uncommon, 1%(0.7 %)of all breast cancer. Nevertheless, the incidence has climbed 26% over the past 25 years. Objetive: Analyze the form of presentation and clinical evolution of patients with male breast cancer studied from 1977 to 2005. Methods: From 1977 to 2005 53 charts were analyzed: age, clinical presentation, stage (st), histological characteristics and nodal involvement. Results: Age: 33 years to 83 years (median= 59 years). Mean durations of symptoms before presentations: 11 months (m) (range 1 - 84 m.) . Forty-six (86.7%) patients (pts) had history of breast lumps, 9 (17%) were painful. Skin involvement and ulceration were present in 5 (9.43%) and 4 (7.54 %) respectively. One case of bilateralism was found. Seven (13.2%) st. I; 18 (33.96%) st. II; 20 (37.73%) st. III and 7 (13.2%) st. IV. Radical mastectomy was done in 41 pts (77.35%). Invasive ductal carcinoma was the most common histological type in 45 (84.9%). One case of lobular carcinoma was found. 60.4% of tumours expressed hormonal receptor. Adyuvant treatment: Adriamycin-based chemotherapy in 20 pts and CMF in 8 pts. Hormonotherapy was offered in 10 (19%) pts of the previous group, radiotherapy to 12 pts. twenthy pts (37.73%) presented recurrence; most common was bone in 10. The st. I and II estimated 5-year survival rate was 68% IC 95% (44–84%), st. III was 44% IC 95% (23 - 67%), st. IV (median = 24 m) with range (16 - 56 m). The 72% IC 95% (48–88%) patients st. I and II was free of disease at the 5-years, st. III was free 24% IC 95% (9–49%), st. IV (median = 7,5 m) with range (7–14 m). Conclusions: The media age at diagnosis was 59 years (10 years less than the international bibliography). (IB). Our group had longer time to presentation: 11 vs. 6 m., (IB) and most of them where in st. III. Hormonal receptore were positive in 60%. No significant financial relationships to disclose.

scholarly journals Diagnosis and treatment of chylous leakage after modified radical mastectomy for breast cancer: a case report

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110213
Author(s):  
Yingcheng Bai ◽  
Xuemei Tao ◽  
Chunhong Xu ◽  
Yanpeng Zhu
Keyword(s):  
Breast Cancer ◽  
Chest Wall ◽  
Ductal Carcinoma ◽  
Rare Complication ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Modified Radical Mastectomy ◽  
Breast Invasive Ductal Carcinoma ◽  
Chylous Leakage ◽  
Meglumine Diatrizoate

The post-operative complication of chylous leakage after breast cancer is relatively rare, and few clinical studies have been published. We report a 64-year-old woman with chylous leakage following modified radical mastectomy. We describe the patient’s diagnostic and treatment process in detail. The patient was diagnosed with grade II (left) breast invasive ductal carcinoma. Post-operatively, the patient's chest wall and axilla were pressurized, and negative pressure drainage was initiated. On the fifth post-operative day, the drainage from the chest wall and axilla increased significantly, and the patient developed chylous leakage on the eighth postoperative day. We injected meglumine diatrizoate (100 mL) and elemene (10 mL) into the patient's axilla, and the chylous leakage gradually resolved 18 days post-operatively. In this report, we focus on managing a case of chylous leakage after modified radical mastectomy for breast cancer. Meglumine diatrizoate combined with elemene is a possible treatment for the management of this rare complication.

STIFF PERSON SYNDROME PRESENTING AS ‘STIFF EYES’

2015 ◽  
Vol 86 (11) ◽  
pp. e4.125-e4
Author(s):  
Maruthi Ravi Vinjam ◽  
Priya Shanmugarajan ◽  
Helen Ford
Keyword(s):  
Eye Movements ◽  
Ductal Carcinoma ◽  
Left Breast ◽  
Double Vision ◽  
Stiff Person Syndrome ◽  
History Of ◽  
Normal Strength ◽  
Movement Problem ◽  
Tendon Reflexes ◽  
Csf Examination

A 47-year previously fit and well lady presented with 6 weeks history of generalised lethargy, weight loss and neck pain. Her examination revealed left supra-clavicular lymph nodes. Subsequent investigations revealed left grade 2 invasive ductal carcinoma of her left breast. This was treated with local excision.She presented to hospital four weeks following her surgery with progressive double vision and unsteadiness. Her cranial nerve examination showed severly restricted pursuit and saccadic horizontal eye movements with intact vertical eye movements. She had normal strength with intact deep tendon reflexes with plantar flexor response. Her MRI head and spine with contrast and CSF examination, including cytology was normal.Two weeks into her admission she progressively developed generalised stiffness and severe axial and peripheral rigidity which was made worse with touch or emotions. These symptoms responded to benzodiazepines and baclofen. Her anti-amphiphysin antibodies were positive confirming the diagnosis of stiff person syndrome.Her breast cancer was treated aggressively with chemotherapy. Her stiffness and rigidity improved briefly following her chemotherapy. Eye movement's problems were described in anti-GAD related stiff person syndrome, which is due to GABA depletion. This is first ever-reported case where eye movement problem (Stiff eyes) is the initial presentation of a anti-amphiphysin antibody related stiff person syndrome.

scholarly journals Invasive papillary ductal carcinoma of the breast: A case report

2020 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Amani S Hadi ◽  
Gamal Abdul Hamid ◽  
Refaat Al-Areqee ◽  
Wafa Abdullah
Keyword(s):  
Papillary Carcinoma ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Residual Tumor ◽  
Excisional Biopsy ◽  
Breast Mass ◽  
Low Grade ◽  
Breast Cancers ◽  
History Of ◽  
Invasive Papillary Carcinoma

The general rate of intrusive papillary carcinoma (IPC) is uncommon, representing for less than 1-2 % of invasive breast cancers. They are most generally observed in postmenposal females and uncommon in males. Invasive papillary carcinomas are low grade tumors originating from large or dilated ducts. They are make out of all around outlined solid nodules of monotones neoplastic cell separated by network of fibrovascular cores, IPC is a remarkable sort of breast cancer and regarded of whether it is in-situ or invasive, it has brilliant prognosis. We presenting two cases of invasive papillary carcinoma in male and female; A case of 55years postmenoposal female who presented with history of left breast mass, which this mass notice after trauma same site for 1 year ago the mass gradually increase in size no tenderness, no signs of inflammation. Excisional biopsy was performed and specimen was histopathology diagnosed as invasive papillary carcinoma, left MRM was performed and histopathology diagnosis confirmed and without residual tumor seen in submitted slides and all submitted lymph nodes were free of tumor infiltration (0/14). IHC show ER and PR negative with HER-2 positive. The second case 70 years male presented with right breast mass and history of post-trauma since one year back with gradual increase in size, right radical mastectomy done and histopathology diagnosed as invasive papillary carcinoma, IHC was done ER and PR positive with HER2- negative.

scholarly journals Case Report: Metastatic breast cancer to the gallbladder

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 343
Author(s):  
Giulia Missori ◽  
Francesco Serra ◽  
Giorgia Prestigiacomo ◽  
Andrea Aurelio Ricciardolo ◽  
Lucio Brugioni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Previous History ◽  
Metastatic Breast ◽  
Left Breast ◽  
Surgical Specimen ◽  
Surgical Interventions ◽  
History Of

Cholecystitis is one of the leading causes of emergency surgical interventions; the occurrence of metastases to the gallbladder is rare and has only been reported in the literature exceptionally. Metastatic breast cancer to the gallbladder is even less frequent; in fact, breast cancer usually metastasizes to bone, lung, lymph nodes, liver and brain. We report the case of an 83-year-old female patient with a previous history of breast surgery with axillary dissection in 1997, followed by adjuvant chemotherapy due to invasive ductal carcinoma of the left breast. The patient was admitted at the emergency department for sepsis and an episode of acute kidney failure, anuria and fever. Right-upper quadrant abdominal pain triggered by food intake and abdominal tenderness was also present, placing the diagnostic suspicion of biliary sepsis due to acute cholecystitis. The histological examination of the surgical specimen highlighted the presence of metastasis from an infiltrating ductal breast carcinoma with positive hormone receptors. We also report here the results of a review of the literature looking at articles describing cases of gallbladder metastasis from breast cancer.

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