scholarly journals Suan Zao Ren Tangin Combination withZhi Zi Chi Tangas a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Lin-lin Hu ◽  
Xin Zhang ◽  
Wen-juan Liu ◽  
Mei Li ◽  
Yong-hua Zhang
Keyword(s):  
Treatment Group ◽  
Sleep Quality ◽  
Pittsburgh Sleep Quality Index ◽  
Therapeutic Option ◽  
Controlled Trial ◽  
Sleep Onset ◽  
Treatment Protocol ◽  
Severity Index ◽  
Improve Sleep Quality ◽  
Insomnia Severity

Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containingSuan Zao Ren Tang(SZRT) andZhi Zi Chi Tang(ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS).Methods.A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n=60) and the lorazepam tablet treatment group (n=59).Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P=0.029), the PSQI (P=0.017), and wake after sleep onset (WASO;P=0.008) scores and improved sleep architecture (P=0.000–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects.Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.

Changes in sleep predict changes in depressive symptoms in depressed subjects receiving vortioxetine: An open-label clinical trial

2019 ◽  
Vol 33 (11) ◽  
pp. 1388-1394 ◽  
Author(s):  
Bing Cao ◽  
Caroline Park ◽  
Joshua D Rosenblat ◽  
Yan Chen ◽  
Michelle Iacobucci ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sleep Quality ◽  
Epworth Sleepiness Scale ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Severity Index ◽  
Major Depressive ◽  
Insomnia Severity Index ◽  
Insomnia Severity

Background Sleep disturbances are frequently reported in patients with major depressive disorder. We aimed to investigate the effects of vortioxetine on sleep quality and association between changes in sleep and treatment response. Methods: This study is a post-hoc analysis of a clinical trial that sought to evaluate the sensitivity to cognitive change of THINC-integrated tool in patients with major depressive disorder. In total, 92 patients (aged 18 to 65) meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe major depressive disorder and 54 healthy controls were included. All patients received open-label vortioxetine (10–20 mg/day, flexibly dosed) for 8 weeks. Herein, the primary outcomes of interest were changes in sleep, as measured by the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index, between weeks 0, 2, and 8. The association between changes in sleep and depressive symptom severity was secondarily assessed. Results: We observed that sleep, as indicated by scores of Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index, was significantly poorer in patients with major depressive disorder compared to healthy controls at weeks 0, 2, and 8 ( p < 0.05). Among patients with major depressive disorder, we observed significant improvements on the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index between weeks 0 and 8 ( p < 0.05). We observed a significant association between improvements on the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Insomnia Severity Index and improvement of depressive symptoms. Conclusion: Improvement of depressive symptoms in major depressive disorder patients treated with vortioxetine was associated with significant improvements in sleep. Furthermore, improvements in sleep were predictive of antidepressant response and were linearly correlated with improvement in overall depressive symptom severity.

scholarly journals The Effectiveness of integrating spirituality into prenatal care on Improving Sleep Quality and Insomnia Severity among Pregnant Women: A Randomized Control Trial

2021 ◽  
Author(s):  
azam maleki ◽  
Nahid Moradi ◽  
Saeedeh Zenoozian
Keyword(s):  
Prenatal Care ◽  
Sleep Quality ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Intervention Group ◽  
Severity Index ◽  
First Trimester ◽  
Routine Care ◽  
Control Group ◽  
Insomnia Severity

Abstract Background To determine the effectiveness of integrating spirituality into prenatal care on Improving Sleep Quality and Insomnia Severity among Pregnant Women. Methods This randomized controlled trial was carried out on 40 pregnant women recruited at five health centers of zanjan, Iran, 2020. The eligible women were allocated into two intervention and control groups according to the randomized design. Group counselling with spiritual content was carried out in eight sessions, two times a week at 16 to 20 weeks of gestation. The control group only received routine care. Data were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) questionnaires in three stages, before the intervention, at 28 and 36 weeks of gestation. Statistical analysis was performed using the SPSS 16.0 software (SPSS Inc., Chicago, IL, USA). Results The results showed that comparing the mean score of insomnia severity, sleep quality and its components in the pre-intervention phase was not statistically significant between the two groups(p>0.05). Comparison of the insomnia severity, sleep quality, and its components scores decreased statistically in the second and third trimesters compared to the first trimester in the intervention group than the control group(p<0.05). The effect of the intervention (Eta score) was 64%. Conclusion The results showed that counselling with spiritual content could effectively ameliorate sleep quality and reduce insomnia severity in pregnant women. It seems that the approach is an acceptable basis to design intervention programs in this field that can be considered by midwives.

scholarly journals Efficacy of transcutaneous electrical acupoint stimulation combined with diazepam for acute alcohol withdrawal syndrome: A double-blind randomized sham-controlled trial

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091005
Author(s):  
Yun Song ◽  
Xiaobin Xue ◽  
Haibin Han ◽  
Cuiluan Li ◽  
Jia Jian ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Pittsburgh Sleep Quality Index ◽  
Controlled Trial ◽  
Alcohol Withdrawal Syndrome ◽  
Control Group ◽  
Double Blind ◽  
Improve Sleep Quality ◽  
Acupoint Stimulation

Objective To compare the efficacy of transcutaneous electrical acupoint stimulation (TEAS) combined with diazepam against diazepam alone for treatment of acute alcohol withdrawal syndrome (AWS). Methods In this double-blind randomized sham-controlled trial, men with acute AWS were randomly allocated to either a group treated with TEAS combined with diazepam (n = 57) or a control group treated with sham TEAS combined with diazepam (n = 60). Treatment was performed at four acupoints twice a day for 14 days. The Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar), visual analogue scale (VAS), Pittsburgh Sleep Quality Index (PSQI) and modified Epworth Sleepiness Scale (mESS) were used to evaluate treatment efficacy. Results All scores improved significantly in both groups during the trial. CIWA-Ar scores were lower in the TEAS group than in the control group from day 3 until the end of observation. VAS and mESS scores were also lower in the TEAS group than in the control group on day 7. VAS and PSQI scores were lower in the TEAS group on day 14. Conclusion Combining diazepam with TEAS may result in milder AWS symptoms than diazepam alone, improve sleep quality and reduce sleepiness.

scholarly journals Sleep in post-COVID-19 recovery period and its impact on different domains of quality of life

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Samir El Sayed ◽  
Sarah Gomaa ◽  
Doaa Shokry ◽  
Ahmed Kabil ◽  
Ahmed Eissa
Keyword(s):  
Quality Of Life ◽  
Sleep Quality ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Sleep Problems ◽  
Recovery Period ◽  
Severity Index ◽  
Insomnia Severity Index ◽  
Insomnia Severity

Abstract Background COVID-19 pandemic became a global health problem affecting the life of millions of people all over the world. The effects of this pandemic were not only on the physical and medical aspects but also on the psychological issues including anxiety disorders, depressive manifestations, sleep problems and others. Sleep disorders were very commonly reported during the novel Coronavirus-19 pandemic either in the acute phase of COVID-19 infection or after recovery. These sleep problems might have a drastic burden on the recovered patients’ life. This study aimed to investigate the sleep in the post-Coronavirus-19 period and if has an impact on the different items of patients’ quality of life. This cross-sectional observational study investigated the sleep problems in 500 patients in the post recovery period using Insomnia Severity Index and Pittsburgh sleep quality index (PSQI), their relation to this critical period and their impact on different domains of Quality of Life which was assessed by the SF36 Health Survey. Results Socio-demographic characteristics of 500 post-Coronavirus-19 patients were collected; the insomnia severity index and Pittsburgh sleep quality index evaluated the sleep pattern. The quality of life was investigated using Short Form 36 scale. The study revealed high scores of insomnia severity index (13.01 ± 4.9), Pittsburgh sleep quality index (15.37 ± 4.43), also high scores of different items of scale of quality of life in the studied group. Conclusion Post-COVID-19 sleep disturbances were commonly reported in the recovery period, also these sleep deficits had an impact on the physical and mental aspects of quality of life, so these sleep problems must be managed properly especially in this critical pandemic era.

scholarly journals 0544 Reconsidering Stimulus Control: Activities in Bed Associated with Sleep-Related Outcomes

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A208-A208
Author(s):  
S Phan ◽  
M L Perlis ◽  
L Hale ◽  
C Branas ◽  
W D Killgore ◽  
...  
Keyword(s):  
Sex Education ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Sleep Latency ◽  
Sleep Onset ◽  
Severity Index ◽  
Severity Scale ◽  
Fatigue Severity ◽  
Watching Tv ◽  
Insomnia Severity

Abstract Introduction The typical advice is that in order to avoid insomnia, people should avoid activities in bed other than sleep. Yet, activities such as reading and watching TV in bed are common. Methods Data were obtained from the Sleep and Health Activity, Diet, Environment, and Socialization (SHADES) Study, N=1,007 adults age 22-60. Sleep hygiene was assessed using items from the Sleep Practices and Attitudes Questionnaire (SPAQ), which asked whether respondents agree/disagree that they do the following in bed: Read, Watch TV, Eat, Work, Worry, and/or Argue. These were analyzed in relation to Insomnia Severity Index (ISI) score, Pittsburgh Sleep Quality Index (PSQI) score, Epworth Sleepiness Scale (ESS) score, Fatigue Severity Scale (FSS) score, and self-reported sleep duration (TST), sleep latency (SL), and wake after sleep onset (WASO). Covariates included age, sex, education, and income. Results Those that frequently engaged in activities were: reading (75%), watching TV (63%), eating (42%), working (32%), worrying (82%), and arguing (23%). Reading was associated with less WASO (B=-14min, p=0.02). Watching TV was associated with higher ISI (B=1.22, p=0.04), PSQI (B=1.04, p=0.007), and ESS (B=0.87, p=0.049), and less TST (B=-0.29, p=0.04). Eating was associated with higher ISI (B=1.75, p=0.01), PSQI (B=1.23, p=0.008), and FSS (B=4.36, p=0.002). Working was associated with higher ISI (B=1.82, p=0.019), PSQI (B=1.65, p=0.001), and ESS (B=1.78, p=0.002). Worrying was associated with higher ISI (B=7.34, p&lt;0.0005), PSQI (B=4.40, p&lt;0.0005), ESS (B=2.53, p=0.001), FSS (B=9.51, p&lt;0.0005), and SL (B=19.39, p&lt;0.0005), and less TST (B=-0.55, p=0.023). Arguing was associated with higher ISI (B=3.78, p&lt;0.0005), PSQI (B=3.15, p&lt;0.0005), ESS (1.47, p=0.023), and SL (B=10.97, p=0.013), and lower TST (B=-0.71, p=0.001). Conclusion Individuals who perform mentally distressing activities such as worrying and arguing experience especially worse sleep, and those who read in bed have fewer awakenings. Support The SHADES study was funded by R21ES022931. Dr. Grandner is supported by R01MD011600.

scholarly journals Randomized Placebo-Controlled Trial of Cognitive Behavioral Therapy and Armodafinil for Insomnia After Cancer Treatment

2015 ◽  
Vol 33 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Joseph A. Roscoe ◽  
Sheila N. Garland ◽  
Charles E. Heckler ◽  
Michael L. Perlis ◽  
Anita R. Peoples ◽  
...  
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Sleep Quality ◽  
Cancer Survivors ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Severity Index ◽  
Cognitive Behavioral ◽  
Placebo Capsule ◽  
After Cancer ◽  
Insomnia Severity

Purpose Insomnia is a distressing and often persisting consequence of cancer. Although cognitive behavioral therapy for insomnia (CBT-I) is the treatment of choice in the general population, the use of CBT-I in patients with cancer is complicated, because it can result in transient but substantial increases in daytime sleepiness. In this study, we evaluated whether CBT-I, in combination with the wakefulness-promoting agent armodafinil (A), results in better insomnia treatment outcomes in cancer survivors than CBT-I alone. Patients and Methods We report on a randomized trial of 96 cancer survivors (mean age, 56 years; female, 87.5%; breast cancer, 68%). The primary analyses examined whether ≥ one of the 7-week intervention conditions (ie, CBT-I, A, or both), when compared with a placebo capsule (P) group, produced significantly greater clinical gains. Insomnia was assessed by the Insomnia Severity Index and sleep quality by the Pittsburgh Sleep Quality Inventory. All patients received sleep hygiene instructions. Results Analyses controlling for baseline differences showed that both the CBT-I plus A (P = .001) and CBT-I plus P (P = .010) groups had significantly greater reductions in insomnia severity postintervention than the P group, with effect sizes of 1.31 and 1.02, respectively. Similar improvements were seen for sleep quality. Gains on both measures persisted 3 months later. CBT-I plus A was not significantly different from CBT-I plus P (P = .421), and A alone was not significantly different from P alone (P = .584). Conclusion CBT-I results in significant and durable improvements in insomnia and sleep quality. A did not significantly improve the efficacy of CBT-I or independently affect insomnia or sleep quality.

Insomnio, TDAH y Patología Dual: estudio transversal en una muestra de 252 pacientes TDAH adultos

2020 ◽  
Author(s):  
Christian Fadeuilhe Grau ◽  
◽  
Vanesa Richarte Fernández ◽  
Montserrat Corrales de la Cruz ◽  
Raúl Felipe Palma-Álvarez ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Quality Index ◽  
Rating Scale ◽  
Pittsburgh Sleep Quality Index ◽  
Severity Index ◽  
Insomnia Severity Index ◽  
Uso De Sustancias ◽  
Dual Material ◽  
Insomnia Severity

Objetivos Identificar la prevalencia y evaluar las características clínicas del insomnio en una muestra de pacientes TDAH adultos con Patología Dual. Material y métodos La muestra la forman 252 pacientes adultos con TDAH remitidos para evaluación diagnóstica al Programa de TDAH del Hospital Universitari Vall d’Hebron. Se realizó una evaluación clínica y psicodiagnóstica, administrándose las escalas SCID-I y SCID-II, CAARS, ADHD Rating Scale y WURS. Igualmente se realizó una evaluación clínica del insomnio complementada con la administración de dos escalas específicas: la Insomnia Severity Index (ISI) y la Pittsburgh Sleep Quality Index (PSQI). Resultados y conclusiones La presencia de insomnio en pacientes adultos con TDAH presentaba una asociación estadísticamente significativa (11.6% vs. 4.3%; p<0.029) en aquellos pacientes que presentaban comórbidamente un Trastorno por uso de sustancias (alcohol, cocaína o cannabis). Esta asociación entre el insomnio y el TDAH adulto también fue identificada en aquellos pacientes adultos con antecedente de Trastorno por uso de sustancias (34.8% vs 15.0%; p<0.0001). Esta asociación era mayor en la presentación combinada del TDAH, observándose igualmente una correlación estadística entre la presencia de insomnio y la severidad clínica del TDAH.

scholarly journals Baseline Sleep Dysfunction Among Matriculating Interns

2012 ◽  
Vol 4 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Samantha J. Pulliam ◽  
Debra F. Weinstein ◽  
Atul Malhotra ◽  
Eric A. Macklin ◽  
Lori R. Berkowitz
Keyword(s):  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Epworth Sleepiness Scale ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Severity Index ◽  
Sleep Habits ◽  
Insomnia Severity Index ◽  
Graduate Medical ◽  
Insomnia Severity

Abstract Background Work hour limitations for graduate medical trainees, motivated by concerns about patient safety, quality of care, and trainee well-being, continue to generate controversy. Little information about sleep habits and the prevalence of sleep disorders among residents is available to inform policy in this area. Objectives To evaluate the sleep habits of matriculating residents, postgraduate year-1 (PGY-1). Design An anonymous, voluntary, self-administered survey study was used with 3 validated questionnaires: the Pittsburgh Sleep Quality Index, the Insomnia Severity Index, and the Epworth Sleepiness Scale, which were fielded to PGY-1 residents entering the Accreditation Council for Graduate Medical Education–accredited programs at Massachusetts General Hospital and/or Brigham and Women's Hospitals in June and July 2009. Results Of 355 eligible subjects, 310 (87%) participated. Mean sleep time for PGY-1 residents was 7 hours and 34 minutes, and 5.6% of PGY-1 residents had Pittsburgh Sleep Quality Index global scores greater than 5, indicating poor quality sleep. Using multiple linear and ordinal logistic regression models, men had higher Pittsburgh Sleep Quality Index sleep latency scores, whereas women and those with children had higher Epworth Sleepiness Scale daytime sleepiness scores, and 18% of PGY-1 residents had abnormal amounts of daytime sleepiness based on the Epworth Sleepiness Scale. The Insomnia Severity Index identified 4.2% of PGY-1 residents with moderate insomnia. Conclusions Some PGY-1 residents may begin residency with sleep dysfunctions. Efforts to provide targeted help to selected trainees in managing fatigue during residency should be investigated.

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