Biologic Agents for Periodontal Regeneration and Implant Site Development

The advancement of molecular mediators or biologic agents has increased tremendously during the last decade in periodontology and dental implantology. Implant site development and reconstruction of the lost periodontium represent main fields in which these molecular mediators have been employed and investigated. Different growth factors trigger different reactions in the tissues of the periodontium at various cellular levels. Proliferation, migration, and differentiation constitute the main target areas of these molecular mediators. It was the purpose of this comprehensive review to describe the origin and rationale, evidence, and the most current understanding of the following biologic agents: Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB), Enamel Matrix Derivate (EMD), Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2), Bone Morphogenic Proteins (BMPs, BMP-2 and BMP-7), Teriparatide PTH, and Growth Differential Factor-5 (GDF-5).

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Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review.

International Journal of Medical and Surgical Sciences ◽

10.32457/ijmss.2017.020 ◽

2018 ◽

Vol 4 (3) ◽

pp. 1196-1202

Author(s):

Felipe Cid

Keyword(s):

Growth Factors ◽

Growth Factor ◽

Transforming Growth Factor ◽

Platelet Rich Plasma ◽

Periodontal Regeneration ◽

The Body ◽

Blood Collection ◽

Platelet Rich Fibrin ◽

Positive Effects ◽

And Function

Regeneration is defined as the reproduction or reconstruction of a lost part or injury of the body in such a way that the architecture and function of the lost or injured tissue are completely restored. The goal of regenerative periodontal therapy is to restore the structure and function of the periodontium. The positive effects of Platelet-rich plasma (PRP) are attributed to the angiogenic, mitogenic and proliferative capacities of growth factors such as platelet-derived growth factor, transforming growth factor and vascular endothelial growth factor. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that allows fibrin membranes enriched with platelets and growth factors to be obtained after starting an anticoagulant-free blood collection without any biomechanical artificial modification. The objective of this review is to know the efficacy of platelet-rich plasma and platelet-rich fibrin in the periodontal regeneration of intrabony defects. The clinical implications for this autologous material are promising. Further long term, larger, multicentred randomized controlled clinical trials are required to determine the effects of PRP and PRF on the regeneration of alveolar bone due to periodontal disease.

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Randomized Placebo‐Controlled and Controlled Non‐Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects

Journal of Bone and Mineral Research ◽

10.1002/jbmr.2738 ◽

2015 ◽

Vol 31 (4) ◽

pp. 806-814 ◽

Cited By ~ 44

Author(s):

Masahiro Kitamura ◽

Motoki Akamatsu ◽

Masamitsu Kawanami ◽

Yasushi Furuichi ◽

Takeo Fujii ◽

...

Keyword(s):

Growth Factor ◽

Periodontal Regeneration ◽

Phase Iii ◽

Fibroblast Growth Factor 2 ◽

Enamel Matrix Derivative ◽

Fibroblast Growth ◽

Enamel Matrix ◽

Intrabony Defects ◽

Phase Iii Trials ◽

Matrix Derivative

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Evaluation of Recombinant Human Platelet-Derived Growth Factor or Enamel Matrix Derivative Plus Calcium Hydroxide for Pulp Capping: A Randomized Controlled Human Clinical Trial

The International Journal of Periodontics & Restorative Dentistry ◽

10.11607/prd.4764 ◽

2020 ◽

Vol 40 (5) ◽

pp. 645-654

Author(s):

Khalid Al-Hezaimi ◽

Jafar Naghshbandi ◽

Raed Alhuzaimi ◽

Faisal Alonaizan ◽

Ibrahim AlQwizany ◽

...

Keyword(s):

Clinical Trial ◽

Growth Factor ◽

Human Platelet ◽

Platelet Derived Growth Factor ◽

Enamel Matrix Derivative ◽

Enamel Matrix ◽

Human Clinical Trial ◽

Pulp Capping ◽

Randomized Controlled ◽

Matrix Derivative

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Do the Fibrin Architecture and Leukocyte Content Influence the Growth Factor Release of Platelet Concentrates? An Evidence-based Answer Comparing a Pure Platelet-Rich Plasma (P-PRP) Gel and a Leukocyte- and Platelet-Rich Fibrin (L-PRF)

Current Pharmaceutical Biotechnology ◽

10.2174/138920112800624382 ◽

2012 ◽

Vol 13 (7) ◽

pp. 1145-1152 ◽

Cited By ~ 156

Author(s):

David M. Dohan Ehrenfest ◽

Tomasz Bielecki ◽

Ryo Jimbo ◽

Giovanni Barbe ◽

Marco Del Corso ◽

...

Keyword(s):

Growth Factor ◽

Platelet Rich Plasma ◽

Evidence Based ◽

Platelet Concentrates ◽

Platelet Rich Fibrin ◽

Growth Factor Release ◽

Prp Gel ◽

Factor Release

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The Combination of Purified Recombinant Human Platelet-Derived Growth Factor-BB and Equine Particulate Bone Graft for Periodontal Regeneration

Journal of Periodontology ◽

10.1902/jop.2011.110298 ◽

2012 ◽

Vol 83 (5) ◽

pp. 565-573 ◽

Cited By ~ 10

Author(s):

Myron Nevins ◽

Marc L. Nevins ◽

Nadeem Karimbux ◽

Soo-Woo Kim ◽

Peter Schupbach ◽

...

Keyword(s):

Growth Factor ◽

Bone Graft ◽

Human Platelet ◽

Periodontal Regeneration ◽

Platelet Derived Growth Factor

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Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs

Dental Materials Journal ◽

10.4012/dmj.2012-171 ◽

2013 ◽

Vol 32 (2) ◽

pp. 256-262 ◽

Cited By ~ 9

Author(s):

Akira SAITO ◽

Emiko SAITO ◽

Yoshinori KUBOKI ◽

Mariko KIMURA ◽

Toshinori NAKAJIMA ◽

...

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Basic Fibroblast Growth Factor ◽

Tricalcium Phosphate ◽

Periodontal Regeneration ◽

Fibroblast Growth Factor 2 ◽

Fibroblast Growth ◽

Class Iii ◽

Beta Tricalcium Phosphate ◽

Furcation Defects

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Regeneration of Furcation Defects Treated with Porous Hydroxyapatite and Platelet-Rich Plasma: A Histological Study

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1714651 ◽

2020 ◽

Vol 10 (02) ◽

pp. 68-73

Author(s):

Avaneendra Talwar ◽

Reshma Amin

Keyword(s):

Growth Factor ◽

Bone Formation ◽

Transforming Growth Factor ◽

Alveolar Bone ◽

Platelet Rich Plasma ◽

Periodontal Diseases ◽

Histological Study ◽

Periodontal Regeneration ◽

Furcation Defects ◽

Osseous Defects

Abstract Introduction The alveolar bone, periodontal ligament (PDL), and cementum are the integral structural components invariably subject to changes during periodontal diseases. Many documents on animal and human studies state that the polypeptide growth factors (GFs) have a role in periodontal regeneration. The platelet-rich fibrin (PRF) is in use since the last decade. It has the potential of delivering GFs into vertical osseous defects. Human platelets contain platelet-derived growth factor and transforming growth factor-β in their α granules. These GFs are involved in wound healing and act as promoters of tissue regeneration. The study aimed to obtain histologic evidence, if any, of new attachment in humans, following treatment of osseous defects with 10-1055-s-0040-1714651_00084_ (HA) and PRF mix. Materials and Methods Five maxillary molar teeth with advanced bone loss were treated with porous 10-1055-s-0040-1714651_00084_ (PHA) mixed with PRF. Distobuccal roots were resected and studied histologically for evidence of bone formation, if any, at 1st, 3rd, and the 5th months. Results The PHA was completely resorbed in all the specimens. There was definitive evidence of bone formation at the 3rd month itself with mature lamellar bone with resting and reversal lines at the fifth postoperative month. There was no evidence of new cementum or PDL formation. Conclusion PRF in conjunction with osteoconductive materials prove to accelerate bone formation in vertical osseous defects.

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