scholarly journals Perivascular Epithelioid Cell Tumour with Intraorbital Location: Report of a Case and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Idania Lubo ◽  
Ileana Fermín ◽  
Olindo Massarelli ◽  
Roberta Gobbi ◽  
Paolo Cossu Rocca
Keyword(s):  
Clinical Outcome ◽  
Clinical Course ◽  
Mitotic Rate ◽  
Epithelioid Cell ◽  
World Health ◽  
Review Of The Literature ◽  
Perivascular Epithelioid Cell ◽  
Mesenchymal Neoplasms ◽  
The World ◽  
Health Organization

The Perivascular Epithelioid Cell tumours (PEComas) are rare mesenchymal neoplasms recognized as entity by the World Health Organization. The tumour cells have an uncertain origin and are characterized by distinctive histological and immunohistochemical features. We report a case of PEComa occurring as intraorbital lesion in a 47-year-old man. We found only two other cases described in the literature and we considered all three cases together in order of histology, immunohistochemistry, and clinical outcome. We found a strict histological overlapping and quite similar immunohistological results. All three cases showed a favourable clinical course probably related to small size of tumours (<5 cm), low mitotic rate (<2 mitoses in 50 HPF), and absence of necrosis.

Co-infection of SARS CoV-2 and influenza A in a Pediatric Patient in Germany

2020 ◽  
Vol 232 (04) ◽  
pp. 217-218 ◽  
Author(s):  
Goetz Wehl ◽  
Monika Laible ◽  
Markus Rauchenzauner
Keyword(s):  
World Health Organization ◽  
Influenza A Virus ◽  
Pediatric Patient ◽  
Influenza A ◽  
Clinical Course ◽  
World Health ◽  
Elderly Adults ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

In December 2019 a novel coronavirus was firstly encountered in Wuhan/China with a massive outbreak of fatal pneumonia leading to a pandemic declared by the World Health Organization in March 2020 (WHO Dashboard COVID-19. [WHO web site]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019), affecting mainly elderly adults with underlying co-morbidities. Clinical course in children below the age of 10 years is considered to be mild or even with subclinical signs (Sinha IP, Ha et al. The Lancet Respiratory medicine 2020;27;S2213–2600(20) 30152-1). We describe a 4 month old infant with co-infection of SARS CoV-2 and influenza A virus.

A Tale of 2 Morphologies: Diagnostic Pitfalls in TFEB-Associated Renal Cell Carcinomas, Including a Novel NEAT1-TFEB Fusion

2020 ◽  
pp. 106689692095627
Author(s):  
Aarti E. Sharma ◽  
Megan Parilla ◽  
Pankhuri Wanjari ◽  
Jeremy P. Segal ◽  
Tatjana Antic
Keyword(s):  
Renal Cell ◽  
Correct Diagnosis ◽  
Epithelioid Cell ◽  
World Health ◽  
Renal Tumors ◽  
Renal Neoplasm ◽  
Renal Cell Carcinomas ◽  
Perivascular Epithelioid Cell ◽  
Variable Morphology ◽  
Health Organization

Aims Translocation-associated renal cell carcinomas (RCCs) have been extensively subcharacterized in recent years, such that each is largely recognized by the 2016 World Health Organization as categorical neoplastic entities in the genitourinary tract. Those belonging to the t(6;11) family of tumors classically have a fusion between TFEB and MALAT1/α, and display a particular histomorphology. Specifically, they show a biphasic population of both small and large epithelioid cells, the smaller component of which surrounds basement membrane-type material. Despite this apt description, the tumors have variable morphology and mimic other RCCs including those with TFE3 translocations. Therefore, a high degree of suspicion is required to make the correct diagnosis. Methods The 2 cases described in this article were of strikingly different appearance, and initially considered consistent with other non-translocation–associated renal tumors. These included clear cell RCC (CCRCC), perivascular epithelioid cell tumor (PEComa), and other eosinophilic RCCs (mainly papillary RCC type 2). Results Using RNA sequencing techniques, they were found to harbor distinct pathogenic rearrangements involving the TFEB gene, namely, fusions with CLTC and NEAT1 (the latter partnering heretofore never reported). Conclusions These alterations manifested in 2 notably dissimilar lesions, underscoring the importance of including this family of carcinomas in the differential of any renal neoplasm that does not display immunophenotypic characteristics consistent with its morphology.

Prevention of suicide following psychiatric hospitalization

2021 ◽  
pp. 511-520
Author(s):  
Natalie B. Riblet ◽  
Brian Shiner
Keyword(s):  
High Risk ◽  
Clinical Outcome ◽  
Suicide Attempts ◽  
Psychiatric Hospitalization ◽  
World Health ◽  
Effective Strategies ◽  
Risk Period ◽  
The World ◽  
Cognitive Therapies ◽  
Health Organization

The period following a psychiatric hospitalization is a high-risk period for suicide and several factors may contribute such as problems with patient engagement. It is vital that researchers identify effective strategies to prevent suicide in the period following hospitalization. Yet, researchers face many challenges in conducting suicide research. Importantly, because the clinical outcome of greatest interest, death by suicide, is rare, researchers must rely heavily on proxy measures of suicide. Furthermore, while there have been over 30 trials of various strategies to mitigate suicide risk following hospital or emergency room discharge, there is mixed evidence regarding the efficacy of these interventions. While some studies have shown significant reduction in suicide attempts, other studies have found no difference. Few studies have demonstrated a significant effect on death by suicide. The most promising interventions include cognitive therapies for suicide prevention, the World Health Organization Brief Intervention and Contact programme.

The perioperative Team Brief: A patient safety initiative or another tick-box exercise?

2019 ◽  
Vol 29 (12) ◽  
pp. 408-412
Author(s):  
Bernard Pennington ◽  
Joanne Garside
Keyword(s):  
Care Quality ◽  
World Health ◽  
Review Of The Literature ◽  
Surgical Safety ◽  
The World ◽  
Care Quality Commission ◽  
The Subject ◽  
Health Organization ◽  
Safety Initiative

The World Health Organization Surgical Safety Checklist has been the subject of many professional discussions following its introduction in 2008. Since the addition of the Team Brief and Debrief in 2010 and the acceptance of the Five Steps to Safer Surgery as the gold standard, compliance has steadily improved (as audited by Care Quality Commission Inspections). This review of the literature therefore examined the perioperative Team Brief and identified gaps in knowledge. Evidence appears to suggest that whilst compliance is good in quantitative terms, there may be inconsistencies within the quality of Team Briefs from organisation to organisation and surgeon to surgeon. Concluding further research is required to establish what an effective Team Brief looks, sounds and feels like to all involved.

Cytokine Storm and Immunomodulation in COVID-19: a Review

Coronaviruses ◽  
2021 ◽  
Vol 02 ◽  
Author(s):  
Amir Mohammad Arsh ◽  
Suhana Mishra ◽  
Vishwas Tripathi ◽  
Amaresh Mishra
Keyword(s):  
Immune Response ◽  
Multiple Organ ◽  
World Health ◽  
Cytokine Storm ◽  
Review Of The Literature ◽  
Global Pandemic ◽  
The World ◽  
The Subject ◽  
Health Organization ◽  
Immunomodulatory Therapies

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has taken over the world, and more than 38 lakh deaths have been reported till now due to this infectious disease. It has been declared a global pandemic by the world health organization. SARS-CoV-2 causes coronavirus disease of 2019 (COVID-19), and the major problem called "Cytokine storm" is reported, which may lead to death among the COVID-19 patients. This study aimed to review the Cytokine storm and its mechanism along with few immunomodulatory therapies for SARS-CoV-2 infection suppression effectively. Methods: The recently published works of literature were selected and reviewed based on the subject of this study. The databases, including Pubmed, ScienceDirect, Scopus, and Google Scholar, were searched extensively. Results: The review of the literature showed that an uncontrolled immune response causes excess inflammation. Evidence from recent trials has demonstrated that cytokine storms can be an important factor in the COVID-19 severity, leading to multiple organ failure and death. Conclusion: This study reviewed immunomodulatory therapies and strategies for SARS-CoV-2 infected patients to suppress the immune response. Ultimately, the cytokine storm can prove to be a boon and reduce the significant death tolls to SARS-CoV-2 infection.

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