scholarly journals The Predictive Effects of Early Pregnancy Lipid Profiles and Fasting Glucose on the Risk of Gestational Diabetes Mellitus Stratified by Body Mass Index

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Chen Wang ◽  
Weiwei Zhu ◽  
Yumei Wei ◽  
Rina Su ◽  
Hui Feng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
High Density Lipoprotein ◽  
Early Pregnancy ◽  
Fasting Glucose ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol

This study aimed at evaluating the predictive effects of early pregnancy lipid profiles and fasting glucose on the risk of gestational diabetes mellitus (GDM) in patients stratified by prepregnancy body mass index (p-BMI) and to determine the optimal cut-off values of each indicator for different p-BMI ranges. A retrospective system cluster sampling survey was conducted in Beijing during 2013 and a total of 5,265 singleton pregnancies without prepregnancy diabetes were included. The information for each participant was collected individually using questionnaires and medical records. Logistic regression analysis and receiver operator characteristics analysis were used in the analysis. Outcomes showed that potential markers for the prediction of GDM include early pregnancy lipid profiles (cholesterol, triacylglycerols, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios [LDL-C/HDL-C], and triglyceride to high-density lipoprotein cholesterol ratios [TG/HDL-C]) and fasting glucose, of which fasting glucose level was the most accurate indicator. Furthermore, the predictive effects and cut-off values for these factors varied according to p-BMI. Thus, p-BMI should be a consideration for the risk assessment of pregnant patients for GDM development.

scholarly journals The effect of breastfeeding on postpartum glucose tolerance and lipid profiles in women with gestational diabetes mellitus

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Alexis Shub ◽  
Manisha Miranda ◽  
Harry M. Georgiou ◽  
Elizabeth A. McCarthy ◽  
Martha Lappas
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Exclusive Breastfeeding ◽  
Fasting Glucose ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Maternal Body Mass Index ◽  
Glucose Levels

Abstract Background We aimed to investigate the association of breastfeeding on postpartum glucose levels and lipid profiles in women diagnosed with gestational diabetes mellitus (GDM) and women without GDM. Methods We performed a secondary analysis of a cohort study of 243 women, 159 women with GDM and 84 normally glucose tolerant women between 2012 and 2017. At approximately 6–10 weeks postpartum, we measured fasting blood glucose and plasma lipid levels. Breastfeeding behaviour was self-defined as exclusive breastfeeding or not exclusive breastfeeding. Results The mean (SD) glucose in the group of women who breastfed exclusively was 4.6 (0.49) mmol/L, compared to 4.9 (0.58) mmol/L (95% CI 0.45, 0.15, p <  0.001) among women who did not exclusively breastfeed. Among women with GDM, the reduction in fasting glucose in women who were breastfeeding was 0.22 mmol/L (95% CI 0.39, 0.05, p = 0.004), and in women who were not GDM, the reduction was 0.14 mmol/L (95% CI 0.37, 0.09, p = 0.24,). After adjustment for GDM status in pregnancy, maternal body mass index (BMI), maternal age and ethnicity, and exclusive breastfeeding was associated with a decreased fasting glucose of 0.19 (95% CI 0.318, 0.061, p = 0.004). After similar adjustment, there was no significant difference in triglycerides, high density lipoprotein cholesterol or low-density lipoprotein cholesterol between women who were breastfeeding and women who were not breastfeeding. Conclusions Breastfeeding is associated with a reduction in fasting glucose levels postpartum, but not maternal lipid profile. Breastfeeding may play a role in reducing glucose intolerance in women who have had GDM.

scholarly journals Vanadium Exposure in Early Pregnancy and Increased Risk of Gestational Diabetes Mellitus

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 727-727
Author(s):  
Xiyu Cao ◽  
Lixia Lin ◽  
Meng Wu ◽  
Daxiang Xiao ◽  
Menghan Tu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipid Profiles ◽  
Dietary Factors ◽  
Lipoprotein Cholesterol

Abstract Objectives To investigate the association between blood vanadium (V) concentrations in early pregnancy and blood lipid profiles and their implications on gestational diabetes mellitus (GDM). Methods We performed a prospective study of 2416 pregnant women from the Tongji Maternal and Child Health Cohort (TMCHC). Demographic characteristics and dietary intake were obtained by questionnaire, and an oral glucose tolerance test (OGTT) was conducted at 24–28 gestational weeks to diagnose GDM. V concentrations and lipid levels were determined by analysis of blood samples, which were collected before 20 gestational weeks, with the use of inductively coupled plasma mass spectrometry (ICP-MS) and commercial assay kits. Multiple linear regression and Logistic regression were used in our analysis. Results The median (inter quartile range) value of V concentrations of all pregnant women was 0.19 (0.24, 0.32) μg/L. After adjusting for demographic and dietary factors, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC) were correlated positively with blood concentrations of V (p for trend = 0.002 for LDL-C, p for trend = 0.006 for TG and p for trend = 0.003 for TC) while there was a significant negative correlation between high-density lipoprotein cholesterol (HDL-C) and V concentrations (p for trend &lt; 0.001). In addition, V concentrations were significantly higher in women with GDM than those without GDM (median value: 0.26μg/L vs. 0.24μg/L, p &lt; 0.001). After adjustment for potential confounders, for each one natural logarithmic unit increase in V concentrations, there was 42% [adjusted odds ratio (OR) = 1.42; 95% confidence interval (CI): 1.14, 1.77] increase in the risk of GDM. Women in the highest quartile for V had a 2.24-fold (95% CI: 1.43, 3.52) higher risk of GDM compared with women in the lowest quartile (p for trend = 0.002). Conclusions To our knowledge, this is the first research of associations between blood V levels during pregnancy and blood lipid profiles or GDM. Our study suggests that pregnant women with higher V exposure levels may have higher risks of dyslipidemia and GDM, either evaluated with or without adjustment of demographic information, dietary factors or other common trace elements’ concentrations. Funding Sources Received from the National Program on Basic Research Project of China (NO.2013FY114200) for Nianhong Yang.

scholarly journals Blastocyst Transfer: A risk Factor for Gestational Diabetes Mellitus in Women undergoing in vitro Fertilization

2021 ◽  
Author(s):  
Huijun Chen ◽  
Jian Li ◽  
Sufen Cai ◽  
Sha Tang ◽  
Suimin Zeng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
High Density Lipoprotein ◽  
Embryo Transfer ◽  
Density Lipoprotein ◽  
Blastocyst Transfer ◽  
Day 3 Embryo

Abstract Background The risk of developing gestational diabetes mellitus (GDM) is higher in women undergoing assisted reproductive treatment than in women conceiving spontaneously. Objectives To determine whether the GDM risk after day-3 embryo transfer differs from the GDM risk after day-5 blastocyst transfer. Methods Prospective observational study in women becoming pregnant after first fresh embryo or blastocyst transfer. Results 1579 women got pregnant and had life birth. 1300 women got day three embryo transfer only, whereas 279 women received at least one blastocyst. 252 out of the 1579 women developed GDM. Age, body mass index, baseline estradiol, baseline high-density lipoprotein, and progesterone on the day of hCG injection were not different in women receiving day three embryos only versus women receiving at least one blastocyst. The number and quality of retrieved oocytes were not different in women receiving day 3 embryo transfer (ET) from those receiving blastocysts. Our study confirmed already established GDM risk factors such as age and body mass index, baseline estradiol and high-density lipoprotein, as well as progesterone after ovarian stimulation. We could furthermore demonstrate that the GDM incidence in women receiving day five blastocyst transfer was significantly higher than those who received day three embryo transfer (21.15% vs. 14.85%, P=.009). Considering confounding factors, we likewise saw that blastocyst transfer was an independent procedure-related GDM risk factor (P = 0.009, Exp (B): 1.56, 95% CI: 1.12-2.18). Conclusion Blastocyst transfer after IVF/ICSI increases the risk of developing GDM.

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