scholarly journals Delta Procalcitonin Is a Better Indicator of Infection Than Absolute Procalcitonin Values in Critically Ill Patients: A Prospective Observational Study

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Domonkos Trásy ◽  
Krisztián Tánczos ◽  
Márton Németh ◽  
Péter Hankovszky ◽  
András Lovas ◽  
...  
Keyword(s):  
Intensive Care ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Area Under The Curve ◽  
Absolute Value ◽  
Intensive Care Patients ◽  
Reactive Protein ◽  
Post Hoc ◽  
Microbiological Data ◽  
New Onset

Purpose. To investigate whether absolute value of procalcitonin (PCT) or the change (delta-PCT) is better indicator of infection in intensive care patients.Materials and Methods.Post hocanalysis of a prospective observational study. Patients with suspected new-onset infection were included in whom PCT, C-reactive protein (CRP), temperature, and leukocyte (WBC) values were measured on inclusion (t0) and data were also available from the previous day (t-1). Based on clinical and microbiological data, patients were groupedpost hocinto infection- (I-) and noninfection- (NI-) groups.Results. Of the 114 patients, 85 (75%) had proven infection. PCT levels were similar att-1: I-group (median [interquartile range]): 1.04 [0.40–3.57] versus NI-group: 0.53 [0.16–1.68],p=0.444. Byt0PCT levels were significantly higher in the I-group: 4.62 [1.91–12.62] versus 1.12 [0.30–1.66],p=0.018. The area under the curve to predict infection for absolute values of PCT was 0.64 [95% CI = 0.52–0.76],p=0.022; for percentage change: 0.77 [0.66–0.87],p<0.001; and for delta-PCT: 0.85 [0.78–0.92],p<0.001. The optimal cut-off value for delta-PCT to indicate infection was 0.76 ng/mL (sensitivity 80 [70–88]%, specificity 86 [68-96]%). Neither absolute values nor changes in CRP, temperature, or WBC could predict infection.Conclusions. Our results suggest that delta-PCT values are superior to absolute values in indicating infection in intensive care patients. This trial is registered with ClinicalTrials.gov identifier:NCT02311816.

scholarly journals A Prospective Observational Study of the Change in Systemic Ionised Calcium following 4% Citrate Locking of Venous Haemodialysis Catheters in Intensive Care Patients

2018 ◽  
Vol 46 (4) ◽  
pp. 381-385
Author(s):  
S. Shewdin ◽  
Y. C. Bong ◽  
S. Okano ◽  
M. D. Chatfield ◽  
J. Walsham
Keyword(s):  
Intensive Care ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Clinical Signs ◽  
Dialysis Catheter ◽  
Citrate Solution ◽  
Arterial Blood Gas ◽  
Intensive Care Patients ◽  
Arterial Blood ◽  
Ionised Calcium

Traditionally heparin has been the anticoagulant of choice for venous dialysis catheter locking. There is systemic leakage of heparin catheter locking solutions at the time of injection. Alternative agents, such as citrate, are increasingly being used. We are not aware of any data in the critical care literature on the effect of citrate locking of venous dialysis catheters on systemic ionised calcium (iCa2+). To assess the effect of 4% citrate locking of venous dialysis catheters on systemic iCa2+ in intensive care patients we performed a prospective observational study of 50 paired samples in 26 intensive care patients receiving 4% citrate dialysis catheter locking in an adult tertiary intensive care unit between May 2016 and December 2016. Arterial blood gas (ABG) analysis was performed prior to venous dialysis catheter locking and a baseline iCa2+ result obtained. The catheter was locked with 4% citrate solution. A further ABG was sampled between 30 and 120 seconds later and the iCa2+ results were compared. Patients were observed for clinical signs of hypocalcaemia. On average, there was little difference between the pre- and post-catheter locking iCa2+ (median pre-locking iCa2+ 1.19 mmol/l, mean change of +0.004 mmol/l, 95% confidence interval [CI] −0.004 to 0.013, P=0.34). There was no evidence this difference differed by length of catheter (P=0.26) or site of catheter (P=0.85) insertion, but there was some evidence that this differed by receipt of citrate dialysis circuit anticoagulation (P=0.013). Patients who received citrate dialysis circuit anticoagulation had an increase in catheter locking iCa2+ by 0.017 mmol/l (95% CI 0.005 to 0.028). Locking of venous dialysis catheters with 4% citrate solution has no clinically significant effect on systemic iCa2+ in intensive care patients with indwelling venous dialysis catheters.

Do Sedation and Neuromuscular Blockade Influence the Outcome of Adult Intensive Care Patients? A Prospective Observational Study

2014 ◽  
Vol 15 (2) ◽  
pp. 122-126
Author(s):  
Pavani Jagan ◽  
Seetharaman Hariharan ◽  
Deryk Chen ◽  
Areti Y Kumar
Keyword(s):  
Intensive Care ◽  
Observational Study ◽  
Neuromuscular Blockade ◽  
Prospective Observational Study ◽  
Intensive Care Patients

Significance of new-onset prolonged sinus tachycardia in a medical intensive care unit: a prospective observational study

2011 ◽  
Vol 26 (5) ◽  
pp. 534.e1-534.e8 ◽  
Author(s):  
Sunghoon Park ◽  
Dong-Gyu Kim ◽  
Gee Young Suh ◽  
Woo Jung Park ◽  
Seung Hun Jang ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Sinus Tachycardia ◽  
Medical Intensive Care Unit ◽  
Medical Intensive Care ◽  
New Onset

High-dosage continuous amiodarone therapy to treat new-onset supraventricular tachyarrhythmias in surgical intensive care patients: an observational study

2004 ◽  
Vol 116 (9-10) ◽  
pp. 310-317 ◽  
Author(s):  
Andreas J. Mayr ◽  
Martin W. Dünser ◽  
Nicole Ritsch ◽  
Werner Pajk ◽  
Barbara Friesenecker ◽  
...  
Keyword(s):  
Intensive Care ◽  
Observational Study ◽  
Amiodarone Therapy ◽  
Surgical Intensive Care ◽  
Intensive Care Patients ◽  
Supraventricular Tachyarrhythmias ◽  
New Onset

scholarly journals C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study

2010 ◽  
Vol 105 (3) ◽  
pp. 318-325 ◽  
Author(s):  
N Al-Subaie ◽  
T Reynolds ◽  
A Myers ◽  
R Sunderland ◽  
A Rhodes ◽  
...  
Keyword(s):  
Intensive Care ◽  
Observational Study ◽  
Prospective Observational Study ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Central venous catheter-related thrombosis in intensive care patients - incidence and risk factors: A prospective observational study

2017 ◽  
Vol 161 (4) ◽  
pp. 369-373 ◽  
Author(s):  
Ondrej Hrdy ◽  
Eva Strazevska ◽  
Petr Suk ◽  
Robert Vach ◽  
Radim Karlik ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Central Venous Catheter ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Venous Catheter ◽  
Central Venous ◽  
Intensive Care Patients ◽  
Catheter Related Thrombosis

Prevalence and clinical implications of anti-PF4/heparin antibodies in intensive care patients: a prospective observational study

2014 ◽  
Vol 39 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Sixten Selleng ◽  
Kathleen Selleng ◽  
Sigrun Friesecke ◽  
Matthias Gründling ◽  
Sven-Olaf Kuhn ◽  
...  
Keyword(s):  
Intensive Care ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Clinical Implications ◽  
Intensive Care Patients
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