scholarly journals Prevalence of Osteoporosis and Its Risk Factors in Men with COPD in Qazvin

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Mahnaz Abbasi ◽  
Mohammadali Zohal ◽  
Banafsheh Atapour ◽  
Zohreh Yazdi
Keyword(s):  
Risk Factors ◽  
Bone Mineral ◽  
Systemic Adverse Effect ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Bone Mineral Densitometry ◽  
Proper Diagnosis ◽  
Prevalence Of Osteoporosis

Introduction. Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Proper diagnosis of osteoporosis as a systemic adverse effect of COPD is of significant importance. The present study aimed at evaluating the prevalence of osteoporosis and its risk factors in men suffering from COPD in Qazvin (2014).Methods. This descriptive-analytical study was conducted on 90 patients with COPD using random sampling. Anthropometric data and results from physical examination were collected. Pulmonary function test and bone mineral densitometry were done for all participants as well.Results.The prevalence of osteopenia and osteoporosis in COPD patients was 31.5 and 52.8 percent, respectively. Bone mineral density (BMD) at the femoral neck was associated significantly with body mass index (BMI), increased severity of COPD, and use of oral corticosteroid (P<0.05).Conclusion.The results showed that patients’ BMI and severity of COPD are two valuable risk factors for osteoporosis screening in COPD patients.

scholarly journals Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Lidwien Graat-Verboom ◽  
Martijn A. Spruit ◽  
Ben E. E. M. van den Borne ◽  
Frank W. J. M. Smeenk ◽  
Emiel F. M. Wouters
Keyword(s):  
Lumbar Spine ◽  
Patient Characteristics ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
Dxa Scan ◽  
Diagnosis Of Osteoporosis ◽  
Copd Patients ◽  
Prevalence Of Osteoporosis

Background. Osteoporosis is an extrapulmonary effect of chronic obstructive pulmonary disease (COPD). Diagnosis of osteoporosis is based on BMD measured by DXA-scan. The best location for BMD measurement in COPD has not been determined. Aim of this study was to assess whole-body BMD and BMD of the hip and lumbar spine (local DXA) in COPD patients and compare the prevalence of osteoporosis at these locations.Methods. Whole body as well as local DXA-scan were made in 168 COPD patients entering pulmonary rehabilitation. Patient-relevant characteristics were assessed. Prevalence of osteoporosis was determined. Characteristics of patients without osteoporosis were compared to patients with osteoporosis on local DXA.Results. A higher prevalence of osteoporosis was found using local DXA compared to whole-body DXA (39% versus 21%). One quarter of patients without osteoporosis on whole body-DXA did have osteoporosis on local DXA. Significant differences in patient characteristics between patients without osteoporosis based on both DXA measurements and patients with osteoporosis based on local DXA only were found.Conclusions. DXA of the hip and lumbar spine should be made to assess bone mineral density in COPD patients. The lowest T-score of these locations should be used to diagnose osteoporosis.

scholarly journals Assessment of Bone Mineral Density in Male Patients with Chronic Obstructive Pulmonary Disease by DXA and Quantitative Computed Tomography

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
George Fountoulis ◽  
Theodora Kerenidi ◽  
Constantinos Kokkinis ◽  
Panagiotis Georgoulias ◽  
Paschal Thriskos ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Chronic Obstructive Pulmonary Disease ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
Male Patients ◽  
Prevalence Of Osteoporosis

The purpose of this study is to identify the prevalence of osteoporosis in male patients with chronic obstructive pulmonary disease (COPD) by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) and to compare the diagnostic abilities of the above methods. Thirty-seven male patients with established COPD were examined with DXA and standard QCT in lumbar spine, including L1, L2, and L3 vertebrae.T-scores and bone mineral density values were calculated by DXA and QCT method, respectively. Comparative assessment of the findings was performed and statistical analysis was applied. QCT measurements found more COPD patients with impaired bone mineral density compared to DXA, namely, 13 (35.1%) versus 12 (32.4%) patients with osteopenia and 16 (43.2%) versus 9 (16.2%) patients with osteoporosis (p=0.04). More vertebrae were found with osteoporosis by QCT compared to DXA (p=0.03). The prevalence of osteoporosis among male patients with COPD is increased and DXA may underestimate this risk. QCT measurements have an improved discriminating ability to identify low BMD compared to DXA measurements because QCT is able to overcome diagnostic pitfalls including aortic calcifications and degenerative spinal osteophytes.

scholarly journals Osteoporosis in Chronic Obstructive Pulmonary Disease: More than just a Comorbidity

2020 ◽  
Vol 07 (03) ◽  
pp. 7-21
Author(s):  
Mradul Kumar Daga ◽  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Pulmonary Disease ◽  
Bone Mineral ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Life Years

Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of mortality and loss of Disability-Adjusted Life-Years (DALYs) worldwide. It often is accompanied by the presence of various systemic comorbidities including osteoporosis which may have an impact on the course of the disease. Osteopenia and osteoporosis are the consequences of loss of Bone Mineral Density (BMD) and have been widely known major comorbidities in COPD patients. Female sex, age, and smoking are common pathogenic factors for both COPD and osteoporosis, other factors such as reduced daily physical activity, malnutrition, low body mass index, hypogonadism, vitamin D deficiency, chronic renal insufficiency, chronic hypoxemia, and drugs like corticosteroids, have been invoked to explain such a frequent association between them. Osteoporosis in COPD is however often undertreated. It has been shown in recent studies that both decreased Bone Mineral Density (BMD) and impaired bone quality contribute to bone fragility, causing fractures in COPD patients. Pulmonary function and activities of the daily life of COPD patients may be further deteriorated by osteoporosis-associated fractures. Calcium and vitamin D, hormone replacement when indicated, calcitonin, and bisphosphonate administration are few effective strategies to tackle bone loss and osteoporosis. Awareness about this high prevalence of osteoporosis in COPD patients is critically important and physicians should look for such fracture risks. Routine screening and early diagnosis of osteoporosis will enable physicians to provide the appropriate treatment to prevent fracture, which leads to improved quality of life as well as better long-term prognosis.

Relationship Between Bone Mineral Density and Syndrome Types Described in Traditional Chinese Medicine in Chronic Obstructive Pulmonary Disease: A Preliminary Clinical Observation

2005 ◽  
Vol 33 (06) ◽  
pp. 867-877 ◽  
Author(s):  
Gang Wang ◽  
Ting-Qian Li ◽  
Bing Mao ◽  
Lei Wang ◽  
Lin Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Obstructive Pulmonary Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Bone Mineral ◽  
Healthy Subjects ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Osteoporosis is a common finding following chronic obstructive pulmonary disease (COPD), but there are few reports on the relationship between bone mineral density (BMD) and the syndrome types described in traditional Chinese medicine (TCM) in patients with COPD. A cross-sectional medical survey was used in this study. Twenty-six male patients with COPD and 26 age-matched male healthy subjects were recruited. The symptom questionnaire survey of TCM was implemented, and thereafter the COPD patients were divided into two subgroups: type of deficiency of the lung and spleen (TDLS) and type of deficiency of the lung, spleen and kidney (TDLSK). BMD of lumbar spine (L2-4), non-dominant femoral neck (Neck), Ward's triangle (Ward's), and great trochanter (Troch) were measured by dual-energy x-ray absorptiometry. In addition, the other bone turnover markers were also examined. The results showed that BMD was much more decreased in TDLSK than that in TDLS patients ( p < 0.05), and BMD in the patients of the TDLS subgroup without symptoms of kidney-vacuity has showed the decreased trend from healthy subjects to TDLS patients. Furthermore, there was a higher incidence of osteoporosis in patients with TDLSK compared with that in TDLS ( p < 0.05, OR > 2.0). Therefore, the data suggest that: (1) BMD might be a marker more sensitive than the symptom for the diagnosis of kidney-vacuity in COPD patients; (2) the deficiency of kidney would be the key factor of bone mineral loss; and (3) that invigorating the kidney should be performed in the phase of TDLS in COPD patients in advance.

scholarly journals Cortical bone dynamics, strength, and densitometry after induction of emphysema in hamsters

2003 ◽  
Vol 95 (2) ◽  
pp. 631-634 ◽  
Author(s):  
Jill E. Shea ◽  
Scott C. Miller ◽  
David C. Poole ◽  
John P. Mattson
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Bone Formation ◽  
Cortical Bone ◽  
Pulmonary Disease ◽  
Bone Mineral ◽  
Bone Structure ◽  
Chronic Obstructive ◽  
Pathophysiological Mechanism ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease

Recent evidence suggests that patients suffering from chronic obstructive pulmonary disease are also at an increased risk of developing osteoporosis. The pathophysiological mechanism(s) linking these progressive diseases is unknown. The goal of this investigation was to determine whether there were alterations in bone mineral density and content, cortical bone structure and strength, and indexes of bone formation and resorption in the elastase-induced emphysematous hamster. At 3 wk after induction of emphysema, the femoral bone mineral content was 8% less ( P = 0.026) and the femoral fracture strength was 6% less ( P = 0.032) in the emphysematous hamster than in controls. The cortical area was 8.4% less ( P = 0.013) and the periosteal mineral appositional rate was 27% less ( P = 0.05) than in controls. Additionally, the endocortical eroded surface in the emphysematous group was about twice that in the control group ( P = 0.003). Differences in some indexes of bone formation and resorption, paralleled by differences in bone structure and strength, were observed 3 wk after induction of emphysema. These differences in skeletal metabolism and strength may help explain some of the skeletal changes associated with chronic obstructive pulmonary disease in humans.

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