scholarly journals Retinal Fibre Layer Thickness Measurement in Normal Paediatric Population in Sweden Using Optical Coherence Tomography

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Marcelo Ayala ◽  
Evangelia Ntoula
Keyword(s):  
Optical Coherence Tomography ◽  
Paediatric Population ◽  
Thickness Measurement ◽  
Healthy Children ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
The Mean ◽  
Refraction Error

Purpose. To evaluate the correlation between peripapillary retinal nerve fibre layer (RNFL) thickness and both age and refraction error in healthy children using optical coherence tomography (OCT). Patients and Methods. 80 healthy children with a mean age of 9.1 years (range 3.8 to 16.7 years) undergoing routine ocular examination at the orthoptic section of the Ophthalmology Department were recruited for this cross-sectional study. After applying cycloplegia, the peripapillary RNFL thickness was measured in both eyes using the Topcon 3D OCT 2000 device. Results. 138 eyes were included in the analysis. The average refractive error (SE) was +1.7 D (range −5.25 to +7.25 D). The mean total RNFL thickness was 105 μm ± 10.3, the mean superior RNFL thickness was 112.7 μm ± 16.5, and the mean inferior RNFL thickness was 132.6 μm ± 18.3. We found no statistically significant effect of age on RNFL thickness (ANOVA, f=0.33, p=0.56). Refraction was proven to have a statistically significant effect (ANOVA, f=67.1, p<0.05) in RNFL measurements. Conclusions. Data obtained from this study may assist in establishing a normative database for a paediatric population. Refraction error should be taken into consideration due to its statistically significant correlation with RNFL thickness.

The volume of peripapillary vessels within the retinal nerve fibre layer: an optical coherence tomography angiography study of normal subjects

2017 ◽  
Vol 102 (5) ◽  
pp. 611-621 ◽  
Author(s):  
Davide Allegrini ◽  
Giovanni Montesano ◽  
Paolo Fogagnolo ◽  
Alfredo Pece ◽  
Roberta Riva ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fibre ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Tissue ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
The Mean ◽  
Nerve Fibre Layer

Background/aimsTo investigate the contribution of vascular volume calculated by optical coherence tomography angiography (OCTA) to the measurement of peripapillary retinal nerve fibre layer (RNFL) thickness.MethodsWe used OCTA scans to build volumetric maps of the RNFL angiograms by thresholding the decorrelation images and summing the number of white pixels along the z-axis at each location. We used these maps to calculate the contribution of the vascular tissue to the RNFL thickness.ResultsWe analysed 51 eyes from 36 subjects. The mean RNFL volume calculated on the peripapillary region was 0.607±0.045 mm3 and the mean vessel volume was 0.217±0.035 mm3, with a mean vessel/total RNFL ratio of 35.627%±3.942%. When evaluated in the peripapillary circular section, the total contribution of the vascular tissue to the global RNFL thickness was 29.071%±3.945%. The superior and inferior sectors showed the highest percentage of vascular tissue within the RNFL circular profile (31.369% and 34.788% respectively).ConclusionsWe found that the vascular contribution to the RNFL thickness is 29.07±3.945%. This is much higher than what has been reported from calculations made on the structural OCT alone (13% reported by Hood et al and 11.3%±1.6% for the Cirrus OCT and 11.8%±1.4% for the Spectralis OCT reported by Patel et al). We conclude that evaluation of the vascular tissue contribution to the RNFL thickness with OCTA might be useful when performing precise quantification of the neuronal tissue.

scholarly journals Functional Monitoring after Trabeculectomy or XEN Microstent Implantation Using Spectral Domain Optical Coherence Tomography and Visual Field Indices—A Retrospective Comparative Cohort Study

Biology ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 273
Author(s):  
Marc Schargus ◽  
Catharina Busch ◽  
Matus Rehak ◽  
Jie Meng ◽  
Manuela Schmidt ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cohort Study ◽  
Visual Field ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Treatment Groups ◽  
Rnfl Thickness ◽  
Comparative Cohort Study ◽  
The Mean ◽  
All Treatment

The aim of this study was to compare the efficacy of trabeculectomy (TE), single XEN microstent implantation (solo XEN) or combined XEN implantation and cataract surgery (combined XEN) in primary open-angle glaucoma cases, naïve to prior surgical treatment, using a monocentric retrospective comparative cohort study. Intraocular pressure (IOP) and the number of IOP-lowering drugs (Meds) were monitored during the first 24 months after surgery. Further disease progression was monitored using peripapillary retinal nerve fiber layer (RNFL) thickness examinations using spectral domain optical coherence tomography (OCT) as well as visual acuity (VA) and visual field (VF) tests. In the TE group (52 eyes), the mean IOP decreased from 24.9 ± 5.9 to 13.9 ± 4.2 mmHg (p < 0.001) and Meds decreased from 3.2 ± 1.2 to 0.5 ± 1.1 (p < 0.001). In the solo XEN (38 eyes) and the combined XEN groups, the mean IOP decreased from 24.1 ± 4.7 to 15.7 ± 3.0 mmHg (p < 0.001) and 25.4 ± 5.6 to 14.7 ± 3.2 mmHg (p < 0.001), while Meds decreased from 3.3 ± 0.8 to 0.8 ± 1.2 (p < 0.001) and 2.7 ± 1.2 to 0.4 ± 1.0 (p < 0.001), respectively. The VF and VA indices showed no sign of further deterioration, the RNFL thickness further decreased in all treatment groups after surgery. TE and XEN led to comparable reductions in IOP and Meds. Although the VA and VF indices remained unaltered, the RNFL thickness continuously decreased in all treatment groups during the 24-month follow-up.

Anterior chamber particles are associated with reduction of intraocular pressure after selective laser trabeculoplasty

2020 ◽  
pp. bjophthalmol-2019-315445
Author(s):  
Alexei N Kulikov ◽  
Dmitrii S Maltsev ◽  
Alina A Kazak ◽  
Maria A Burnasheva
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Selective Laser Trabeculoplasty ◽  
Cross Sectional ◽  
Laser Trabeculoplasty ◽  
The Mean

PurposeTo study the correlation between intraocular pressure (IOP) reduction and the number of hyper-reflective particles appearing in the anterior chamber following selective laser trabeculoplasty (SLT).Material and methodsIn this prospective interventional study, we included primary open-angle glaucoma patients. All participants received a standardised SLT session, which consisted of 100 pulses of 0.9 mJ over 360°. Anterior segment optical coherence tomography (4×4 mm volume scan, 101 horizontal cross-sectional scans) and applanation tonometry were performed before SLT and 15 min, 1 day, 1 week, 1 month and 3 months after. Particles were counted on cross-sectional scans using a standardised algorithm.ResultsIn this study, we included 25 patients (25 eyes), 14 males and 11 females, with a mean age of 68.9±10.5 and baseline IOP of 21.4±4.5 mm Hg. IOP at month 1 and month 3 after SLT was 18.0±4.0 and 17.4±3.3 mm Hg, respectively. The mean number of anterior chamber particles before and 15 min after SLT was 0.62±0.2 and 7.1±2.0 particles/mm2, respectively (p=0.036). There was a statistically significant correlation between the mean number of anterior chamber particles 15 min after SLT and IOP reduction at 1 month (r=0.62, p=0.03) and 3 months (r=0.71, p=0.01).ConclusionThe number of the anterior chamber particles graded using anterior segment optical coherence tomography after the procedure correlates with the IOP-lowering effect of SLT.

scholarly journals Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Timm Oberwahrenbrock ◽  
Sven Schippling ◽  
Marius Ringelstein ◽  
Falko Kaufhold ◽  
Hanna Zimmermann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Large Scale ◽  
Retinal Nerve Fibre Layer ◽  
Spectral Domain ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Spectral Domain Oct ◽  
Rnfl Thickness

Background.Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes.Objective.To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology.Methods.In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination.Results.Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (P<0.001for all subtypes). RNFL thickness was lower in secondary progressive MS (SPMS) eyes compared to relapsing-remitting MS (RRMS) eyes (P=0.007), and TMV was reduced in SPMS and primary progressive MS (PPMS) eyes compared to RRMS eyes (SPMS:P=0.039, PPMS:P=0.005). Independent of the subtype a more pronounced RNFL thinning and TMV reduction were found in eyes with a previous optic neuritis compared to unaffected eyes.Conclusion.Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings. Furthermore it carves out distinct patterns in different MS subtypes.

scholarly journals A Normative Database of A-Scan Data Using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography Machine

2021 ◽  
Author(s):  
Joos Meyer ◽  
Roshan Karri ◽  
Helen Danesh-Meyer ◽  
Kate Drummond ◽  
Andrew Symons
Keyword(s):  
Optical Coherence Tomography ◽  
Reference Values ◽  
Age Groups ◽  
Plexiform Layer ◽  
Retinal Nerve Fibre Layer ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Normative Database ◽  
The Mean

AbstractPurposeDevelop the first normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine.MethodsThis study is a retrospective cross sectional analysis of macular and circumpapillary OCT scans of healthy individuals. All participants had a full ophthalmic examination, including best corrected visual acuity, intraocular pressure, biomicroscopy, posterior segment examination and OCT scan. The volume and thickness of each of the nine Early Treatment Diabetic Retinopathy zones at the macula were analysed for the total retinal thickness, retinal nerve fibre layer (RNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL). The thickness of the circumpapillary RNFL was analysed at the disc. De-identified A-scans were extracted from the OCT machine as separate tab-separated text file and made available according to the data sharing statement.ResultsTwo-hundred eyes from 144 participants were included of which 98 (49%) were female. The mean age (SD) was 48.52 (17.52). Participants were evenly distributed across four age groups and represented nine broad ethnic groups in proportions comparable to the local distribution. All the macular scans were 20° x 20° (5.9 mm x 5.9 mm), with a total scan density between 12,800 and 49,152 A-scans. The peripapillary scans were all 12° (3.5 mm), at a scan density of 768 A-scans. The mean retinal, GCL and IPL volumes were significantly greater in males than females. Age and total retinal volume (r = –0.2561), GCL volume (– 0.2911) and IPL volume (–0.3194) were negatively correlated. No significant correlation was found between the RNFL and age.ConclusionThis study provides a normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine.

scholarly journals COMPARISON OF RETINAL NERVE FIBER LAYER THICKNESS BETWEEN EMMETROPES AND HIGH MYOPES

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Neha Yadav
Keyword(s):  
High Myopia ◽  
Thickness Measurement ◽  
Mean Value ◽  
Analysis Of Covariance ◽  
Field Analysis ◽  
P Value ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Rnfl Thickness ◽  
The Mean

Background: The present study aims to compare RNFL thickness of high myopes of > - 6D and compare with emmetropic patients, so as to interpret and distinguish the physiological changes of high myopia from accompanying diseases in such individuals. Methods: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction and visual field analysis. Optical coherence tomography was used for RFNL thickness measurement. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance. Results: The mean value of average RNFL thickness in both groups was found to be 85.40 in group 1 and 99.34 in group 2. P value was 0.0001, showing that there was significant statistical difference between both the groups and average RNFL thickness was thinner in myopic group. Conclusion: RNFL was found to be significantly thin in high myopia. Keywords: RNFL thickness, Myopia, Emmetropes

scholarly journals Prevalence of Glaucoma among High Myopia

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
O M Abdelfatah ◽  
O A Salem ◽  
A I Elawamry ◽  
Y A Elzanklony
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
High Myopia ◽  
Cross Sectional Study ◽  
Automated Perimetry ◽  
Optical Coherence ◽  
Spherical Equivalent ◽  
Sectional Study ◽  
Cross Sectional ◽  
Rnfl Thickness

Abstract Background Glaucoma is an optic neuropathy that is characterized by the selective loss of retinal ganglion cells and their axons, which manifests as the loss of the retinal nerve fiber layer (RNFL). Numerous studies have shown that the extent of RNFL damage correlates with the severity of functional deficit in the visual field (VF), and that RNFL measurement by optical coherence tomography (OCT) has good sensitivity for the detection of glaucoma. Purpose To assess the prevalence of glaucoma among high myopic patients and the association between them using standard automated perimetry (SAP) and optical coherence tomography (OCT). Patients and Methods A prospective observational randomized cross sectional study included a total of 80 eyes with high myopia, in the period from November 2017 to April 2018. This cross sectional study included 44 subjects with 80 eyes regarding high myopia using the outpatient services of the Qlawoon Hospital, Cairo, who satisfied the inclusion and exclusion criteria between November 2017 and April 2018 aiming to determine the prevalence of glaucoma in high myopic patients. Results In our study, we depended on the following highly significant parameters in detection of prevalence of glaucoma among high myopic patients: Spherical equivalent median is -12, Vertical cup/disc ratio mean is 0.55, MD median of visual field is – 5.38, PSD mean of visual field is 3.53, GHT is 64.7% outside normal limits, 17.6% border line and 17.6% general reduction of sensitivity and RNFL thickness mean is; for average thickness is 86.37, for superior thickness is 90.06 and for inferior thickness is 82.68 a highly significant P-value. Conclusion Prevalence of glaucoma among our study group is 42.5% depending on Spherical equivalent median, Vertical cup/disc ratio mean, MD median of visual field, PSD mean of visual field, GHT and RNFL thickness.

Evaluation of choroidal thickness in children with acute asthma attack by optical coherence tomography

2021 ◽  
pp. 112067212110393
Author(s):  
Isil Kurultay ◽  
Ozlem Sancakli
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Post Treatment ◽  
Control Group ◽  
Healthy Children ◽  
Optical Coherence ◽  
Asthma Attack ◽  
Before And After ◽  
Children With Asthma ◽  
The Mean

Objective: To evaluate the change in central choroidal thickness in children with asthma attack before and after treatment with β2 agonists. Materials and methods: About 100 eyes of 50 patients (5–17 years old) with visual acuity of 20/20 who had no retinal, choroidal, and systemic comorbidity were examined by enhanced depth optical coherence tomography (EDI-OCT) before and after asthma attack treatment. Sixty eyes of 30 healthy children of similar age and gender were evaluated as the control group. The central choroidal thickness, peak expiratory flow (PEF), forced expiratory volume 1(FEV1), oxygen saturation, and heart rate were evaluated. Results: The mean age of the patients was 9.2 ± 3.1 years, and the mean saturation values of patients was 97.2 ± 1.3 before treatment, and it increased to 98.3 ± 0.9 after treatment with a statistically significant difference. The mean FEV1 values were 80.8 ± 15.2 before, and 92.7 ± 12.9 after the treatment and PEF values were 75.9 ± 18.6 before and 89.3 ± 18.9 after treatment. This differences were statistically significant ( p < 0.001). The average choroidal thickness before the treatment were 310.4 ± 34.2 μm and decreased to 302.7 ± 34.4 μm after the treatment, this decrease was statistically significant ( p < 0.001). The mean choroidal thickness of the control group was 303.0 ± 7.3 μm and compared to the pre-treatment and post-treatment values, it was more similar to the post-treatment values, although there was no statistically difference. Conclusion: In our study, it was shown that choroidal thickness was significantly reduced in children with asthma who received attack treatment with β2 agonists, and it was similar to the control group after the treatment.

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